• 한국식품과학회지
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• 제41권4호
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• pp.413-416
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• 2009

면역증진기능성 식품으로서 자작나무 수액의 개발 가능성을 확인하기 위하여 자작나무로부터 채취한 수액을 동결건조하여 이를 수컷 ICR mouse에 경구 투여한 후 탄소제거시험과 부동시간 측정을 통해 면역증진 효과를 살펴보았다. 탄소제거능 시험에서 500 mg/kg B.W.의 용량으로 자작나무 수액 동결건조물을 투여하였을 때 멸균생리식염수만을 투여한 대조군에 비해 유의성있는 (p<0.05) 탐식지수(phagocytic index)의 증가가 있었으며, 강제수영 부하시험(FST) 결과 부동시간(immobility time)은 2주간 500 mg/ kg B.W의 용량으로 시험물질을 투여한 동물에서 대조군의 부동 시간과 비교하여 유의적으로 감소하였다(p<0.05). 125, 250, 500 mg/kg의 용량으로 6주간 투여한 동물에서 대조군 보다 부동 시간이 감소하였다. 특히 250, 500 mg/kg 용량 투여군에서 통계적으로 유의한(p<0.05) 부동시간의 감소가 관찰되었으며, 혈액학적 검사결과 백혈구계 세포 수의 증가를 나타내었다.

• Annals of Rehabilitation Medicine
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• 제41권6호
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• pp.1019-1027
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• 2017

Objective To analyze the clinical characteristics between neurogenic and non-neurogenic cause of vocal cord immobility (VCI). Methods The researchers retrospectively reviewed clinical data of patients who underwent laryngeal electromyography (LEMG). LEMG was performed in the bilateral cricothyroid and thyroarytenoid muscles. A total of 137 patients were enrolled from 2011 to 2016, and they were assigned to either the neurogenic or non-neurogenic VCI group, according to the LEMG results. The clinical characteristics were compared between the two groups and a subgroup analysis was done in the neurogenic group. Results Among the 137 subjects, 94 patients had nerve injury. There were no differences between the neurogenic and non-neurogenic group in terms of demographic data, underlying disease except cancer, and premorbid events. In general characteristics, cancer was significantly higher in the neurogenic group than non-neurogenic group (p=0.001). In the clinical findings, the impaired high pitched 'e' sound and aspiration symptoms were significantly higher in neurogenic group (p=0.039 for impaired high pitched 'e' sound; p=0.021 for aspiration symptoms), and sore throat was more common in the non-neurogenic group (p=0.014). In the subgroup analysis of neurogenic group, hoarseness was more common in recurrent laryngeal neuropathy group than superior laryngeal neuropathy group (p=0.018). Conclusion In patients with suspected vocal cord palsy, impaired high pitched 'e' sound and aspiration symptoms were more common in group with neurogenic cause of VCI. Hoarseness was more frequent in subjects with recurrent laryngeal neuropathy. Thorough clinical evaluation and LEMG are important to differentiate underlying cause of VCI.

• 농업과학연구
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• 제46권1호
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• pp.113-124
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• 2019

Insect-resistant transgenic (Bt-9) rice was generated by inserting mCry1Ac1, a modified gene from the soil bacterium Bacillus thuringiensis, into the genome of a conventional variety of rice (Ilmi). With regard to potential problems such as safety, an evaluation of non-target organisms is necessary as an essential element of an environmental risk assessment of genetically modified (GM) crops. We studied the effects of the Bt-9 rice on the survival of cantor Daphnia magna, a commonly used model organism in ecotoxicological studies. D. magna fed on the Bt-transgenic rice (Bt-9) and its near non-GM counterparts (Ilmi) grown in the same environment (a 100% ground rice suspension). The Bt-9 rice was confirmed to have the inserted T-DNA and protein expression evident by the PCR and ELISA analyses. The feeding study showed a similar cumulative immobility and abnormal response of the Daphnia magna between the Bt-9 rice and Ilmi. Additionally, the 48 h-EC50 values of the Bt-9 and Ilmi rice were 4,400 mg/L (95% confidence limits: 3861.01 - 5015.01 mg/L) and 5,564 mg/L (95% confidence limits: 4780.03 - 6476.93 mg/L), respectively. The rice NOEC (No observed effect concentration) value for D. magna was suggested to be 1,620 mg/L. We conclude that the tested Bt-9 and Ilmi have a similar cumulative immobility for D. magna, a widely used model organism, and the growth of Bt-9 did not affect non-target insects.

• 농업과학연구
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• 제47권4호
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• pp.791-802
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• 2020

Theoredoxin (TRX) transgenic soybeans were developed using the human Theoredoxin gene under the control of the ��-conglycinin promoter with a selection marker, the phosphinothricin acetyltransferase (PAT) gene. This study was done to assess the acute toxicity of a genetically modified (GM) soybean using the fresh water planktonic crustacean Daphnia magna. The acute toxicity effect of the TRX soybean and non-GM soybean (Gwangan) on D. magna was investigated at different concentrations (0, 156, 313, 625, 1,250, 2,500, and 5,000 mg·L-1). The TRX soybean used for the test was confirmed to express the TRX/PAT genes by PCR and enzyme-linked immunosorbent assay (ELISA). D. magna feeding tests showed no significant differences in the cumulative immobility or an abnormal response with either the TRX soybean or non-GM soybean. The feeding study showed a similar abnormal response and cumulative immobility of the D. magna between the TRX soybean and Gwangan treatments. Additionally, the 48 h-EC50 values for the TRX and Gwangan soybeans were 755.6 and 778 mg·L-1, respectively. The soybean NOEC (no observed effect concentration) value for D. magna was suggested to be 156 mg·L-1. These results suggest that there is no significant difference in toxicity to Daphnia magna between the TRX soybean and its non-GM counterpart.

• 한국자원식물학회지
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• 제35권4호
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• pp.411-416
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• 2022

본 연구에서는 다양한 실험모델을 활용하여 참당귀 추출물의 면역조절 효능을 평가하였다. 특히 강제수영부하실험에서 참당귀 추출물의 경구투여는 부동시간의 감소 및 신장기능 지표인 BUN 및 근육의 피로관련 생화학적 지표인 LDH 활성 조절로 체력증진 효과를 나타내는 것으로 확인하였다. T세포를 활용한 참당귀 추출물의 면역조절 효능 평가를 위하여 IL-2, IL-4 및 IFN-𝛾 mRNA 발현 변화에 대한 영향을 측정하였다. 실험결과, 참당귀 추출물은 IL-2, IL-4 및 IFN-𝛾 세포 활성물질의 생성 조절을 통하여 면역조절 효능이 있음을 확인하였다. 본 연구결과를 통해 규명된 결과는 참당귀 추출물의 체력증진 및 면역조절을 위한 건강 기능성 제품개발에 활용 가능성을 제시하였다.

• 대한한의학방제학회지
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• 제30권3호
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• pp.109-121
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• 2022

Objective : This study is conducted to investigate the effect of Astragali Radix on Post Traumatic Stress Disorder(PTSD) induced by the Single Proposed Stress(SPS). Methods : The experiment was conducted with five groups; SAL groups with only saline treatment, SPS group, SPS + ARX25 group, SPS + ARX50 group, and SPS + ARX100 group. After applying SPS, saline and ARX were administered for 14 days to identify the change of body weight, sucrose intake amount, and behavioral changes through Open Field Test(OFT) and Forced Swimming Test(FST). After the behavioral experiment, plasma corticosterone levels, serotonin, norepinephrine and dopamine concentrations were measured by enzyme-linked immunoassay in medical prefrontal cortex, hippocampus, and amygdala. Brain-derived neurotrophic factor(BDNF) in the hippocampus was measured using Reverse Transcription Polymerase Chain Reaction. Results : Weight change has significantly decreased in the SPS group compared to the SAL group(p<0.05). On day 14, the sucrose intake of rats has significantly increased in the SPS + ARX100 group compared to the SPS group(p<0.05). In OFT, the number of staying in the central space has significantly increased in the SPS + ARX100 group(p<0.01). In FST, immobility has significantly decreased in SPS + ARX50 group and SPS + ARX100 group(p<0.05). The concentration of serotonine, dopamine and BDNF expression has increased significantly in SPS + ARX100 group compared to SPS group(p<0.05) Conclusions : In the SPS-induced PTSD experiment, ARX increased sucrose intake and the numbers of crossing in the central zone space in OFT, decreased immobility time in FST, and increased concentration of serotonin, dopamine, and BDNF. It can be postulated that the ARX could be effective for the treatment of PTSD.

• 대중서사연구
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• 제27권3호
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• pp.195-228
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• 2021

이 연구의 목적은 『모빌리티와 푸코』에서 제기하고 있는 새로운 모빌리티 연구방법을 검토하고, 이를 텍스트 분석에 적용해보는 것이다. 이 책은 푸코의 주요 개념을 모빌리티 연구에 적용한 논문 7편을 담고 있어 양쪽 연구 모두에 지적 자극을 주고 있다. 푸코는 이성/비이성, 정상/비정상을 구분하는 기술을 통해 작동한 규율 권력에 대한 탁월한 연구를 보여주었기 때문에, 그의 작업은 감옥으로 대표되는 폐쇄적 공간에 대한 연구처럼 보이기 쉽다. 하지만 『모빌리티와 푸코』의 필자들은 푸코의 작업에 이미 모빌리티에 대한 충분한 연구가 들어있었음에 주목하며 이를 모빌리티 연구에 적극적으로 접목시킨다. 푸코가 말한 통치성이자 장치로서의 모빌리티에 주목했을 때, 모빌리티와 임모빌리티 사이의 긴장감과 역동성이 강조되어 단순한 이분법을 가로지르는 모빌리티 연구의 가능성이 열린다. 본고는 이같은 연구방법을 적용해 김중혁의 소설 <1F/B1>과 김혜진의 단편소설을 분석한다. <1F/B1>은 건물 안에 흡사 갇혀있는 듯 보이는 건물관리인의 서사를 담고 있지만, 소설 속 관리인의 모빌리티는 기성의 통념을 관통하며 새로운 공간을 창출하는 데에로 나아가며, 김혜진의 단편소설 <목화맨션>, <치킨 런>, <줄넘기> 등은 움직이지 못하고 주저하는 모빌리티의 재현을 통해 주체를 구성하는 장치로서의 모비리티를 보여준다. 『모빌리티와 푸코』의 연구를 참조했을 때 우리는 텍스트 속 모빌리티와 임모빌리티의 역동성에 주목하여 서사를 재독하게 된다. 이 연구는 모빌리티 텍스트 연구를 새롭게 확장한다는 데에 의의가 있다. 그간 모빌리티 연구를 적용한 텍스트 분석은 대개 여행기나 표류기, 디아스포라 서사 등 명백하게 이동하는 서사에 집중되어 있었는데, 『모빌리티와 푸코』는 권력과 모빌리티의 관계, 모빌리티와 임모빌리티의 역동성 등에 주목하게 하여 새로운 텍스트 연구를 추동한다. 따라서 이 논문은 아무도 이동하지 않는 것처럼 보이는 서사 속 모빌리티 재현에 주목했을 때 드러나는 텍스트의 새로운 의미를 확인하고, 모빌리티 텍스트 연구 방법의 확장을 모색한다는 의의를 갖는다.

• 대한본초학회지
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• 제22권2호
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• pp.137-146
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• 2007

Objectives : Investigation of the anitstress effects of Lycii Radicis Cortex. Methods : Behavior was measured in PAT and FST after applying stress to rats. Also, TH expression-degree in the regions of VTA and LC was measured, respectively. Results : The memory was improved in the LH 50mg/kg treated group in the passive avoidance test(P<0.01). The duration of immobility in the forced swimming test was significantly decreased in the LR 50mg/kg and 400mg/kg treated groups(P<0.0l). Stress-induced TH increases were meaningfully suppressed in the LR 100mg/kg and 400mg/kg treated group(P<0.001). Conclusion : Lycii Radicis Cortes has the effect of memory improving and antidepressant.

• 대한후두음성언어의학회지
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• 제20권2호
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• pp.126-130
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• 2009

Arytenoid motion has long been recognized as complex. Misunderstandings about the specifics of arytenoid motion remain prevalent. The resultant misunderstandings have led to erroneous or suboptimal clinical approaches to the treatment of vocal fold immobility. A thorough understanding of the anatomy of the arytenoid and cricoid cartilages, the cricoarytenoid joint, and related ligaments, muscles, and other structures is essential in order to fully understand laryngeal motion disorders. Arytenoid motion occurs in three directions. Movements involving a change anteriorly and posteriorly, as well as vertically, are due to the revolving or pitchlike motion of the arytenoid along the minor axis of the cricoid's elliptically shaped facet. The medial and lateral movements are due to the orientation of the arytenoid which in turn is determined by the forward, lateral, and inferior inclination of the cricoid-arytenoid facet. During adduction it is the outward angulation of the vocal process from the body of the arytenoid that allows the entire length of the vocal proceses to approximate one another and to have this meeting occur at the proper vertical height.

• 한국실내디자인학회논문집
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• 제34호
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• pp.10-19
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• 2002

The sublime as one of categories of aesthetics has given a great influence over art. Particularly, painters of Color-field Abstract, which can be considered as the art of the sublime, have tried to sublimate their art to the level of spirituality through expression of sublimity. The purpose of this study is to grasp distinctive peculiarities of sublimity expressed by Rothko, a Color-field painter, in his architectural work, Rothko Chapel, and manifested by Feldman through his musical piece, also titled Rothko Chapel, respectively.In conclusion, it is found that sublimity was expressed in both works through ‘immobile procession’ corresponding to ‘dualism’ of the sublime as Kant defined. More specifically, it is clarified that such immobility was expressed through the attributes of the sublime as suggested by Burke, and they implied dualism.