• International Journal of Control, Automation, and Systems
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• 제1권3호
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• pp.282-288
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• 2003

It is known that HIV (Human Immunodeficiency Virus) infection, which causes AIDS after some latent period, is a dynamic process that can be modeled mathematically. Effects of available anti-viral drugs, which prevent HIV from infecting healthy cells, can also be included in the model. In this paper we illustrate control theory can be applied to a model of HIV infection. In particular, the drug dose is regarded as control input and the goal is to excite an immune response so that the symptom of infected patient should not be developed into AIDS. Finite horizon optimal control is employed to obtain the optimal schedule of drug dose since the model is highly nonlinear and we want maximum performance for enhancing the immune response. From the simulation studies, we found that gradual reduction of drug dose is important for the optimality. We also demonstrate the obtained open-loop optimal control is vulnerable to parameter variation of the model and measurement noise. To overcome this difficulty, we finally present nonlinear receding horizon control to incorporate feedback in the drug treatment.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.1951-1956
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• 2003

It is known that HIV (Human Immunodeficiency Virus) infection, which causes AIDS after some latent period, is a dynamic process that can be modeled mathematically. Effects of available anti-viral drugs, which prevent HIV from infecting healthy cells, can also be included in the model. In this paper we illustrate control theory can be applied to a model of HIV infection. In particular, the drug dose is regarded as control input and the goal is to excite an immune response so that the symptom of infected patient should not be developed into AIDS. Finite horizon optimal control is employed to obtain the optimal schedule of drug dose since the model is highly nonlinear and we want maximum performance for enhancing the immune response. From the simulation studies, we find that gradual reduction of drug dose is important for the optimality. We also demonstrate the obtained open-loop optimal control is vulnerable to parameter variation of the model and measurement noise. To overcome this difficulty, we finally present nonlinear receding horizon control to incorporate feedback in the drug treatment.

• Journal of Computing Science and Engineering
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• 제9권2호
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• pp.98-107
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• 2015

Hierarchical constraints and constraint satisfaction were analyzed in order to solve the problem of conflict detection in collaborative design. The constraints were divided into two sets: one set consisted of known constraints and the other of unknown constraints. The constraints of the two sets were detected with corresponding methods. The set of the known constraints was detected using an interval propagation algorithm, a back propagation (BP) neural network was proposed to detect the set with the unknown constraints. An immune algorithm (IA) was utilized to optimize the weights and the thresholds of the BP neural network, and the steps were designed for the optimization process. The results of the simulation indicated that the BP neural network that was optimized by IA has a better performance in terms of convergent speed and global searching ability than a genetic algorithm. The constraints were described using the eXtensible Markup Language (XML) for computers to be able to automatically recognize and establish the constraint network. The implementation of the conflict detection system was designed based on constraint satisfaction. A wind planetary gear train is taken as an example of collaborative design with a conflict detection system.

• Asian-Australasian Journal of Animal Sciences
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• 제18권6호
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• pp.898-907
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• 2005

Chromium has emerged as an essential trace mineral in nutrition. However, it readily causes toxicity because of slightly excessive dose and/or form of chromium supplement. Therefore, developing a noble form of chromium supplement which is capable of not only an increased availability but also a reduced toxicity has been a critical issue in chromium nutrition. Chromium-methionine chelate has been, so far, one of the latest developments in its kind. Although not much information is available for the chromium-methionine chelate, especially in view of animal performances upon dietary supplementation, several studies indicated chromium methionine chelate could be effective to improve meat quality by increasing muscle mass but decreasing body fat. Highly-graded beef was produced by dietary chromium methionine supplementation during fattening stage of Korean native steers. Body muscle was increased in replace of decreasing body fat in both pig and rat that were dietary supplemented with chromium methionine chelate. However, a pig farm study did not show any significant improvement of body gain upon supplementation of chromium methionine. Immune responses of pig and rat were not always dependent upon chromium form but were varied by species. These results suggest there could be a different mode of responses due to species as well as onset time of dietary supplementation of chromium methionine. It is still early to conclude the bio-efficacy of chromium methionine chelate presumably due to its recent appearance into the field. But the chelate is certainly worth more application to animal since it certainly reduced the application level of dietary chromium.

• ETRI Journal
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• 제38권6호
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• pp.1153-1162
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• 2016

This paper addresses the resource allocation (RA) problem in multi-cell cognitive radio networks. Besides the interference power threshold to limit the interference on primary users PUs caused by cognitive users CUs, a proportional fairness constraint is used to guarantee fairness among multiple cognitive cells and the impact of imperfect spectrum sensing is taken into account. Additional constraints in typical real communication scenarios are also considered-such as a transmission power constraint of the cognitive base stations, unique subcarrier allocation to at most one CU, and others. The resulting RA problem belongs to the class of NP-hard problems. A computationally efficient optimal algorithm cannot therefore be found. Consequently, we propose a suboptimal RA algorithm composed of two modules: a subcarrier allocation module implemented by the immune algorithm, and a power control module using an improved sub-gradient method. To further enhance algorithm performance, these two modules are executed successively, and the sequence is repeated twice. We conduct extensive simulation experiments, which demonstrate that our proposed algorithm outperforms existing algorithms.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권1호
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• pp.74-90
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• 2014

Routing in mobile wireless sensor networks (MWSNs) is an extremely challenging issue due to the features of MWSNs. In this paper, we present a novel bio-inspired trusted routing protocol (B-iTRP) based on artificial immune system (AIS), ant colony optimization (ACO) and Physarum optimization (PO). For trust mechanism, B-iTRP monitors neighbors' behavior in real time and then assesses neighbors' trusts based on AIS. For routing strategy, each node proactively finds routes to the Sink based on ACO. When a backward ant is on the way to return source, it senses the energy residual and trust value of each node on the discovered route, and calculates the link trust and link energy of the route. Moreover, B-iTRP also assesses the availability of route based on PO to maintain the route table. Simulation results show how B-iTRP can achieve the effective performance compared to existing state-of-the-art algorithms.

• 설비공학논문집
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• 제18권11호
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• pp.933-940
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• 2006

In this study multi-zone modeling program CONTAM 2.4 developed by NIST is used for estimating the air disinfection rate of the interior of a room which is set up the indoor air disinfection system with filter and ultra violet germicidal irradiation (UVGI). Developed models those enable to predict the transmission of air home contagion such as bacteria and fungus generated in our daily life are useful model for designning air cleaning & ventilation system of building. Also, results indicate that these models are enable to compute the real situation that is almost impossible of carrying out experiment in an actual condition due to biohazard problems and suggest that engineers will use these models as a design tool for the future immune building system.

• Fisheries and Aquatic Sciences
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• 제26권1호
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• pp.58-68
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• 2023

This study was conducted to determine dietary threonine (Thr) requirement for juvenile olive flounder (Paralichthys olivaceus). A total of 450 juvenile fish (23.2 ± 0.4 g) were randomly distributed to 18 tanks (215 L) with 25 fish per tank. Experimental diets included with graded levels of Thr at 0.0%, 0.4%, 0.8%, 1.2%, 1.6%, and 2.0% were assigned for triplicate groups of fish and fed two times daily to apparent satiation for 12 weeks. Weight gain, specific growth rate, feed intake, feed utilization and survival were significantly (p < 0.05) increased in fish fed with dietary Thr levels over 0.8%, and no significant differences were observed between 0.8% to 2.3% levels. Non-specific immune parameters of serum lysozyme, myeloperoxidase activity, antiprotease activity, and total immunoglobulin were significantly increased by dietary Thr over 0.8%. Based on the broken-line regression analysis, the Thr requirement for the optimum growth and immune response in olive flounder is likely to be 1.03% in the diet.

• Fisheries and Aquatic Sciences
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• 제26권10호
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• pp.583-592
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• 2023

Celebes rainbow (Marosantherina ladigesi) is one of Indonesia's exported ornamental fish commodities, but the exploitation of this fish only relies on wild catches. The rise of unlimited fishing, especially those using poison, has changed the aquatic environment, threatening sustainability and causing fish extinction. This study aimed to evaluate the effectiveness of several types of feed in improving the absolute growth rate (AGR), specific growth rate (SGR), survival rate (SR), feed conversion ratio (FCR), feed efficiency (FE), hematology, and immune response of Celebes rainbow. The fish used in this study were male ornamental Celebes rainbow (M. ladigesi) weighing 1.32 ± 0.21 g/ind, reared in 54 L-aquariums at a stocking density of 30 individuals/aquarium for six weeks. The fish were fed according to the test diet consisting of live Tubifex sp worms, dry Tubifex sp worms, Spirulina platensis, and crumble pellets. The parameters observed were AGR, SGR, SR, FCR, FE, hematology, intestinal histology, liver histology, and a challenge test with the pathogenic bacteria Aeromonas hydrophila. The results showed that fish-fed live Tubifex sp worms had better AGR, SGR, SR, FCR, FE, hematology, and disease resistance compared to all other treatments. These results indicate that live Tubifex sp worms are the best feed for rearing Celebes rainbow.

• Animal Bioscience
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• 제36권8호
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• pp.1241-1251
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• 2023

Objective: Egg yolk immunoglobulin (IgY) is an antibiotic alternative to prevent and fight intestinal pathogenic infections. This study aimed to investigate the effects of sodium alginate/chitosan/sodium alginate IgY microcapsules on the growth performance, serum parameters, and intestinal health of broiler chickens. Methods: One-day-old broilers (Ross 308) were divided into five treatments, each with 10 replicates of five chickens. The dietary treatments were maintained for 28 days and consisted of a basal diet (NC), basal diet + 500 mg chlortetracycline/kg diet (CH), basal diet + 50 mg non-microencapsulated IgY/kg diet (NM), basal diet + 600 mg low levels microencapsulated IgY/kg diet (LM), and basal diet + 700 mg high levels microencapsulated IgY/kg diet (HM). Results: Throughout the 28-day trial period, the NM, LM, HM, and CH groups increased average daily gain compared with the NC group (p<0.05), and the HM group reduced feed conversion ratio compared with the CH group (p<0.05). The LM and HM groups increased relative organ weights of thymus and spleen compared with the CH and NM groups (p<0.05). The HM group improved the duodenal, jejunal and ileum villi height (VH) and villus height to crypt depth ratio (VH:CD) compared with the CH and NM groups (p<0.05). Compared with the CH group, the HM group increased serum immunoglobulin (IgA), immunoglobulin G (IgG), superoxide dismutase, total antioxidant capacity, and glutathione peroxidase levels (p<0.05), and decreased serum malondialdehyde levels (p<0.05). Compared with the NC group, the NM, LM, HM, and CH groups reduced colonic Escherichia coli and Salmonella levels (p<0.05). and the HM group promoted the levels of lactic acid bacteria and bifidobacteria compared with the CH group (p<0.05). Conclusion: Microencapsulation could be considered as a way to improve the efficiency of IgY. The 700 mg high levels microencapsulated IgY/kg diet could potentially be used as an alternative to antibiotics to improve the immune performance and intestinal health, leading to better performance of broiler chickens.