• Molecules and Cells
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• v.28 no.1
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• pp.1-5
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• 2009

Vascular endothelial growth factor (VEGF) is essential for many angiogenic processes both in normal and pathological conditions. However, the signaling pathways involved in VEGF-induced angiogenesis are incompletely understood. The protein kinase D1 (PKD1), a newly described calcium/calmodulin-dependent serine/threonine kinase, has been implicated in cell migration, proliferation and membrane trafficking. Increasing evidence suggests critical roles for PKD1-mediated signaling pathways in endothelial cells, particularly in the regulation of VEGF-induced angiogenesis. Recent studies show that class IIa histone deacetylases (HDACs) are PKD1 substrates and VEGF signal-responsive repressors of myocyte enhancer factor-2 (MEF2) transcriptional activation in endothelial cells. This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis.

• 한국신재생에너지학회:학술대회논문집
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• 2011.11a
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• pp.35.2-35.2
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• 2011

A wind turbine power performance test is very important to wind turbine manufacturers because a wind farm developer or planner must want to define power performance characteristics and reliability of new wind turbines. Based on the IEC 61400-12-1, A wind turbine test site has to be nicely installed at flat terrain for testing. We are developing the wind power system which is IEC wind class IIa model with rated power of 3MW. KEPCO's Gochang power testing center was considered as candidates to build the test site without site calibration. This paper aims to verify the validity of the test site by using implement site assessment result that was based on IEC 61400-12-1.

• Proceedings of the Microbiological Society of Korea Conference
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• 2008.05a
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• pp.33-34
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• 2008

• Applied Biological Chemistry
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• v.39 no.4
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• pp.265-267
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• 1996

The methanol extracts of AraIia elata showed antimicrobial activity against bacteria. The antimicrobial active principle was successively purified with solvent fractionation, silica gel adsorption column chromatography, Sephadex LH-20 column chromatography, silica gel partition column chromatography and HPLC. The active substance was isolated by HPLC on $C_{18}$ column with an acetic acid-MeOH system. The active substance was identified as trans-4-hydroxycinnamic acid by MS, $^1H-NMR\;and\;^{13}C-NMR$.

• Environmental and Resource Economics Review
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• v.16 no.3
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• pp.427-449
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• 2007

This study estimates the recreation benefits of rafting on the Hantan River. A choice experiment is conducted and the economic values of controlling water stream and water quality are estimated. Both the conditional logit and the multinomial pro bit models are estimated. This study rejects the IIA assumption of the conditional log it model and supports using a more flexible model such as the multinomial probit model.

• YAKHAK HOEJI
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• v.40 no.3
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• pp.273-278
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• 1996

The 2,3-dichloro-1,4-naphthoquinone was reacted with diethyl methylmalonate and sodium amide in the toluene to yield 3-chloro-2-(1-methyl-1-diethoxycarbonyl)-methyl-1,4-naphthoq uinone(I). When this compound I was reacted with some alkylamines (methylamine, ethylamine, ethanolamine, 2-bromoethylamine, propylamine, isopropylamine, cyclohexylamine, benzylamine, 4-piperidylmethylamine), 3-methyl-2,3-dihydrobenz(f)indole-2,4,9-trione derivatives(IIa-i) were obtained via intramolecular cyclization.

• Bulletin of the Korean Chemical Society
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• v.32 no.3
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• pp.821-828
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• 2011

Design and synthesis of new 3,4-diarylpyrazole-1-carboxamide derivatives are described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the synthesized compounds showed moderate activity against A375, compared with Sorafenib. On the other hand, compounds Ia, Ie, IIb, and IIh were more potent than Sorafenib. In addition, compound IIa was equipotent to Sorafenib. Among all of these derivatives, compound IIb which has diethylamino and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line. Virtual screening was carried out through docking of the most potent compound IIb into the domain of V600E-b-Raf and the binding mode was studied.

• Archives of Pharmacal Research
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• v.28 no.8
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• pp.909-913
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• 2005

We screened natural products to find compounds with anti-osteoporotic potential using a coculture-based system by which osteoclast differentiation is effectively achieved. We found that methylene chloride soluble fraction of the root of Salvia miltiorrhiza Bunge (Labiatae) suppressed osteoclast differentiation. Five tanshinones, tanshinone IIA (1), tanshinone I (2), cryptotanshinone (3), 15,16-dihydrotanshinone I (4), and ferruginol (5) were subsequently isolated from fraction. Among the five compounds, compounds 1-4 reduced the formation of TRAP­positive multinuclear osteoclasts. These results suggest that the identified tanshinones may be useful candidates for development of therapeutic agents to treat osteoporosis and other bone-resorptive diseases.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.87-88
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• 2015

We present results of our R-band polarimetry of a bright-rimmed cloud, IC1396A (with BRC 36), associated with the H II region S131 and the cometary globule LDN 1616 to study their magnetic field geometry. The distances of these clouds have been reported to be ~ 750 pc and ~ 450 pc, respectively in the literature. The young open cluster Trumpler 37 in the vicinity of IC1396A and the high mass stars in the Orion belt near L1616 are found to be responsible for the structure of these clouds. We made polarimetry of foreground stars inferred from their distances measured by the Hipparcos satellite to subtract the foreground contribution to the observed polarization results. We discuss the optical polarimetric results and compare our findings with MHD simulations towards BRCs and CGs.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.137-141
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• 2004

Many monopropellant thrusters use a catalyst for decompose the propellant, hydrazine. The catalyst directly affects the thruster performances and lifetime. Therefore, it is important to confirm that the catalyst is suitable for our thrusters. Until 2002, we used She1l405 catalyst, for satellite RCS thrusters, and H-IIA and M-V launch vehicle upper-stage RCS thrusters. In 2002, however, Shell Chemical Inc. ceased manufacturing She1l405 catalyst and transferred the product to AEROJET, where it was renamed S405. We subsequently investigated the characteristics of AEROJET's S405 catalyst and SOLVAY's KC12GA catalyst, (SOLVAY is a Belgian chemical company, and KC12GA is used for ASTRIUM's thruster) and conducted thruster firing tests using the new catalysts. After conducting, we confirm that the KC12GA catalyst was suitable for our thrusters, and decided to use KC12GA for two satellite programs.