• Journal of Life Science
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• v.29 no.6
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• pp.735-739
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• 2019

The dried rhizomes and roots of Gentiana scabra (GS) have been frequently prescribed as a traditional folk medicine in East Asia (including China, Japan, and Korea) for the treatment of various pathophy-siological conditions, such as inflammatory skin diseases, anorexia, indigestion, gastric infections, and diabetes mellitus. In the present study, the effects of aqueous (GS-W) and ethanolic (GS-E) extracts of GS on gastrointestinal (GI) motor function were investigated by measuring the in vivo gastric emptying rate (GER) and the intestinal transit rate (ITR) in mice. The GER was significantly increased by GS-W at a dose of 1 g/kg. The ITR was significantly increased by GS-W (at doses of 0.1 and 1 g/kg) or GS-E (at a dose of 1 g/kg) in a dose-dependent manner. Furthermore, the ITR value of GS-W (at a dose of 1 g/kg) appeared to be higher than that of cisapride, which was the most prominent prokinetic agent in the 1900s but was removed from the market in 2000 due to its fatal side effects. The above results suggest that GS-W might be a potential prokinetic agent to replace cisapride.

• Proceeding of EDISON Challenge
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• 2016.03a
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• pp.339-343
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• 2016

본 연구에서는 양자역학적 전하수송 모델링을 바탕으로 channel length ($L_{ch}$), equivalent oxide thickness (EOT), supply voltage ($V_{DS}$) 등의 소자 파라미터들에 초점을 맞춰 저전력 소자를 구현하였다. 본 연구에서 나타낸 최적의 소자 특성으로부터 ITRS에서 제시하고 있는 2021년 예측되는 소자 특성에 비하여 더 낮은 $V_{DS}$에서 동작을 하면서 더 높은 $I_{on}$과 낮은 SS 로서 구동하는 것이 가능할 것으로 기대된다. 뿐만 아니라 inverter 동작에 있어서 ideal inverter에 가까운 동작을 할 것으로 기대된다.

• Herbal Formula Science
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• v.28 no.1
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• pp.71-80
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• 2020

Obejectives : The purpose of this study was to investigate the effects of Yijin-tang on pacemaker potentials of small intestinal interstitial Cells of Cajal (ICC). Methods : To dissociate the ICC, we used enzymatic digestions from the small intestine in mice. The electrophysiological whole-cell patch-clamp configuration was used to record pacemaker potentials in the cultured ICC and the in vivo effects of Yijin-tang on GI motility were investigated by calculating percent intestinal transit rates (ITR). Results : 1. The ICC generated pacemaker potentials in the murine small intestine. Yijin-tang produced membrane depolarization with concentration-dependent manners in the current clamp mode. 2. Pretreatment with a Ca²⁺ free solution and thapsigargin, a Ca²⁺-ATPase inhibitor in the endoplasmic reticulum, stopped the pacemaker potentials. In the case of Ca²⁺-free solutions and thapsigargin, Yijin-tang did not induce membrane potential depolarizations. 3. U73122, a phospholipase C (PLC) inhibitors, blocked the Yijin-tang-induced membrane potential depolarizations. However, U73343, an inactive PLC inhibitors, did not block. 4. In the presence of protein kinase C (PKC) inhibitors, staurosporine or Rottlerin, Yijin-tang depolarized the pacemaker potentials. However, in the presence of Go6976, Yijin-tang did not depolarize the pacemaker potentials. 5. In mice, intestinal transit rate (ITR) values were significantly and dose-dependently increased by the intragastric administration of Yijin-tang. Conclusions : These results suggest that Yijin-tang can modulate the pacemaker activity of ICC through an internal/external Ca²⁺ and PLC/PKC-dependent pathway in ICC. In addition, Yijin-tang is a good candidate for the development of a prokinetic agent.

• Herbal Formula Science
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• v.29 no.3
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• pp.119-125
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• 2021

Obejectives : The purpose of this study is to find out the efficacy of pacemaker potentials of interstitial Cells of Cajal (ICC) by Fermented Lotus Root (FLR) in small intestine. Methods : Enzyme digestions were used to separate the ICC. Using electrophysiological methods, pacemaker potentials were measured and intestinal transit rates (ITR) experiments were conducted to identify in vivo gastrointestinal motility. Results : 1. FLR (0.5-10 mg/ml) caused membrane depolarization by electrophysiological methods. 2. In the case of pretreatment with a Ca²⁺ free solution and thapsigargin, the pacemaker potential disappeared and in this case, FLR did not have a membrane depolarization reaction. 3. Lowering the concentration of extracellular Na⁺ concentration stoped the pacemaker potentials and inhibited the reaction caused by FLR. Flufenamic acid also inhibited the reaction by FLR. 4. In mice, ITR was increased by FLR. Conclusions : This study shows that FLR can control ICC by an internal/external Ca²⁺ and Na⁺. It also shows that FLR can be a good candidate for gastrointestinal motility medication development.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.7
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• pp.1307-1313
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• 1992

The end-point position control of a flexible manipulator is a non-minimum phase system. The PD feedback of the end-point position is not stable in contrast with that of the hub jangle. However, the system can be stabilized conditionally by the feedback of both the hub rate angle and the end-point position. Even in the non-minimum system, the LQG/LTR control law is more systmatic controller design method than the classical control law which uses a root-locus technique.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.486-487
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• 2013

ITU는 2012년 말, 개최된 세계국제전기통신회의에서는 '인터넷 규제' 관련 조항이 가장 큰 관심을 집중시켰다. 국제전기통신규칙 개정에는 193개 회원국 가운데 89개국이 서명하고, 55개국은 서명을 거부했다. 서명을 주도한 국가는 러시아, 중국을 비롯해 중동, 남미 국가들이며, 한국도 포함된다. 반면 미국, 영국, 캐나다를 포함, 유럽 국가들은 서명을 거부했다. 결국 서방 국가들의 반발로 개정조문에는 인터넷 규제 관련조문은 삽입되지 못했고, 정보보호나 스팸방지 등의 문제에 회원국들이 공조할 수 있다는 선언적 의미만 들어가게 되었다. 따라서 당장 인터넷 규제 방식에 큰 변화는 수반되지 않을 것으로 전망되며, 향후 국제회의에서 지속적으로 논의될 것으로 보인다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.5A
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• pp.537-544
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• 2004

In this paper, we p개pose DS-CDM-SQAM(Superposed Quadrature Amplitude Modulation) which is characterized by its smooth phase transition and small envelope fluctuation, and improves the power efficiency as compared to DS-CDM-QPSK of satellited-based DMB system(ITR-R BO.1130-4 System E) in a nonlinearly amplified channel. Computer simulation results show that the proposed DS-CDM-SQAM improves Eb/No by 1.7㏈ to maintain BER=1${\times}$$10^{-3}$ in nonlinearly amplified multipath mobile radio environments. Therefore, the proposed DS-CDM-SQAM system significantly improves the power efficiency in nonlinear land mobile satellite DMB environments.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.11 no.2
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• pp.151-157
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• 2000

The ITU-R model for cross-polarization, which is accurate enough in real rainfall environments, is proposed in this paper. By comparing this with measurement data and the ITU-R model, we have also derived a prediction model for rain cross-polarization applicable upto millimeter wave band.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.14 no.3
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• pp.40-50
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• 2006

This study investigates how airline customers evaluate e-ticket process newly adopted by many of airlines. Customers are highly satisfied with the easy of confirmation on their itineraries and the channel provided through while they are worry about the likelihood of leakage of personal information during e-ticket process. Highly experienced customers on the usage of e-ticket are more concerned about ancillary aspects such as visual image of I.T.R(Itinerary and Receipt) and travel information than functional aspect such as easy of confirmation on itinerary. And also experienced customers are more likely to repurchase e-ticket and when purchasing tickets they do it through internet and call center of airlines rather than travel agencies and ticket office of airlines.

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2002.10a
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• pp.146-146
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• 2002

No Abstract, See Full Text