• Journal of Evidence-Based Herbal Medicine
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• v.2 no.2
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• pp.1-7
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• 2009

Pulsatillae Radix, the root of Pulsatilla koreana Nakai (Ranunculaceae), has been traditionally used as a remedy for leukorrhea and amoebic dysentery by taking internally‘ and as an antimicrobial for external use. We carried out this study to examine the anti-dandruff effect of 70% Ethanol-Extract of Pulsatillae Radix (EPX) compared with 1 % zinc pyrithione used commercially as anti-dandruff. The EPX showed significant antimicrobial activity against Pityrosporum ovale, major cause of dandruff, and also showed significant anti-dandruff and itch-improvement effect of head skin.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1125-1131
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• 2009

Lophatheri Herba, Patriniae Radix, Alli tuberosi Herba, and Menthae Herba have long been used externally for treatment of injuries or inflammations in Korea. This study was carried out to examine the anti-dandruff effect of the mixture made with equal parts of 70%-ethanol extracts of Lophatheri Herba, Patriniae Radix, Allii tuberosi Herba, and Menthae Herba (LPAM) and of each one above, compared with 1%-zinc pyrithione (Standard) used commercially as anti-dandruff. The results showed the mixture was more effective than each crude drug. The 10%-LPAM produced no toxicity in skin reaction test and eye irritation test, and showed significant antimicrobial activity against Pityrosporum ovale, the major cause of dandruff, and also showed significant anti-dandruff and itch-improvement effects on head skin.

• Research in Community and Public Health Nursing
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• v.11 no.1
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• pp.262-277
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• 2000

In order to find out the sex- and age-related prevalence rate of allergic diseases in the community. as well as the causes of those diseases. questionnaires were given to 2.415 subjects (1.206 males and 1.209 females) from May to June. 1998. As a second stage. skin tests were given to 452 of the original subjects between July and August. 1998. Finally. from March to November 1999. the results of the tests were compared with those of other countries to make a comparative analysis of epidemiological research on allergic diseases. The results of this study were as follows: The frequency of allergic symptoms by sex was 50.1% in males and 56.7% in females. respectively, which displayed significant difference between males and females(p<.01). By age, the frequency of allergic symptoms in males was highest for those under the age of 9 at 60.6%, whereas in females the highest frequency was between the ages of 30 to 39 at 75.1 %. The relationship between economic level of the subjects and their frequency of allergic diseases showed significant difference (P<.05). There was a high degree of correlation between family history and the frequency of allergic diseases(P<.01). In allergic symptoms, the highest prevalence in both males and females occurred with urticaria, itch and skin rash (33.6% with males and 38.0% with females). Rhinitis, nasal blocking and sneezing had the second highest frequency in both sexes (11.8% of males and 14.0% of females). With regard to the causes of allergic symptoms among the people with allergies, the rate in males was 30.1% in food. 25.0% in pollen, and among females the rate was 30.7% in food, 26.6% in pollen. The frequency of food allergies by sex was 25.6% in males and 25.8% in females, with little difference between males and females, and by age, males of the ages between 40 to 49 and females of the ages between 30 and 39 showed the highest frequency, 31.8% and 32.6% respectively. Among 585 people with food allergies, the sympoms occurring with the allergy in males were 81.5% with urticaria, itch and skin rash. 5.9% with diarrhea and stomachache, and 5.2% with rhinitis, nasal blocking and sneezing. Among females with food allergies, the symptoms were 82.6% with urticaria, itch, skin rash, 9.1% with diarrhea and stomachache, and 4.7% with rhinitis, nasal blocking and sneezing. The type of food most often causing allergy in males was mackerel (6.6%) and females peaches (7.4%). In respect to a positive rate in the skin test by sex, of the 379 males taking the skin test, 21.4% were positive for allergies, whereas 14.7% of the 346 females tested were positive. Among food items found to cause positive allergic reactions, hops had the highest frequency in males (58.9%) and whole eggs had the greatest effect on females (36.4%). The estimated prevalence of food allergies in terms of skin tests was 5.0% of 1.206 males and 3.6% of 1.209 females. In the estimated frequency of food allergy by age group, males of the ages between 40 and 49 and females of the ages from 30 to 39 had the highest rate (6.5% with males and 4.5% with females). In a comparative analysis of epidemiological research on allergic diseases by country group, allergic diseases occurred in 18-50% of each population studied, and the occurrence of allergic diseases when categorized according to symptoms displayed the following as such: allergic rhinitis (3.8-52%), allergic asthma (1.6-17%), and atopy dermatitis (0.33-20.4%). The prevalence of food-related allergies was 6.6-64.9% and the foods causing allergies frequently included milk, eggs, eggs, peanuts, fish, etc.

• The Korean Journal of Pesticide Science
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• v.17 no.1
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• pp.41-49
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• 2013

This study was performed to investigate the cultivation pattern and perception, such as safety awareness, of environmentally-friendly organic materials among Korean farmers. The main reason for participation of the environmentally-friendly agriculture was for the production of safe agricultural crops. Compared to small-acreage farmer were more aware about the safety of environmentally-friendly organic materials to the subjects. Accordingly, 23.6% among the respondents with environmentally-friendly agriculture certification experienced the adverse effect by using the environmentally-friendly organic materials, compared to 33.8% of among the respondent without the certification. The experienced type of adverse effects consisted mainly 'eyes itch', 'hands and feet itch' and 'fatigue'. Also, respondent experiencing the adverse effects by using the environmentally-friendly organic materials more comply with the usage standard as how to use marked in wrapping paper, compared to the respondent without experiencing the adverse effects, which indicate that the compliance with the usage standard as how to use marked in wrapping paper is closely related the experience the adverse effects. Further study should be needed for more precise investigation of comment for the farmers in order to suggest the effective improvement in terms of policy or education for their safety.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.2
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• pp.191-199
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• 2015

To elucidate the immuno-stimulatory activity of traditional fermented vinegar, six kinds of crude polysaccharides were isolated from traditional fermented vinegars manufactured with different raw materials in domestic or foreign countries, after which their chemical properties and immuno-stimulatory activities were evaluated. Of the six samples, three kinds of crude polysaccharides prepared from Korean brown rice vinegar (KBV-0), Japanese brown rice vinegar (JBV-0), and Korean persimmon vinegar (KPV-0) showed higher yields and interleukin (IL)-6 production by macrophages and were thus selected for further study. Anti-complementary activities of KBV-0, KPV-0, and JBV-0 increased dose-dependently. KBV-0 and KPV-0 showed higher anti-complementary activities ($ITCH_{50}$ 62 and 65%) than JBV-0 at $1,000{\mu}g/mL$. KBV-0, KPV-0, and JBV-0 did not affect growth of peritoneal macrophages at a dose of 1.6 to $1,000{\mu}g/mL$, where as they significantly augmented production of IL-6, IL-12, and TNF-${\alpha}$ in a dose-dependent manner. However, immuno-stimulatory activity of KPV-0 was the most potent among the tested polysaccharides. These results suggest that Korean fermented vinegars contain selected polysaccharides that confer immuno-stimulatory activities beneficial to human health.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.765-779
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• 2003

Physiological lipid mixtures comprised of cholesterol, ceramide and free fatty acid better maintain epidermal homeostasis and have been recently used for dermatoses induced by skin barrier damage, for example for atopic dermatitis and xerotic skin. Itching and dry atopic dermatitis of the skin may be related to altered skin barrier function. In a previous study, the use of multi-lamellar emulsion (MLE), which is a lipid mixtures containing cholesterol, pseudoceramide and free fatty acid, has been shown to accelerate the recovery of the epidermal permeability barrier. In this study, we assessed the efficacy of MLE compared with a currently used anti-itch moisturizer (AIM), the active ingredients of which are menthol and camphor, on barrier recovery after barrier disruption. To clarify the effect of MLE and AIM after acute barrier perturbation, we measured the relation between transepidermal water loss (TEWL) and the barrier recovery rate at 3, 6, 24, and 48 hours after tape stripping hairless mice and then observed changes in the stratum corneum (SC), including the intercellular lipid structure and secretion of lamellar bodies, by electron microscopy. MLE treated skin recover skin barrier function more rapidly, and AIM treated skin delayed barrier repair. Morphological changes in the epidermis, of MLE treated skin revealed well-conserved lipid multi-lamellar structures at 24 h after tape stripping, whereas AIM treated skin showed altered lamellar bilayers within the SC interstices at 48 h. In addition, MLE treated skin showed an increase in the number of LBs and in their secretions and a decrease in the number of SC layers versus AIM treated skin. These results suggest that MLE may accelerate the production of an epidermal permeability barrier in hairless mice by increasing the number and secretion of LB and improve the dryness and itch associated with an altered epidermal permeability barrier.

• Journal of environmental and Sanitary engineering
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• v.21 no.4 s.62
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• pp.1-10
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• 2006

This research is based on self-filling survey which 220 dental hygienists who work in seoul participated on July 2006 through August 2006. This survey was analyzed the experience item and occurred time of the symptoms and the time of acute and vanish of the symptoms that dental office's working environment effects on physical subjective symptom. We suggest a plan to minimizing physical subjective symptom for health manage of dental hygienist. We found out the fact that dental hygienists were unsatisfied with hospital air condition and this polluted air condition cause them physical subjective symptom in work place. As follows analyzed results ventilation time is below the 3-times a day, this may be have some trouble in indoor air quality. The experience the symptoms level is higher then non-experience level in "Fatigue and sleepiness", "Dorsalgia, omarthralgia, cervicodynia", "Hypersensitivity", "Dry eye, itch, smarting", "Headaches" and a subjective symptom is occurred at after 11:00(am) more then 60%, 50% of the dental hygienist. This experience the symptom' pain is vanished after the work and reduced when go out the office and building, respectively. The ratio of the experience the symptoms and starting time the symptoms is anywhere from 12 noon to 4 pm (73.2%) in a day. The time of acute pain the symptoms is anywhere from 12 noon to 4 pm (78.7%) refer to the individual characteristics and work environment.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.145-150
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• 2005

This paper presents an Electrotactile Display System (ETCS). One of the most important human sensory systems for human computer interaction is the sense of touch, which can be displayed to human through tactile output devices. To realize the sense of touch, electrotactile display produces controlled, localized touch sensation on the skin by passing small electric current. In electrotactile stimulation, the mechanoreceptors in the skin may be stimulated individually in order to display the sense of vibration, touch, itch, tingle, pressure etc. on the finger, palm, arm or any suitable location of the body by using appropriate electrodes and waveforms. We developed an ETCS and investigated effectiveness of the proposed system in terms of the perception of roughness of a surface by stimulating the palmar side of hand with different waveforms and the perception of direction and location information through forearm. Positive and negative pulse trains were tested with different current intensities and electrode switching times on the forearm or finger of the user with an electrode-embedded armband in order to investigate how subjects recognize displayed patterns and directions of stimulation.

• Natural Product Sciences
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• v.9 no.4
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• pp.286-290
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• 2003

Ratanjot is attributed to eight species of Boraginacae species belonging to genera Alkanna, Arnebia, Maharanga and Onosma and regarded as one of the important herbal drugs of indigenous systems of medicine. The root and root stock, which form the actual drug, are considered to be an anthelmintic, antipyretic and antiseptic. They are also claimed to be useful in burn, eczema, wounds and eruptions, and used for treating the diseases of eyes, bronchitis, abdominal pains, itch, etc. Several workers reported that the Naphthaquinones (arnebins), the main active constituents of the drug, are responsible for its colour and therapeutic efficacy. It is claimed that the Arnebia nobilis was imported to India from Afghanistan but the red coloured roots resembling with A. nobilis were found to be gathered by local people for commercial purposes during the course of botanical surey of Himalayan region. Hence, it is decided to evaluate Arnebia nobilis pharmacognostically. The important macro-microscopic features of this species are roots 1-5 cm broad; outermost xylem with broad vessels and innermost with groups of radially arranged narrow vessels while the middle region occupied by alternate rings of clusters of broad and narrow vessels and presence of pith. Besides the percentage of arnebin-1, -3 and 4 are 9.37, 10.53 and 1.72 respectively.

• Korean Journal of Acupuncture
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• v.20 no.2
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• pp.101-120
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• 2003

This study is performed to investigate the cause, symptom and acupuncture on Dudurugi through the literature of oriental medicine. The findings of this study are as follows: 1. Dudurugi is caused by exogenous pathogenic factors(wind, heat, cold, damp), sthenic inter damage factors(heat accumulated in the intestine and stomach, blood-heat, blood-stasia) and asthenia inter damage factors(asthenia of the spleen and stomach, blood-asthenia, asthenia of energy-blood, yin-asthenia and blood-dryness, yan-asthenia and energy-asthenia). 2. The symptom of Dudurugi is appeared in the skin and its surface is processed apparently or itch. 3. The treatment of Dudurugi was used by expelling the wind with removing pathogen. 4. In the treatment of Dudurugi, The su-yangmyong taejang-kyong of 12 merdians was mainly used and, the kokchi(LI11) of acupoints was most used in the acupuncture and moxibustion. 5. In the treatment of Dudurugi, acupoints of tok-maek and chok-t'aeyangkyong were mainly used in the case of showing symptoms caused by exogenous pathogenic factors and, acupoints of chok-t'aemkyong were mainly used in the case of showing symptoms caused by damp-heat accumulated in the intestine and stomach. When there were any other symptoms accompanied, other acupoints were more used.