[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2011.32.3.821

Design and Synthesis of 3-(3-Chloro-4-substituted phenyl)-4-(pyridin-4-yl)-1Hpyrazole- 1-carboxamide Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line

El-Gamal, Mohammed I. (Department of Biomolecular Science, University of Science and Technology)
Oh, Chang-Hyun (Biomaterials Center, Korea Institute of Science and Technology)

Publication Information

Bulletin of the Korean Chemical Society / v.32, no.3, 2011 , pp. 821-828 More about this Journal

Abstract

Design and synthesis of new 3,4-diarylpyrazole-1-carboxamide derivatives are described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the synthesized compounds showed moderate activity against A375, compared with Sorafenib. On the other hand, compounds Ia, Ie, IIb, and IIh were more potent than Sorafenib. In addition, compound IIa was equipotent to Sorafenib. Among all of these derivatives, compound IIb which has diethylamino and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line. Virtual screening was carried out through docking of the most potent compound IIb into the domain of V600E-b-Raf and the binding mode was studied.

Keywords

Antiproliferative activity; 1H-Pyrazole-1-carboxamide; 3,4-Diarylpyrazole; A375; Melanoma;

Citations & Related Records

Times Cited By Web Of Science : 1 (Related Records In Web of Science)
Times Cited By SCOPUS : 1

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