• Journal of Korean Society for Quality Management
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• v.45 no.4
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• pp.781-810
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• 2017

Purpose: This paper studied about the integration for management system of representative international standard related to sustainable development. The well-known International standards such as ISO 9001, ISO 14001 and OHSAS 18001 (ISO 45001) can be operated in accordance with the organizational situation individually, or in a variety of ways of integration. It can be applied to help organizations utilizing the newly established "ISO IEC Directive Part1 Annex SL", when integrating quality, environmental and safety & health management systems based on international standards. Methods: We conducted an empirical survey of management executives and experts to study how three factors (management systems, organizational capabilities and integration methods) could affect business performance. Results: The questionnaire was analyzed using AMOS structural equation model. Quality, environmental and safety and health management systems affected management performance, and integration methods of management system affected business efficiency, risk performance and financial performance. Integration method is also important because organizational competence affects various aspects of integrated management. However, factors that affect integration should also be considered in terms of organizational capabilities. This is because organizational capacity influences the integration plan. Conclusion: To integrate the document system at the strategic level, management should actively participate in integrated operations to integrate organizations, eliminate duplicate tasks, and foster document integration experts to reflect the characteristics of individual standard. In the case of document integration, quality management is focusing, but once ISO 45001 is issued, the use of Annex SL is increasing, and Quality, environment and safety & health integration will also be expanded. It is possible to increase the effect of integration by strategically approaching and establishing organization document system rather than simple integration according to management system standard arrangement.

• BMB Reports
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• v.45 no.4
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• pp.207-212
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• 2012

Retroviruses have often been used for gene therapy because of their capacity for the long-term expression of transgenes via stable integration into the host genome. However, retroviral integration can also result in the transformation of normal cells into cancer cells, as demonstrated by the incidence of leukemia in a recent retroviral gene therapy trial in Europe. This unfortunate outcome has led to the rapid initiation of studies examining various biological and pathological aspects of retroviral integration. This review summarizes recent findings from these studies, including the global integration patterns of various types of retroviruses, viral and cellular determinants of integration, implications of integration for gene therapy and retrovirus-mediated infectious diseases, and strategies to shift integration to safe host genomic loci. A more comprehensive and mechanistic understanding of retroviral integration processes will eventually make it possible to generate safer retroviral vector platforms in the near future.

• Journal of Mechanical Science and Technology
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• v.17 no.7
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• pp.986-998
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• 2003

In this paper, an adaptive numerical integration scheme, which does not need non-overlapping and contiguous integration meshes, is proposed for the MLPG (Meshless Local Petrov-Galerkin) method. In the proposed algorithm, the integration points are located between the neighboring nodes to properly consider the irregular nodal distribution, and the nodal points are also included as integration points. For numerical integration without well-defined meshes, the Shepard shape function is adopted to approximate the integrand in the local symmetric weak form, by the values of the integrand at the integration points. This procedure makes it possible to integrate the local symmetric weak form without any integration meshes (non-overlapping and contiguous integration domains). The convergence tests are performed, to investigate the present scheme and several numerical examples are analyzed by using the proposed scheme.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.129.2-129.2
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• 2010

As a part of the government renewable energy policy, KOWEPO is constructing 300MW IGCC plant in Taean. IGCC plant consists of gasification block, air separation unit and power block, which performance test is separately conducted. Overall performance test for IGCC plant is peformed to comply with ASME PTC 46. Major factors affected on the overall efficiency for IGCC plant are external conditions, each block performance(gasification, ASU, power block), water/steam integration and air integration. Performance parameters of IGCC plant are cold gas efficiency, oxygen consumption, sensible heat recovery of syngas cooler for gasification block and purity of oxygen, flow amount of oxygen and nitrogen, power consumption for air separation unit and steam/water integration among the each block. The gas turbine capacity applied to the IGCC plant is 20 percent higher than NGCC gas turbine due to the low caloric heating value of syngas, therefor it is possible to utilize air integration between gas turbine and air separation unit to improve overall efficiency of the IGCC plant and there is a little impact on the ambient condition. It is very important to optimize the air integration design with consideration to the optimized integration ratio and the reliable operation. Optimized steam/water integration between power block and gasification block can improve overall efficiency of IGCC plant where the optimized heat recovery from gasification block should be considered. Finally, It is possibile to achieve the target efficiency above 42 percent(HHV, Net) for 300MW Taean IGCC plant by optimized design and integration.

• Health Policy and Management
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• v.5 no.1
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• pp.80-105
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• 1995

Assuming that we introduced integration of medical insurance society for self-employed, this study was conducted to examine effects and results after the integration and to research more effective method for integration. To assess effects and results of the finacial status of 266 insurance societies after intergration, the data were obtained from "The Medical Insurance Program for Self-Employeds Statistical Yearbook in 1992". The major finding are as follows : 1. Three alternative integration proposals were made. First alternative proposal was consisted of 232 medical insurance societies, second was 187, and third was 115. 2. As the results of average number of the insured per insurance societies of medical insurance program for self-employed every alternative proposal, first was 88, 119 persons, second was 108, 576, and third was 178, 967 from 76, 576 persons of present socienties. 3. It was true that the more average size of societies increased, the more average administration expenditure per 1, 000 insured reduced. 4. The average size of societies grew bigger, the rate of general expenditure to general revenue more improved. Also, the rate of benefits to contributions was changed for better. But if not to have had correct analysis and precise preparation for integration, effects and results of integration were always not optiized. 5. According to results of simple regression formulas, it was proved that the more the average size of societies was increased, the more result was advantaged. 6. The law of majority and the economy of scale were applied in this study, and it was necessary to analyze and assess effectiveness and efficiency of integration. Therefore, when the integration of medical insurance societies for self-employeds will be performed, it must be taken into consideration. Among three alternative proposals, third was showed more effective alternative than anothe, second was presented more ineffective result than present system. To achieve more effective and efficient integration of regional medical insurance societies throughout the result of the regression formula on present cost curve, it is necessary to operate well-integrated societies and to know appropriative countermeasures of present situation of each societies. Also, for integrating regional medical insurance societies, it is necessary to continue more deep research through practical model activity and to investigate the effective size and managed method of the societies.societies.

• Asia pacific journal of information systems
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• v.7 no.1
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• pp.139-150
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• 1997

• Structural Engineering and Mechanics
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• v.65 no.1
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• pp.91-98
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• 2018

Three structure-dependent integration methods with no numerical dissipation have been successfully developed for time integration. Although these three integration methods generally have the same numerical properties, such as unconditional stability, second-order accuracy, explicit formulation, no overshoot and no numerical damping, there still exist some different numerical properties. It is found that TLM can only have unconditional stability for linear elastic and stiffness softening systems for zero viscous damping while for nonzero viscous damping it only has unconditional stability for linear elastic systems. Whereas, both CEM and CRM can have unconditional stability for linear elastic and stiffness softening systems for both zero and nonzero viscous damping. However, the most significantly different property among the three integration methods is a weak instability. In fact, both CRM and TLM have a weak instability, which will lead to an adverse overshoot or even a numerical instability in the high frequency responses to nonzero initial conditions. Whereas, CEM possesses no such an adverse weak instability. As a result, the performance of CEM is much better than for CRM and TLM. Notice that a weak instability property of CRM and TLM might severely limit its practical applications.

• Structural Engineering and Mechanics
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• v.13 no.5
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• pp.569-589
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• 2002

In performing the dynamic analysis, the step size used in a step-by-step integration method might be much smaller than that required by the accuracy consideration in order to capture the rapid chances of dynamic loading or to eliminate the linearization errors. It was first found by Chen and Robinson that these difficulties might be overcome by integrating the equations of motion with respect to time once. A further study of this technique is conducted herein. This include the theoretical evaluation and comparison of the capability to capture the rapid changes of dynamic loading if using the constant average acceleration method and its integral form and the exploration of the superiority of the time integration to reduce the linearization error. In addition, its advantage in the solution of the impact problems or the wave propagation problems is also numerically demonstrated. It seems that this time integration technique can be applicable to all the currently available direct integration methods.

• International Journal of Railway
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• v.3 no.4
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• pp.117-122
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• 2010

In transportation geotechnical engineering, stress-strain behavior of earth structures has been analyzed by numerical simulations with the implemented plasticity constitutive model. It is a fact that many advanced plasticity constitutive models on predicting the mechanical behavior of soils have been developed as well as experimental research works for geotechnical applications in the past decades. In this study, recently developed, a unified constitutive model for both clay and sand, which is referred to as CASM (clay and sand model), was compared with a classical constitutive model, Cam-Clay model. Moreover, integration methods of stress-strain rate equations using CASM were presented for simulation of undrained and drained triaxial compression tests. As a conclusion, it was observed that semi-implicit integration method has more improved accuracy of capturing strain rate response to applied stress than explicit integration by the multiple correction and iteration.

• Korea Trade Review
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• v.47 no.5
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• pp.181-200
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• 2022

After the COVID-19 pandemic, a global economic downturn and a recession in the shipping market are expected, it is important for domestic shipping companies to establish appropriate strategy in response to the recession. Accordingly, domestic shipping companies should grow into integrated logistics companies that combine shipping and logistics in the future. And for this purpose, it is necessary to actively promote logistics integration with external shipping and logistics companies. This paper presents the direction of logistics integration for domestic shipping companies to develop as integrated logistics operators with competitiveness in the global shipping market, and presents detailed alternatives. Domestic shipping companies lack the infrastructure such as ships, port terminals, and warehouses, so they have a weak capacity to independently promote logistics integration. At the shipping company level, a logistics integration promotion strategy should be established, and accordingly, logistics infrastructure, service network, and logistics integration operating system should be established. The government should provide tax benefits for logistics integration, financial support for M&As led by domestic shipping companies, a standardized information sharing system, and preparation of educational courses for nurturing digital manpower.