• Journal of Life Science
• /
• v.8 no.4
• /
• pp.464-471
• /
• 1998

This study was carried out to determine whether Kamihaengche-tang plus Yukmijihwang-tang (KCYH) exerts the protective effect against oxidant-induced liver cell injury. Cell injurt was estimated by measuring lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) release, and lipid peroxidation was estimated by measuring malondialdehyde, a product of lipid peroxidation in rabbit liver slices. $H_2O_2$increased LDH release which was significantly prevented by 1% KCYHT. The protective effect of KCYH against $H_2O_2$-induced cell injury was dose-dependent in the range of 0.05-1% concentrations. Similary, KCYH inhibited $H_2O_2$ induced lipid peroxidation in a dose-dependent manner. When liver tissuse were exposed to Hg(0.5 mM), ALT activity in the medium and lipid erpoxidation in tissues were markedly increased. These changes were prevented by 1% KCYH. KCHY restored Hg-induced inhibition of cellular GSH content. These result indicate that KCYH exerts the protective effect oxidant-induced liver cell injury, and this effect is attributed to prevented to prevention of lipid peroxidation. These dffects may be due to an increase in concentration of endogenous antioxidants.

• The Korea Journal of Herbology
• /
• v.21 no.3
• /
• pp.69-74
• /
• 2006

Objectives : This study was undertaken to determine if a combined(SPe) has a protective effect against functional failure induced by $CCl_4$ in rat liver. Methods : Acute liver injury which initiated from free radical induced by $CCl_4$, were applied to rats and data were obtained. Liver injury was estimated by measuring aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activity in serum. Lipid peroxidation was examined by measuring malondialdehyde, a product of lipid peroxidation. GSH activities in liver tissues were also measured. Results : When rats were treated intraperitoneally with $CCl_4$, serum AST and ALT were increased compared with the control, which was significantly inhibited by pretreatment of SPe. SPe also prevented reduction in GSH induced by $CCl_4$. Conclusion : Above results suggest that SPe exerts protective effect against $CCl_4$ by its antioxidant action in liver tissues. Thus, SPe may be used in prevention and treatment of drug-induced liver cell injury. However, the precise mechanisms of SPe protection remain to be determined.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.12 no.1
• /
• pp.99-105
• /
• 2004

The car seat head restraint is used for neck injury(whiplash injury) prevention in rear end impacts. The purpose of this study was to evaluate the seat head restraints for the total number of 34 domestic cars. H-POINT machine and HRMD(head restraint measuring device) were applied to measure backset(the distance between head and seat head restraint) and height(height gap between head and seat head restraint). For tendency study of driver's head position, we took the 320 driver's pictures in the street. As results, There were only five percent drivers in good and acceptable zone. For car seat head restraint system, the results was 9 cars for good zone, 10 cars for acceptable zone, 9 cars for marginal zone and 6 cars for poor zone were evaluated. For a precise evaluation the of whiplash injury, detailed FE neck model will be developed and the clinical database should be constructed for model validation.

• Journal of Preventive Medicine and Public Health
• /
• v.45 no.1
• /
• pp.8-13
• /
• 2012

Objectives: Recently injury has become a major world-wide health problem. But studies in Korea about injuries were very few. Thus, this study was conducted to analyze the trend of major injuries from 1991 to 2006 and to provide basic data for preventing injuries. Methods: This study was based on the National Statistical Office data from 1991 to 2006 and calculated to estimate the burden of major injuries by using the standard expected years of life lost (SEYLL) and total lost earnings equation. Results: For transport accidents, mortality, SEYLL and total lost earnings were increased from 1991 to 1996 and decreased from 2000 to 2006. On the other hand, for suicides, these were increased gradually. Since 2003, falls were included in ten leading causes of death. This study showed that injury causes major social and economical losses. Conclusions: We could reduce injury related premature death through active interest in injury prevention program.

• Microbiology and Biotechnology Letters
• /
• v.50 no.1
• /
• pp.157-163
• /
• 2022

Alcoholic liver disease (ALD), which encompasses alcoholic steatosis, alcoholic hepatitis, and alcoholic cirrhosis, is a major cause of morbidity and mortality worldwide. Although the economic and health impacts of ALD are clear, few advances have been made in its prevention or treatment. We recently demonstrated that the insect-derived antimicrobial peptide CopA3 exerts anti-apoptotic and anti-inflammatory activities in various cell systems, including neuronal cells and colonic epithelial cells. Here, we tested whether CopA3 inhibits ethanol-induced liver injury in mice. Mice were intraperitoneally injected with ethanol only or ethanol plus CopA3 for 24 h and then liver injury and inflammatory responses were measured. Ethanol enhanced the production of proinflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interferon (IFN)-γ, and IL-10. It also induced hepatocyte apoptosis and ballooning degeneration in hepatocytes. Notably, all these effects were eliminated or significantly reduced by CopA3 treatment. Collectively, our findings demonstrate that CopA3 ameliorates ethanol-induced liver cell damage and inflammation, suggesting the therapeutic potential of CopA3 for treating ethanol-induced liver injury.

• The Journal of the Korea Contents Association
• /
• v.19 no.3
• /
• pp.114-125
• /
• 2019

The frequency of official injury of fire-fighting officers exposed to an extreme situation in disaster areas has been continuously increased. In spite of increase of injury, procedures of injury approval are complex, so the working environment of fire-fighting officers is very poor in terms of safety management. This study was, therefore, conducted to provide basic data for improvement of the injury management system for fire-fighting officers, by empirically analyzing the system for those in Busan city. The findings of the empirical analysis are as follows: first, the frequency of injury experienced by them is higher than that of other occupations; second, application for injury is not actively made; third, fire-fighting officers should bear the expense if injury is approved. On the basis of such an analysis on actual conditions, an analysis on policy factors for improving the injury management system shows; first, various high-risk matters should be considered in the review of application for injury, for improvement factors of the application for injury, while it is necessary to extend the benefit and support project for injured officers, for operation improvement factors of the injury management system, and the compensation act should be improved, for the improvement factors of the injury system. Second, it is urgent to develop damage prevention and coping education program for improving the injury management system. In addition, the simplification of administrative procedures of application for injury and the extension of benefit and support project for injured officers should be realized as soon as possible, moreover, the enhancement of directors' interest and support is also required.

• Journal of muscle and joint health
• /
• v.21 no.1
• /
• pp.11-18
• /
• 2014

Purpose: The purpose of this study was to understand care workers' fall-related knowledge and caring behaviors for fall prevention in nursing home. Methods: This study was a descriptive survey study. Data have been collected from 125 care workers in 5 nursing homes. Data were analyzed using frequency, t-test, one-way analysis of variance (ANOVA), and Pearson correlation coefficients. Results: 1) The average percentage of correct answers for care workers' fall-related knowledge was 72.2%. There were significant differences in fall-related knowledge by age, experiences of re-education about care for fall injuries, and experiences to transfer fall patients to another hospital. 2) The average level of care workers' caring behaviors for fall prevention was 3.81 points out of 4. There were significant differences by experiences of education about care for fall injuries in nursing home and concern of fall injury prevention. 3) There was a significant correlation between fall-related knowledge and caring behaviors for fall prevention (r=.320, p<.001). Conclusion: The level of fall-related knowledge is positively correlated to the level of caring behaviors for fall prevention. Therefore, nurses should prepare education programs to increase care workers' fall-related knowledge and caring behaviors for fall prevention.

• Journal of Korea Society of Industrial Information Systems
• /
• v.20 no.3
• /
• pp.71-79
• /
• 2015

In South Korea, few researches have been conducted into the incidence of injury diseases and into their demographic and sociologic characteristics. This research has estimated and analyzed the results of an questionnaire investigation carried out by the Korea medical panel (2008) and the social economic costs. In particular, an estimation has been conducted of social costs for each type of accident, injury and intoxication and of medical use for the injuries. For the future, it is necessary to develop concrete programs customized for age, education level, economic income and to continually implement injury prevention education, with a view to reducing the injury incidence and medical expenses; and also, individuals' participation in and social and national efforts are required for an efficient operation of the health insurance, for the purpose of reducing social and/or economic costs for injuries in South Korea.

• Journal of Korean Neurosurgical Society
• /
• v.60 no.6
• /
• pp.710-716
• /
• 2017

Objective : Among pediatric injury, brain injury is a leading cause of death and disability. To improve outcomes, many developed countries built neurotrauma databank (NTDB) system but there was not established nationwide coverage NTDB until 2009 and there have been few studies on pediatric traumatic head injury (THI) patients in Korea. Therefore, we analyzed epidemiology and outcome from the big data of pediatric THI. Methods : We collected data on pediatric patients from 23 university hospitals including 9 regional trauma centers from 2010 to 2014 and analyzed their clinical factors (sex, age, initial Glasgow coma scale, cause and mechanism of head injury, presence of surgery). Results : Among all the 2617 THI patients, total number of pediatric patients was 256. The average age of the subjects was 9.07 (standard deviation${\pm}6.3$) years old. The male-to female ratio was 1.87 to 1 and male dominance increases with age. The most common cause for trauma were falls and traffic accidents. Age (p=0.007), surgery (p<0.001), mechanism of trauma (p=0.016), subdural hemorrhage (SDH) (p<0.001), diffuse axonal injury (DAI) (p<0.001) were statistically significant associated with severe brain injury. Conclusion : Falls were the most common cause of trauma, and age, surgery, mechanism of trauma, SDH, DAI increased with injury severity. There is a critical need for effective fall and traffic accidents prevention strategies for children, and we should give attention to these predicting factors for more effective care.

• The Journal of Korean Medicine
• /
• v.36 no.3
• /
• pp.111-125
• /
• 2015

Objectives: The purpose of this study was to analyze the current cases of oriental medical injury relief data from Korea Consumer Agency (KCA), and to report the current change of oriental medical disputes pattern. Methods: Oriental medical injury relief cases processed by KCA from January 2010 to February 2015 were collected and analyzed. Results: 149 Oriental medical injury relief cases from KCA were analyzed for the study. The highest number that had been relieved was 43 in 2014. In monthly status, 18 case in September was The highest. According to the record, the bigger city had the bigger amount of relief cases which was 53(Seoul), 43(Gyeng-gi), 11(Busan) and so on. In age categories, 30s had the highest number of injury relief cases. The injury relief cases of package program had been rapidly increasing since 2013. Cancellation was the dominant claims cause of package program and consumer required the refund of prepayment. Breast augmentation was the majority treatment type of injury relief cases of package program. Average prepayment of package program was \3,166,085. Conclusions: This study finded that the major cause of oriental medical dispute was changed from side effect of clinical treatment to patient's satisfaction of medical service.