• Journal of Ginseng Research
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• v.47 no.3
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• pp.458-468
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• 2023

Background: As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined. Recent studies demonstrated that Ginsenoside Rg1 (Rg1) has promising neuroprotective properties, but the effect and mechanism in diabetes-associated cognitive dysfunction (DACD) deserve further investigation. Methods: After establishing the T2DM model with a high-fat diet and STZ intraperitoneal injection, Rg1 was given for 8 weeks. The behavior alterations and neuronal lesions were judged using the open field test (OFT) and Morris water maze (MWM), as well as HE and Nissl staining. The protein or mRNA changes of NOX2, p-PLC, TRPC6, CN, NFAT1, APP, BACE1, NCSTN, and Ab1-42 were investigated by immunoblot, immunofluorescence or qPCR. Commercial kits were used to evaluate the levels of IP3, DAG, and calcium ion (Ca²⁺) in brain tissues. Results: Rg1 therapy improved memory impairment and neuronal injury, decreased ROS, IP3, and DAG levels to revert Ca²⁺ overload, downregulated the expressions of p-PLC, TRPC6, CN, and NFAT1 nuclear translocation, and alleviated Aβ deposition in T2DM mice. In addition, Rg1 therapy elevated the expression of PSD95 and SYN in T2DM mice, which in turn improved synaptic dysfunction. Conclusions: Rg1 therapy may improve neuronal injury and DACD via mediating PLC-CN-NFAT1 signal pathway to reduce Aβ generation in T2DM mice.

• Proceedings of the Korea Contents Association Conference
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• 2018.05a
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• pp.435-436
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• 2018

3차원 GIS연계를 통한 보안 플랫폼개발은 3차원 공간정보가 가진 융합의 특성을 잘 활용하여 개별적인 IT기반 물리 보안시스템을 통합관리 하고 미래의 기술변동 흐름을 잘 반영할 뿐만 아니라 보안요원의 개입을 줄이는 것을 목적으로 시스템 자체가 판단하고 관리할 수 있는 능동형 보안 플랫폼 기술이다. 개발 플랫폼은 IP카메라 기반 영상데이터 위에 GIS 기반 좌표 값이 부여된 형태의 기술로, 증강현실 기반의 보안관제 서비스 제공 기반을 마련하는데 효과가 기대된다.

• Proceedings of the Korea Information Processing Society Conference
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• 2001.04a
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• pp.107-110
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• 2001

화상회의시스템이란 영상 및 멀티미디어를 활용하여 원격 회의를 가능하게 하는 정보전달 매체로 가격이 저렴해지면서 학교 현장에 보급되기 시작하였다. 이 시스템의 활용 범위가 확장되어 교육청과 학교간의 회의뿐만 아니라 실시간 원격연수에도 활용이 가능하게 되었다. 그러나 현장의 교사들은 화상회의 시스템에 대한 지식과 응용 프로그램의 사용 경험 부족으로 적극적인 활용에 어려움을 겪고 있다. 본 연구에서는 현재 학교에 널리 보급되어 있는 MCU방식과 최근 새롭게 개발된 IP 멀티캐스팅 방식의 원격교육 시스템에 대한 장단점을 비교하고 분석하여 교육 현장에 적합한 화상회의시스템에 대한 평가를 할 것이다. 그리고, 실시간 원격교육 프로그램을 위한 화면의 설계 결과와 화상회의 시스템과의 인터페이스 방법에 대한 설계 결과를 제시할 것이다.

• Journal of Engineering Education Research
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• v.22 no.1
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• pp.55-60
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• 2019

This paper deals with the process and requirements of a capstone design project performed by undergraduate students. We discuss about the preliminary study for the capstone design, the derivation of a subject, the level descriptor of the subject, and the system requirements. And then, we summarize the results of the capstone design project entitled as Microsoft Azure based IoT (Internet of Things) system which is performed by 4 undergraduate students during 10 months. This system is composed of a Zigbee sensor network, the TCP/IP Internet, an IoT server, and a smartphone application program, with which we can gather the sensor data and control actuators at the far away area.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.6877-6882
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• 2015

Background: Cisplatin (CDDP) is one of the most active cytotoxic agents in the treatment of cancer. We investigated the effect of selenium (Se) with high dose vitamin E (VE) administration to prevent CDDP-induced nephrotoxicity in rats. Materials and Methods: In this study, 40 female Wistar rats were randomly divided into five equal groups. The first group, which served as the control, was administered physiological saline (2.5 cc/day, 5 days) intraperitoneally (IP), while group A was administered cisplatin (6 mg/kg BW/ single dose) plus physiological saline IP. Groups B, C, D received IP five doses of Se (1.5 mg/kg BW), and a high dose of VE (1000 mg/kg BW) (Se-VE) in combination before, simultaneously, and after CDDP, respectively. The rats were sacrificed five days after CDDP administration. Plasma malondialdehide (MDA), glutathione peroxidase (GSH-Px), reduced glutathione (GSH), catalase, urea, creatinine levels, renal histopathological changes were measured. Results: The histopathological injury score, plasma levels of MDA, urea, creatinine were found to increase in group A compared to the control (p<0.05), while plasma levels of GSH-Px, GSH and catalase decreased (p<0.05). In contrast, plasma levels of MDA decreased (p<0.05) in groups B, C, D, which were treated with Se- VE, whereas levels of GSH-Px, GSH were found to increase only for group D (p<0.05). Plasma urea, creatinine levels improved in the treatment groups compared to group A (p<0.001). Histopathological changes caused by CDDP were also significantly improved after Se-VE treatment (p<0.05). Conclusions: Oxidative stress increases with CDDP-induced nephrotoxicity in rats. Se-VE supplementation might thus play a role in the prevention of CDDP-induced nephrotoxicity in patients.

• Journal of Digital Convergence
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• v.11 no.8
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• pp.367-373
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• 2013

Mobile SNS is a new paradigm of the communication. These days, mobile services communicate with server by client applications. TALK or PUSH provide services using TCP/IP software in operation system through massage or data by socket. Thus, SNS and mobile convergence are necessary and new service is constructed using platform of SNS. In this paper, we design and implement TALK and PUSH services between clients by location based SNS using the socket type.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.24 no.6
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• pp.177-182
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• 2010

As the technology is developing, the power system is also developing. Nowaday the power system operation has been complicated because of new technology development, new electric equipments and new operation method of the power system. As the electric equipments performance developing, the fault ratio of power system has been decreased. Therefore, new operation method is needed. More complicated the power system operation method, we need more the power system simulator to train and educate the novice power system operators. In this paper, we made real-time power system simulator using LabVIEW through the TCP/IP communication. With this simulator the instructor can simulate the trainee within various unpredicted cases that real power system could happen.

• Proceedings of the KSPS conference
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• 2007.05a
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• pp.240-242
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• 2007

The goal of this paper is to investigate effects of three prosodic factors, such as phrasal accent (accented vs. unaccented), prosodic boundary (IP-initial vs. IP-medial) and coda voicing (e.g., bed vs. bet), on acoustic realization of English vowels (/i, $_I/$, $/{\varepsilon}$, ${\ae}/$) as produced by native (Canadian) and nonnative (Korean) speakers. The speech corpus included 16 minimal pairs (e.g., bet-bat, bet-bed) embedded in a sentence. Results show that phonological contrast between vowels are maximized when they were accented, though the contrast maximization pattern was not the same between the English and Korean speakers. However, domain-initial position do not affect the phonetic manifestation of vowels. Results also show that phonological contrast due to coda voicing is maximized only when the vowels are accented. These results propose that the phonetic realization of vowels is affected by phrasal accent only, and not by the location within prosodic position.

• Asia-Pacific Journal of Business
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• v.9 no.4
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• pp.99-117
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• 2018

This study has investigated Linear Programming (LP) applications to special decision making problems in managerial accounting with the help of spreadsheet Solver tools. It uses scenario approaches to case examples having three products and three resources in make-and-supply business operations, which is applicable to cases having more variables and constraints. Integer Programmings (IP) are applied in order to model situations when products are better valued in integer values or logical constraints are required. Three cases in one-time-only special order decisions include Goal Programming approach, Knapsack problems with 0/1 selections, and fixed-charge 0/1 integer modelling techniques for set-up operation costs. For the decisions in outsourcing problems, opportunity-costs of resources expressed by shadow-prices are considered to determine their precise contributions. It has also shown that the improvement in work-shop operation for an unprofitable product must overcome its 'reduced cost' by the sum of direct manufacturing cost savings and its shadow-price contributions. This paper has demonstrated how various real situations of special decision problem in managerial accounting can be approached without mistakes by using LP's and IP's, and how students both in accounting and management science can acquire LP skills in their education.

• Journal of Convergence for Information Technology
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• v.9 no.6
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• pp.13-18
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• 2019

This paper proposes efficient and secure two-way authentication protocol for binding update messages between mobile devices and home agents / correspondent nodes in IoT and Mobile IPv6 (MIPv6) environments with limited computing power and resources. Based on the MIPv6 message exchange, the proposed protocol satisfies both the authentication and the public key exchange optimized for both sides of the communication with minimum modification. In the future, we will carry out a performance analysis study by implementing the proposed protocol in detail.