• The Korea Journal of Herbology
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• v.21 no.3
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• pp.103-109
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• 2006

Objectives : The purpose of this study was to investigate the TLR-4 mediated anti-inflammatory effects of extract from Xanthii Fructus(XF) on the peritoneal macrophage. Methods : To evaluate of TLR-4 mediated inflammatory of XF, we examined NO and cytokine production in TRL-4 ligand(LPS-lipopolysacchride) induced macrophages. Furthermore, we checked molecular mechanism using western blot. Results : l.Extract from XF reduced LPS-induced Nitric oxide (NO), tumor necrosis factor-a (TNF-a), interleukin (IL)-6 and IL-12 production in peritoneal macrophages 2.Extract from XF itself does not have any cytotoxic effect.XS inhibited degradation of IkBa in the TLR-4 mediated peritoneal macrophages Conclusion : XF down-regulated TLR4 ligand(LPS)-induced NO and cytokine productions.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.39 no.9
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• pp.28-34
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• 2002

In this paper, a new type predistorter using a low frequency intermodulation signals terms of harmonic generator is proposed. A vector modulator, in which fundamental signal is modulated with low frequency intermodulation signals derived from harmonic generator, generates predistorted third and fifth IM components. Using predistorted signals, intermodulation distortion signals of power amplifier suppressed. The suggested predistorter has been manufactured to operate in Korean PCS base-station transmitting band (1840~1870MHz). The test results show that the third IMD signal level is reduced more than 20dB and the fifth IMD signal is reduced about 10dB for CW two-tone signals. The predistorter improves the Adjacent Channel Power Ratio (ACPR) more than 10dB for CDMA (IS-95) signals.

• YAKHAK HOEJI
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• v.36 no.6
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• pp.598-603
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• 1992

The purpose of this study was to assess the effect of three formulations; product A (polyethylene glycol was used as a main dispersing agent), product B (wax mixture was used as a main dispersing agent) and product C(silicon dioxide was used as a main dispersing agent) on bioavailability of acetaminophen soft gelatin capsules(softgels) and to develop an effective acetaminophen softgel which exhibits an excellent bioavailability. Acetaminophen softgels of various formulations were prepared as 4 minim round type by rotary die method. Four softgels of the three formulation (A, B, C), each of which contained 50 mg acetaminophen, were administered orally to 12 normal healthy rabbits using a three-way cross over design. Plasma acetaminophen concentrations were measured by HPLC. The results obtained in this study were as follows: 1. The Tmax rank order of acetaminophen softgel was C$(63.75{\pm}10.62\;min)$>A$(36.25{\pm}5.37\;min)$>B$(35{\pm}6.74\;min)$. 2. The decreasing Cmax order of softgel product was A$(93.51{\pm}0.55\;{\mu}g/ml)$>B$(3.16{\pm}0.37\;{\mu}g/ml)$>C$(2.6{\pm}0.55\;{\mu}g/ml)$. 3. The $[AUC]^{\infty}_0$ rank order for three acetaminophen softgel formulations was A $(14.89{\pm}1.56\;{\mu}g/ml{\cdot}min)$ >B$(14.39{\pm}1.43\;{\mu}g/ml{\cdot}min)$>C$(11.45{\pm}1.49\;{\mu}g/ml{\cdot}min)$. 4. Pharmacokinetic parameters such as Tmax, Cmax and $[AUC]^{\infty}_0$ of product A and B did not differ significantly(p>0.05). On the other hand, those of product C were significantly different(p>0.05).

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.8 s.99
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• pp.825-834
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• 2005

In this paper, a new signal canceller that input signals are equally group-delayed and cancelled each other is proposed and feedforward linearizing power amplifier that adopt the proposed signal cancellers is fabricated. Although the conventional signal canceller can't matches the phase and the group delay time of input signals simultaneously, the proposed signal canceller matches those simultaneously. Simultaneous matching of the phase and the group delay time can makes wideband signal cancellation. The main signal cancellation loop of the fabricated feedforward amplifier with the proposed signal cancellers cancel input signal more than 26.3 dB and the intermodulation distortion signal cancellation loop cancel more than 15.2 dB for 200 MHz bandwidth. And the proposed feedforward power amplifier improves C/I ratio by 20.8 dB with two tones at 2,115 MHz, 2,165 MHz, respectively.

• Korean Journal of Materials Research
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• v.17 no.1
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• pp.11-17
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• 2007

Turbulent in-situ mixing process is a new material process technology to get dispersed phase in nanometer size by controlling reaction of liquid/solid, liquid/gas, flow ana solidification speed simultaneously. In this study, mixing which is the key technology to this synthesis method was studied by computational fluid dynamics. For the simulation of mixing of liquid metal, static mixers investigated. Two inlets for different liquid metal meet ana merge like 'Y' shape tube having various shapes and radios of curve. The performance of mixer was evaluated with quantitative analysis with coefficient of variance of mass fraction. Also, detailed plots of intersection were presented to understand effect of mixer shape on mixing. The simulations show that the Reynolds number (Re) is the important factor to mixing and dispersion of $TiB_2$ particles. Mixer was designed according to the simulation, and $Cu-TiB_2$ nano composites were evaluated. $TiB_2$ nano particles were uniformly dispersed when Re was 1000, and cluster formation and reduction in volume fraction of $TiB_2$ were found at higher Re.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.3
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• pp.647-653
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• 2016

Recently, the data image processing has been applied to a variety of fields including broadcasting, communication, computer graphics, medicine, and so on. Generally, the image data may develop the noise during their transmission. Therefore, the studies have been actively conducted to remove the noise on the image. There are diverse types of noise on the image including salt and pepper noise, AWGN, and mixed noise. Hence, the filter algorithm for the image recovery was proposed that salt and pepper noise was processed by histogram and spatial weighted values after defining the noise to lessen the impact of mixed noise added in the image, and AWGN was processed by the pixel information of local mask establishing the weighted values in this study. Regarding the processed results by applying Lena images which were corrupted by salt and pepper noise(P=50%) and AWGN(${\sigma}=10$), suggested algorithm showed the improvement by 7.06[dB], 10.90[dB], 5.97[dB] respectively compared with the existing CWMF, A-TMF, AWMF.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.37 no.2
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• pp.91-97
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• 2000

Tn this paper, a novel control circuit applicable to the error sensor loop block in the feedforward linearizer system is proposed. The proposed control circuit is applied to the error sensor loop block, where in the 11dB power range, it operates stably, and makes main carrier signals to be eliminated more than 40dB below 3$\^$rd/ order IM level. In the operating point, the amplitude control error is 0.05∼0.12dB, and the phase control error is smaller than 0.02。. It is verified theoretically as well as experimentally that the control circuit can precisely compensate the variation of nonlinear characteristics in a high power amplifier, due to the variations of input power, operating temperature, humidity and the other system environments.

• The Korea Journal of Herbology
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• v.27 no.4
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• pp.73-80
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• 2012

Objectives : Under normal condition melanin protects the skin from extracellular stimuli including ultraviolet (UV)-induced oxidative skin damages, but excess production and accumulation of melanin can induce hyperpigmentation causing esthetic problems. Therefore, in this study we tried to search for natural skin whitening materials from marine natural resources. Methods : Water and ethanol extracts of marine natural resources were prepared from Porphyra thalli (PT), Laminariae thallus (LT), Ostreae concha (OC), Sargassum thallus (ST), Undaria thallus (UT), Codium thalli (CT), Enteromorpha thalli (ET), Syngnathoides biaculeatus (SB), and Hippocampus coronatus (Hc). Their effects against UVB and ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH)-induced melanogenesis were investigated based on melanin formation in B16 mouse melanoma cells. The mRNA and protein expression of enzymes involved in the melanogenic process were further examined by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis, respectively. Results : Water extract of Ostreae concha (OCW/E) effectively inhibited UVB and ${\alpha}$-MSH-induced melanin production in B16 melanocytes, which seemed to be mediated by inhibition of mRNA expression of tyrosinase and tyrosinase-related protein 1 (TRP-1). In another experiment, ethanol extracts from Porphyra thalli (PTE/E), Laminariae thallus (LTE/E), Sargassum thallus (STE/E), Undaria thallus (UTE/E), Codium thalli (CTE/E), Syngnathoides biaculeatus (SBE/E), and Hippocampus coronatus (HcE/E) significantly suppressed UVB and ${\alpha}$-MSH-induced melanin formation. Furthermore, ethylacetate fraction isolated form LTE/E (LTE/EEt) decreased UVB and ${\alpha}$-MSH-elevated extracellular melanin levels via inhibition of tyrosinase protein expression. Conclutions : These results suggest that marine natural resources such as Porphyra thalli, Laminariae thallus, Ostreae concha, Sargassum thallus, Undaria thallus, Codium thalli, Syngnathoides biaculeatus and Hippocampus coronatus have anti-melanogenic effects, thereby exhibiting high potentials to be utilized as one of the ingredients for the development of new whitening functional cosmetics.

• Bulletin of the Korean Chemical Society
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• v.29 no.10
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• pp.1915-1919
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• 2008

Second-order rate constants ($k_N$) have been measured spectrophotometrically for reactions of 3,4-dinitrophenyl benzoates (5b) with a series of alicyclic secondary amines in 80 mol % $H_2O$/20 mol % DMSO at 25.0 ${\pm}$ 0.1 ${^{\circ}C}$. The kinetic data have been compared with the data reported previously for the corresponding reactions of 2,4- dinitrophenyl benzoates (5a) to investigate the effect of changing the nucleofuge from 2,4-dinitrophenoxide to 3,4-dinitrophenoxide on reactivity and mechanism. The kinetic results show that aminolyses of 5a and 5b proceed through the same mechanism, i.e., a zwitterionic tetrahedral intermediate ($T^{\pm}$) with a change in the rate-determining step (RDS). Substrate 5a is more reactive than 5b when breakdown of $T^{\pm}$ is the RDS but less reactive when formation of $T^{\pm}$ is the RDS. Dissection of kN values into the microscopic rate constants (e.g., $k_1$ and $k_2/k_{-1 }$ ratio) has revealed that 5a results in larger $k_2/k_{-1}$ ratios but smaller k1 values than 5b for all the amines studied. Since 2,4-dinitrophenoxide is less basic and a better nucleofuge than 3,4-dinitrophenoxide, the larger $k_2/k_{-1}$ ratios determined for the reactions of 5a than for those of 5b are as expected. The steric hindrance exerted by the ortho-nitro group on 5a contributes to the smaller k1 values found for the reactions of 5a than for those of 5b.

• Journal of IKEEE
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• v.19 no.1
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• pp.87-93
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• 2015

In this paper, a $145{\mu}W$, 87dB SNR, Low power 3rd order Sigma-Delta Modulator with Op-amp sharing is proposed. Conventional architecture with analog path and digital path is improved by adding a delayed feed -forward path for disadvantages that coefficient value of the first integrator is small. Proposed architecture has a larger coefficient value of the first integrator to remove the digital path. Power consumption of proposed architecture using op-amp sharing is lower than conventional architecture. Simulation results for the proposed SDM designed in $0.18{\mu}m$ CMOS technology with power supply voltage 1.8V, signal bandwidth 20KHz and sampling frequency 2.8224MHz shows SNR(Signal to Noise Ratio) of 87dB, the power consumption of $145{\mu}W$.