• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.287-287
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• 2022

In this study, we analyze RNA-seq data from OxF3Hand WT at several points (Oh, 3 h, 12 h, and 24 h) after WBPH infection. A number of the genes were further validated by RT-qPCR. Results revealed that highest number of DEGs (4,735) between the two genotypes detected after 24 h of infection. Interestingly, many of the DEGs between the WT and OsF3H under control conditions were also found to be differentially expressed in OsF3H in response to WBPH infestation. These results indicate that significant differences in gene expression between the "OxF3H" and "WT" exist as the infection time increases. Many of these DEGs were related to oxidoreductase activity, response to stress, salicylic acid biosynthesis, metabolic process, defense response to pathogen, cellular response to toxic substance, and regulation of hormones level. Moreover, genes involved in salicylic acid (SA) and Ethylene (Et) biosynthesis were upregulated in OxF3H plants while jasmonic acid (JA), Brassinosteroid (Br), and abscisic acid (ABA) signaling pathways were found downregulated in OxF3H plant during WBPH infestation. Interestingly, many DEGs related to pathogenesis such as OsPR1, OsPR1b, NPR1, OsNPR3 and OsNPR5 were found significantly upregulated in OxF3H plants. Additionally, genes related to MAPKs pathway, and about 30 WRKY genes involved in different pathways were found upregulated in OxF3H plants after WBPH infestation. This suggests that overexpression of the OxF3H gene leads to multiple transcriptomic changes and impact plant hormones, pathogenic related and secondary metabolites related genes and enhancing the plant resistance to WBPH infestation.

• Korean Journal of Culture and Social Issue
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• v.16 no.1
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• pp.81-101
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• 2010

The purposes of this study were: (a) to examine the relationship between parental/occupational role reconstruction and psychological well-being in middle and old age, (b) to investigate the psychological factors to affect parental/occupational roles reconstruction. The role reconstruction was measured as the extent to obsess with parental and occupational role in transition. Mail survey was conducted on 378 Japanese married men and women in ages between 50 and 69. As results, the hypothetical pathway was identified in women as follows. The obsession with parental and occupational roles raised parental and occupational role loss anxiety. And both of role loss anxiety lower psychological well-being. For men, obsessed with the occupational role was significantly influenced by autonomy, gender role attitude, social support network. For women, gender role attitude significantly influenced on occupational and parental role obsession, and social support networks had significant impact on parental role obsession. Results of this study were discussed in terms of the importance of role reconstruction in middle and old age, gender difference in role reconstruction according to gender role socialization.

• Journal of The Korean Society of Agricultural Engineers
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• v.66 no.1
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• pp.49-66
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• 2024

Extreme rainfall will become intense due to climate change, increasing inundation risk to agricultural land. Hydrological and hydraulic simulations for the entire watershed were conducted to analyze the impact of climate change. Rainfall data was collected based on past weather observation and SSP (Shared Socio-economic Pathway)5-8.5 climate change scenarios. Simulation for flood volume, reservoir operation, river level, and inundation of agricultural land was conducted through K-HAS (KRC Hydraulics & Hydrology Analysis System) and HEC-RAS (Hydrologic Engineering Center - River Analysis System). Various scenarios were selected, encompassing different periods of rainfall data, including the observed period (1973-2022), near-term future (2021-2050), mid-term future (2051-2080), and long-term future (2081-2100), in addition to probabilistic precipitation events with return periods of 20 years and 100 years. The inundation area of the Aho-Buin district was visualized through GIS (Geographic Information System) based on the results of the flooding analysis. The probabilistic precipitation of climate change scenarios was calculated higher than that of past observations, which affected the increase in reservoir inflow, river level, inundation time, and inundation area. The inundation area and inundation time were higher in the 100-year frequency. Inundation risk was high in the order of long-term future, near-term future, mid-term future, and observed period. It was also shown that the Aho and Buin districts were vulnerable to inundation. These results are expected to be used as fundamental data for assessing the risk of flooding for agricultural land and downstream watersheds under climate change, guiding drainage improvement projects, and making flood risk maps.

• Journal of Microbiology and Biotechnology
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• v.34 no.4
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• pp.812-827
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• 2024

Phloroglucinol (PG) is one of the abundant isomeric benzenetriols in brown algae. Due to its polyphenolic structure, PG exhibits various biological activities. However, the impact of PG on anagen signaling and oxidative stress in human dermal papilla cells (HDPCs) is unknown. In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling. Various biochemical analyses revealed that PG upregulated β-Catenin signaling without affecting the expression of Wnt. In particular, PG elevated the phosphorylation of protein kinase B (AKT), leading to an increase in the inhibitory phosphorylation of glycogen synthase kinase 3 beta (GSK3β) at serine 9. Treatment with the selective phosphoinositide 3-kinase/AKT inhibitor, LY294002, restored the increased AKT/GSK3β/β-Catenin signaling and anagen-inductive proteins induced by PG. Moreover, conditioned medium from PG-treated HDPCs promoted the proliferation and migration of human epidermal keratinocytes via the AKT signaling pathway. Subsequently, we assessed the antioxidant activities of PG. PG ameliorated the elevated oxidative stress markers and improved the decreased anagen signaling in hydrogen peroxide (H₂O₂)-induced HDPCs. The senescence-associated β-galactosidase staining assay also demonstrated that the antioxidant abilities of PG effectively mitigated H₂O₂-induced senescence. Overall, these results indicate that PG potentially enhances anagen signaling and improves oxidative stress-induced cellular damage in HDPCs. Therefore, PG can be employed as a novel therapeutic component to ameliorate hair loss symptoms.

• Journal of the International Relations & Interdisciplinary Education
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• v.4 no.2
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• pp.63-76
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• 2024

Digital technology is progressively transforming rural education and offering unprecedented opportunities for advancement. This study aims to analyze the impact of digital technology on rural education, focusing on the usage of digital resources in Wencheng County, Zhejiang Province, as a case study. The primary objective of this research is to explore how the application of digital technology contributes to balanced educational development in rural areas and to identify the key challenges and issues that accompany such technological advancements. The study revealed several significant issues in Wencheng County's rural education system, including inefficient use of digital resources, inadequate digital skills among educators, and insufficient exploration of digital innovation. In particular, the redundant purchasing of digital educational resources and the inefficient utilization of these resources, coupled with the low adaptability of teachers to digital technologies, emerged as major concerns. The study proposes strategies to address these issues. Ultimately, it presents an optimized pathway for successfully implementing digitalization in rural education and offers policy insights that could be applied in other regions to achieve similar improvements.

• Journal of the Korea Society of Computer and Information
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• v.29 no.9
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• pp.217-224
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• 2024

This study aims to examine the mediating effects of national identity and social withdrawal in the relationship between parental support and life satisfaction among multicultural adolescents, and to explore ways to enhance the life satisfaction level of multicultural adolescents. To achieve this, the study utilized structural equation modeling (SEM) analysis on the 9th wave (2019) of panel data on multicultural adolescents to verify the mediating effects. The analysis results indicate that parental support has a direct impact on life satisfaction. Additionally, national identity and social withdrawal were found to have indirect mediating effects in the pathway between parental support and life satisfaction. Based on this, such analysis results suggest practical and policy implications for developing specialized programs for parents and youth, and for improving the life satisfaction levels of multicultural adolescents in external environments such as schools and communities.

• Nuclear Engineering and Technology
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• v.56 no.10
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• pp.4423-4436
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• 2024

The development and assessment of pharmaceutical dosage forms make considerable use of gamma-scintigraphy. Gamma scintigraphy is an imaging technique that is integrated with CT to assess and evaluate the targeting of drugs to various delivery sites, the impact of treatment, and the severity of the disease. A small number of radioisotopes were tagged with the delivery system and emitted radiation can be visualized by the gamma camera which forms a 2-D image displaying the tissue-specific distribution of radioactivity. The isotopes that are used widely include Technetium-99 m (99Tc), Iodine (131I), Fluorodeoxyglucose (18F-FDG), Fluoromisonidazole (18F-FMISO) and Gallium (Ga67), Indium (111In). This review mainly covers different applications of gamma scintigraphy for the assessment of drug targeting via different routes to different organs and their visualization by gamma scintigraphy. The review mainly focuses assessment of drug targeting in the tumor tissue, thyroid gland, brain, pulmonary pathway, skin deposition, detection of renal impairment as well as cardiac diseases, drug release from formulations, drug deposition in arthritis, drug retention in the scalp, and behavior of formulation when administered via intra-vaginal route. Various pre-clinical and clinical studies were included in the review that demonstrates the importance and future of gamma scintigraphy in sensing drug delivery.

• Journal of Environmental Impact Assessment
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• v.29 no.4
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• pp.286-297
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• 2020

This research studied human health risk assessment of PAHs (Polycyclic Aromatic Hydrocarbons) in road dust sediments collected from 6 sites in four different cities in Korea. PAHs are well known to be human carcinogens and toxic compounds that are commonly generated from incomplete combustion of fuels and energy products. Such compounds which is absorbed by atmospheric suspended dust can be emitted into air in gaseous form and often deposited on road dust sediments. The PAHs which is deposited on sediment particles can also be re-dispersed by vehicles or winds on the road surface. It can be harmful for humans when exposed via breathing, ingestion and dermal contact. This study examined human health risk assessment of PAHs in deposited road dust sediments. Results showed that the excess cancer risk estimates were above 1.0×10-6 at main traffic roads and resident area in Ulsan city. According to the result of deterministic risk assessment, dermal-contact was the major pathway, while the contribution of the risk from inhalation was less than 1%. The probabilistic risk assessment showed similar levels of cancer risk derived from the deterministic risk assessment. The result of sensitivity analysis reveal that exposure time is the most contributing factor (69%). Since the values of carcinogenic risk assessment were higher than 1.0 × 10^-6, further detailed monitoring and refined risk assessment for PAHs may be required to identify more reliable and potential cancer risks for those who live in the study locations in Ulsan city.

• Clean Technology
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• v.24 no.2
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• pp.146-153
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• 2018

The water footprint is an important component of the Single Market for Green Product initiative based on the EU's Roadmap to a Resource Efficient Europe. In July 2014, the EU has established the International Standard for Water Footprint (ISO 14046) and Korea has complied with the Korean Industrial Standard (KS I ISO 14046) in April 2015. If a certification system based on the international standard (ISO 14046) is introduced, developing countries such as India and Vietnam, which are not equipped with bases, can become a trade barriers in exporting, so Korea should establish a strategy to reverse them. On the other hand, water footprints are designed to take into account local environmental impacts when compared to similar footprints (eg, carbon footprint) using LCA, so that products manufactured and manufactured in Korea will have an impact on domestic waters Should be considered. Therefore, the method of the water footprint should conform to the standard for compatibility with other countries. In order to consider the domestic water condition, it is necessary to identify suitable indicator or factor for estimating water footprint on Korea. For this purpose, this study analyzed the water footprint estimation study conducted at domestic and foreign based on international standards and through the analysis of statistical data related to domestic water resources, we confirmed the applicability of the water footprint methodology in Korea.

• Journal of Korea Water Resources Association
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• v.46 no.6
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• pp.569-583
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• 2013

This study is to evaluate the future climate change impact on hydrological components in the Seolmacheon ($8.54km^2$) mixed forest catchment located in the northwest of South Korea using SWAT (Soil and Water Assessment Tool) model. To reduce the uncertainty, the model was spatially calibrated (2007~2008) and validated (2009~2010) using daily observed streamflow, evapotranspiration, and soil moisture data. Hydrological predicted values matched well with the observed values by showing coefficient of determination ($R^2$) from 0.74 to 0.91 for streamflow, from 0.56 to 0.71 for evapotranspiration, and from 0.45 to 0.71 for soil moisture. The HadGEM3-RA future weather data of Representative Concentration pathway (RCP) 4.5 and 8.5 scenarios of the IPCC (Intergovernmental Panel on Climate Change) AR5 (Assessment Report 5) were adopted for future assessment after bias correction of ground measured data. The future changes in annual temperature and precipitation showed an upward tendency from $0.9^{\circ}C$ to $4.2^{\circ}C$ and from 7.9% to 20.4% respectively. The future streamflow showed an increase from 0.6% to 15.7%, but runoff ratio showed a decrease from 3.8% to 5.4%. The future predicted evapotranspiration about precipitation increased from 4.1% to 6.8%, and the future soil moisture decreased from 4.3% to 5.5%.