• Journal of Microbiology and Biotechnology
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• 제25권12호
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• pp.2125-2134
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• 2015

IrrE is a highly conserved global regulator in the Deinococcus genus and contributes to survival from high doses of UV radiation, ionizing radiation, and desiccation. Drad-IrrE and Dgob-IrrE from Deinococcus radiodurans and Deinococcus gobiensis I-0 each share 66% sequence identity. However, Dgob-IrrE showed a stronger protection phenotype against UV radiation than Drad-IrrE in the D. radiodurans irrE-deletion mutant (ΔirrE), which may be due to amino acid residues differences around the DNA-binding HTH domain. Site-directed mutagenesis was used to generate a Drad-IrrE A184S single mutant, which has been characterized and compared with the ΔirrE mutant complemented strain with Drad-irrE, designated ΔirrE-E. The effects of the A184S mutation following UV radiation and mitomycin C (MMC) shock were determined. The A184S mutant displayed significantly increased resistance to UV radiation and MMC shock. The corresponding A184 site in Dgob-IrrE was inversely mutated, generating the S131A mutant, which exhibited a loss of resistance against UV radiation, MMC shock, and desiccation. qPCR analysis revealed that critical genes in the DNA repair system, such as recA, pprA, uvrA, and ddrB, were remarkably induced after UV radiation and MMC shock in the ΔirrE-IE and A184S mutants. These data suggested that A184S improves the ability against UV radiation and MMC shock, providing new insights into the modification of IrrE. We speculated that the serine residue may determine the efficiency of DNA binding, leading to the increased expression of IrrE-dependent genes important for protection against DNA damage.

• 산업경영시스템학회지
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• 제45권4호
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• pp.167-173
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• 2022

Investors must adopt profitable investment opportunities to maximize their wealth. Almost all investment, finance, engineering economics textbooks explain that net present value (NPV) measures the profitability (or value) of investment opportunities in absolute size, and internal rate of return (IRR) measures the profitability of investment opportunities in relative proportions. However, NPV is a measure of the relative size of the return on investment opportunity to do-nothing alternative. Moreover, IRR can occur in multiple investment opportunities and may not exist. To make matters worse, IRR and NPV also have conflicting problems in accept-or-reject decisions. In this study, the reason why NPV and IRR cannot accurately measure the profitability of investment opportunities is identified, and fundamental characteristics that investment opportunity profitability measures should have are presented.

• 한국산업경영시스템학회:학술대회논문집
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• 한국산업경영시스템학회 2002년도 춘계학술대회
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• pp.9-18
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• 2002

A capital investment problem is essentially one of determining whether the anticipated cash Inflows from a proposed project are sufficiently attractive to invest funds in the project. The net present value(NPV) criterion and internal rate of return(IRR) criterion are widely used as means of making investment decisions. A positive NPV means the equivalent worth of the inflows is greater than the equivalent worth of outflows, so, the project makes profit. Business people are familiar with rates of return because they all borrow money to finance ventures, even If the money they borrow is their own. Thus they are apt to use the IRR in preference to the NPV. The IRR can be defined as the discount rate that causes the net present value of a cash flow to equal zero. Why the project are accepted if the project's IRR is greater than the investor's minimum attractive rate of return. Against the NPV, the definition cannot distinctly explain the concept of the IRR as decision criterion. We present a new definition of the IRR as the ratio of profit on the invested capital.

• 산업경영시스템학회지
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• 제25권5호
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• pp.9-14
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• 2002

A capital investment problem is essentially one of determining whether the anticipated cash inflows from a proposed project are sufficiently attractive to invest funds in the project. The net present value(NPV) criterion and internal rate of return(IRR) criterion are widely used as means of making investment decisions. A positive NPV means the equivalent worth of the inflows is greater than the equivalent worth of outflows, so, the project makes profit. Business people are familiar with rates of return because they all borrow money to finance ventures, even if the money they borrow is their own. Thus they are apt to use the IRR in preference to the NPV. The IRR can be defined as the discount rate that causes the net present value of a cash flow to equal zero. Why the project are accepted if the project's IRR is greater than the investor's minimum attractive rate of return\ulcorner Against the NPV, the definition cannot distinctly explain the concept of the IRR as decision criterion. We present a new definition of the IRR as the ratio of profit on the invested capital.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2010년도 제35회 추계학술대회논문집
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• pp.563-564
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• 2010

IRR의 부스팅 모드 시 흡입구에 발생하는 압력진동을 감쇄하기 위한 방안을 수치적으로 연구하였다. 축대칭 형태의 초음속 흡입구에 slit을 장착하여 유입되는 공기 유량을 줄여가며 흡입구 내부의 압력 진동을 조사하였다. 흡입되는 유량이 감소함에 따라 압력의 진폭은 감소하고 내부 압력의 최댓값 역시 감소하였으며, 주파수는 약간 증가하는 경향을 보였다. 흡입구의 slit을 이용하여 최적화된 압력 진폭과 주파수대를 얻어낼 수 있다면, 이 방안은 IRR의 부스팅 모드 및 천이 모드에서의 안정성을 높이는데 활용될 수 있을 것으로 판단된다.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.602-607
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• 2013

Financial risks associated with capital investments are often measured with different feasibility indicators such as the net present value (NPV), the internal rate of return (IRR), the payback period (PBP), and the benefit-cost ratio (BCR). This paper aims at demonstrating practical applications of probabilistic feasibility analysis techniques for an integrated feasibility evaluation of the IRR and PBP. The IRR and PBP are concurrently analyzed in order to measure the profitability and liquidity, respectively, of a cash flow. The cash flow data of a real wind turbine project is used in the study. The presented approach consists of two phases. First, two newly reported analysis techniques are used to carry out a series of what-if analyses for the IRR and PBP. Second, the relationship between the IRR and PBP is identified using Monte Carlo simulation. The results demonstrate that the integrated feasibility evaluation of stochastic cash flows becomes a more viable option with the aide of newly developed probabilistic analysis techniques. It is also shown that the relationship between the IRR and PBP for the wind turbine project can be used as a predictive model for the actual IRR at the end of the service life based on the actual PBP of the project early in the service life.

• 한국수정란이식학회지
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• 제30권3호
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• pp.201-206
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• 2015

본 연구는 방사선 조사 후, 난소 적출을 한 흰쥐에 있어서 골회복과정 중에 셀레늄(Se)에 의한 보호 작용을 평가한 연구이다. 목적 수행을 위해 난소 적출술을 실시한 암컷 Sprague-Dawley계 흰쥐 80마리를 무작위로 ovariectomized(Ov), Ov/Se, Ov/irradiated(Irr) 그리고 Ov/Se/Irr와 같이 4개의 처리군으로 구분하였다. 골 결손은 난소적출(ovariectomy) 후, 40일에 모든 공시동물의 경골(tibia)에서 만들어졌다. 수술 후, 48시간에 Ov/Se군과 Ov/Se/Irr 처리구의 흰쥐에만 0.8 mg Se/kg을 투여하였다. 수술 후, 72시간에 Ov/Irr 군과 Ov/Se/Irr 처리구의 흰쥐에만 10Gy의 X-rays 조사를 사지부위(limb region)에 실시하였다. 수술 후, 모든 공시동물은 7, 15, 22 그리고 29일에 안락사를 시키고, 섬유주골형(trabecular bone)의 개수 분석(Masson Trichrome) 과 복 굴절 분석(Picrosirius)에 의해서 골 회복과정을 평가하였다. 난소적출한 군 및 방사선 조사한 군에서 골 재생 과정이 지연되는 현상을 확인이 가능하였다. 결론적으로, 셀렌산염 (sodium selenite)은 독성 없이 난소 적출을 한 흰쥐의 경골(tibia)의 골 재생과정에서 방사선 보호작용을 할 가능성을 제시하였다.

• 수산경영론집
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• 제29권2호
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• pp.199-216
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• 1998

An economic appraisal of a proposed marine ranching project is analysed using capital budgeting model such as net present value(NPV) and internal rate of return( IRR) as well as sensitivity analysis and goal seeking model. Of the factors for economic appraisal, direct benefits are to be determined by estimated harvest, prices and costs incurred by catching fishes, and indirect benefits include the additional economic effect of recreational fishing. And judging the worth of these project options depends upon the choice of discount rate of which 8.5% is recommended here. On the basis of estimated production, prices and costs the project is expected to yield NPV=615 million won and IRR=8.8%, which is quite accepted for an economic feasibility, under the first scenario, and NPV= -127 million won and IRR=7.93%, which is rejected, under the second scenario. Sensitivity analysis has been performed by calculating the switching value and sensitivity indicator in respect of the main project parameters. The results suggest that the project NPV and IRR are especially sensitive to fishes(rock fish and other rock fish) prices and fixed costs. Finally goal seeking analysis is carried out in order to reach a desired level of performance like NPV=0 in respect of the amount of hatchery-reared juverniles, the prices and the discount rate.

• Journal of Microbiology and Biotechnology
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• 제20권7호
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• pp.1156-1162
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• 2010

During ethanol fermentation, bacterial strains may encounter various stresses, such as ethanol and acid shock, which adversely affect cell viability and the production of ethanol. Therefore, ethanologenic strains that tolerate abiotic stresses are highly desirable. Bacteria of the genus Deinococcus are extremely resistant to ionizing radiation, ultraviolet light, and desiccation, and therefore constitute an important pool of extreme resistance genes. The irrE gene encodes a general switch responsible for the extreme radioresistance of D. radiodurans. Here, we present evidence that IrrE, acting as a global regulator, confers high stress tolerance to a Zymomonas mobilis strain. Expression of the gene protected Z. mobilis cells against ethanol, acid, osmotic, and thermal shocks. It also markedly improved cell viability, the expression levels and enzyme activities of pyruvate decarboxylase and alcohol dehydrogenase, and the production of ethanol under both ethanol and acid stresses. These data suggest that irrE is a potentially promising gene for improving the abiotic stress tolerance of ethanologenic bacterial strains.

• 한국산림과학회지
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• 제101권1호
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• pp.46-52
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• 2012

본 연구의 목적은 구기자를 새로이 재배하고자 하는 사람들이나 재배면적을 늘이고자 하는 사람들에게 구기자의 경영실태 및 소득과 투자 수익성을 분석하여 투자에 대한 정보를 제공하고자 하는 것이다. 수익성 분석기법은 IRR, B/C Ratio, NPV를 이용하였다. 구기자 주산단지인 충남 청양, 전남 진도지역의 52가구의 구기자 재배농가를 대상으로 2009년 5월부터 9월까지 작업공정별 투입노동 및 자재비 등에 관해 면접방문조사를 실시하였다. 그 결과 현지판매가격과 투자수익성의 판단기준이 되는 가격을 기준으로 IRR, B/C Ratio, 조수익, 소득, 순수익, 소득율 등을 구하였다. 할인율 3%를 적용하였다. 최근 5년간 농가평균판매가격 kg당 15,000원은 B/C Ratio가 0.89로 나타나 투자수익성이 없는 것으로 나타났다. 적어도 수익성을 맞출려면 IRR=3.00%, B/C Ratio=1.00을 나타내는 구기자 판매가격이 16,800원/kg이상이 되어야 한다고 판단되며, 이때의 소득율은 21.75%인 것으로 나타났다.