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Antimutagenic Activities of 24 Synthetic Flavones with The Salmonella Microsomal Assay

  • Laget, M.;De Meo, M.;Wallet, J.C.;Gaydou, E.M.;Guiraud, H.;Dumenil, G.
    • Archives of Pharmacal Research
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    • v.18 no.6
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    • pp.415-422
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    • 1995
  • Twenty-four flavones were synthesized with various hydroxyl and/or methoxyl groups on A and B rings. Their antimutagenic properties were evaluated against ben:w(a)pyrene (BaP) and a pool of mutagenic urine concentrate (U) using a modified liquid incubation method of Ames test. The tester strain was Salmonella typhimurium TA98+S9 Mix. The antimutagenic activities were calculated by non linear regression analysis and the doses of flavones (in nmoles) required for a 50% reduction of induced revertants with BaP and U were defined as the inhibition doses (TEX>$ID_{508}{\;}and{\;}ID_{508}$ respectively). Seventeen flavones possessed significant antimutagenic activity against BaP. $ID_{508}$ ranged from 15.1 nmoles (F22) to 1000.6 nmoles (F13). Eighteen f1avones showed significant antimutagenic activity against U. $ID_{50U}$ ranged from 23.5 nmoles (F22) to 354.6 nmoles (F3). The 2',3',4'-trihydroxyflavone (F22, $ID_{508}=15.1$ nmoles, $ID_{50U}=23.5$ nmoles) and the 2',3',4',7-tetrahydroxyflavone (F20, $ID_{508}=37.8$ nmoles; $ID_{50U}=62.3$ nmoles) had antimutagenic activities similar to those of chlorophyllin ($ID_{508}=19.6$ nmoles and $ID_{50U}=44.2$ nmoles) and were evaluated against B(alP 7,8-dihydrodiol-9,10-epoxide. Against this last mutagen, the flavones which included three OH in B ring showed the highest activity and this property seemed independent of the substituent groups on A ring.

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Effect of Phenolic Mediators and Humic Acid on the Removal of 1-Indanone Using Manganese Oxide (망간산화물(Birnessite)을 이용한 1- Indanone 제거 시 페놀계 반응매개체와 휴믹산(HA) 영향 평가)

  • Choi, Chan-Kyu;Eom, Won-Suk;Shin, Hyun-Sang
    • Journal of Korean Society of Environmental Engineers
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    • v.34 no.7
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    • pp.445-453
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    • 2012
  • An investigation for removal of 1-indanone (1-ID), which were commonly produced from the biological and/or chemical treatment and natural weathering of the PAHs-contaminated soils, via oxidative transformation mediated by birnessite in the presence of various phenolic mediators is described. This study also examines the potential effect of the natural occurring substance humic acid (HA) on the oxidative transformation. The experiment was carried out in aqueous phase as a batch test (10 mg/L 1-ID, 0.3 mM phenolic mediators, $1.0g/L\;{\delta}-MnO_2$, at pH 5). All of the 11 tested phenoilic mediators belong to the group of natural occurring phenols and are widely used as model constituents of humic substances. From the results of HPLC analysis, it is demonstrated that 1-ID was not reactive to birnessite itself, but it can be effectively removed in birnessite-mediated cross coupling reactions in the presence of the phenolic mediators. The percent removals of 1-ID after 2 day incubation were ranged from 9.2 to 71.2% depending on the phenolic mediators applied. The initial rate constant ($K_{int}$, $hr^{-1}$) values for the 1-ID removals obtained from the pseudo-first-order kinetic plots also widely ranged from 0.18 to 15.0. Results of the correlative analysis between the removal efficiencies and structural characteristics of phenolic mediators indicate that the transformation of the 1-ID was considerably enhanced by the addition of electron-donating substituents (e.g., -OH, $-OCH_3$) at the benzne ring, and much less enhanced by the addition of electron-withdrawing substituents (e.g., -COOH, -CHO). The presence of HA showed that removal efficiencies of 1-ID in the birnessite-phenolic mediator systems decreased with increasing HA concentrations. However at low concentration of HA (< 2 mg/L), it caused some enhancement in the removals of 1-ID as compared to the control.

Genotoxicity Tests on Hyrubicin ID6105, a Novel Anthracycline Anticancer Agent (새로운 Anthracycline계 항암제 Hyrubicin ID6105에 대한 유전독성연구)

  • 장호송;정미숙;이홍섭;유정수;김태영;김윤배;강종구
    • Toxicological Research
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    • v.18 no.4
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    • pp.385-391
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    • 2002
  • The genotoxic potential of Hyrubicin lD6105, a novel anthracycline anticancer agent, was examined on bacterial mutagenicity, mammalian cell chromosome aberration and mouse micronucleus tests. In mutagenicity (Ames') test, Salmonella typhimurium strain TA98, TA100, TA1535 and TA1537, and Escherichia coli WP2uvrA- were treated with ID6105 at doses of 312.5, 625, 1,250, 2,500 and 5,000 $\mu\textrm{g}$/ plate with or without a metabolic activation system (S9 mix). Interestingly, ID6105 significantly enhanced the number of revertant colonies of TA98 strain at all dose levels used, in the presence or absence of S9 mix, without affecting other strains of S. typhimurium and E. coli. In chromosome aberration test using cultured chinese hamster lung fibroblasts, ID6105 (1.25, 2.5 and 5 $\mu\textrm{g}$/ml) did not increase the number of aberrant cells, compared with vehicle control. in the presence or absence of S9 mix. In addition, ID6105 treatment (2.5, 5 and 10 mg/kg) did not induce micronucleated polychromatic erythrocytes in mice. Taken together, it is suggested that ID6105 might not affect chromosome integrity in mammalian system in vitro and in vivo, although it may induce frame shift mutation of specific bacterial strain such os S. typhimurium TA98.

Additional Data Transmission Scheme Using TxID Signal for ATSC System (ATSC 지상파 DTV 시스템에서 TxID를 이용한 부가데이터 전송 기법)

  • Kang, Dong-Hoon;Park, Sung-Ik;Kim, Heung-Mook;Oh, Wang-Rok
    • Journal of Broadcast Engineering
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    • v.16 no.1
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    • pp.64-72
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    • 2011
  • In a Single Frequency Network (SFN) for Advanced Television Systems Committee (ATSC) terrestrial digital television (DTV) system, the interferences induced by the multiple transmitters and/or repeaters using same frequency are unavoidable. To ease the interference handing in the SFN for ATSC DTV system, transmitter identification (TxID) signal is recommended in the ATSC terrestrial DTV system. The TxID signal is embedded in the ATSC DTV signal and transmitted from each transmitter and repeater within the SFN and in ATSC recommended practice (RP) A/111, Kasami sequence is recommended as the TxID signal. In this paper, we propose an additional data transmission scheme using the TxID signal. In the proposed scheme, the Kasami sequence not only acts as the conventional TxID of the SFN for ATSC terrestrial DTV system but also carriers the additional data bits on its polarity and the code phase.

2D Crank-Nicolson FDTD Method Based on Isotropic-Dispersion Finite Difference Equation for Lossy Media (손실 매질에 대한 Isotropic-Dispersion 유한 차분식의 2D Crank-Nicolson FDTD 기법)

  • Kim, Hyun;Koh, Il-Suek;Yook, Jong-Gwan
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.21 no.7
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    • pp.805-814
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    • 2010
  • The Crank-Nicolson isotropic-dispersion finite difference time domain(CN ID-FDTD) scheme is proposed based on isotropic-dispersion finite difference(ID-FD) $equation^{[1],[2]}$. The dispersion relation of CN ID-FDTD is derived for lossy media by solving the eigenvalue problem of iteration matrix in spatial spectral domain, in addition, the weighting factors and scaling factors of the CN ID-FDTD scheme are presented for low dispersion error. The CN ID-FDTD scheme makes the dispersion error drastically reduced and shows accurate numerical results compared to the conventional Crank-Nicolson FDTD method.

The Case Report of Tinea Pedis with Id Reaction (이드반응이 동반된 족부백선 환자 치험 1례)

  • Kwon, Kang;Kim, Chul-Yun;Lee, Dong-Jin;Kim, Nam-Kwen;Seo, Hyung-Sik
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.28 no.1
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    • pp.134-142
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    • 2015
  • Objective : This study was carried out to find out the effect of Korean medical treatments on tinea pedis with id reaction. Method : We treated a 33-year-old man was afflicted with tinea pedis complicating id reaction with herbal medicine, acupuncture, ointment, wet-dressing and steam treatment. After treatments, we measured the status of scales, fissures and the degree of pruritus. We followed up symptom changes by taking pictures and compared before and after. Result & Conclusion : Three days after admission, erythema occurred at upper and lower limbs and the degree of pruritus increased by id reaction. As tinea pedis improved, id reaction decreased, too. Consequently, both sites of primary lesions of tinea pedis and secondary id reactions were significantly improved, and accompanied symptoms were resolved simultaneously.

An Access Control Based Privacy Protection Model in ID Management System (ID관리시스템의 접근통제기반 프라이버시 보안모델)

  • Choi Hyang-Chang;Noh Bong-Nam;Lee Hyung-Hyo
    • Journal of Internet Computing and Services
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    • v.7 no.1
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    • pp.1-16
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    • 2006
  • The vulnerability of privacy in the Identity Management System (IMS) is the most pressing concern of ordinary users. Uncertainty about privacy keeps many users away from utilization of IMS. Therefore, this paper proposes an access-control oriented privacy model for IMS. The proposed model protects privacy using access control techniques with privacy policies in a single circle of trust. We address characteristics of the components of for the proposed model and describe access control procedures. After that, we show the architecture of privacy enforcement and XML-based schema for privacy policies.

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Effects of Indigestible Dextrin on Lipid Metabolism in Rats Fed Normal or High Fat Diet (식이지방 수준이 다른 식이를 섭취한 흰쥐의 체내 지질대사에 대한 난소화성 덱스트린의 섭취 효과)

  • 우동호;강현숙;이연숙;박양자;이현수
    • Journal of Nutrition and Health
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    • v.31 no.6
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    • pp.981-990
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    • 1998
  • The effects of indigestible dextrin on lipids in serum, tissue, and feces were investigated in two experiments carried out with 64 male Sprague-Dawley rats for eight weeks. Experiment I diet(normal fat diet) containing 5% corn oil and experiment II diet(high fat diet) containing 18% fat(13% beef tallow and 5% corn oil) and 1% cholesterol were divided into four groups with 0.5% cellulose(0.5CL : control), 10% cellulose(10CL), 10% Indigestible dextrin I(ID-I) and 10% indigestible dextrin II(ID-II), respectively. ID-I and ID-II diets produced a decrease in serum total lipid and cholesterol concentrations in both normal and high fat diets but more significantly in the groups fed high fat diet. ID-I, ID-II, and 10CL of high fat diet decreased serum glucose concentration. ID-I and ID-II diets also decreased liver cholesterol and triglyceride concentrations in rats fed normal and high fit diets. The fecal excretion of cholesterol in ID-II/high fat diet was significantly higher than that of 0.5CL diet. Bile acid excretion was increased in the rats fed 10CL and ID-II diets of normal and high fat diets. These observations indicat the hypolipidemic and hypocholesterolemic effects of indigestible dextrin on the rats. These effects are mediated by the increase of facal cholesterol and bile acid excretion. (Korean J Nutrition31(6) : 981-990, 1998)

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ID 관리 기술과 표준화 동향

  • Jung, Young-Gon;Jang, Ki-Hun;Lee, Sang-Rae;Jang, Jae-Hoon;Jin, Seung-Hun;Youm, Hong-Youl
    • Review of KIISC
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    • v.21 no.1
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    • pp.74-80
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    • 2011
  • 인터넷이 활발히 보급되고 활성화 되면서 그로 인하여 사용자는 많은 정보를 다루게 되고 수많은 자신의 정보를 기억하고 활용하기는 쉽지 않다. 이렇게 수많은 자신의 정보를 효율적이고 안전하게 관리하는 ID관리 중요성과 필요성이 대두되었다. 본 고에서는 국내외적으로 개발된 ID관리 기술들을 조사하고 분석하고 ID관리와 관련된 표준화의 동향을 국내외 표준화 기구를 대상으로 살펴본다. 또한 요즘 들어 이슈화되고 있는 클라우드 컴퓨팅과 ID관리 기술을 융합하는 기술과 표준화의 동향을 알아본다.

Anti-collision algorithm using Bin slot information for UHF (Bin 슬롯 정보를 이용한 UHF 대역 Anti-collision 알고리즘)

  • Choi Ho-Seung;Kim Jae-Hyun
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.43 no.1 s.343
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    • pp.41-48
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    • 2006
  • An anti-collision algorithm is very important in the RFID system because it decides tag identification time and tag identification accuracy. We propose improved anti-collision algorithms using Bin slot in RFID system. In the proposed algorithms, if the reader memorizes the Bin slot information, it can reduce the repetition of unnecessary PingID command and the time to identify tags. If we also use ScrollA11ID command in the proposed algorithm, the reader knows the sequence of collided E bits. Using this sequence, the reader can reduce the repetition of PingID command and tag identification time. We analyze the performance of the proposed anti-collision algorithms and compare the performance of the proposed algorithms with that of the conventional algorithm. We also validate analytic results using simulation. According to the analysis, for the random tag n, comparing the proposed algorithms with the conventional algorithm, the performance of the proposed algorithms is about $130\%$ higher when the number of the tags is 200. And for the sequential tag ID, the performance of the conventional algorithm decreases. On the contrary, the performance of the proposed algerian using ScrollA11ID command is about $16\%$ higher than the case of using random tag ID.