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http://dx.doi.org/10.7317/pk.2013.37.3.288

Synthesis of Molecularly Imprinted Polymers for Chiral (S)-Ibuprofen and Their Molecular Recognition Mechanism  

Huangfu, Fengyun (Textile Auxiliaries Company Ltd. of Tianjin Polytechnic University)
Wang, Bing (State Key Laboratory of Hollow Fiber Membrane Materials and Processes (Tianjin Polytechnic University), School of Environmental and Chemical Engineering, Tianjin Polytechnic University)
Sun, Yan (State Key Laboratory of Hollow Fiber Membrane Materials and Processes (Tianjin Polytechnic University), School of Environmental and Chemical Engineering, Tianjin Polytechnic University)
Publication Information
Polymer(Korea) / v.37, no.3, 2013 , pp. 288-293 More about this Journal
Abstract
A group of molecularly imprinted polymers (MIPs) with specific recognition for chiral (S)-ibuprofen were successfully prepared based on hydrogen bonds, utilizing ${\alpha}$-methacrylic acid as a functional monomer. The IR analysis of MIPs showed that the blue- and red-shifted hydrogen bonds were formed between templates and functional monomers in the process of self-assembly imprinting and re-recognition, respectively. According to UV-Vis analysis, we found that the ratio of host-guest complexes between template molecule and functional monomer was 1:1. The effect of cross-linker's quantity on the polymerization was studied by transmission electron microscope (TEM). The adsorption selectivity experiments indicated that MIPs exhibited higher selectivity to (S)-ibuprofen than those to ketoprofen and (R)-ibuprofen, (S)-ibuprofen's structural analogs.
Keywords
(S)-ibuprofen; molecularly imprinted polymer; chiral separation; hydrogen bond; separation factor;
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