• 동의생리병리학회지
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• 제20권3호
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• pp.642-650
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• 2006

As an effective non-pharmacological method of pain relief, hydrotherapy was widely used. And bath additive has been used for enhancing the efficacy of hydrotherapy, In the present study, as a bath additive, the analgesic activity of HAC, which composed of Corydalis turtschaninovii, Atractylodes japonica, and Harpagophytum procumbens(HAC), was investigated in the ventrolateral periaqueductal gray (VIPAG), lateral PAG (IPAG), central nuclei of amygdala (CeA), and the paraventricular nucleus of the hypothalamus (PVN) in mice, using writhing test and immunohistochemistry for c-Fos. Male C57BU6 mice weighing $25{\;}{\pm}{\;}2g$ (8 weeks of age) were used for this experiment. The animals were divided into five groups: the control group, the acetic acid treatment group, the acetic acid treatment and 0.01 g/L HAC-immersed group, the acetic acid treatment and 0.1 g/L HAC-immersed group, and the acetic acid treatment and 1.0 g/L HAC-immersed group. To induce somato-visceral pain in the experimental animals, a single intraperitoneal (i.p.) injection of acetic acid was administrated to each animal, and the animals of the control group received injections of equivalent doses of normal saline. The animals of the HAC-immersed groups were immersed the water with HAC powder at the respective doses deep enough to cover the mice body, and those of the control group and the acetic acid treatment group immersed the water without HAC powder at 10 min immediately after the acetic acid injection. Our present study has shown that the HAC reduced the acetic acid-induced abdominal constrictions and the acetic acid-Induced increase of numbers of c-Fos-positive cells in the VIPAG, IPAG, PVN, and CeA. The most potent analgesic effect appeared with the treatment of 1.0 g/L KB-immersed group. Based on our present results, it is very possible that HAC can be a potent therapeutic bath additive for alleviating pain without the fear of addiction to the drugs and side-effects associated with the prescription of multiple analgesic drugs.

• 한국전산유체공학회지
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• 제20권2호
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• pp.103-108
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• 2015

Fluid-body interaction analysis of floating body with six degree-of-freedom motion is presented. In this study, three-dimensional incompressible Navier-Stokes equations are employed as a governing equation. The numerical method is based on a finite-volume approach on a cartesian grid together with a fractional-step method. To represent the body motion, the immersed boundary method for direct forcing is employed. In order to simulate the coupled six degree-of-freedom motion, Euler's equations based on rigid body dynamics are utilized. To represent the complex body shape, level-set based algorithm is utilized. In order to describe the free surface motion, the volume of fluid method utilizing the tangent of hyperbola for interface capturing scheme is employed. This study showed three different continuums(air, water and body) are simultaneously simulated by newly developed code. To demonstrate the applicability of the current approach, two different problems(dam-breaking with stationary obstacle and water entry) are simulated and all results are validated.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.2737-2742
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• 2007

Strong wind flow around a building complex was numerically studied by LES. The original motivation of this work stemmed from the efforts to develop a risk assessment technique for windstorm hazards. Lagrangian-averaged scale-invariant dynamic subgrid-scale model was used for turbulence modeling, and a log-law-based wall model was employed on all the solid surfaces including the ground and the surface of buildings to replace the no-slip condition. The shape of buildings was implemented on the Cartesian grid system by an immersed boundary method. Key flow quantities for the risk assessment such as mean and RMS values of pressure on the surface of the selected buildings are presented. In addition, characteristics of the velocity field at some selected locations vital to safety of human beings is also reported.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2010년 춘계학술대회논문집
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• pp.508-516
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• 2010

An efficient code has been developed to predict dispersion of indoor air pollutants The computing capability of the code has been compared with that of a commercial code inn a benchmark test. After that, the code has been employed to compute dispersion of a pollutant released from a new furniture, a kind of Sick Building Syndrome (SBS). A sofa which generates formaldehyde is implemented by using an immersed boundary method. Large Eddy Simulation (LES) is employed to obtain time-dependent velocity and scalar fields. LES has bee regarded as an academic tool, but the newly-developed code reveals a possibility of application of LES to practical problems, especially dispersion of indoor pollutants.

• 대한기계학회논문집B
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• 제31권6호
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• pp.566-573
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• 2007

Flows around two oscillating cylinders in side-by-side arrangement at Re=185 are simulated using an immersed boundary method. The cylinders oscillate vertically in opposite directions in uniform cross-flow. We describe flow patterns, drag and lift forces by varying distance between two cylinders $(1.4{\leq}g{\leq}2.2,\;1.0{\leq}g{\leq}1.8)$ and oscillating frequency ratios $(f_e/f_o=0.8,\;f_e/f_o=1.0\;and\;f_e/f_o =1.2)$. Wake patterns, drag and lift coefficients are affected by both of frequency ratio and gap between two cylinders. Near wakes of each case are classified with the definition of previous studies.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2011년 춘계학술대회논문집
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• pp.266-268
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• 2011

We present a mathematical model of left heart governed by the partial differential equations. This heart is coupled with a lumped model of the whole circulatory system governed by the ordinary differential equations. The immersed boundary method is used to investigate the intracardiac blood flow and the cardiac valve motions of the normal circulation in humans. We investigate the intraventricular velocity field and the velocity curves over the mitral ring and across outflow tract. The pressure and flow are also measured in the left and right heart and the systemic and pulmonary arteries. The simulation results are comparable to the existing measurements.

• 설비공학논문집
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• 제22권11호
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• pp.735-744
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• 2010

An efficient code has been developed to predict dispersion of indoor air pollutants. The computing capability of the code has been compared with that of a commercial code in a benchmark test. After that, the code has been employed to compute dispersion of a pollutant released from a new furniture, a kind of Sick Building Syndrome(SBS). A sofa which generates formaldehyde is implemented by using an immersed boundary method. Large Eddy Simulation (LES) is employed to obtain time-dependent velocity and concentration fields. LES has been regarded as an academic tool, but the newly-developed code reveals a possibility of application of LES to practical problems, especially dispersion of indoor pollutants.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회B
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• pp.2477-2482
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• 2008

Effect of computational domain size in simulating of periodic obstacle flow has been investigated for the flow past tube banks. Reynolds number, defined by freestream velocity (U) and cylinder diameter (d), was fixed as 200, and center-to-center distance (P) as 1.5d. In-line square array was considered. Drag coefficient, lift coefficient and Strouhal number were calculated depending on domain size. Circular cylinders were implemented on a Cartesian grid system by using an immersed boundary method. Boundary condition is periodic in both streamwise and lateral directions. Previous studies in literature often use a square domain with a side length of P, which contains only one cylinder. However, this study reveals that size is improper. Especially, RMS values of flow-induced forces are most sensitive to the domain size.

• Nuclear Engineering and Technology
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• 제51권1호
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• pp.31-44
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• 2019

This study simulated a control rod assembly (CRA), which is a part of reactor shutdown systems, in immersed and fluid flow conditions. The CRA was inserted into the reactor core within a predetermined time limit under normal and abnormal operating conditions, and the CRA (which consists of complex geometric shapes) drop behavior is numerically modeled for simulation. A full-scale prototype CRA drop test is established under room temperature and water-fluid conditions for verification and validation. This paper describes the details of the numerical modeling and analysis results of the several conditions. Results from the developed numerical simulation code are compared with the test results to verify the numerical model and developed computer code. The developed code is in very good agreement with the test results and this numerical analysis model and method may replace the experimental and CFD method to predict the drop behavior of CRA.

• 대한조선학회논문집
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• 제49권1호
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• pp.26-32
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• 2012

The 3-D unsteady viscous flow around an impulsively started rotating marine propeller is simulated using VIC(Vortex-In-Cell) method which is adequate to analyze the strong vortical flow around complicatedly-shaped body. The computational procedure is governed by the vorticity transport equation in Lagrangian form. In order to solve the equation, a regular grid which is independent to the shape of a body is introduced and each term of the equation is evaluated numerically on the grid by applying immersed boundary concept. In this paper, the overall algorithm including the formulation of governing equations and boundary conditions is described and some computational results are presented with discussing their physical validity.