• Clinical and Experimental Reproductive Medicine
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• 제22권2호
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• pp.163-170
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• 1995

Growth factors (GFs) produced by the embryo or by the maternal reproductive tract have been reported to regulate the embryonic development and differentiation. Among GFs, EGF as a mitogen plays a role in mitosis and functional differentiation of trophectoderm cells in mouse. The present study was carried out to investigate the effect of EGF on development of mouse embryos and to localize EGF in the mouse oocytes and embryos, which has been reported to be detected in the reproductive tract in mammals. To investigate the effect of EGF on the development of the embryo, mouse 2-cell embryos were cultured to blastocysts stage in Ham's F10 medium, treated with EGF(10-50 ng/ml) for 72 hrs. Immunocytochemistry was performed from oocyte to blastocyst stage with anti-EGF and anti-Mouse IgG, in order to determine the stage which EGF would be expressed in mouse. Exogenous EGF (more than 10 ng/ml) in the culture medium improved the developmental and hatching rates in the mouse embryos. As a result of immunocytochemistry, the embryonic EGF was expressed after the late 4-cell stage. EGF is thought to enhance preimplantation embryonic development and hatching. Exogenous EGF in the culture medium is thought to activate EGF receptor in the late 4-cell embryos and to enhance blastulation and hatching in mouse embryos. It is concluded that EGF enhances the developmental and hatching rates in the mouse embryos.

• 한국식품영양과학회지
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• 제24권6호
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• pp.837-842
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• 1995

고추가루 첨가 식이가 체액성 면역기능에 미치는 영향을 조사하였다. 실험동무로 흰쥐를 사용하여 대조군과 2%, 5%, 10% 고추가루 첨가 식이군을 설정한 후 27일간 실험식이로 사육하였다. 실험종료 10일 전에 각군의 흰쥐를 면양적혈구로 세차례 면역시킨 후 항체생성 세포수 및 혈청 중 항체 농도 등 체액성 면역기능을 중심으로 조사하였다. 그 결과, 대조군에 비해 고추가루 첨가 식이군의 항체 생성 세포수, 적혈구 응집반응 및 혈청중 항체 농도가 높은 것으로 나타났으며, 또한 이때 고추가루 첨가식이군의 각 장기조직 중 AsA 함량은 대조군에 비해 높은 것으로 나타났다. 이들 결과로 보아, 고추성분은 체액성 면역기능의 활성화에 기여하는 물질을 함유하고 있을 뿐만이 아니라, AsA의 공급효과가 뛰어난 것이 확인되었다.

• 한국정보과학회논문지:데이타베이스
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• 제32권1호
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• pp.12-23
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• 2005

지난 10년간 CPU의 속도는 메모리의 속도에 비해 급속한 속도로 발전하였다 그 결과 데이터 베이스 시스템을 포함한 다른 컴퓨터 응용분야에서 메모리의 접근이 병목현상을 일으키게 되었다. 메모리의 접근 속도를 줄이기 위해 캐시 메모리가 도입되었다 하지만 캐시 메모리는 원하는 데이타가 캐시에 옮겨져 있어야 메모리 접근 속도를 줄일 수 있다. 때문에 응용프로그램에서 데이타를 어떤 순서로 액세스 하느냐에 따라 캐시의 활용도가 달라지고 응용프로그램의 성능이 달라지게 된다. 이 시점에서 현재 컴퓨터에서 B+-트리가 T-트리보다 더 빠르다는 사실이 알려졌다. B+-트리가 T-트리보다 캐시를 더 효율적으로 사용하기 때문이다. 또한 B+-트리를 개선하여 캐시를 더욱 효율적으로 사용하는 CSB+-트리(Cache Sensitive B+-tree)가 제안되기도 하였다 본 논문의 목표는 T-트리가 캐시를 효율적으로 사용하도록 새로운 T-트리 구조를 개발하는 것이다. CSB+-트리와 같이 시스템의 L2 캐시를 최대한 활용하며 기존 T-트리가 가지는 장점을 가지는 새로운 CST-트리(Cache Sensitive T-트리)를 설계 개발하고, 실험을 통해 기타 다른 인덱스 구조에 비교하여 CST-트리의 우수성을 보인다.

• 동의생리병리학회지
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• 제19권2호
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• pp.380-388
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• 2005

In this study, the immunological effect of a traditional Korea herbal medicine, Sochungyong-tang (SCRT) that has been widely used for the treatment of various immunological disorders including allergic asthma in Korea, was examined in vitro. In our previous study demonstrated that SCRT decreases the expression of IL-4 mRNA, that plays pivotal role in Th2 cell development, while increases $IFN-{\gamma}{\tilde{a}}expression$, which is one of the key cytokines for Th1 lineage development in Th0 condition. That study strongly implies that SCRT can correct Th2 dominant condition directly affecting to the CD4+ T cell development. Present study designated to further evaluate the SCRT on helper T cell development by monitoring Th1/Th2 specific cytokine secretion patterns in artificially induced Th1 or Th2 polarized condition. The results demonstrated that Th2 cells were dramatically under-populated in Th2 driven condition with SCRT treatment, while Th1 cells were not altered in Th1 skewed condition. Furthermore, under Th2-skewed conditions the levels of and IL-4 were considerably decreased with SCRT treatment. However, the expression of GATA-3, a transcription factor that plays pivotal role in Th2 lineage programming, was not changed with SCRT, suggesting that the suppression of Th2 cell development by SCRT was not mediated by GATA-3. Present study implies that the effect on CD4+ T cell may be the one of key pharmacological effect point for treating IgE medicated allergic asthma by SCRT. These results also suggest that SCRT might be desirable agent for the correction of Th2 dominant pathological disorders.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제2권2호
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• pp.233-239
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• 1999

Acrodermatitis enteropethica (AE) is a rare autosomal recessive disorder of zinc absorption leading to chronic diarrhea and characteristic skin lesion. The term is also applied to any acquired zinc deficiency state resulting in the same clinical pictures. We experienced one case of AE in 1 month old male infant who had bacterial enterocolitis. The skin around mouth, anus, eyes, ears, hands and legs became reddish, vesicular and eczematoid. Serum zinc level was decreased to $51.4\;{\mu}g/dL$ (N=70~150). Endoscopic finding revealed pale gastric mucosa and villous atrophy of small intestine. Biopsy finding of small intestine showed no villi due to mucosal atrophy. On 13 day of admission jaundice with DIC were noted and AST & ALT were elevated to 110 & 36.8 IU/L, respectively. Diarrhea was improved but jaundice and liver function were not recovered until discharge from hospital. After discharge when the patient was 4 months of age serum bilirubin and AST/ALT had not been normalized. CMV shell vial culture of urine and CMV Ig G antibody were positive. So intravenous ganciclovir injection of 7.5 mg/kg, two times a day for 2 weeks and then 10 mg/kg/day for 3 months was done from 4 to 6 months of age. No virus was found in the urine and AST & ALT were normalized at 2 months after stopping ganciclovir treatment.

• Childhood Kidney Diseases
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• 제10권1호
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• pp.52-57
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• 2006

저자들은 스테로이드 반응성 재발성 신증후군의 과거력이 있는 환아에서 관해기에 발병한 Kimura 병을 종괴의 전절제 후 스테로이드 및 cyclosporin 투여로 치료한 증례를 경험하고 이를 보고하는 바이다.

• 대한전자공학회논문지TC
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• 제46권4호
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• pp.13-28
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• 2009

DTN(Delay/Disruption Tolerant Network)에서 라우팅 프로토콜은 전송 지연 및 성공적인 전달 확률의 성능을 개선하기 위해 중요하다. 이 논문에서 우리는 이동성 유형 기반의 라우팅(MPR ; Mobility Pattern based Routing)이라는 효과적인 DTN 라우팅 알고리즘을 제안하는데 이는 이동 노드의 이동성 유형에 근거해 복사되는 메시지의 수를 제어하게 된다. 또한, 우리는 인간 이동성 유형을 가장 잘 나타낼 수 있는 확산성이 매우 큰(super-diffusive) 성질을 가지는 실제적인 "Levy Walk" 이동성 유형을 고려하였다. 우리는 제안된 MPR 알고리즘과 Levy Walk 이동성 유형의 검증을 위해 ONE simulator를 이용한 DTN simulator를 구현하였다. 시뮬레이션 결과 이동성 유형이 DTN 라우팅 성능의 정확한 분석을 위해 매우 중요하다는 것과 제안한 MPR이 실제 이동성 유형 하에서 성공적인 전달 확률이나 전송 지연 측면에서 라우팅 성능을 향상시킴을 보였다.

• 대한금속재료학회지
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• 제50권12호
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• pp.939-948
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• 2012

A 3-ply clad metal consisting of aluminum and copper was fabricated by roll bonding process and the microstructures and mechanical properties of the roll-bonded and post-roll-bonding heat treated Cu/Al/Cu clad metal were investigated. A brittle interfacial reaction layer formed at the Cu/Al interfaces at and above $400^{\circ}C$. The thickness of the reaction layer increased from $12{\mu}m$ at $400^{\circ}C$ to $28{\mu}m$ at $500^{\circ}C$. The stress-strain curves demonstrated that the strength decreased and the ductility increased with heat treatment up to $400^{\circ}C$. The clad metal heat treated at $300^{\circ}C$ with no indication of a reaction layer exhibited an excellent combination of the strength and ductility and no delamination of layers up to final fracture in the tensile testing. Above $400^{\circ}C$, the ductility decreased rasxpidly with little change of strength, reflecting the brittle nature of the intermetallic interlayers. In Cu/Al/Cu clad heat treated above $400^{\circ}C$, periodic parallel cracks perpendicular to the stress axis were observed at the interfacial reaction layer. In-situ optical microscopic observation revealed that cracks were formed in the Cu layer due to the strain concentration in the vicinity of horizontal cracks in the intermetallic layer, promoting the premature fracture of Cu layer. Vertical cracks parallel to the stress axis were also formed at 15% strain at $500^{\circ}C$, leading to the delamination of the Cu and Al layers.

• 대한금속재료학회지
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• 제50권5호
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• pp.345-351
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• 2012

A three-point bending test was performed on roll-bonded Mg/Al/STS clad-metal plates under two different testing conditions (Mg layer in tension, or STS in tension) and their mechanical response and fracture behavior were investigated. Bending strength was found to be greater under the condition of Mg layer in tension. Heat treatment at $200^{\circ}C$ increased the bending formability, suggesting the interfacial strength increased at $200^{\circ}C$. Under the condition of Mg in tension, the clad heat-treated at $300^{\circ}C$ and $400^{\circ}C$ fractured in two steps, with the first step associated with the interfacial fracture between Mg and Al, and the second the fracture of the Mg layer. STS/Al layers were found to be bent without complete fracture. Under the condition of STS in tension, the clad heat-treated at $300^{\circ}C$ and $400^{\circ}C$ exhibited a very small load drop at the displacement, which is similar to that of the first load drop associated with the interfacial fracture under the condition of Mg in tension. In this case, no interfacial cracks were found and the complete cut-through fracture of clad was observed at low temperature heat treatment conditions, suggesting excellent interfacial strength. When the heat treatment temperature was higher than $300^{\circ}C$, interfacial cracks were observed. The local stress condition and the position of the interface with respect to the surface were found to have a great influence on the fracture behaviors of clad metals.

• 한국연극학
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• 제48호
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• pp.171-196
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• 2012

In der vorliegende Arbeit wird die neue politische $M{\ddot{o}}glichkeit$ des Theaters untersucht. Wie die politische Propaganda, die Volk mit den absoluten Dogmen zu ${\ddot{u}}berzeugen$, immer seltner geworden ist, haben die alten Versuche des Theaters, ein Publikum mit einem Botschaft $aufzukl{\ddot{a}}ren$ und zu ${\ddot{u}}berreden$, ihre ehemalige ${\ddot{U}}berzeugungskraft$ verloren. In der heutigen Welt kann Theater leider nicht als eine moralische Anstalt mehr funktioniert. An diesem Endpunkt, wo Theater heute anzukommen scheint, gibt es aber auch Versuche, Theater auf neue Weise politisch zu machen. Es handelt sich hier $nat{\ddot{u}}rlich$ nicht um Wiedergabe einer ideologischen Diskurs mehr, sondern um die $St{\ddot{o}}rung$ der Wahrnehmung der Zuschauer durch das $Enth{\ddot{u}}llung$ des Anderen, den die System des Neo-liberalismus $verh{\ddot{u}}llt$. Damit der Anderen aufgezeigt wird, machen die verschiedene theatralische Experimente die $B{\ddot{u}}hne$ zu einem leeren Raum, indem sie den $gew{\ddot{o}}hnlichen$ dramatischen Rahmen zu $zerst{\ddot{o}}ren$ versucht. In diesem Raum wird die Vorstellungskraft der Zuschauer erst aktiviert, dadurch die Zuschauer selbst entscheiden $k{\ddot{o}}nnenn$, was sie verstehen $m{\ddot{o}}chten$ und wie sie sich dazu verhalten sollen. All diese Prozesse $m{\ddot{u}}ssen$ die Zuschauer auch als Individuum konstruieren. Die von tradtionellen Theater $getr{\ddot{a}}umte$ Zuschauergemeinschaft, die der Botschaft aus der $B{\ddot{u}}hne$ $gleichm{\ddot{a}}{\ss}ig$ zugestimmt hat, ist daher nicht mehr da. Im heutigen Theater handelt es sich um jeden Zuschauer, der selbst aktiv handelt. Solche Subjekt ist die echte demokratische, die in der heutigen politischen Wissenschaft mehrmals betont wird.