• 한국측량학회지
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• 제19권4호
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• pp.373-383
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• 2001

본 연구에서는 중해상도 위성영상으로 대표적인 SPOT, 아리랑, IRS-1C위성영상에 대하여 각기 하나의 입체모델을 이용한 지도제작 실험을 수행하였으며, 각각에 대한 위치정확도, 판독 및 묘사가능한 지형지물의 분석, 기존 수치지도와의 비교 등을 통하여, 제작가능한 지도축척의 범위에 대한 기술적인 검토 및 경제성 검토를 하였다. 도화작업에 있어서, SPOT 영상은 수치입체도화기를 사용한 3차원 도화를 하였으며, 아리랑 및 IRS-lC 위성영상은 데이터에 대한 시스템 지원상의 문제가 있어서 영상정합 방법으로 수치표고모형을 생성한 후 정사보정영상을 제작하여 head-up digitizing에 의한 2차원 도화를 실시하였다. 실험 결과 중해상도 영상으로 큰 도로, 하천, 수애선 등 일부 항목에 대하여 판독과 묘사가 가능하였지만, 불가능한 항목이 많았다. 지도제작 측면에서 SPOT은 1/50,000지형도 수정용, 아리랑 및 IRS-lC는 1/25,000지형도의 수정용으로 활용이 가능하다고 판단되었다.

• BMB Reports
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• 제51권5호
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• pp.209-210
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• 2018

NAFLD induces the development of advanced liver diseases such as NASH and liver cancer. Therefore, understanding the mechanism of NAFLD development is critical for its prevention and treatment. Ablation of PTEN or Hippo pathway components induces liver cancer in a murine model by hyperactive AKT or YAP/TAZ, respectively. Although the regulation of these two pathways occurs in the same hepatocyte, the details of crosstalk between Hippo-YAP/TAZ and PTEN-AKT pathways in liver homeostasis and tumorigenesis still remain unclear. Here, we found that depletion of both PTEN and SAV1 in liver promotes spontaneous NAFLD and liver cancer through hyperactive AKT via YAP/TAZ-mediated up-regulation of IRS2 transcription. Conversely, NAFLD is rescued by both ablation of YAP/TAZ and activation of the Hippo pathway. Furthermore, human HCC patients with NAFLD showed strong correlation between YAP/TAZ and IRS2 or phospho-AKT expression. Finally, the inhibition of AKT by MK-2206 treatment attenuates NAFLD development and tumorigenesis. Our findings indicate that Hippo pathway interacts with AKT signaling during the intervention with IRS2 to prevent NAFLD and liver cancer.

• 천문학회보
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• 제38권1호
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• pp.50.1-50.1
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• 2013

As part of the DIGIT key program, we observed GSS30-IRS1, a Class I object located in Ophiuchus (d=125 pc), with Herschel-PACS. More than 70 lines were detected: CO lines of $J=14{\rightarrow}13$ to $41{\rightarrow}40$, several $H_2O$ lines of Eu=100 to 1500 K, 16 OH lines, and two atomic [OI] lines at 63 and 145 ${\mu}m$. All lines, except for [OI], were detected only at the central spaxel of $9.4^{\prime\prime}{\times}9.4^{\prime\prime}$ while the [OI] emission is extended along the NE-SW direction. One interesting feature in GSS30-IRS1 is that the continuum is extended beyond PSF, unlike the line emission. For detail analysis, we apply the non-LTE LVG model, RADEX as well as simple rotational diagrams to the detected line fluxes. We will discuss about the physical conditions around GSS30-IRS1, learned by the line flux analysis.

• Molecules and Cells
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• 제38권4호
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• pp.356-361
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• 2015

Mitochondrial dysfunction is associated with insulin resistance and diabetes. We previously showed that retinoid X receptor ${\alpha}$ ($RXR{\alpha}$) played an important role in transcriptional regulation of oxidative phosphorylation (OXPHOS) genes in cells with mitochondrial dysfunction caused by mitochondrial DNA mutation. In this study, we investigated whether mitochondrial dysfunction induced by incubation with OXPHOS inhibitors affects insulin receptor substrate 1 (IRS1) mRNA and protein levels and whether $RXR{\alpha}$ activation or overexpression can restore IRS1 expression. Both IRS1 and $RXR{\alpha}$ protein levels were significantly reduced when C2C12 myotubes were treated with the OXPHOS complex inhibitors, rotenone and antimycin A. The addition of $RXR{\alpha}$ agonists, 9-cis retinoic acid (9cRA) and LG1506, increased IRS1 transcription and protein levels and restored mitochondrial function, which ultimately improved insulin signaling. $RXR{\alpha}$ overexpression also increased IRS1 transcription and mitochondrial function. Because $RXR{\alpha}$ overexpression, knock-down, or activation by LG1506 regulated IRS1 transcription mostly independently of mitochondrial function, it is likely that $RXR{\alpha}$ directly regulates IRS1 transcription. Consistent with the hypothesis, we showed that $RXR{\alpha}$ bound to the IRS1 promoter as a heterodimer with peroxisome proliferator-activated receptor ${\delta}$ ($PPAR{\delta}$). These results suggest that $RXR{\alpha}$ overexpression or activation alleviates insulin resistance by increasing IRS1 expression.

• 기술혁신연구
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• 제27권2호
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• pp.73-98
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• 2019

본 연구는 특허출원이 기업 성과에 영향을 미친다는 가정 하에 중소중견기업을 위한 산업별 맞춤형 특허 활동성 제고 전략 5가지를 제안함으로서 향후 중소중견기업의 특허활동 성과 제고에 기여하고자 하였다. 연구대상은 특허 활동이 활발한 25개 산업을 대상으로 2010년부터 5년간의 특허 활동성 통계자료와 2014년도 기준 기업성과 통계자료를 활용하였다. 연구절차는 DEA-BCC 효율성 분석과 특허 활동성 분석, 그리고 특허 포트폴리오 분석을 각각 실시한 후, 이를 종합한 특허 활동성 제고 전략을 제안하는 순으로 진행하였다. 연구 결과, 특허 활동성이 높고 IRS(규모수익체증)형태를 보인 5개 산업의 경우, 특허 효율성이 높은 산업으로서 기업성과 향상에 실질적인 도움이 되고 있음을 확인하였다, 반면, 특허 활동성은 높으나 규모수익이 IRS(규모수익체중)/DRS(규모수익체감)형태로 나타난 12개 산업을 비롯, 특허 활동성도 낮고 규모수익이 DRS(규모수익체감)형태, CRS/IRS 혼합형태, 그리고 IRS 형태로 나타난 8개 산업 모두, 산업별 특성에 따라 특허 효율성도 다양한 형태로 나타날 수 있음을 확인하였다.

• 지질공학
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• 제29권2호
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• pp.153-162
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• 2019

풍화대의 기하학적인 변화(두께 등)와 낮은 속도는 육상 탄성파 자료의 반사면 이미징에 큰 영향을 끼친다. 풍화대 모델을 얻기 위한 일반적인 방법은 초동 시간을 이용하는데, 이것은 수작업으로 진행되어 정확한 초동 발췌가 어렵고 그 과정에서 많은 시간이 요구되는 문제점들이 있어왔다. 초동시간 대신 굴절 곱말기 겹쌓기로 신호대잡음비가 향상된 초동신호를 이용하는 새로운 기법인 간섭 굴절보정(IRS)이 본 연구에서 시도되었다. 이 기법의 적용성 검토를 위해 지표탐사(굴절법, 여러채널 표면파 탐사)와 시추공탐사(토모그래피, SPS 검층) 자료에서 해석된 속도 구조를 토대로 만든 모델 자료를 이용하였다. 곱말기 겹쌓기로 향상된 초동신호를 이용하는 IRS 기법은 초동시간 발췌에 비해 겹쌓기 단면에 나타나는 장파장 성분을 대부분 제거하여 반사면의 연속성 및 수평 분해능을 향상시켰고 굴절곱말기 겹쌓기 연산과정에서 그 상부의 굴절면(천부 풍화대의 기저면)이 그려지는 효과가 있었다.

• 한국작물학회지
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• 제37권1호
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• pp.59-67
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• 1992

벼 기계이앙을 위한 어린모 육묘에 이앙 가능한 최단기 육묘일수와 맷트형성기간을 구명하기 위하여 육묘온도와 깔판재료를 달리하여 그 효과를 조사하였던 바 다음과 같은 결과를 얻었다. 1. 육모온도가 높을수록, 또 육묘기간이 길어질수록 어린모의 맷트형성이 양호하였으며, Metalaxyl(25% 수화제, 1,000 배액) 종자침종처리는 무처리에 비하여 맷트형성 기간이 단축되었다. 2. Metalaxyl 침종처리는 무처리에 비하여 어린모의 초장신장 효과가 있었고, 경엽중과 근중도 무거웠으며, 입고병과 뜸묘의 발생을 방지하였다. 3. 어린모의 맷트형성 촉진 보조재로서 흡수지깔판(키친타올 1컵)의 효과가 인정되었으며, ＆apos;Metalaxyl 침종＋비닐＋흡수지＆apos;처리는 다른 처리에 비하여 맷트형성 기간을 1～2일 단축시켰다. 4. 어린모의 최소 육묘일수는 파종 후 5일이였다. 육묘조건은 종자를 Metalaxyl 1,000배액에 24시간 침종한 후 비닐＋흡수지 깔판에 파종하여 30/2$0^{\circ}C$(획 / 야) 온도에서 육묘한다. 5. 일반농가 비닐하우스에서 어린모 육묘시(중부지방)에는 5월의 하우스내 온도를 야간 11～16$^{\circ}C$, 획간 28～32$^{\circ}C$ 정도로 볼 때, 산파상자를 사용할 경우에는 ＆apos;Metalaxyl 침종＋비닐깔판＆apos;처리로, 또 어린모 전용 육묘상자를 사용할 경우에는 ＆apos;Metalaxyl 침종＆apos;처리로 육묘하면 파종 후 6일에 안전 이앙이 가능한 것으로 판단된다.

• 천문학회보
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• 제39권1호
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• pp.63.2-63.2
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• 2014

As a part of the "Dust, Ice, and Gas In Time" (DIGIT) key program on Herschel, we observed GSS30-IRS1, a Class I protostar located in Ophiuchus (d =125 pc), with Herschel/Photodetector Array Camera and Spectrometer (PACS). More than 70 lines were detected within a wavelength range from 50 ${\mu}m$ to 200 ${\mu}m$: CO lines from J = 14-13 to 41-40, several $H_2O$ lines of Eup = 100 K to 1500 K, 16 transitions of OH rotational lines, and two atomic [O I] lines at 63 and 145 ${\mu}m$. The [C II] line, known as a tracer of externally heated gas by the interstellar radiation field, is also detected at 158 ${\mu}m$. All lines, except [O I] and [C II], are detected only at the central spaxel of $9^{\prime\prime}.4{\times}9^{\prime\prime}.4$. The [O I] emission is extended along a NE-SW orientation, which is consistent with the known outflow direction, while the [C II] line is detected over all spaxels. One possible explanation of the detection of the [C II] line and no correlation of its spatial distribution with any other molecular emission is the existence of the enhanced ISRF nearby GSS30-IRS1. One interesting feature of GSS30-IRS1 is that the continuum emission is extended beyond the point-spread function (PSF), unlike the molecular line emission, indicative of significant external heating. The best-fit continuum model of GSS30-IRS1 with the physical structure including flared disk, envelope, and outflow shows that the internal luminosity is 11 $L_{\odot}$, and the region is also externally heated by a radiation field enhanced by a factor of 25 compared to the local standard interstellar field.

• 한국산업융합학회 논문집
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• 제25권4_2호
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• pp.655-662
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• 2022

Recently, with the increase in the use of UAV(unmanned aerial vehicles), research on horizontal maintenance stations that can take off and land in various environments has been actively conducted. These stations can safely land UAV through multiple DOF(degrees of freedom) or at least 2-DOF-based actuator actuation. Among them, many researchers are dealing with the multi-DOF stewart platform due to its high safety. However, the stewart platform requires high-precision control technology because it requires a lot of torque to actuate according to the load action. Therefore, in this paper, to solve the mentioned problem, a bevel gear-based 2-DOF horizontal maintenance station system is proposed. The proposed system is configured to prevent damage due to air resistance when maintaining ships and to install it in a small space. Also, in terms of system configuration, the bevel gear-based horizontal maintenance system has the main advantage of being able to take off and land UAVs of various sizes through the replacement of station pads. The driving of the system consists of a simple form that can control the motor by adjusting the rotation speed of the motor according to the sea waveform.

• 한국발생생물학회지:발생과생식
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• 제23권3호
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• pp.223-229
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• 2019

Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR). T2DM is correlated with obesity and most T2DM medications have been developed for enhancing insulin sensitivity. Silk protein fibroin (SPF) from spiders has been suggested as an attractive biomaterial for medical purposes. We generated transgenic rice (TR) expressing SPF and fed it to diabetic $BKS.Cg-m+/+Lepr^{db}$ mice to monitor the changes in blood glucose levels and adipose tissue proteins associated with energy metabolism and insulin signaling. In the present study, the adipocyte size in abdominal fat in TR-SPF-fed mice was remarkably smaller than that of the control. Whereas the adenosine monophosphate-activated protein kinase (AMPK)-activated protein kinase and insulin receptor substrate 1 (IRS1) protein levels were increased in abdominal adipose tissues after TR-SPF feeding, levels of six-transmembrane protein of prostate 2 (STAMP2) proteins decreased. Phosphorylation of AMPK at threonine 172 and IRS1 at serine 307 and tyrosine 632 were both increased in adipose tissues from TR-SPF-fed mice. Increased expression and phosphorylation of IRS1 at both serine 307 and tyrosine 632 in adipose tissues indicated that adipocytes obtained from abdominal fat in TR-SPF-fed mice were more susceptible to insulin signaling than that of the control. STAMP2 protein levels decreased in adipose tissues from TR-SPF-fed mice, indicating that STAMP2 proteins were reducing adipocytes that were undergoing lipolysis. Taken together, this study showed that TR-SPF was effective in reducing blood glucose levels in diabetic mice and that concurrent lipolysis in abdominal adipocytes was associated with alterations of AMPK, IRS1, and STAMP2. Increased IRS1 expression and its phosphorylation by TR-SFP were considered to be particularly important in the induction of lipolysis in adipocytes, as well as in reducing blood glucose levels in this animal model.