• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.105-105
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• 2018

2017년 이상기후 보고서에 따르면, 지난해 장마기간(6월 24일~7월 29일) 동안 전국 평균 강수량은 291.7mm로 평년(356.1mm)의 81%에 그쳤고, 7월 전국 평균기온은 $26.4^{\circ}C$로 평년($24.5^{\circ}C$) 보다 $1.9^{\circ}C$ 높았으며, 폭염일수는 평년대비 1.5배 많았음을 보고했다. 이러한 극심한 기후변화는 유역환경에 영향을 미쳐 미래 수자원 계획과 관리에 어려움을 가중시킬 것으로 예상된다. 이에 본 연구에서는 금강유역($9,865km^2$)을 대상으로 SWAT(Soil and Water Assessment Tool)모형과 RCP(Representative Concentration Pathway) 기후변화 시나리오를 이용하여 극한 기후변화 사상에 따른 수문 수질 거동을 평가하고자 하였다. 유역의 물수지 분석을 위해 금강 유역을 표준단위유역으로 구분 하였고, 기상자료와 다목적댐 2개(대청댐, 용담댐)과 다기능 보 3개(공주보, 백제보, 세종보)의 운영 자료와 국가 수자원관리 종합 정보 시스템(WAMIS)에서 관측 및 관리하고 있는 수문, 기상 자료를 수집하였다. SWAT 모형의 신뢰성 있는 수문 및 수질 보정을 위해 금강 소유역 내 위치하는 다목적 댐 2개 및 다기능 보 3개의 실측 방류랑을 이용하여 댐 운영모의를 하였으며, 댐 운영 자료와 수질 자료를 이용하여 모형의 검정 및 보정(2000~2015)을 실시하였다. 미래 극한 기후변화 사상을 모의하기 위해 기후변화 시나리오는 APCC의 26개 CMIP5 GCM 자료 중 RCP 8.5 시나리오를 활용했으며, 극한 기후 시나리오 선정을 위해 STARDEX에서 제시한 강우관련 극한지수를 이용했다. 선정된 홍수 및 가뭄 시나리오에 대해 Historical기간(1976~2005)과 미래기간(2006~2099)을 설정하여 미래 극한 기후변화 사상에 따른 금강유역의 수문 및 수질의 거동을 평가하였다.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.24-24
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• 2018

최근 10년간 우리나라에 빈번하게 발생한 가뭄 가운데 2014년과 2015년에 발생한 가장 극심한 가뭄으로 금강유역은 평년의 84.4%의 강수량을 기록하였고, 특히 2015년 6월부터 9월까지의 강수량은 343.1 mm로 평년 대비 38.3% 수준에 머물렀다. 금강유역 내에 위치한 보령댐은 충남 서부지역 8개 시 군에 생활용수와 공업용수를 공급하고 있는 중요한 수원으로 현재 심각한 물 부족으로 저수율이 30%를 밑돌고 있어 대상지역의 현재 및 장래 물 부족 대책이 필요한 실정이다. 본 연구에서는 보령댐 유역($297.4km^2$)을 대상으로 SWAT(Soil and Water Assessment Tool) 모델과 GCM(General Circulation Model) 기후변화 시나리오를 활용하여 극한 기후변화 사상이 반영된 보령댐의 내한능력을 평가하고자 하였다. 유역의 물수지 분석을 위해 보령댐 유역을 대상으로 기상자료, 보령댐 운영자료를 수집하였으며. SWAT 모형의 신뢰성 있는 유출량 보정을 위해 보령댐의 실측 방류량을 이용하여 댐 운영모의를 고려하였고 유입량 및 방류량 자료를 활용하여 모형의 보정(2005~2009)과 검증(2010~2017)을 실시하였다. 기후변화에 따른 내 저수지 내한능력평가를 위해 APCC의 26개 CMIP5 GCM 자료 중 RCP(Representative Concentration Pathway) 4.5와 RCP 8.5 시나리오 특성을 분석하여 극한 기후 시나리오를 선정하여 Historical 기간(1980~2017)과 미래 기간(2000~2099)을 대상으로 극한 기후변화 사상에 따른 보령댐 유역의 내한능력을 평가하였다.

• Journal of Digital Convergence
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• v.17 no.11
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• pp.395-407
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• 2019

This study attempted to verify the structural model of the effects of stress, self-efficacy, and self-control on smartphone addiction in University students. The subjects of this study were 440 University students in G and P city. Results, First the most influential variables on smartphone addiction were self-control, followed by stress, and two variables explained explanation about smartphone addiction in 34%. Second, self-efficacy had a positive effect on self-control and stress had a negative effect. Both variables had an indirect effect on smartphone addiction through self-control. In groups less than 4 hours and above, there was a partial regulation effect because of differences between groups in the smartphone addiction pathway coefficients of stress and self-efficacy. Therefore, in order to reduce smartphone addiction, it is important to find ways to reduce stress and increase self-control and self-efficacy, and necessary to develop various programs and tailor educational interventions for each individual situation.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.1
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• pp.407-417
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• 2021

This study aims to establish the relationship between the Green Marketing Orientation (GMO) variables and the performance of Green Small and Medium Enterprises (GSMEs) across the building and energy sectors in Malaysia, using customer satisfaction as a means of performance measurement. The GMO variables examined include Greening the Process (GTP), Green Supply Chain Management (GSCM), Green Strategic Policy Initiatives (GSPI), Proactive Energy Conservation (PEC) and Green Promotion (GP). The items used to measure these variables were extracted from literature and adapted to the context of the variables based on feedback from Focus Group Discussions and Expert Opinion sessions. This study employs a survey sample of 300 respondents but only 238 completed questionnaires were returned. The results reveal that GTP, GSCM and PEC have a positive impact on Customer Satisfaction but not GSPI and GP. The findings suggest that owners or managers of GSMEs should focus on maintaining and improving GTP, GSCM and PEC in order to create greater satisfaction among their customers. The significance of this study is that it enables the creation of a framework that enables GSMEs to design a pathway towards achieving a cleaner production of goods and services in line with United Nations Sustainable Development Goals.

• Journal of Korean Neurosurgical Society
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• v.64 no.5
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• pp.716-725
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• 2021

Objective : The anti-tumor effect of the beta-adrenergic receptor antagonist propranolol in breast cancer is well known; however, its activity in glioblastoma is not well-evaluated. The Notch-Hes pathway is known to regulate cell differentiation, proliferation, and apoptosis. We investigated the effect of propranolol to human glioblastoma cell lines, and the role of Notch and Hes signaling in this process. Methods : We performed immunohistochemical staining on 31 surgically resected primary human glioblastoma tissues. We also used glioblastoma cell lines of U87-MG, LN229, and neuroblastoma cell line of SH-SY5Y in this study. The effect of propranolol and isoproterenol on cell proliferation was evaluated using the MTT assay (absorbance 570 nm). The impact of propranolol on gene expression (Notch and Hes) was evaluated using real-time polymerase chain reaction (RT-PCR, whereas protein levels of Notch1 and Hes1 were measured using Western blotting (WB), simultaneously. Small interfering RNA (siRNA) was used to suppress the Notch gene to investigate its role in the proliferation of glioblastoma. Results : Propranolol and isoproterenol caused a dose-dependent decrease in cell proliferation (MTT assay). RT-PCR showed an increase in Notch1 and Hes1 expression by propranolol, whereas WB demonstrated increase in Notch1 protein, but a decrease in Hes1 by propranolol. The proliferation of U87-MG and LN229 was not significantly suppressed after transfection with Notch siRNA. Conclusion : These results demonstrated that propranolol suppressed the proliferation of glioblastoma cell lines and neuroblastoma cell line, and Hes1 was more closely involved than Notch1 was in glioblastoma proliferation.

• International Journal of Oral Biology
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• v.46 no.4
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• pp.168-175
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• 2021

To investigate the perceptions and attitudes of dental hygienists toward radiation safety management in Korea. A total of 800 dental hygienists were randomly selected for an anonymous survey, and 203 of them participated. The questionnaire items included the following: sex, career period, type of installed radiographic equipment, recognition of the diagnostic reference level (DRL), participation in radiation safety education, and attitudes toward radiation protection for both patients and dental hygienists. The participants were divided into two groups according to their years of experience (< 10 years versus ≥ 10 years). The difference between the groups was investigated according to frequency distribution. Fisher's exact test or Pearson's chi-square (𝛘²) test was used as appropriate. A regression analysis was performed to investigate the impact of wearing a thyroid collar for personnel protection during patient radiation exposure. The types of installed radiographic equipment included panoramic radiography (96.1%), cephalometric radiography (76.9%), intraoral radiography (72.9%), and cone-beam computed tomography (69.5%). Significant differences were observed in the learning pathway for the DRL (Fisher's exact test, p < 0.05), satisfaction with radiation safety education (Pearson's 𝛘² test = 5.3975, Pr = 0.02), and use of personnel radiation monitoring systems (Pearson's 𝛘² test = 18.1233, Pr = 0.000) between the groups. Significant differences were also observed in personnel protection using a thyroid collar and patient protection during panoramic radiography (odds ratio = 14.2). Dental hygienists with more than 10 years of experience were more satisfied with radiation safety education and more interested in radiation monitoring. Considering career experience, customized, continuous, and effective radiation safety management education should be provided.

• Journal of Animal Science and Technology
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• v.64 no.4
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• pp.752-769
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• 2022

Wheat gluten is an increasingly common ingredient in poultry diets but its impact on the small intestine in chicken is not fully understood. This study aimed to identify effects of high-gluten diets on chicken small intestines and the variation of their associated transcriptional responses by age. A total of 120 broilers (Ross Strain) were used to perform two animal experiments consisting of two gluten inclusion levels (0% or 25%) by bird's age (1 week or 4 weeks). Transcriptomics and histochemical techniques were employed to study the effect of gluten on their duodenal mucosa using randomly selected 12 broilers (3 chicks per group). A reduction in feed intake and body weight gain was found in the broilers fed a high-gluten containing diet at both ages. Histochemical photomicrographs showed a reduced villus height to crypt depth ratio in the duodenum of gluten-fed broilers at 1 week. We found mainly a significant effect on the gene expression of duodenal mucosa in gluten-fed broilers at 1 week (289 differentially expressed genes [DEGs]). Pathway analyses revealed that the significant DEGs were mainly involved in ribosome, oxidative phosphorylation, and peroxisome proliferator-activated receptor (PPAR) signaling pathways. These pathways are involved in ribosome protein biogenesis, oxidative phosphorylation and fatty acid metabolism, respectively. Our results suggest a pattern of differential gene expression in these pathways that can be linked to chronic inflammation, suppression of cell proliferation, cell cycle arrest and apoptosis. And via such a mode of action, high-gluten inclusion levels in poultry diets could lead to the observed retardation of villi development in the duodenal mucosa of young broiler chicken.

• Journal of Animal Science and Technology
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• v.64 no.1
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• pp.110-122
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• 2022

The reduction of milk yield caused by heat stress in summer is the main condition restricting the economic benefits of dairy farms. To examine the impact of hyperthermia on bovine mammary epithelial (MAC-T) cells, we incubated the MAC-T cells at thermal-neutral (37℃, CON group) and hyperthermic (42℃, HS group) temperatures for 6 h. Subsequently, the cell viability and apoptotic rate of MAC-T cells, apoptosis-related genes expression, casein and amino acid transporter genes, and the expression of the apoptosis-related proteins were examined. Compared with the CON group, hyperthermia significantly decreased the cell viability (p < 0.05) and elevated the apoptotic rate (p < 0.05) of MAC-T cells. Moreover, the expression of heat shock protein (HSP)70, HSP90B1, Bcl-2-associated X protein (BAX), Caspase-9, and Caspase-3 genes was upregulated (p < 0.05). The expression of HSP70 and BAX (pro-apoptotic) proteins was upregulated (p < 0.05) while that of B-cell lymphoma (BCL)2 (antiapoptotic) protein was downregulated (p < 0.05) by hyperthermia. Decreased mRNA expression of mechanistic target of rapamycin (mTOR) signaling pathway-related genes, amino acid transporter genes (SLC7A5, SLC38A3, SLC38A2, and SLC38A9), and casein genes (CSNS1, CSN2, and CSN3) was found in the heat stress (HS) group (p < 0.05) in contrast with the CON group. These findings illustrated that hyperthermia promoted cell apoptosis and reduced the transport of amino acids into cells, which inhibited the milk proteins synthesis in MAC-T cells.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.91-91
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• 2023

General circulation models(GCMs)은 여러 국가 기관들의 물리적 기후 모의 프로세스를 기반으로 과거 및 미래 기후변화의 영향을 정량화하기 위해 개발되었으며 현재 미래 기후변화를 예측하는데 가장 효과적인 도구이다. 그러나 GCMs에 내포된 여러 불확실성 요소 및 넓은 격자형식의 기후 데이터는 GCMs 기후 데이터를 사용한 지역적 기후 모의 시 주요 걸림돌로 인식되어지고 있다. 편의보정 방법은 GCMs을 사용한 지역적 기후 모의 시 기후 모의 성능을 향상시키기 위해 여러 연구에서 사용되어져 왔으나 다른 연구에서는 이러한 편의보정 방법의 문제점을 언급했다. 따라서 본 연구는 편의보정 방법이 GCMs 기후 모의 결과에 미치는 영향을 정량화하고 더 나아가 GCMs 기후 변수에 따른 유량 모의 결과에 미치는 영향을 분석했다. 연구대상지 과거 기간 기후 모의를 위해 coupled model intercomparison project(CMIP)6의 GCMs을 사용했으며, 미래 기후 모의를 위해 shared socioeconomic pathway(SSP) 시나리오를 사용했다. 편의보정 방법으로는 분위사상법을 사용했으며, 편의보정 전후 GCMs 기후 모의 성능평가를 위해 5개 평가 지표를 사용했다. 연구대상지 장기 유출 모의를 위해 storm water management model(SWMM)이 사용되었으며, 기후 입력 자료로는 일 단위 강수량, 최고 및 최저온도를 고려했다. 미래 기후 및 유량 모의 결과의 불확실성은 square root of error variance(SREV) 방법을 통해 정량화됐다. 결과적으로 과거 기간 GCMs 기후 및 유량 모의성능은 편의보정 전보다 편의보정 후에서 향상되었으며 특히, 강수 및 유량 모의 성능이 크게 향상되었다. 미래 기간의 경우 편의보정 후에서 기후 및 유량의 극값을 더 잘 반영함을 확인했다. 본 연구의 결과는 GCMs 기후 변수를 사용한 지역적 기후 및 유량 모의 시 편의보정 방법이 미치는 영향에 대한 구체적인 정보를 제공할 수 있다.

• Genomics & Informatics
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• v.21 no.1
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• pp.8.1-8.19
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• 2023

Cancer of the stomach is the second most frequent cancer-related death worldwide. The survival rate of patients with gastric cancer (GC) remains fragile. There is a requirement to discover biomarkers for prognosis approaches. Helicobacter pylori in the stomach is closely associated with the progression of GC. We identified the genes associated with poor/favorable prognosis in H. pylori-induced GC. Multivariate statistical analysis was applied on the Gene Expression Omnibus (GEO) dataset GSE54397 to identify differentially expressed miRNAs (DEMs) in gastric tissues with H. pylori-induced cancer compared with the H. pylori-positive with non-cancerous tissue. A protein interaction map (PIM) was built and subjected to DEMs targets. The enriched pathways and biological processes within the PIM were identified based on substantial clusters. Thereafter, the most critical genes in the PIM were illustrated, and their prognostic impact in GC was investigated. Considering p-value less than 0.01 and |Log2 fold change| as >1, five microRNAs demonstrated significant changes among the two groups. Gene functional analysis revealed that the ubiquitination system, neddylation pathway, and ciliary process are primarily involved in H. pylori-induced GC. Survival analysis illustrated that the overexpression of DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, and TXNIP was associated with poor prognosis, while increased MRPS5 expression was related to a favorable prognosis in GC patients. DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, TXNIP, and MRPS5 may be considered prognostic biomarkers for H. pylori-induced GC. However, experimental validation is necessary in the future.