• 제목/요약/키워드: IPD(R)

검색결과 16건 처리시간 0.018초

영상 융합하여 분석한 파킨슨씨병 환자영상의 유용성 (Usefulness of Registration in the Evaluation of Parkinson′s Disease)

  • 주라형;김재승;문대혁;최보영;서태석
    • 한국의학물리학회지:의학물리
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    • 제14권4호
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    • pp.268-278
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    • 2003
  • 목 적 : $^{123}$ I IPT SPECT에서 선조체 섭취율(specific striatal binding ratio: SBR)과 미상핵과 전$.$후 조가비핵의 비(anterior/posterior ratio: APR)를 측정하기 위해 육안적인 방법으로 설정한 수동 관심영역설정 방법과 MR template을 영상 융합하여 해부학적 영상을 기준으로 관심영역을 설정하는 방법에서 수동방법과 영상 융합 방법간 차이의 유의성과 분석 그룹간의 유의성과 재현성을 분석하고자 한다. 대상 및 방법: Early parkinson군 17명(남/녀:8/9, 56.6$\pm$10.8세)과 severe parkinson군 13명(남/녀:8/5, 56.4$\pm$11.1세), 정상인 11명(남/녀:7/4, 57.8$\pm$14.4세)을 대상으로 $^{123}$ I IPT 259 MBq을 정맥 주사한 후 얻은 $^{123}$ I IPT SPECT 영상에서 수동 ROI와 영상융합방법에 의한 ROI를 설정하였다. 영상융합방법에 의한 자동 관심영역 설정방법은 NMI 방법으로 $^{123}$ I IPT SPECT와 MNI T1 template를 영상 융합하여 midthalamic level에서 선조체의 경계를 따라 하부조직을 7개의 관심영역으로 구분하여 SBR과 APR을 측정하고 수동방법으로 측정한 SBR과 APR과 통계적 유의성을 분석하였다. 결 과:수동 관심영역 설정방법과 자동 관심영역 설정방법에 의한 두 분석 방법간 비교에서 SBR은 정상인 그룹(r=0.853, P=0.001), early parkinson군(H&Y stage I, II) (r=0.841, P=0.000), severe parkinson군(H&Y stage III, IV) (r=702, P=0.007) 모두에서 유의한 상관관계를 보였으나 APR은 early parkinson군에서만 유의한 상관관계(r=0.720, P=0.001)를 보였고 정상인(r=0.567, P=0.069), severe parkinson군(r=0.413, P=0.161)로 유의한 상관관계를 보이지 않았다. 분석그룹간 비교에서 수동 관심영역 설정방법에서 정상인과 early parkinson군(P=0.000), 정상인과 severe parkinson군(P=0.000), early parkinson군과 severe parkinson군(P=0.013) 모두 유의한 결과를 보였고, 자동 관심영역 설정방법에서 정상인과 early parkinson군(P=0.000), 정상인과 severe parkinson군(P=0.000), early parkinson군과 severe parkinson군(P=0.003)에서는 유의한 결과를 보였다. APR은 수동 관심영역 설정방법에서는 분석그룹간에 유의한 차이를 보이지 않았다(정상인과 early parkinson군:P=0.316, 정상인과 severe parkinson군:P=0.256, early parkinson군과 severe parkinson군:P=0.969). 자동 관심영역 설정방법에서는 정상인과 early parkinson군(P=0.038), 정상인과 severe parkinson군(P=0.027)에서는 유의한 결과를 보였으나 early parkinson군과 severe parkinson군에서는 유의한 결과를 보이지 않았다(P=0.948). 재현성은 CV값으로 자동 관심영역 설정방법이 7.2%, 수동 관심영역 설정방법이 31%로 자동 관심영역 설정방법의 재현성이 4.3배 높았다. 결 론:$^{123}$ I IPT SPECT영상에서 SBR과 APR의 측정이 해부학적 표준영상인 T1 template를 기준으로 영상 융합하여 선조체와 하부조직을 미상핵과 조가비핵 전측과 후측으로 구분하여 섭취율을 측정하는 방법이 수동으로 관심영역을 설정하여 분석하는 방법보다 통계적으로 유의하고 재현성 있는 결과를 보였다.

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Study of point defects caused by a thin contamination layer in a-Si TFT-LCD

  • Oh, Jae-Young;Lee, Jae-Kyun;Yang, Moung-Su;Kang, In-Byeong
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
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    • pp.845-848
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    • 2007
  • Analysis of point defects invisible by a microscope has been studied on the a-Si thin film transistor panel. The point defects which were named Invisible Point Defect (IPD) is characterized by no particles or distortion of patterns on a pixel structure and randomly distributed on panels. To investigate the IPD, measurements were carried out: gray level driving, transistor transfer characteristic, focused ion beam (FIB), and secondary ion mass spectrometry (SIMS). The results showed that a contamination layer had a bad influence on an active surface. The contamination layer consisted of oxygen and iron from a water supply line during cleaning process. After the process tuning, IPD has been stabilized.

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Diplexer 구조를 이용한 Dual Band 방향성 커플러 (A Dual Band Directional Coupler with Feedback Compensation Using Diplexer Structure)

  • 김기중;박자영;정영학;배효근;김남흥;김학선
    • 한국전자파학회논문지
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    • 제16권8호
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    • pp.783-789
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    • 2005
  • 본 논문은 glass 기판 위에 RE IPD(Integrated Passive Device) 기술을 이용하여 dual band 방향성 커플러의 새로운 설계와 구현을 하였으며, 이러한 구조는 전력 증폭기의 출력부에 closed loop 전력 제 어용 GSM/GPRS cellular phones에 적용할 수 있다. 커플러는 방향성 향상을 위하여 보상 capacitor를 이용하였으며, 상호 밴드의 간섭을 최소화하기 위하여 새로운 방법의 필터링 구조(diplexer)를 갖는 커플러를 구현하였다.

RETRIEVAL OF LOCAL INTERPLANETARY DUST EMISSIVITY BY ASTRO-F

  • HONG S. S.;KWON S. M.;PYO J.;UENO M.;ISHIGURO M.;USUI F.;WEINBERG J. L.
    • 천문학회지
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    • 제37권4호
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    • pp.159-169
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    • 2004
  • This is a proposal to probe local part of the interplanetary dust (IPD) cloud complex and retrieve mean volume emissivity of the local IPDs at mid-infrared wavelengths. This will be done by monitoring, with Infrared Camera (IRC) aboard the ASTRO-F, the annual modulation of the zodiacal emission. In pointing mode of the ASTRO-F mission the spacecraft can make attitude maneuvering over approximately ${\pm}1^{\circ}$ range centered at solar elongation $90^{\circ}$ in the ecliptic plane. The attitude maneuvering combined with high sensitivity of the IRC will provide us with a unique opportunity observationally to take derivatives of the zodiacal emission brightness with respect to the solar elongation. From the resulting differential of the brightness over the ${\pm}1^{\circ}$ range, one can directly determine the mean volume emissivity of the local IPDs with a sufficient accuracy to de-modulate the annual emissivity variations due to the Earth's elliptical motion and the dis-alignment of the maximum IPD density plane with respect to the ecliptic. The non-zero eccentricity ($e_{\oplus}$= 0.0167) of the Earth's orbit combined with the sensitive temperature dependence of the Planck function would bring modulations of amplitude at least $3.34\%$ to the zodiacal emission brightness at mid-infrared wavelengths, with which one may determine the IPD temperature T(r) and mean number density n(r) as functions of heliocentric distance r. This will in turn fix the power-law exponent $\delta$ in the relation $T(r) = T_o(r/r_o)^{-\delta}$ for the dust temperature and v in $n(r) = n_o(r/r_o)^-v$ for the density. We discuss how one may de-couple the notorious degeneracy of cross-section, density, reference temperature $T_o$ and exponent $\delta$.

Production of Indole-3-acetate in Corynebacterium glutamicum by Heterologous Expression of the Indole-3-pyruvate Pathway Genes

  • Kim, Yu-mi;Kwak, Mi-hyang;Kim, Hee-sook;Lee, Jin-ho
    • 한국미생물·생명공학회지
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    • 제47권2호
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    • pp.242-249
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    • 2019
  • Biosynthesis of indole-3-acetate (IAA) from L-tryptophan via indole-3-pyruvate pathway requires three enzymes including aminotransferase, indole-3-pyruvate decarboxylase, and indole-3-acetate dehydrogenase. To establish a bio-based production of IAA, the aspC, ipdC, and iad1 from Escherichia coli, Enterobacter cloacae, and Ustilago maydis, respectively, were expressed under control of the tac, ilvC, and sod promoters in C. glutamicum. Cells harboring ipdC produced tryptophol, indicating that the ipdC product is functional in this host. Analyses of SDS-PAGE and enzyme activity revealed that genes encoding AspC and Iad1 were efficiently expressed from the sod promoter, and their enzyme activities were 5.8 and 168.5 nmol/min/mg-protein, respectively. The final resulting strain expressing aspC, ipdC, and iad1 produced 2.3 g/l and 7.3 g/l of IAA from 10 g/l L-tryptophan, respectively, in flask cultures and a 5-L bioreactor.

플랜지 체결 시 금속 개스킷의 구조해석 (Structure analysis of metal gaskets in tightened flanges)

  • 인상렬;윤병주
    • 한국진공학회지
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    • 제15권5호
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    • pp.475-484
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    • 2006
  • 컨플래트 (Con-Flat) 및 개량형 (IPD) 플랜지에서 개스킷을 넣고 체결할 때 나사의 체결력 또는 선하중에 따라 플랜지 및 개스킷에 발생하는 변형량, 응력 분포, 접촉 면압 따위의 계산을 통해 플랜지 날의 형상이나 체결조건이 기밀에 미치는 영향을 분석 또는 예측하는 것이 가능한지를 판단해 보았다.

Salivary Gland Uptake on 18F-FP-CIT PET as a New Biomarker in Patients With Parkinsonism

  • Seo Young Kang;Ji Young Yun;Yeon-Koo Kang;Byung Seok Moon;Hai-Jeon Yoon;Min Young Yoo;Bom Sahn Kim
    • Korean Journal of Radiology
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    • 제24권7호
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    • pp.690-697
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    • 2023
  • Objective: 18F-FP-CIT positron emission tomography (PET) is known for its high sensitivity and specificity for evaluating striatal dopamine transporter (DAT) binding. Recently, for the early diagnose of Parkinson's disease, many researchers focused on the diagnosis of synucleinopathy in organs involved in non-motor symptoms of Parkinson's disease. We investigated the feasibility of salivary gland uptake on 18F-FP-CIT PET as a new biomarker in patients with parkinsonism. Materials and Methods: A total of 219 participants with confirmed or presumed parkinsonism, including 54 clinically diagnosed idiopathic Parkinson's disease (IPD), 59 suspected and yet undiagnosed, and 106 with secondary parkinsonism, were enrolled. The standardized uptake value ratio (SUVR) of the salivary glands was measured on both early and delayed 18F-FP-CIT PET scans using the cerebellum as the reference region. Additionally, the delayed-to-early ratio (DE_ratio) of salivary gland was obtained. The results were compared between patients with different PET patterns. Results: The SUVR in early 18F-FP-CIT PET scan was significantly higher in patients with IPD pattern compared that in the non-dopaminergic degradation group (0.5 ± 0.19 vs. 0.6 ± 0.21, P < 0.001). Compared with the non-dopaminergic degradation group, the DE_ratio was significantly lower in patients with IPD (5.05 ± 1.7 vs. 4.0 ± 1.31, P < 0.001) or atypical parkinsonism patterns (5.05 ± 1.7 vs. 3.76 ± 0.96, P < 0.05). The DE_ratio was moderately and positively correlated with striatal DAT availability in both the whole striatum (r = 0.37, P < 0.001) and posterior putamen (r = 0.36, P < 0.001). Conclusion: Parkinsonism patients with an IPD pattern exhibited a significant increase in uptake on early 18F-FP-CIT PET and a decrease in the DE_ratio in the salivary gland. Our findings suggest that salivary gland uptake of dual-phase 18F-FP-CIT PET can provide diagnostic information on DAT availability in patients with Parkinson's disease.

Analysis of the Current-voltage Curves of a Cu(In,Ga)Se2 Thin-film Solar Cell Measured at Different Irradiation Conditions

  • Lee, Kyu-Seok;Chung, Yong-Duck;Park, Nae-Man;Cho, Dae-Hyung;Kim, Kyung-Hyun;Kim, Je-Ha;Kim, Seong-Jun;Kim, Yeong-Ho;Noh, Sam-Kyu
    • Journal of the Optical Society of Korea
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    • 제14권4호
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    • pp.321-325
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    • 2010
  • We analyze the current density - voltage (J - V) curve of a Cu(In,Ga)$Se_2$ (CIGS) thin-film solar cell measured at different irradiation power densities. For the solar-cell sample investigated in this study, the fill factor and power conversion efficiency decreased as the irradiation power density (IPD) increased in the range of 2 to 5 sun. Characteristic parameters of solar cell including the series resistance ($r_s$), the shunt resistance ($r_{sh}$), the photocurrent density ($J_L$), the saturation current density ($J_s$) of an ideal diode, and the coefficient ($C_s$) of the diode current due to electron-hole recombination via ionized traps at the p-n interface are determined from a theoretical fit to the experimental data of the J - V curve using a two-diode model. As IPD increased, both $r_s$ and $r_{sh}$ decreased, but $C_s$ increased.