YAKHAK HOEJI (약학회지)
- Volume 40 Issue 3
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- Pages.273-278
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of 3-Methyl-2,3-dihydrobenz(f)indole-2,4,9-trione Derivatives
3-메칠-2,3-디히드로 벤즈(f)인돌-2,4,9-트리온 유도체의 합성
- Suh, Myung-Eun (College of Pharmacy, Ewha Womans University) ;
- Jeoung, Hyun-Jung (College of Pharmacy, Ewha Womans University)
- Published : 1996.06.01
Abstract
The 2,3-dichloro-1,4-naphthoquinone was reacted with diethyl methylmalonate and sodium amide in the toluene to yield 3-chloro-2-(1-methyl-1-diethoxycarbonyl)-methyl-1,4-naphthoq uinone(I). When this compound I was reacted with some alkylamines (methylamine, ethylamine, ethanolamine, 2-bromoethylamine, propylamine, isopropylamine, cyclohexylamine, benzylamine, 4-piperidylmethylamine), 3-methyl-2,3-dihydrobenz(f)indole-2,4,9-trione derivatives(IIa-i) were obtained via intramolecular cyclization.
Keywords
- Diethyl methylmalonate;
- 2-chlore-2-(1-methyl-1-diethoxycarbonyl)-methyl-1,4-na-phthoquinone;
- 1,3-dimethyl-2,3-dihydro-benz(f)indole-2,4,9-trione;
- 1-N-ethyl-3-methyl-2,3-dihydrobenz(f)indole-2,4,9-trione.