• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.19 no.5
• /
• pp.502-508
• /
• 1986

Extracts of six seaweeds obtained from solvents such as water, methanol, hexane and ethyl ether have been tested for desmutagenic activities in the Salmonella typhimurium/microsome systems. Water extracts obtained from tangle, sea-tangle, and gompi were moderately effective on the mutagenicity of Trp-P-2 and aflatoxin $B_1$. Methanol extracts of sea-tangle and gompi were effective against Trp-p-2, and all samples of methanol extracts were very effective from 1.0mg to 2.0mg per plate on the mutagenicity of MeIQ and aflatoxin $B_1$. Hexane extracts of tangle, ses-tangle, gompi and sea-straghorn were very effective on the mutagenicity of Trp-p-2, MeIQ and aflatoxin $B_1$ except laver and green laver. Ethyl ether extracts of gompi and sea-straghorn were most effective from 1.0mg to 2.0mg per plate on the mutagenicity of Trp-P-2. Especially, ethyl ether extracts of all samples were great effective on the mutagenicity of MeIQ and aflatoxin $B_1$.

• Preventive Nutrition and Food Science
• /
• v.6 no.1
• /
• pp.57-61
• /
• 2001

Conjugated linoleic acid (CLA), when incorporated into mouse liver microsomal membranes, selectively inhibits the mutagenesis of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ). Nine-week old female ICR mice were given (p.o.) 0.1 mL olive oil alone (control), 0.1 mL olive oil plus 0.1 mL linoleic acid, or 0.1 mL olive oil plus 0.1 mL CLA, twice weekly for four weeks. The animals were then sacrificed and liver S-9 fractions were prepared. Activation of IQ for mutagenesis by the liver S-9 from CLA-treated mice was significantly reduced in comparison wit liver S-9 from control or linolic acid-treated mice. By contrast, the activation of 7,12-dimethylbenz[a] anthracene (DMBA) and benzo[a] pyrene (BP) was unaffected. Hence, CLA incorporated into phospholipids may selectively affect cytochrome P450 isozymes responsible for activating IQ, but not those which activate BP or DMBA. The addition of free CLA or the methyl esters of CLA, linoleic acid, or oleic acid, to control S-9 inhibited the activation of all three mutagens (IQ, BP, and DMBA).

• Archives of Pharmacal Research
• /
• v.21 no.4
• /
• pp.363-369
• /
• 1998

Glutathione S-transferase placental form (GST-P) positive foci development and its expression in liver exposed by nongenotoxic carcinogens phenobarbital (PB) and clofibrate (CF), and genotoxic carcinogen 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) were investigated as a measure of carcinogenic potential of these chemicals. Male F344 rats were initially given a single intraperitioneal injection of diethyinitrosamine (200 mg/kg), and 2 weeks later, animals were fed diets containing 0.03% IQ or 0.5% CF or 0.05% PB or basal diet as a control for 6 weeks. All rats were subjected to two-thirds partial hepatectomy (PH) at week 3. Sequential sacrifice of rats was performed at 8 weeks or 52 weeks, and liver tissues were examined for immunohistochemical staining of GST-P positive foci. The numbers (No./$cm^2$) and areas ($mm^2$/ $cm^2$) of GST-P positive foci were increased by IQ or PB, but were decreased by CF compare to the control. Consistent with the development of GST-P positive foci, a time-related increase in the expression of GST-P mRNA was found in the rats treated with IQ, whereas CF decreased it. The incidence of hepatocellular carcinoma at 52 weeks was increased by all three chemicals. These results show that PB and IQ induced GST-P positive foci, but the peroxisome proliferator CF did not, which suggest that the prediction of carcinogenic potency based on the development of prenoplastic foci may cause false negative in a particular category compounds like peroxisome proliferators.

• Korean Journal of Child Studies
• /
• v.31 no.1
• /
• pp.113-124
• /
• 2010

This study analyzed the relationships between home environment, child characteristics and school readiness. In particular, it examined the influence of home environment and child characteristics upon children's school readiness with a focus on attitudes towards and other socio-emotional aspects. 57 children's characteristics, including such items as IQ performance and demographic variables were obtained by means of both individual testing of the child and through a questionnaire given to their parents. Relative levels of school readiness were then rated by teachers. Pearson correlations, and a multiple regression analysis were carried out using the SPSS Win 12.0 program. Our results indicated that (1) school readiness was positively related with mother's job, HOME, the ages of the children, Performance IQ, and Total IQ. (2) The level of the other's education, her job and the child's age was found to significantly predict the level of school readiness.

• Proceedings of the IEEK Conference
• /
• 2008.06a
• /
• pp.399-400
• /
• 2008

This paper presents a new architecture of unified IP/IT/IQ/MC circuit for H.264 decoder based on operation sharing and efficient scheduling. The resultant circuit based on the proposed architecture uses only 12 adders and 1 multiplier. We further reduced the circuit size by sharing buffers. Our circuit consists of 47,810 gates and operates at the maximum operating frequency of 117MHz with 130nm standard cells.

• Proceedings of the KIPE Conference
• /
• 1998.10a
• /
• pp.876-881
• /
• 1998

The compensation strategy of shunt active power filters is one of the most important link that determine its compensation characteristics. In this paper, a new interpretation of the instantaneous reactive power theory in three-phase circuits was proposed. A compensation strategy (ip, iq mode) was introduced on the basis of the new interpretation. This compensation strategy was compared with other two compensation strategies(P, q mode and UPF mode). When source voltage is distorted, a sinusoidal, the three compensation strategies are equivalent to each other. When source voltage is distorted, a sinusoidal source current may result only by using ip, iq mode. This is the advantage of ip, iq mode. The result is verified by simulation.

• Journal of IKEEE
• /
• v.14 no.2
• /
• pp.76-81
• /
• 2010

The need for dedicated hardware continue to decrease as the mobile CPU's performance increases. But, there is a limit to a mobile CPU's performance. GP-GPU(General-Purpose computing on Graphics Processing Units) can improve performance without adding other dedicated hardware. This paper presents the implementation of Inverse Quantization, Inverse DCT and Color Space Conversion module in H.264/AVC decoder using GP-GPU for a mobile environments. The proposed architecture improves approximately 40% of performance when it use all the features.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2010.05a
• /
• pp.162-164
• /
• 2010

H.264/AVC(Advanced Video Coding) is a standard for video compression. H.264/AVC provides good video quality at substantially lower bit rates than previous standards. In this papers, we propose the efficient architecture of H.264/AVC decoder using GPGPU. GPGPU can process many of operation in parallel. IQ/IDCT is possible that parallel processing in H.264/AVC decoding algorithm.

• Environmental Mutagens and Carcinogens
• /
• v.23 no.3
• /
• pp.94-98
• /
• 2003

Quercetin and naringenin are representative flavonoids that not only exert anti estrogenic, cholesterol-lowering and antioxidant activities but also can modulate the metabolism of many xenobiotics. The activity of the specific form(s) of CYP450 is likely to be a major determinant of susceptibility to chemically induced carcinogenesis between which varies among between individuals due to different dietary habits as well as genetic characteristics. People consume cooked meat or fish together with various vegetables containing substantial amounts of quercetin and naringenin that can modify the enzyme activity of CYP1A2 to stimulate or to inhibit the mutagenic activities of HCAs. Heterocyclic amines (HCAs) produced by cooking meat products at high temperatures are promutagens that are activated by cytochrome P450 (CYP) lA2. Using a newly developed Salmonella typhimurium TA1538/1A2bc-b5 strain, we tested the effect of quercetin and naringenin on the mutagenicity of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). TA1538/1A2bc-b5 bears two plasmids, one expressing human CYP1A2 and NADPH-P450 reductase (NPR), and the other plasmid which expresses human cytochrome b5 (cyp b5). TA1538/1A2bc-b5 cells showed high activities of 7-ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase (MROD) associated with CYP1A2 and are very sensitive to mutagenesis induced by several HCAs. MeIQ was found to be the strongest mutagen among the HCAs tested in this system. Mutagenicity of MeIQ was enhanced 50 and 42% by quercetin at 0.1 and 1 mM, respectively, but suppressed 82% and 96% at 50 mM and 100 mM. Naringenin also increased the MeIQ-induced mutation about 37% and 22% at 0.1 and 1 mM, but suppressed it 32% and 63% at 50 mM and 100 mM concentrations, respectively, in TA 1538/1A2bc-b5 cells. Thus, they stimulated the MeIQ induced mutation at low concentrations, but strongly suppressed it at high concentrations. This biphasic effect of flavonoids was due to the stimulation or the inhibition of CYP1A2 activity in a dose-dependent manner judging by the activities of EROD or MROD in the Salmonella cells. Collectively, it is likely that the biphasic effects of quercetin and naringenin on the MeIQ-induced mutagenesis in S. typhimurium TA1538/CYP1A2bc-b5 were due to their differential modification of the CYP1A2 activity in these cells.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.20 no.1
• /
• pp.21-28
• /
• 2009

DFT-spread OFDM(Discrete Fourier Transform-Spread Orthogonal Frequency Division Multiplexing) is very effective for solving the PAPR(Peak-to-Average Power Ratio) problem. Therefore, the SC-FDMA(Single Carrier-Frequency Division Multiple Access) which is basically same to the DFT spread OFDM was adopted as the uplink standard of the 3GPP LTE ($3^{rd}$ Generation Partnership Project Long Term Evolution). Unlike the ordinary OFDM system, the SC-FDMA using DFT spreading method is vulnerable to the ICI(Inter-Carrier Interference) problem caused by the phase noise and IQ(In-phase/Quadrature) imbalance and effected FDE(Frequency Domain Equalizer). In this paper, the ICI effects from the phase noise and IQ imbalance which can be problems in uplink transmission are analyzed according the back-off level of HPA. Next, we propose the equalizer algorithm to remove the ICI effects. This proposed equalizer based on the FDE can be considered as up-graded and improved version of PNS(Phase Noise Suppression) algorithm. This proposed equalizer effectively compensates the ICI resulting from the phase noise and IQ imbalance. Finally, through the computer simulation, it can be shown that about SNR=14 dB is required for the $BER=10^{-4}$ after ICI compensation when the back-off is 4.5 dB, $\varepsilon=0.005$, $\phi=5^{\circ}$, and $pn=0.06\;rad^2$.