• Title/Summary/Keyword: IL-6 and IL-10

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A Case of Pulmonary Paragonimiasis with Recurrent Pleural Effusion and Cured by Four Cycles of Chemotherapy (세 차례 재발하여 4회 약물 요법으로 치료한 폐흡충증 1예)

  • Cho, Gye Jung;Lim, Jung Hwan;Chae, Dong Ryeol;Chi, Su Young;Ban, Hee Jung;Yoon, Byeong Kab;Kwon, Yong Soo;Oh, In Jae;Kim, Kyu Sik;Kim, Yu Il;Lim, Sung Chul;Kim, Young Chul
    • Tuberculosis and Respiratory Diseases
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    • v.66 no.6
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    • pp.451-456
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    • 2009
  • Paragonimiasis is a parasitic infection that occurs following the ingestion of infectious Paragonimus metacercariae, which occurs as a result of eating raw or undercooked freshwater crabs or crayfish. Pulmonary paragonimiasis is the most common clinical manifestation of this infection. Human paragonimiasis occurs sporadically. We experienced a case of pulmonary paragonimiasis in a 35-year-old woman with left lower chest pain. The patient had hypereosinophilia and a pleural effusion. The diagnosis was confirmed by positive ELISA (Enzyme-linked immunosorbent assay) that detected Paragonimiasis westermani antibody in the serum. We treated the patient with praziquantel for two days at a daily dosage of 75 mg/kg. Left pleuritic pain and pleural effusion improved after treatment. However, similar symptoms and pleural effusion developed recurrently for the first 3 courses of treatment with praziquantel. Upon the fourth round of treatment, the patient made a full recovery.

Lipoprotein and Lipid Abnormalities in Uremic Children with Maintenance Dialysis (투석 치료중인 만성 신부전 소아에서의 지질 및 지질단백 이상)

  • Kim Jung-Sue;Song Jung-Han;Park Hye-Won;Cheong Hae-Il;Kim Jin-Q;Choi Yong;Ko Kwang-Wook
    • Childhood Kidney Diseases
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    • v.1 no.2
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    • pp.109-116
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    • 1997
  • Purpose : Chronic renal failure is often accompanied by severe dyslipidemia, a known risk factor for cardiovascular disease. Lipoprotein(a) [Lp(a)] has recently been characterized as a risk factor for atherosclerosis and thrombosis. Cardiovascular disease is the leading cause of death in adult patients on dialysis. However, there are only limited data available concerning risk factors for atherosclerosis in uremic children. We have measured serum levels of lipids, lipoproteins, apolipoproteins and Lp(a) in uremic children with maintenance dialysis. Methods : Ten uremic children with hemodialysis (HD) and 14 with peritoneal dialysis (PD) in our dialysis unit were included in this study. The mean age of HD patients was $162{\pm}59$ months and the male to female ratio was 7:3. The mean age and sex ratio of PD patients were $123{\pm}63$ months and 6:8, respectively. The levels of cholesterol, triglyceride, lipoproteins, apolipoproteins and Lp(a) were measured from serum sampled after 14 hours of fasting. The normal control levels were cited from 2 articles presenting the normal blood lipid and lipoprotein levels of primary school and middle school children in Korea. Results : There was no difference in age, sex ratio, body mass index and duration of dialysis between the HD and the PD group. The serum concentration of the cholesterol, triglyceride and apolipoprotein B were significantly elevated in dialysis patients compared with normal subjects. The serum level of Lp(a) was significantly elevated in only PD group. The serum Lp(a) level was below 30 mg/dl in 13 and above 30 mg/dl in 11 patients. The serum albumin level was significantly decreased in high Lp(a) group than in low Lp(a) group. Conclusion : The uremic children receiving dialysis reveal abnormal serum lipid and lipoprotein profiles. These results suggest that they have a higher risk for coronary heart disease, although there has been no clinical evidence of coronary heart disease at present. A long-term follow-up study of these children to clarify the suggestion should be started now.

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The structural analysis and design methods considering joint bursting in the segment lining (조인트 버스팅을 고려한 세그먼트 라이닝 구조해석 및 설계방법)

  • Kim, Hong-Moon;Kim, Hyun-Su;Jung, Hyuk-Il
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.20 no.6
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    • pp.1125-1146
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    • 2018
  • Segment lining applied to the TBM tunnel is mainly made of concrete, and it requires sufficient structural capacity to resist loads received during the construction and also after the completion. When segment lining is design to the Limit State Design, both Ultimate Limit State (ULS) and Service Limit State (SLS) should be met for the possible load cases that covers both permanent and temporary load cases - such as load applied by TBM. When design segment lining, it is important to check structural capacity at the joints as both temporary and permanent loads are always transferred through the segment joints, and sometimes the load applied to the joint is high enough to damage the segment - so called bursting failure. According to the various design guides from UK (PAS 8810, 2016), compression stress at the joint surface can generate bursting failure of the segment. This is normally from the TBM's jacking force applied at the circumferential joint, and the lining's hoop thrust generated from the permanent loads applied at the radial joint. Therefore, precast concrete segment lining's joints shall be designed to have sufficient structural capacity to resist bursting stresses generated by the TBM's jacking force and by the hoop thrust. In this study, bursting stress at the segment joints are calculated, and the joint's structural capacity was assessed using Leonhardt (1964) and FEM analysis for three different design cases. For those three analysis cases, hoop thrust at the radial joint was calculated with the application of the most widely used limit state design codes Eurocode and AASHTO LRFD (2017). For the circumferential joints bursting design, an assumed TBM jack force was used with considering of the construction tolerance of the segments and the eccentricity of the jack's position. The analysis results show reinforcement is needed as joint bursting stresses exceeds the allowable tensile strength of concrete. This highlights that joint bursting check shall be considered as a mandatory design item in the limit state design of the segment lining.

Comparison of Nutritional and Functional Constituents, and Physicochemical Characteristics of Mulberrys from Seven Different Morus alba L. Cultivars (뽕나무(Morus alba L.) 품종별 오디의 영양 및 기능성 성분과 이화학적 품질 특성 비교)

  • Kim, Eun-Ok;Lee, Yu-Jin;Leem, Hyun-Hee;Seo, Il-Ho;Yu, Myeong-Hwa;Kang, Dae-Hun;Choi, Sang-Won
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.39 no.10
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    • pp.1467-1475
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    • 2010
  • Nutritional and functional components, and physicochemical characteristics of mulberry fruits from Morus alba L. cultivars, including Daejappong, Iksuppong, Daesungppong, Yongppong, Cheongilppong, Gwasang 1 and Gwasang 2, were investigated and compared. Among the 7 mulberry cultivars examined, Iksuppong, Cheongilppong and Gwasang 2 had higher contents of nitrogen free extract, total sugar and total reducing sugar, than other mulberry cultivars, while contents of protein, fat, and fiber were lowest. Gwasang 1 and Daesungppong had the highest content of total phenolic, total flavonoid, and total anthocyanin. Daesungppong, Gwasang 1 and Gwasang 2 had higher contents of C3G and C3R than other mulberry cultivars, although C3R content of Cheongilppong was the highest. Four flavonoid contents varied among of 7 mulberry cultivars. Contents of two major flavonoids, rutin and quercetin, were the highest in Gwasang 2, while Iksuppong and Cheongilppong were the lowest. Contents of piceid and 4-prenylmoracin were the highest in Daesungppong and Cheongilppong, respectively. Cheongilppong of mulberrys had the highest content of GABA. Iksuppong and Gwasang 2 with moderate weight and dark color had higher contents of total soluble solid than other mulberry cultivars, while contents of titratable acidity were lower. Our results provide useful information on nutritional and functional constituents of mulberry fruits according to cultivars, and their physicochemical and processing properties.

Analysis of Amygdalin of Content Prunus mume by Variety, Harvest Time, and Fermentation Conditions (품종과 수확시기 및 발효조건에 따른 매실의 아미그달린 함량에 관한 연구)

  • Son, Seok Jun;Jeong, Young Jae;Kim, Sun Young;Choi, Ji Hae;Kim, Na Young;Lee, Hyun-Sun;Bae, Jung Min;Kim, Seon-Il;Lee, Hye-Suk;Shin, Jong Sup;Han, Jin Soo
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.46 no.6
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    • pp.721-729
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    • 2017
  • This study aimed to improve customer perception of Prunus mume through analysis of amygdalin contents according to changes in variety, harvest time, and fermentation conditions. Five Prunus mume domestic cultivars were harvested at five harvest times. We compared cyanogenic glucosides in four types of fruits on the market. For amygdalin contents in seeds and flesh of Prunus mume by variety and harvest time, seeds contained higher amygdalin contents than flesh with time. As Prunus mume ripened, both amygdalin contents in seed and flesh increased. However, the rate of increase gradually decreased. For prunasin contents in Prunus mume, we determined that the dramatic increase in amygdalin from May 3 to 19 was due to amygdalin synthesis from prunasin. Moreover, in the case of fermented Prunus mume, we observed lower amygdalin content as the sugar ratio and fermentation time increased until around 90 days, followed by a decrease. Furthermore, we analyzed alteration of organic acids in Prunus mume and fermented solution based on analysis of amygdalin content in four other market fruits. Amygdalin was detected at $252.37{\pm}2.3$, $22.01{\pm}0.31$, and $8.75{\pm}0.14mg$ per 100 g in plums, peaches, and grape seeds, respectively. In flesh of plums and peaches, amygdalin contents were detected at $84.14{\pm}0.26$ and $7.54{\pm}0.06mg$ per 100 g, respectively. These results suggest scientific improvements for consumption and breeding lines.

Evaluation of Basic Oxygen Furnace Slag as Soil Conditioner in the Rice Paddy Field (논토양 벼재배에서 제강슬래그의 토양개량제로서의 시용 효과)

  • Lim, June-Taeg;Lee, Yeen;Park, In-Jin;Lee, Choong-Il;Hyun, Kyu-Hawn;Kwon, Byung-Sun;Kim, Hak-Jin
    • Korean Journal of Soil Science and Fertilizer
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    • v.32 no.3
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    • pp.295-303
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    • 1999
  • An experiment was conducted to evaluate the possibility of using basic oxygen furnace (BOF) slag as a soil conditioner in rice paddy field. In 1997, rice (Oryza sativa B. cv. Dongjinbyeo) crop was cultivated under different application rates of BOF slag at three different places, Inandong Sunchon city, Youjunglee Bosung province, and Nampyung Najoo city. In each paddy field, five treatments, four application rate of BOF slag (0, 4, 8, $12Mg\;ha^{-1}$) and one application rate of lime ($2Mg\;ha^{-1}$) were tried with three replications. Plant height, number of tillers per hill, leaf area per hill, leaf dry weight, calm dry weight or shoot dry weight per hill were measured five times at the interval of seven days. Chemical contents of rice plants and soil were also measured at the same sampling date Yield were estimated by harvesting $6.6m^2$ per experimental unit and yield components were measured by sampling 10 plants per experimental unit at the harvest date. Application of BOF slag hardly affected contents of soil organic matter, available phosphate and potassium in soil. Soil pH and contents of Ca, Mg, Fe and $SiO_2$ enhanced as BOF slag rate increased. Enhancement of soil pH by ROF slag treatment appeared to be closely related with increase in soil Ca content. Application tate of $2Mg\;ha^{-1}$ of lime showed almost the same effect, in increase of soil Ca content as application rate of $4{\sim}8Mg\;ha^{-1}$ of BOF slag, Fe content in soil decreased sharply as time passed after slag treatment and stabilized more or less at the later sampling date. Contents of inorganic matter in plant such as total nitrogen, phosphate, potassium and Mg were not affected by BOF slag treatment. However, contents of Ca, Fe, and $SiO_2$ in plants increased as slag rate became higher. The growth of rice plants with BOF slag treatment was more or less slower but continued persistently up to the later growth stage, so that growth of plants with BOF slag treatment was almost the same nr even greater than that of control or lime treatment. However, BOF slag rate of $12Mg\;ha^{-1}$ seemed to be too high because all the measurements of plant, growth at this rate showed lower values than those of other treatments at all the sampling dates. Treatments of BOF slag $4Mg\;ha^{-1}$ or $8Mg\;ha^{-1}$ showed higher rough rice yield than other treatments, so that the optimum BOF slag ratein rice paddy field seemed to be in the rage of $4{\sim}8Mg\;ha^{-1}$.

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Identification of Differentially Expressed Genes Between Somatic Cell Nuclear Transfer and Normal Placenta in Cattle (소의 체세포핵이식태반과 정상태반간의 차등 발현 유전자 분석)

  • Yu, Seong-Lan;Jeong, Hang-Jin;Sang, Byung-Chan;Ryoo, Seung-Heui;Jung, Kie-Chul;Yoon, Jong-Taek;Seong, Hwan-Hoo;Jin, Dong-Il;Lee, Jun-Heon
    • Journal of Animal Science and Technology
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    • v.50 no.5
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    • pp.641-648
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    • 2008
  • There has been great success for making transgenic animals using somatic cell nuclear transfer(SCNT) up to this time. However, the success rates of the production of live transgenic animals are still very low. The current research has been carried out for delineation of differentially expressed genes between SCNT and normal placenta in cattle. In the present observations, high expression has been observed for CTSZ, LOC509426 and ELF1 genes in normal placenta. On the other hand, TIMP2, PAG1B, PAG-21, LOC782894, SERPINB6 and mKIAA2025 protein were highly expressed in SCNT placenta. Five genes, which were highly expressed in SCNT placenta, have been further investigated using semi-quantitative real-time PCR. The results were similar to that we observed using ACP. In the future, all genes affecting the SCNT and normal placenta have to be discovered and their networks will be fully investigated. The genes were identified in this study would be great help for identifying differential gene expressions in SCNT placenta.

Toxicity Assessment of Silver Ions Compared to Silver Nanoparticles in Aqueous Solutions and Soils Using Microtox Bioassay (Microtox 생물검정법을 이용한 은 이온과 은 나노입자의 수용액과 토양에서의 독성 비교 평가)

  • Wie, Min-A;Oh, Se-Jin;Kim, Sung-Chul;Kim, Rog-Young;Lee, Sang-Phil;Kim, Won-Il;Yang, Jae E.
    • Korean Journal of Soil Science and Fertilizer
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    • v.45 no.6
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    • pp.1114-1119
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    • 2012
  • This study was conducted to assess the microbial toxicity of ionic silver solution ($Ag^+N$) and silver nanoparticle suspension ($Ag^0NP$) based on the Microtox bioassay. In this test, the light inhibition of luminescent bacteria was measured after 15 and 30 min exposure to aqueous solutions and soils spiked with a dilution series of $Ag^+N$ and $Ag^0NP$. The resulting dose-response curves were used to derive effective concentration (EC25, $EC_{50}$, EC75) and effective dose ($ED_{25}$, $ED_{50}$, $ED_{75}$) that caused a 25, 50 and 75% inhibition of luminescence. In aqueous solutions, $EC_{50}$ value of $Ag^+N$ after 15 min exposure was determined to be < $2mg\;L^{-1}$ and remarkably lower than $EC_{50}$ value of $Ag^0NP$ with $251mg\;L^{-1}$. This revealed that $Ag^+N$ was more toxic to luminescent bacteria than $Ag^0NP$. In soil extracts, however, $ED_{50}$ value of $Ag^+N$ with 196 mg kg-1 was higher than $ED_{50}$ value of $Ag^0NP$ with $104mg\;kg^{-1}$, indicating less toxicity of $Ag^+N$ in soils. The reduced toxicity of $Ag^+N$ in soils can be attributed to a partial adsorption of ionic $Ag^+$ on soil colloids and humic acid as well as a partial formation of insoluble AgCl with NaCl of Microtox diluent. This resulted in lower concentration of active Ag in soil extracts obtained after 1 hour shaking with $Ag^+N$ than that spiked with $Ag^0NP$. With longer exposure time, EC and ED values of both $Ag^+N$ and $Ag^0NP$ decreased, so their toxicity increased. The toxic characteristics of silver nanomaterials were different depending on existing form of Ag ($Ag^+$, $Ag^0$), reaction medium (aqueous solution, soil), and exposure time.

Control of Microorganisms in School Refectories and Kitchens Using Ozone Water and Ozone Gas (오존수 및 오존가스를 이용한 학교급식에서의 미생물 제어)

  • Choi, Jin-Kyung;Shin, Il-Shik;Kim, Dae Uk;Kim, Hee-Yun
    • Korean Journal of Food Science and Technology
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    • v.47 no.5
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    • pp.586-592
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    • 2015
  • This study was performed to determine optimum approaches for control of microorganisms in school refectories and kitchens. A reduction of more than 5.0 log CFU/mL was noted for Escherichia coli O157:H7, Salmonella Typhimurium, Listeria monocytogenes, Staphylococcus aureus, and Streptococcus mutans after treatment with 5 ppm ozone water for 60 s. Treatment of different vegetables with ozone water for 5 min showed bactericidal effects with 2-4 log reduction of viable cell number; the bactericidal effects differed according to the kinds of vegetables. The viable cell number on kitchen apparatus and tableware was not detected by ozone water treatment for 60 s. In addition, the count of the bacteria floating in the air in refectories and kitchens decreased 2.0 log CFU/1,000 L air to 0-1 CFU/1,000 L air on treatment with 45 ppm ozone gas for 12 hr. Therefore, ozone water and ozone gas may be good candidates as antimicrobial agents that can be used to improve sanitary conditions in school refectories and kitchens.

Modeling and Validation of Population Dynamics of the American Serpentine Leafminer (Liriomyza trifolii) Using Leaf Surface Temperatures of Greenhouses Cherry Tomatoes (방울토마토에서 잎 표면온도를 적용한 아메리카잎굴파리(Liriomyza trifolii) 개체군 밀도변동 모형작성 및 평가)

  • Park, Jung-Joon;Mo, Hyoung-Ho;Lee, Doo-Hyung;Shin, Key-Il;Cho, Ki-Jong
    • Korean journal of applied entomology
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    • v.51 no.3
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    • pp.235-243
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    • 2012
  • Population dynamics of the American serpentine leafminer, Liriomyza trifolii (Burgess), were observed and modeled in order to compare the effects of air and tomato leaf temperatures inside a greenhouse using DYMEX model builder and simulator (pre-programed module based simulation programs developed by CSIRO, Australia). The DYMEX model simulator consisted of a series of modules with the parameters of temperature dependent development and oviposition models of L. trifolii were incorporated from pre-published data. Leaf surface temperatures of cherry tomato leaves (cv. 'Koko') were monitored according to three tomato plant positions (top, > 1.8 m above the ground level; middle, 0.9 - 1.2 m; bottom, 0.3 - 0.5 m) using an infrared temperature gun. Air temperature was monitored at the same three positions using a self-contained temperature logger. Data sets for the observed air temperature and average leaf surface temperatures were collected (top and bottom surfaces), and incorporated into the DYMEX simulator in order to compare the effects of air and leaf surface temperature on the population dynamics of L. trifolii. The initial population consisted of 50 eggs, which were laid by five female L. trifolii in early June. The number of L. trifolii larvae was counted by visual inspection of the tomato plants in order to verify the performance of DYMEX simulation. The egg, pupa, and adult stage of L. trifolii could not be counted due to its infeasible of visual inspection. A significant positive correlation between the observed and the predicted numbers of larvae was found when the leaf surface temperatures were incorporated into the DYMEX simulation (r = 0.97, p < 0.01), but no significant positive correlation was observed with air temperatures(r = 0.40, p = 0.18). This study demonstrated that the population dynamics of L. trifolii was affected greatly by the leaf temperatures, though to little discernible degree by the air temperatures, and thus the leaf surface temperature should be for a consideration in the management of L. trifolii within cherry tomato greenhouses.