The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Extrat of Xanthii Fructus down-regulate TLR-4 mediated murine peritoneal macrophage inflammatory response by limiting NO synthase and $IkB-{\alpha}$ degradation

TLR-4 로 유도한 동물 복강 대식세포에서 창이자 추출물의 NO 합성과 $IkB-{\alpha}$ 분해 억제에 의한 염증 반응 억제 효과

  • Jung, Won-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Seo, Sang-Wan (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Cho, Joon-Ji (Dept. of Internal Medicine, IKsan Oriental Hospital, Wonkwang University) ;
  • Son, Ji-Woo (Dept. of Internal Medicine, IKsan Oriental Hospital, Wonkwang University) ;
  • Park, Min-Cheol (Dept. of Internal Medicine, IKsan Oriental Hospital, Wonkwang University) ;
  • Choi, Chang-Min (Dept. of Internal Medicine, Kwangju Oriental Hospital, Wonkwang University) ;
  • Yeom, Seung-Ryong (Dept. of Internal Medicine, Kwangju Oriental Hospital, Wonkwang University) ;
  • Hwang, Sang-Wook (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Yong-Woo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Dal-Soo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Chae, Young-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Choi, Won-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • No, Jeong-Eun (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Yun, Han-Ryoung (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Yeong-Mok (Dept. of Oriental Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Min-Kyo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Jon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
  • 정원석 (원광대학교 한의과대학 본초학 교실) ;
  • 서상완 (원광대학교 한의과대학 본초학 교실) ;
  • 조준기 (원광대학교 익산 한방병원) ;
  • 손지우 (원광대학교 익산 한방병원) ;
  • 박민철 (원광대학교 익산 한방병원) ;
  • 최창민 (원광대학교 광주 한방병원) ;
  • 염승룡 (원광대학교 광주 한방병원) ;
  • 황상욱 (원광대학교 한의과대학 본초학 교실) ;
  • 김영우 (원광대학교 한의과대학 본초학 교실) ;
  • 송달수 (원광대학교 한의과대학 본초학 교실) ;
  • 채영석 (원광대학교 한의과대학 본초학 교실) ;
  • 최원석 (원광대학교 한의과대학 본초학 교실) ;
  • 노정은 (원광대학교 한의과대학 본초학 교실) ;
  • 윤한룡 (원광대학교 한의과대학 본초학 교실) ;
  • 김영목 (원광대학교 한의과대학 한방 병리학 교실) ;
  • 박성주 (원광대학교 한의과대학 본초학 교실) ;
  • 신민교 (원광대학교 한의과대학 본초학 교실) ;
  • 송호준 (원광대학교 한의과대학 본초학 교실)
  • Published : 2006.09.30
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Abstract

Objectives : The purpose of this study was to investigate the TLR-4 mediated anti-inflammatory effects of extract from Xanthii Fructus(XF) on the peritoneal macrophage. Methods : To evaluate of TLR-4 mediated inflammatory of XF, we examined NO and cytokine production in TRL-4 ligand(LPS-lipopolysacchride) induced macrophages. Furthermore, we checked molecular mechanism using western blot. Results : l.Extract from XF reduced LPS-induced Nitric oxide (NO), tumor necrosis factor-a (TNF-a), interleukin (IL)-6 and IL-12 production in peritoneal macrophages 2.Extract from XF itself does not have any cytotoxic effect.XS inhibited degradation of IkBa in the TLR-4 mediated peritoneal macrophages Conclusion : XF down-regulated TLR4 ligand(LPS)-induced NO and cytokine productions.

Keywords