• 한국정밀공학회지
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• 제21권11호
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• pp.195-199
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• 2004

For the present study, the cryogenic ball milling process was applied to make Ibuprofen microsized. The cryogenic ball milling was performed at low temperature of about -18$0^{\circ}C$ for 6 hours. The particle size distribution was determined before and after the cryogenic process. X-ray diffraction (XRD) measurement was made to determine the effect of cryogenic process on the crystallinity of Ibuprofen. The results showed that the size of Ibuproffn was reduced about 10 times by the cryogenic process. The degree of crystallinity of Ibuproffn was slightly reduced by the cryogenic process.

• 약학회지
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• 제44권6호
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• pp.572-577
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• 2000

The effects of ibuprofen on bioavailability of ciprofloxacin were studied in rabbits. Animals were divided into three groups ; group A received 60 mg/kg of ciprofloxacin; group B and C received 60 mg/kg of ciprofloxacin with 60 and 240 mg/kg of ibuprofen, respectively. Ciprofloxacin and ibuprofen were given by single oral administration. Serum concentrations of ciprofloxacin were measured by high performance liquid chromatography with UV detector and pharmacokinetic parameters were calculated. Area under the serum concentrations versus time curve (${\pm}\;S.E.$) of ciprofloxacin were decreased in group B and C compared with group A ($12.26\;{\pm}\;0.94$ and $12.57\;{\pm}\;0.94$ vs. $15.71\;{\pm}\;1.06\;{\mu}g{\cdot}hr/ml$, p<0.05), whereas total clearances were increased ($1.81\;{\pm}\;0.13$ and $1.76\;{\pm}\;0.12$ vs. $1.40\;{\pm}\;0.09\;l/hr/kg$, p<0.05). No significant differances in these parameters were observed between group B and C. Relative bio-availability of group B and C to group A were 78 and 80%, respectively. These results suggest that the coadministration of ibuprofen with ciprofloxacin may reduce the bioavailability of ciprofloxacin.

• 폴리머
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• 제37권3호
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• pp.288-293
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• 2013

A group of molecularly imprinted polymers (MIPs) with specific recognition for chiral (S)-ibuprofen were successfully prepared based on hydrogen bonds, utilizing ${\alpha}$-methacrylic acid as a functional monomer. The IR analysis of MIPs showed that the blue- and red-shifted hydrogen bonds were formed between templates and functional monomers in the process of self-assembly imprinting and re-recognition, respectively. According to UV-Vis analysis, we found that the ratio of host-guest complexes between template molecule and functional monomer was 1:1. The effect of cross-linker's quantity on the polymerization was studied by transmission electron microscope (TEM). The adsorption selectivity experiments indicated that MIPs exhibited higher selectivity to (S)-ibuprofen than those to ketoprofen and (R)-ibuprofen, (S)-ibuprofen's structural analogs.

• IMMUNE NETWORK
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• 제10권3호
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• pp.92-98
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• 2010

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain, reduce fever and inhibit inflammation. NSAIDs function mainly through inhibition of cyclooxygenase (COX). Growing evidence suggests that NSAIDs also have immunomodulatory effects on T and B cells. Here we examined the effects of NSAIDs on the antigen presenting function of dendritic cells (DCs). Methods: DCs were cultured in the presence of aspirin or ibuprofen, and then allowed to phagocytose biodegradable microspheres containing ovalbumin (OVA). After washing and fixing, the efficacy of OVA peptide presentation by DCs was evaluated using OVA-specific CD8 and CD4 T cells. Results: Aspirin and ibuprofen at high concentrations inhibited both MHC class I and class II-restricted presentation of OVA in DCs. In addition, the DCs generated in the presence of low concentrations of the drugs exhibit a profoundly suppressed capability to present MHC-restricted antigens. Aspirin and ibuprofen did not inhibit the phagocytic activity of DCs, the expression level of total MHC molecules and co-stimulatory molecules on DCs. Ibuprofen rather increased the expression level of total MHC molecules and co-stimulatory molecules on DCs. Conclusion: These results demonstrate that aspirin and ibuprofen inhibit the intracellular processing event of the phagocytosed antigen, and further suggest that prolonged administration of NSAIDs in high doses may impair the capability of DCs to present antigens in asiociation with MHC molecules.

• Clinical and Experimental Pediatrics
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• 제60권6호
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• pp.175-180
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• 2017

Purpose: Plasma level of B-type natriuretic peptide (BNP), an emerging, sensitive, and specific biomarker of hemodynamically significant patent ductus arteriosus (PDA), rapidly decreases in infants receiving cyclooxygenase inhibitors for ductal closure. We investigated the usefulness of serial BNP measurement as a guide for individual identification of early constrictive responses to ibuprofen in preterm infants with symptomatic PDA (sPDA). Methods: Before March 2010, the standard course of pharmacological treatment was initiated with indomethacin (or ibuprofen) and routinely followed by 2 additional doses at intervals of 24 hours. After April 2010, individualized pharmacological treatment was used, starting with the first dose of ibuprofen and withholding additional ibuprofen doses if the BNP concentration was <600 pg/mL and clinical symptoms of PDA improved. Results: The BNP-guided group received significantly fewer doses of ibuprofen than the standard group did during the first course of treatment and the entire study period. The need for further doses of cyclooxygenase inhibitors and for surgical ligation was not significantly different between the 2 groups. No significant differences were seen in clinical outcomes and/or complications related to sPDA and/or pharmacological treatment. Conclusion: Individualized BNP-guided pharmacological treatment may be used clinically to avoid unnecessary doses of cyclooxygenase inhibitors without increasing the ductal closure failure and the short-term morbidity related to sPDA.

• 한국간담췌외과학회지
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• 제26권3호
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• pp.251-256
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• 2022

Backgrounds/Aims: Postoperative pain management is a key to enhanced recovery after surgery. The aim of this study was to evaluate clinical effect of preoperative intravenous (IV) non-steroidal anti-inflammatory drugs (NSAIDs) on relief of postoperative pain in patients after laparoscopic cholecystectomy. Methods: This single center, retrospective study was conducted between September 2019 and May 2020. A total of 163 patients were divided into two groups: Ibuprofen group (preoperative IV ibuprofen, n = 77) and Ketorolac group (preoperative IV ketorolac, n = 86). The primary outcome was postoperative pain score measured immediately in the recovery room. Results: There was no difference in demographic characteristics between the two groups of patients. Postoperative pain score measured immediately in the recovery room was significantly higher in the Ibuprofen group than in the Ketorolac group (mean value: 5.09 vs. 4.61; p = 0.027). The number of patients who needed analgesics immediately in the recovery room was also higher in the Ibuprofen group than in the Ketorolac group (28 [36.4%] vs. 18 [20.9%]; p = 0.036). Conclusions: In this study, preoperative IV injection with ketorolac reduced postoperative pain and analgesic requirement in the recovery room more effectively than that with ibuprofen. However, both showed similar effects on peak pain and pain at discharge. Numbers of patients requiring additional analgesics were also similar between the two groups.

• Clinical and Experimental Pediatrics
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• 제49권12호
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• pp.1315-1323
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• 2006

목 적 : 미숙아 동맥관 개존 치료시 기존 치료제인 indomethacin 사용시 소변량 감소등의 부작용이 있으나 ibuprofen은 비슷한 효능을 보이면서도 부작용의 빈도는 낮다는 외국의 보고가 있어 국내에서는 처음으로 ibuprofen의 효능과 안전성에 대하여 알아보고자 본 연구를 시행하였다. 방 법 : 2005년 4월부터 2005년 12월까지 고려대학교 의료원 안산병원에서 출생한 재태연령 25주 이상 34주 미만의 미숙아 중 임상적 증상이 있는 동맥관 개존으로 진단되어 ibuprofen을 투여한 환아 12명과 2003년 2월부터 2005년 3월까지 같은 진단으로 indomethacin을 투여한 미숙아 중 임의로 20명을 선택하여 두 군으로 나누어 동맥관 개존의 치료 효과 및 약물의 부작용 및 임상 경과 등을 비교하였다. 결 과 : Ibuprofen 투여군에서 12례 중 11례(92%)에서 동맥관이 폐쇄되었고 indomethacin 투여군에서는 20례 중 18례(90%)에서 동맥관이 폐쇄되어 두 군간의 차이는 없었다(P=1.000). 혈청 나트륨 농도는 두 군 모두 투여시기에 따라 유의하게 감소하였으며(P<0.0001) 투여 전에 비해 3차 용량 투여 48시간 이후에 의미있게 감소하였다(P=0.0011). 혈청 BUN 및 creatinine 농도는 두 군 모두 약물 투여 전후에 차이가 없었으며 군간에서도 차이가 없었다. 소변 배설량도 두 군간 차이는 없었고 각 군별 투여시기에 따른 비교에서도 통계적으로 유의한 차이는 없었다(P=0.0725). 임상적 경과 및 주산기 합병증의 빈도는 두 군간 차이는 없었다. 결 론 : 정주용 ibuprofen은 미숙아 동맥관 개존의 치료에 있어서 정주 indomethacin과 비교할 때 폐쇄율과 합병증 빈도에서 비슷한 효과를 나타내었으나 혈청 나트륨 농도의 변화도 유사한 변화를 보이는 사실로 보아 indomethacin의 대안적인 약물로 사용할 수 있다고 생각한다.

• KSBB Journal
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• 제19권4호
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• pp.263-268
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• 2004

최근 생체 내에서 다른 약리활성을 보이는 키랄물질의 고순도 제조에 관심이 증가되고 있다. 현재 널리 사용되고 있는 것은 키랄고정상을 이용한 기존 분리방법에 비해서, 제조 후 안정성과 환경적인 측면을 고려한 초임계유체를 이용한 분리방을 시도하였다. 본 연구에서는 키랄물질인 ibuprofen의 최적의 분리 조건을 구하기 위해서 온도와 압력, 첨가되는 IPA의 양에 따른 체류인자와 분리도의 영향을 고찰하였다. 온도가 감소하고 압력이 증가할수록 체류인자는 감소하였다. IPA의 양에 따라 더 큰 영향을 받아서 IPA의 양이 많을수록 분리도는 감소하는 경향을 보였다. 실험으로부터 정한 최적의 분리조건은 130 bar, 311.15 K, 4% IPA (vol.)일 때이었다. 동일한 주입량에서 액체 크로마토그래피에서는 비선형의 용출곡선을 보였지만, 초임계유체 크로마토그래피에서는 선형의 용출곡선을 얻었다.

• The Korean Journal of Pain
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• 제11권1호
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• pp.74-80
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• 1998

Background: Myprodol, a newly introduced combination analgesics with codeine, ibuprofen and paracetamol was evaluated in the dental surgery patients for its efficacy and side effects. Methods: Total 60 ASA I or II outpatients dental surgical patients were randomly assigned into three groups(n=20 each). After various oral procedures, one of three oral analgesics, myprodol, ibuprofen or codeine, was prescribed to each patients in double blind fashion for three days. Each patient was followed carefully by daily phone calls for verbal analog pain scale, side effects and patient's satisfaction level. Results: Demographic data and duration of surgery revealed no statistical differences in all three groups. Myprodol group showed better verbal analgesic scores consistently for the study period than ibuprofen or codeine group. Adverse effects were minimal. Patients' satisfaction level was high in all three groups. Conclusion: We conclude that myprodol is an excellent oral analgesic for day-surgery based dental procedure patients. This effect appears to be synergistic among different analgesics rather than additive.

• Tuberculosis and Respiratory Diseases
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• 제55권2호
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• pp.206-210
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• 2003

호산구성 폐렴은 폐 간질내에 호산구의 침윤을 보이는 질환으로 말초 혈액에서의 호산구증을 동반하기도 한다. 많은 약제가 호산구성 폐렴을 유발할 수 있지만 비스테로이드성 소염제에 의한 증례는 드물다. 하지만, 비전문의약품으로 분류되는 비스테로이드성 소염제의 종류가 많아지고 이의 오용과 남용이 증가하여 이에 의한 호산구성 폐렴의 발생도 증가하리라 사료된다. 저자들은 기침을 주소로 내원한 남자 환자에서 ibuprofen이 원인으로 추정되는 호산구성 폐렴 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.