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Sochungyong-tang, Tradititional Korean Medicine, Suppresses Th2 Lineage Development  

Jeong, Hyuk-Joon (Department of Physiology, College of Oriental Medicine, KyungHee University)
Hong, Moo-Chang (Department of Physiology, College of Oriental Medicine, KyungHee University)
Shin, Min-Kyu (Department of Physiology, College of Oriental Medicine, KyungHee University)
Bae, Hyun-Su (Purimed R&D Institute)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.2, 2005 , pp. 380-388 More about this Journal
Abstract
In this study, the immunological effect of a traditional Korea herbal medicine, Sochungyong-tang (SCRT) that has been widely used for the treatment of various immunological disorders including allergic asthma in Korea, was examined in vitro. In our previous study demonstrated that SCRT decreases the expression of IL-4 mRNA, that plays pivotal role in Th2 cell development, while increases $IFN-{\gamma}{\tilde{a}}expression$, which is one of the key cytokines for Th1 lineage development in Th0 condition. That study strongly implies that SCRT can correct Th2 dominant condition directly affecting to the CD4+ T cell development. Present study designated to further evaluate the SCRT on helper T cell development by monitoring Th1/Th2 specific cytokine secretion patterns in artificially induced Th1 or Th2 polarized condition. The results demonstrated that Th2 cells were dramatically under-populated in Th2 driven condition with SCRT treatment, while Th1 cells were not altered in Th1 skewed condition. Furthermore, under Th2-skewed conditions the levels of and IL-4 were considerably decreased with SCRT treatment. However, the expression of GATA-3, a transcription factor that plays pivotal role in Th2 lineage programming, was not changed with SCRT, suggesting that the suppression of Th2 cell development by SCRT was not mediated by GATA-3. Present study implies that the effect on CD4+ T cell may be the one of key pharmacological effect point for treating IgE medicated allergic asthma by SCRT. These results also suggest that SCRT might be desirable agent for the correction of Th2 dominant pathological disorders.
Keywords
Sochungyong-tang; Th1; Th2; allergy; asthma; $IFN-{\gamma}$; IL-4; T-bet; GATA-3;
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Times Cited By KSCI : 1  (Citation Analysis)
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