• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.19 no.4
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• pp.373-383
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• 2001

This study conducted pilot mapping project to know the possibility of mapping with medium resolution satellite imageries. For this purpose, mapping experiments were conducted with each stereo model imageries of SPOT, KOMPSAT, and IRS- lC. And positional accuracy, analysis of detectable and describable features, and comparison with existing digital map were checked, possible mapping scale and cost analysis were conducted with these results. Regarding SPOT imagery, digital photogrammetric workstation was used for stereoplotting. Regarding KOMPSAT and IRS-lC imageries, because there were data format support problems. head-up digitizing was performed with ortho imageries rectified with DEMs generated by image matching. The results of experiments show that such features as wide road, river, coast line, etc are possible to detect and depict but many other features are not for SPOT, KOMPSAT, and IRS-lC imageries. On the aspect of mapping, therefore, SPOT is available for 1/50,000 topographic map revision, KOMPSAT and IRS-lC for 1/25.000 topographic map revision.

• BMB Reports
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• v.51 no.5
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• pp.209-210
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• 2018

NAFLD induces the development of advanced liver diseases such as NASH and liver cancer. Therefore, understanding the mechanism of NAFLD development is critical for its prevention and treatment. Ablation of PTEN or Hippo pathway components induces liver cancer in a murine model by hyperactive AKT or YAP/TAZ, respectively. Although the regulation of these two pathways occurs in the same hepatocyte, the details of crosstalk between Hippo-YAP/TAZ and PTEN-AKT pathways in liver homeostasis and tumorigenesis still remain unclear. Here, we found that depletion of both PTEN and SAV1 in liver promotes spontaneous NAFLD and liver cancer through hyperactive AKT via YAP/TAZ-mediated up-regulation of IRS2 transcription. Conversely, NAFLD is rescued by both ablation of YAP/TAZ and activation of the Hippo pathway. Furthermore, human HCC patients with NAFLD showed strong correlation between YAP/TAZ and IRS2 or phospho-AKT expression. Finally, the inhibition of AKT by MK-2206 treatment attenuates NAFLD development and tumorigenesis. Our findings indicate that Hippo pathway interacts with AKT signaling during the intervention with IRS2 to prevent NAFLD and liver cancer.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.1
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• pp.50.1-50.1
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• 2013

As part of the DIGIT key program, we observed GSS30-IRS1, a Class I object located in Ophiuchus (d=125 pc), with Herschel-PACS. More than 70 lines were detected: CO lines of $J=14{\rightarrow}13$ to $41{\rightarrow}40$, several $H_2O$ lines of Eu=100 to 1500 K, 16 OH lines, and two atomic [OI] lines at 63 and 145 ${\mu}m$. All lines, except for [OI], were detected only at the central spaxel of $9.4^{\prime\prime}{\times}9.4^{\prime\prime}$ while the [OI] emission is extended along the NE-SW direction. One interesting feature in GSS30-IRS1 is that the continuum is extended beyond PSF, unlike the line emission. For detail analysis, we apply the non-LTE LVG model, RADEX as well as simple rotational diagrams to the detected line fluxes. We will discuss about the physical conditions around GSS30-IRS1, learned by the line flux analysis.

• Molecules and Cells
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• v.38 no.4
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• pp.356-361
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• 2015

Mitochondrial dysfunction is associated with insulin resistance and diabetes. We previously showed that retinoid X receptor ${\alpha}$ ($RXR{\alpha}$) played an important role in transcriptional regulation of oxidative phosphorylation (OXPHOS) genes in cells with mitochondrial dysfunction caused by mitochondrial DNA mutation. In this study, we investigated whether mitochondrial dysfunction induced by incubation with OXPHOS inhibitors affects insulin receptor substrate 1 (IRS1) mRNA and protein levels and whether $RXR{\alpha}$ activation or overexpression can restore IRS1 expression. Both IRS1 and $RXR{\alpha}$ protein levels were significantly reduced when C2C12 myotubes were treated with the OXPHOS complex inhibitors, rotenone and antimycin A. The addition of $RXR{\alpha}$ agonists, 9-cis retinoic acid (9cRA) and LG1506, increased IRS1 transcription and protein levels and restored mitochondrial function, which ultimately improved insulin signaling. $RXR{\alpha}$ overexpression also increased IRS1 transcription and mitochondrial function. Because $RXR{\alpha}$ overexpression, knock-down, or activation by LG1506 regulated IRS1 transcription mostly independently of mitochondrial function, it is likely that $RXR{\alpha}$ directly regulates IRS1 transcription. Consistent with the hypothesis, we showed that $RXR{\alpha}$ bound to the IRS1 promoter as a heterodimer with peroxisome proliferator-activated receptor ${\delta}$ ($PPAR{\delta}$). These results suggest that $RXR{\alpha}$ overexpression or activation alleviates insulin resistance by increasing IRS1 expression.

• Journal of Technology Innovation
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• v.27 no.2
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• pp.73-98
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• 2019

This study aims to contribute to the improvement of the patent activity of small and medium-sized enterprises in the future by proposing five strategies for enhancing customized patent activity for small and medium-sized enterprises under the assumption that patent application affects firm performance. The subjects of this study were 25 years of active patent activity, using patent activity statistics for 5 years from 2010 and statistical data of business performance based on 2014. The research procedure was conducted in the order of DEA-BCC efficiency analysis, patent activity analysis, and patent portfolio analysis, and then propose a strategy to improve patent activity. As a result of the research, it was confirmed that 5 industries with high patent activity and IRS type have a substantial effect on improving corporate performance as an industry with high patent efficiency. On the other hand, there are 12 industries in the form of IRS/DRS, and 8 industries with low patent activity, DRS, CRS/IRS mixed type and IRS, and that the efficiency of the patent may vary depending on the characteristics of each industry.

• The Journal of Engineering Geology
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• v.29 no.2
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• pp.153-162
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• 2019

Rapid variations in the geometry (i.e., thickness) of the refractor and low velocities affect greatly the imaging of the reflectors of land seismic data. Conventional solutions to obtain the weathering models utilizes first break picking method, which requires time consuming steps and causes the human error in picking the first arrivals. A new interferometric approach (interferometric refraction statics, IRS) which utilizes the first arrival signal (S/N enhanced by refraction convolution stack) instead of first break picking, is tested in this study to the synthetic data from the velocity structure provided by surface geophysics (refraction, MASW) and borehole geophysics (tomography, SPS logging) for the Cheongju granitic bodies. The results of IRS approach are found to be better than the ones from conventional first break picking in terms of continuities and horizontal resolution of the reflectors. The unresolved long-wavelength statics in brute stack are much removed by IRS weathering correction and the overlying refractors (the base of shallow weathering zone) are incidentally delineated in the refraction convolution stack.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.37 no.1
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• pp.59-67
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• 1992

The duration of raising seedling of infant rice seedling(IRS) in machine transplanting is 8 to 10 days. This experiment was conducted to investigate the minimum duration of IRS's raising seedling and its method by the combination of several treatments such as plant growth regulator, root-break-seat and temperature. The rice seeds of Hwaseongbyeo was soaked in the solution of metalaxyl for 24 hours at room temperature. Metalaxyl (25% wettable powder), a fungicide, was used in 1, 000 times dilution as a promting substance on the root-mat formation of IRS. The application of fungicide in the nursery soil for the controlling of damping-off and physiologyical seedling rot was omitted due to the metalaxyl seed-soaking treatment. Seeding rate was 220g per seed tray (30$\times$60$\times$3cm). To promote the root-mat formation of IRS, the sheets of polyethylene vinyl and absorptive paper were placed bottom the seed tray. The root-mat formation of IRS was promoted at higher temperature and longer duration of raising seedling. The metalaxyl-treated seeds markedly increased the root length and rooting activity of IRS as compared with the control, thus the root-mat formation was excellent. The absorptive paper with polyethylene vinyl as root-break-seat showed a better root-mat formation compared with control, polyethylene vinyl, alone. The minimum duration of raising seedling of IRS was 5 days after sowing based on the root-mat formation and seedling height under the condition of metalaxyl seed treatment, absorptive paper with polyethylene vinyl as a root-break-seat and the raising seedling temperature 30/2$0^{\circ}C$ (day /night).

• The Bulletin of The Korean Astronomical Society
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• v.39 no.1
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• pp.63.2-63.2
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• 2014

As a part of the "Dust, Ice, and Gas In Time" (DIGIT) key program on Herschel, we observed GSS30-IRS1, a Class I protostar located in Ophiuchus (d =125 pc), with Herschel/Photodetector Array Camera and Spectrometer (PACS). More than 70 lines were detected within a wavelength range from 50 ${\mu}m$ to 200 ${\mu}m$: CO lines from J = 14-13 to 41-40, several $H_2O$ lines of Eup = 100 K to 1500 K, 16 transitions of OH rotational lines, and two atomic [O I] lines at 63 and 145 ${\mu}m$. The [C II] line, known as a tracer of externally heated gas by the interstellar radiation field, is also detected at 158 ${\mu}m$. All lines, except [O I] and [C II], are detected only at the central spaxel of $9^{\prime\prime}.4{\times}9^{\prime\prime}.4$. The [O I] emission is extended along a NE-SW orientation, which is consistent with the known outflow direction, while the [C II] line is detected over all spaxels. One possible explanation of the detection of the [C II] line and no correlation of its spatial distribution with any other molecular emission is the existence of the enhanced ISRF nearby GSS30-IRS1. One interesting feature of GSS30-IRS1 is that the continuum emission is extended beyond the point-spread function (PSF), unlike the molecular line emission, indicative of significant external heating. The best-fit continuum model of GSS30-IRS1 with the physical structure including flared disk, envelope, and outflow shows that the internal luminosity is 11 $L_{\odot}$, and the region is also externally heated by a radiation field enhanced by a factor of 25 compared to the local standard interstellar field.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.4_2
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• pp.655-662
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• 2022

Recently, with the increase in the use of UAV(unmanned aerial vehicles), research on horizontal maintenance stations that can take off and land in various environments has been actively conducted. These stations can safely land UAV through multiple DOF(degrees of freedom) or at least 2-DOF-based actuator actuation. Among them, many researchers are dealing with the multi-DOF stewart platform due to its high safety. However, the stewart platform requires high-precision control technology because it requires a lot of torque to actuate according to the load action. Therefore, in this paper, to solve the mentioned problem, a bevel gear-based 2-DOF horizontal maintenance station system is proposed. The proposed system is configured to prevent damage due to air resistance when maintaining ships and to install it in a small space. Also, in terms of system configuration, the bevel gear-based horizontal maintenance system has the main advantage of being able to take off and land UAVs of various sizes through the replacement of station pads. The driving of the system consists of a simple form that can control the motor by adjusting the rotation speed of the motor according to the sea waveform.

• Development and Reproduction
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• v.23 no.3
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• pp.223-229
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• 2019

Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR). T2DM is correlated with obesity and most T2DM medications have been developed for enhancing insulin sensitivity. Silk protein fibroin (SPF) from spiders has been suggested as an attractive biomaterial for medical purposes. We generated transgenic rice (TR) expressing SPF and fed it to diabetic $BKS.Cg-m+/+Lepr^{db}$ mice to monitor the changes in blood glucose levels and adipose tissue proteins associated with energy metabolism and insulin signaling. In the present study, the adipocyte size in abdominal fat in TR-SPF-fed mice was remarkably smaller than that of the control. Whereas the adenosine monophosphate-activated protein kinase (AMPK)-activated protein kinase and insulin receptor substrate 1 (IRS1) protein levels were increased in abdominal adipose tissues after TR-SPF feeding, levels of six-transmembrane protein of prostate 2 (STAMP2) proteins decreased. Phosphorylation of AMPK at threonine 172 and IRS1 at serine 307 and tyrosine 632 were both increased in adipose tissues from TR-SPF-fed mice. Increased expression and phosphorylation of IRS1 at both serine 307 and tyrosine 632 in adipose tissues indicated that adipocytes obtained from abdominal fat in TR-SPF-fed mice were more susceptible to insulin signaling than that of the control. STAMP2 protein levels decreased in adipose tissues from TR-SPF-fed mice, indicating that STAMP2 proteins were reducing adipocytes that were undergoing lipolysis. Taken together, this study showed that TR-SPF was effective in reducing blood glucose levels in diabetic mice and that concurrent lipolysis in abdominal adipocytes was associated with alterations of AMPK, IRS1, and STAMP2. Increased IRS1 expression and its phosphorylation by TR-SFP were considered to be particularly important in the induction of lipolysis in adipocytes, as well as in reducing blood glucose levels in this animal model.