• The Korean Journal of Physiology and Pharmacology
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• v.14 no.4
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• pp.235-240
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• 2010

Toll-like receptors (TLRs) functionally expressed in salivary epithelial cells, but their roles remain elusive. Among TLRs family, TLR3 is activated by dsRNA, a byproduct of viral infection. The aim of this study was to investigate the role of TLR3 in the inflammatory immune responses using HSG cells. Reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR and ELISA were performed to identify expression of TLRs and TLR3-mediated chemokine inductions. The chemotaxis assay of activated T lymphocytes was also performed. Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-$\gamma$-inducible protein 10 (IP-10), interferoninducible T-cell $\alpha$ chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner. Anti-TLR3 antibody blocked the increases of IP-10 and I-TAC genes. Poly(I:C)-induced increases of IP-10 and I-TAC were also confirmed at protein levels from cell lysates, but their release into extracellular medium was detected only in IP-10. We found that the culture media from HSG cells stimulated with poly(I:C) significantly increases T lymphocyte migration. Our results suggest that TLR3 plays an important role in chemokine induction, particularly IP-10, in salivary epithelial cells.

• Pediatric Infection and Vaccine
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• v.26 no.1
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• pp.51-59
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• 2019

Purpose: The aim of this study was to evaluate the relationships between cytokine and chemokine levels and the clinical severity of Mycoplasma pneumoniae pneumonia. Methods: A retrospective analysis of clinical and laboratory parameters were performed. Serum levels of interleukin (IL)-6, IL-8, IL-10, IL-18, interferon-${\gamma}$-inducible protein-10 (IP-10), macrophage inflammatory $protein-1{\beta}$, and tumor necrosis $factor-{\alpha}$ were measured. The severity of patients' clinical course and radiologic findings were also assessed. Results: Seventy-two patients (35 males and 37 females) with a median age of 3.9 years (range, 1-16 years) were enrolled. Patients with lobar pneumonia (n=29) had significantly higher C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and IL-18 values than those with broncho-interstitial pneumonia (n=43). However, the cytokine and chemokine values did not differ between the group that was treated with corticosteroids (n=31) and the one that was not (n=41). The CRP, ESR, lactate dehydrogenase (LDH), IL-18, and IP-10 values showed positive correlations with fever duration prior to admission. The CRP and ESR values were positively correlated with IL-18, and LDH, with IP-10 levels. Conclusions: CRP, ESR, LDH, IL-18, and IP-10 values were associated with the severity of the disease, manifesting lobar pneumonia or prolonged fever duration prior to admission.

• Journal of information and communication convergence engineering
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• v.8 no.1
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• pp.1-5
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• 2010

In this paper, we propose for improving QoS in wireless micro cellular network using Cellular-IP/PRC(Paging Route Cache) with Paging Cache and Route Cache in Cellular-IP and propose for performance of realtime and non-real time handoff service using Handoff state machine Paging Route Cache. Although the Cellular-IP/PRC technology is devised for mobile internet communication, it bas its vulnerability in frequent handoff environment. On the other hand, Cellular IP combines the capability of cellular networks to provide high performance handoff and efficient location management of active and idle mobile users with the inherent flexibility, robustness and scalability found in IP networks. Also Cellular-IP/PRC use semi-soft handoff. During semi-soft hand off a mobile host may be in contact with either of the old and new base stations and receive packets from them. Packets intended to the mobile node are sent to both base stations and buffered, so when the mobile host eventually moves to the new location it can continue to receive packets without interruption. It should be suitable for realtime service such as multimedia traffic. But, much waste of resource will occur in this method, especially for non-real time services such as FTP and E-mail. Therefore, a new algorithm that performs different handoff according to characteristic of each traffic by use of reserved field in IP packet is proposed in this thesis. This hand off state machine using differentiated handoff improves quality of services in Cellular-IP/PRC. Suggested algorithm shows better performance than existing technology in wireless mobile internet communication environment. Matlab simulation results are improving QoS, show call drop and call blocking provided to Paging Router Cache during handoff state machine in Cellular-IP/PRC.

• KIISE Transactions on Computing Practices
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• v.20 no.12
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• pp.688-693
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• 2014

With the advent of ubiquitous environments, the smart phone has come into wide use and the demand for various content increases. Thus, in order to efficiently utilize limited resources cognitive radio technology is regarded as a possible solution. Besides spectrum sensing or access schemes, the provision of VoIP traffic service for secondary users with limited spectrum resources is a very important issue. In this paper, a resource allocation and control system for VoIP QoS provision in cognitive radio networks is proposed. Firstly, as the system model, the time structure of the network is addressed and, according to the structure, a bandwidth broker is proposed. In addition, based on available bandwidth estimated by the bandwidth broker, a connection admission control for secondary users is developed. It is demonstrated that the provision of VoIP QoS is greatly affected by channel utilization, the number of channels, and the length of timeslot.

• The Journal of Society for e-Business Studies
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• v.22 no.4
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• pp.129-139
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• 2017

With the advent of FinTech, many financial services have become available in the mobile Internet environment and recently, there is an internet bank that provides all bank services online. As the proportion of financial services over the Internet increases, it offers convenience to users, but at the same time, the threat of financial network is increasing. Financial institutions are investing heavily in security systems in case of an intrusion. However attacks by hackers are getting more sophisticated and difficult to cope with. However, applying an IP Trace-back method that can detect the actual location of an attacker to a financial network can prepare for an attacker's arrest and additional attacks. In this paper, we investigate IP Trace-back technology that can detect the actual location of attacker and analyze it to apply it to financial network. And we propose a new IP Trace-back method through Infra-structure construction through simulation experiments.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.1
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• pp.130-140
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• 2010

SIP (Session Initiation Protocol) is a signaling protocol to provide IP-based VoIP (Voice over IP) service. However, many security vulnerabilities exist as the SIP protocol utilizes the existing IP based network. The SIP Malformed message attacks may cause malfunction on VoIP services by changing the transmitted SIP header information. Additionally, there are several threats such that an attacker can extract personal information on SIP client system by inserting malicious code into SIP header. Therefore, the alternative measures should be required. In this study, we analyzed the existing research on the SIP anomaly message detection mechanism against SIP attack. And then, we proposed a Co-occurrence based SIP packet analysis mechanism, which has been used on language processing techniques. We proposed a association rule generation and an attack detection technique by using the actual SIP session state. Experimental results showed that the average detection rate was 87% on SIP attacks in case of using the proposed technique.

• Journal of Pharmaceutical Investigation
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• v.30 no.1
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• pp.21-26
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• 2000

Bioavailability of ipriflavone (3-phenyl-7-isopropoxy-4H-I-benzopyran-4-one, IP), an antiosteoporotic drug with poor water-solubility, was studied for various types of pharmaceutical preparation in SD rats. The IP preparation types included (1) intact IP, (2) freezer milled IP (FIP), (3) freezer milled IP physically mixed with freezer milled poly-N-vinylpyrrolidone (PVP) (FIP+FPVP) and (4) spray-dried IP with PVP (SIP). Upon oral administration, SIP showed significantly higher absorption and elimination half-lives and the lag time $(t_{lag})$ than those of FIP+FPVP (approximately 2-fold). These results may be due to a sustained releasing effect of IP in the gastrointestinal tract by spray-drying with PVP. The $C_{max}$ of SIP was about 2 and 10 times higher than those of FIP+FPVP and FIP, respectively. The AUC of SIP was about 6 times higher than that of FIP+FPVP and 60 times that of FIP. Scanning electron microscopy (SEM) showed that SIP consisted of the finest particle size and minimal aggregation than other IP preparations. It is concluded that the IP formula prepared by the spray-drying method with PVP is the most effective approach to the improvement of bioavailability of IP.

• Journal of the Korean Society of Earth Science Education
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• v.5 no.3
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• pp.256-266
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• 2012

The purpose of this study is to use DARTs (Directed Activities Related to text) to foster inquiry problems while actively engaging accelerated gifted elementary students in the field of earth sciences. This study is continually evolving in the classroom on the proposition that accelerate the scientific thought whether inquiry problems show any change according to the extent of prior background knowledge through DARTs. Researchers appointed the accelerated gifted elementary students with 14 investigation problems and it was their duty to not only classify the inquiry problems, but to analyze using interviewing methods according to type classification framework. Many scientific terms were used concretely in the inquiry problems that were propose after DART. The students gave a direct effect to the inquiry problem to be proposed according to the level of the content that it is presented in the DARTs worksheet. As a result, the NP-IP type and the EC-IP, NC-IP inquiry problem type proposed above much as a whole in DARTs former and prior. Particularly, the EMC-IP type and etc. was variously proposed after the DARTs. And the students proposing the inquiry problem of above average proposed the inquiry problem of the EP-IP type much unlike the general average student after the DARTs. The EC-IP, NC-IP and NF-IP type were changed much after DARTs used. Particularly, the EC-IP and NC-IP type were changed much.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.2
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• pp.317-326
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• 2016

In this paper, a logic eFuse (electrical Fuse) OTP (One-Time Programmable) memory IP (Intellectual Property) using only logic transistors to reduce the development cost and period of OTP memory IPs is designed. To secure the reliability of other IPs than the OTP memory IP, a higher voltage of 2,4V than VDD (=1.5V) is supplied to only eFuse links of eFuse OTP memory cells directly through an external pad FSOURCE coming from test equipment in testing wafers. Also, an eFuse OTP memory cell of which power is supplied through FSOURCE and hence the program power is increased in a two-dimensional memory array of 128 rows by 8 columns being also able to make the decoding logic implemented in small area. The layout size of the designed 1kb eFuse OTP memory IP with the Dongbu HiTek's 110nm CIS process is $295.595{\mu}m{\times}455.873{\mu}m$ ($=0.134mm^2$).

• Journal of the Korea Institute of Information Security & Cryptology
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• v.14 no.1
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• pp.79-89
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• 2004

Mobile IP Low Latency Handoffs allow greater support for real-time services on a Mobile W network by minimizing the period of time when a mobile node is unable to send or receive IP packets due to the delay in the Mobile IP Registration process. However, on Mobile IP network with AAA servers that are capable of performing Authentication, Authorization, and Accounting(AAA) services, every Registration has to be traversed to the home network to achieve new session keys, that are distributed by home AAA server, for a new Mobile IP session. This communication delay is the time taken to re-authenticate the mobile node and to traverse between foreign and home network even if the mobile node has been previously authorized to old foreign agent. In order to reduce these extra time overheads, we present a method that performs Low Latency Handoffs without requiring funker involvement by home AAA server. The method re-uses the previously assigned session keys. To provide confidentiality and integrity of session keys in the phase of key exchange between agents, it uses a key sharing method by gateway foreign agent that Performs a ousted thirty party. The Proposed method allows the mobile node to perform Low Latency Handoffs with fast as well as secure operation