• Archives of Pharmacal Research
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• 제22권4호
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• pp.335-339
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• 1999

The oxidation-reduction potentials of cosmetic raw materials, showing tyrosinase inhibitory action, and phenolic compounds structurally similar to L-tyrosine were determined by cylcic voltammetry. The voltammograms obtained could be classified ito 4 patterns (patterns 1-4). Patterns 1, characterized by oxidation and reduction peaks as a pair, was observed with catechol, hydroquinone or phenol, and pattern 2 exhibiting another oxidation peak in addition to oxidation and reduction peaks as a pair was found with arbutin, kojic acid, resorcinol, methyl p-hydroxybenzoate and L-tyrosine as the substrate of tyrosinase. Pattern 3 with an independent oxidation peak only was expressed by L-ascorbic acid, and pattern 4 with a reduction peak only at high potentials, by hinokitiol. The tyrosinase inhibitory activity of these compounds was also evaluated using the 50% inhibitory concentration ($IC_{50}$) and the inhibition constant (Ki) as parameters. Hinokitiol, classified as patterns 4, showed the highest inhibitory activity (lowest $IC_{50}$ and Ki). Hydroquinone showing the second highest activity belonged to pattern 1, which also included compounds exhibiting pattern 2 was relatively low with Ki values being in the order of 10-4 M. Although there was no consistent relationship between oxidation-reduction potentials and tyrosinase inhibitory action, the voltammetry data can be used as an additional index to establish the relationship between the structure and the tyrosine inhibitory activity.

• 한국마이크로전자및패키징학회:학술대회논문집
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• 한국마이크로전자및패키징학회 2003년도 기술심포지움 논문집
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• pp.239-242
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• 2003

Optical module package is a hermetic metal-ceramic package for carrying optical IC. In case of LD(laser diode) module, window is used for both the path of optical signal and hermetic sealing of package. So, window has the metallization pattern on the surface for brazing process with package wall. In this study, several method were investigated for metallization. Thin film, thick film and mixed method were used for fabrication of metallization pattern. After brazing process, hermeticity and adhesion strength were tested for characterization of metallization pattern.

• 제어로봇시스템학회논문지
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• 제10권1호
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• pp.54-59
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• 2004

We suggest a 3D vision inspection algorithm which is based on the external shape feature. Because many electronic parts have the regular shape, if we have the database of pattern and can recognize the object using the database of the object s pattern, we can inspect many types of electronic parts. Our proposed algorithm uses the geometrical pattern matching method and 3D database on the electronic parts. We applied our suggested algorithm fer inspecting several objects including typical IC and capacitor. Through the experiments, we could find that our suggested algorithm is more effective and more robust to the inspection environment(rotation angle, light source, etc.) than conventional 2D inspection methods. We also compared our suggested algorithm with the feature space trajectory method.

• 대한화학회지
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• 제43권4호
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• pp.461-468
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• 1999

Acetolactate synthase (ALS)는 가지를 가진 필수아미노산 Val, Leu, Ile의 생합성 과정에서 공통적으로 작용하는 효소이다. ALS는 서로 구조적 유사성이 없는triazolopyrimidine, imidazolinone,sulfonylurea, 그리고 pyrimidyl-oxy-benzoate 제초제들의 공통적인 작용 표적이다. 보리로부터 부분 정제한 ALS를 이용하여 새로이 합성한 triazolopyrimidine sulfonamide 유도체들의 저해 활성을 측정하였다. 활성을 가진 유도체들의 $IC_{50}$ 값은 0.5nM∼8${\mu}M$ 범위였으며, 그 중에서 탁월한 저해 활성을 갖는 것은 TP1과TP2 유도체로 $IC_{50}$ 값은 각각 0.5 nM과 1.6 nM이였다. 이 저해제들은 기존의 상품화된 제초제인 Metosulam ($IC_{50}$;3.6 nM), Flumetsulam ($IC_{50}$;126 nM), 그리고 Cadre ($IC_{50};4 {\mu}M$)에 비해 보리 ALS에 대한 저해 활성이 보다 우수하였다. 보리 ALS에 대한 TP2의 저해 활성은 반응시간이 증가함에 따라 증가하였고, 혼합형 저해 유형을 보였다. TP2와 imidazolinone 계열의 제초제인 Cadre, 그리고 되먹임(feedback) 저해제인 Leu에 대한 이중저해 (dual inhibition) 실험 결과 TP2와 Cadre의 경우는 평행한 반응속도론적 형태가 그러나 TP2와 Leu의 경우는 한 점에서 만나는 반응속도론적 헝태가 얻어졌다. 이는 TP2와 Cadre의 결합 부위가 최소한 부분적으로 중복되고 있음을 시사한다. Cys 잔기에 대한 화학적 변형은 TP2와 Cadre의 결합에는 영향을 미치지 않으나, Leu의 결합에는 영향을 미쳤다.

• 대한전자공학회논문지SD
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• 제39권7호
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• pp.81-88
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• 2002

본 논문에서는 패턴 집단 생성 방식을 사용한 새로운 내장형 자체 테스트를 위한 테스트 패턴 생성기를 제안하였다. 제안된 기술은 클럭당 테스트 환경에서 작은 하드웨어 크기를 가지면서 미리 계산된 결정 테스트 집합을 가진다. 테스트를 제어하기 위한 회로는 간단하여 자동적으로 합성된다. 새로운 패턴 생성기를 기존의 방법들과 비교한 결과를 ISCAS 벤치마크 회로를 가지고 검증하였다.

• 제어로봇시스템학회논문지
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• 제16권9호
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• pp.913-917
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• 2010

To inspect the defects of printed markings on the surface of IC package, the OCV (Optical Character Verification) method based on NCC (Normalized Correlation Coefficient) pattern matching is widely used. In order to detect the micro pattern defects appearing on the small portion of the markings, a Partitioned NCC pattern matching method was proposed to overcome the limitation of the NCC pattern matching. In this method, the reference pattern is first partitioned into several blocks and the NCC values are computed and are combined in these small partitioned blocks, rather than just using the NCC value for the whole reference pattern. In this paper, we proposed a method to decide the proper number of partition blocks and a method to inspect and combine the NCC values of each partitioned block to identify the defective markings.

• Biomolecules & Therapeutics
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• 제11권2호
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• pp.133-138
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• 2003

The vascular relaxant and antihypertensive effects of newly developed salts of amlodipine-maleate and camsylate-were evaluated on isolated aorta from rats and in spontaneously hypertensive rats, and compared with those of amlodipine besylate, a standard drug. Amlodipine besylate concentration-dependently inhibited $Ca^{2＋}$-induced contraction in depolarised rat aorta($IC_{50}$/: 4.17 nM), with a very slow onset of action. Amlodipine maleate and amlodipine camsylate also showed vascular relaxant effect with a pattern and a potency similar to those of amlodipine besylate($IC_{50}$/: 3.62 and 3.28 nM, respectively). Amloclipine besylate produced a dose-dependent and long-lasting(>10∼24h) antihypertensive effect with a slow onset of action (ED$_{20}$: 2.31 mg/kg) in spontaneously hypertensive rats. Amlodipine maleate and amlodipine camsylate also exerted antihypertensive effects with a pattern and a potency similar to those of amlodipine besylate(ED$_{20}$: 2.09 and 2.21 mg/kg, respectively). These results suggest that amlodipine maleate and amlodipine camsylate are not statistically differ with amlodipine besylate in relaxant effect of $Ca^{2＋}$-induced contraction in depolarised rat aorta and in antihypertensive effect in spontaneously antihypertensive rats.

• Biomolecules & Therapeutics
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• 제12권1호
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• pp.19-24
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• 2004

The vascular relaxant effect of amlodipine adipate, a new salt of amlodipine, was evaluate in isolated rat aorta, and compared with that of amlodipine besylate. Furthermore, antihypertensive effects were measured in hypertensive rat models, such as spontaneously hypertensive rats (SHR) and rena1 hypertensive rats (RHR). Amlodipine adipate concentration-dependently inhibited $Ca^{2+}$-induced contraction of rat aorta with a very slow onset of action (reached its maximum at 3.5 h;$IC_{50}$: 3.76 nM), having a pattern and a potency similar to those of amlodipine besylate ($IC_{50}$: 4.01 nM). In SHR and RHR, orally administered amlodipine adipate produced a dosedependent and long-lasting (>10-24 h) antihypertensive effect ($ED_{20}$: 2.48 and 1.57 mg/kg, respectively), with a pattern and a potency similar to those of amlodipine besylate ($ED_{20}$: 2.50 and 1.99 mg/kg in SHR and RHR, respectively). These results suggest that amlodipine adipate is a potent and long-lasting antihypertensive agent and that its antihypertensive effect is not significantly different to that of amlodipine besylate.

• 한국ITS학회 논문지
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• 제19권1호
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• pp.58-70
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• 2020

고속도로 우회는 명절이나 연휴 등 교통수요가 집중되는 시점에 운전자들이 정체되는 고속도로 일부구간을 우회하여 국도 및 지방도를 이용하는 것을 의미한다. 기존에는 영업소 출구차량 우회 설문조사를 통해 우회행태를 분석하였으나 적은 설문조사 샘플로 인해 실 우회율 산정에는 어려움이 존재하였다. 이에 본 연구에서는 DSRC 기반 경로형 데이터를 활용해서 실 우회율 산정, 우회 시 통행시간 개선 효과, 그리고 고속도로 본선 소통상황과의 상관관계 등 '내-외내', '내-내' 우회행태에 대한 실증연구를 수행한다. 추석전날 및 당일 주요 우회도로인 기흥동탄IC→오산IC, 서평택IC→월곶JC에 대해 승용차, 버스 및 화물차를 포함한 3종 차량의 우회행태를 분석한 결과, 본선의 정체시간대에서 우회도로 이용률이 점차 증가하였다. 본선 정체가 극심한 경우에는 우회도로 이용 시 통행시간이 개선되었지만, 본선 정체가 극심하지 않는 시간대는 오히려 우회도로 이용 시 통행시간이 증가하였다. 또한 고속도로 본선 소통상황과 실 우회율의 상관관계는 음의 상관성을 가지며, 이는 본선의 정체 행태와 일치함을 확인할 수 있었다. 본 연구 결과는 기존의 설문조사에 기초했던 우회행태 연구의 한계를 극복할 수 있으며, 교통수요가 집중되는 고속도로 구간의 우회전략 수립 등에 활용되어질 수 있을 것으로 판단된다.

• 한국주조공학회지
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• 제16권2호
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• pp.109-115
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• 1996

Effect of various austempered structures on fracture characteristics of C/V graphite cast iron has studied. The tensile strength and hardness reached the maximum value of 971.4MPa and HB302 at the austempering temperature of $250^{\circ}C$, respectively. As the austempering temperature increased, the amount of retained austenite increased from 18% to 22, 29%, while $K_{IC}$ values ranged from the value of $65MPa{\cdot}m^{12} to 70MPa{\cdot}m^{1/2}, 66MPa{\cdot}m^{1/2}. This fact that $K_{IC}$ value was not sensitive to the increase of the amount of the retained austenite was that $K_{IC}$ was dependent on the matrix structure in lower bainitic matrix, while dependent on the notch effect from C/V graphite shape in upper bainitic matrix. Fractured surfaces showed a ductile fracture pattern at $300^{\circ}C$. Very large coalescence by C/V graphite and relatively small voids by spheroidal graphite were observed.