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http://dx.doi.org/10.7732/kjpr.2022.35.4.411

The Regulatory Effect of Angelica gigas Nakai on Immune Enhancement and Cytokine Production in vivo and in vitro  

Jeon, Yong-Deok (Department of Korean Pharmacy, Woosuk University)
Kim, Su-Jin (Department of Biotechnology and Convergence, Daegu Haany University)
Publication Information
Korean Journal of Plant Resources / v.35, no.4, 2022 , pp. 411-416 More about this Journal
Abstract
Natural products are important sources for drug development because they have a wide variety of useful biological properties. Angelica gigas Nakai (AGN) has been used as an herbal medicine for treatment of colds, pain, and anemia. The present study was designed to evaluate the regulatory effect of AGN on immune enhancement in vivo and in vitro. To investigate the immune-enhancing effect of AGN, we used forced swimming test (FST) experimental model. Mice were orally administered by AGN or distilled water for 14 days and then immobility time and biological parameters in serum were measured. The results showed that immobility time in AGN treatment group was significantly reduced in comparison with the control group. Plasma levels of blood urea nitrogen and lactate dehydrogenase in AGN group was significantly decreased compared with control group. Additionally, we showed that AGN treatment significantly increased immune-related cytokines such as interleukin (IL)-4, IL-2, and interferon (IFN)-𝛾 levels in Molt-4 cells. Collectively, the findings provide experimental evidence that AGN may be effective in improving immune function.
Keywords
Angelica gigas Nakai; Immune enhancement; T cell;
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