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Inhibition of Osteoclast Differentiation by Tanshinones from the Root of Salvia miltiorrhiza Bunge  

Lee Song-Yi (College of Pharmacy, Chosun University)
Choi Doo-Youn (College of Pharmacy, Chosun University)
Woo Eun-Rhan (College of Pharmacy, Chosun University)
Publication Information
Archives of Pharmacal Research / v.28, no.8, 2005 , pp. 909-913 More about this Journal
Abstract
We screened natural products to find compounds with anti-osteoporotic potential using a coculture-based system by which osteoclast differentiation is effectively achieved. We found that methylene chloride soluble fraction of the root of Salvia miltiorrhiza Bunge (Labiatae) suppressed osteoclast differentiation. Five tanshinones, tanshinone IIA (1), tanshinone I (2), cryptotanshinone (3), 15,16-dihydrotanshinone I (4), and ferruginol (5) were subsequently isolated from fraction. Among the five compounds, compounds 1-4 reduced the formation of TRAP­positive multinuclear osteoclasts. These results suggest that the identified tanshinones may be useful candidates for development of therapeutic agents to treat osteoporosis and other bone-resorptive diseases.
Keywords
Salvia miltiorrhiza; Labiatae; Tanshinones; Osteoclast differentiation;
Citations & Related Records

Times Cited By Web Of Science : 19  (Related Records In Web of Science)
Times Cited By SCOPUS : 20
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