Antihypertensive Effect of Amlodipine Adipate, a Novel Salt of Amlodipine, in Hypertensive Rat Models |
Lee, Byung-Ho
(Medicinal Science Division, Korea Research Institute of Chemical Technology)
Seo, Ho-Won (Medicinal Science Division, Korea Research Institute of Chemical Technology) Chae, Myeong-Yun (R&D Center of Pharmaceuticals, CJ Corp.) Yeon, Kyu-Jeong (R&D Center of Pharmaceuticals, CJ Corp.) |
1 | Burges, R. A., Gardiner, D. G., Gwilt, M., Higgins, A. J., Blackburn, K. J., Campbell, S. F., Cross, P. E. and Stubbs, J. K. (1987). Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors J. Cardiavasc. Pharmacal. 9, 110-119 |
2 | Burges, R. and Moisey, D. (1994). Unique pharmacologic properties of amlodipine. Am. J. Cardial. 73, 2A-9A DOI ScienceOn |
3 | Cangiano, J. L., Rodriguez-Sargent, C. and Martinez-Maldonado, M. (1979). Effects of antihypertensive treatment on systolic blood pressure and renin in experimental hypertension in rats. J. Pharmacal. Exp. Ther. 208, 310-313 |
4 | Cauvin, C., Loutzenhiser, R. and Van Breemen C. (1983). Mechanisms of calcium antagonist-induced vasodilation. Annu. Rev. Pharmacal. Toxical. 23, 373-396 DOI ScienceOn |
5 | Dodd, M. G., Gardiner, D. G., Carter, A. J., Sutton, M. R. and Burges, R. A. (1989). The hemodynamic properties of amlodipine in anesthetised and conscious dogs: comparison with nitrendipine and influence of beta-adrenergic blockade. Cardiovasc. Drugs Ther. 3, 545-555 DOI |
6 | Mathur, S., Syme, H., Brown, C. A, Elliot, J., Moore, P. A, Newell, M. A, Munday, J. S., Cartier, L. M., Sheldon, S. E. and Brown, S. A (2002). Effects of the calcium channel antagonist amlodipine in cats with surgically induced hypertensive renal insufficiency. Am. J. Vet. Res. 63, 833-839 DOI ScienceOn |
7 | Meredith, P. A and Elliott, H. L. (1992). Clinical pharmacokinetics of amlodipine. Clin. Phannacokinet. 22,22-31 DOI ScienceOn |
8 | Stopher, D. A., Beresford, A. P., Macrae, P. V. and Humphrey, M. J. (1988). The metabolism and pharmacokinetics of amlodipine in humans and animals. J. Cardiovasc. Pharmacol. 12, S55-S59 DOI |
9 | Phillips, R. A., Kloner, R. A., Grimm, R. H. Jr. and Weinberger, M. (2003). The effects of amlodipine compared to losartan in patients with mild to moderately severe hypertension. J. Clin. Hypertens. (Greenwich) 5, 17-23 |
10 | Shin, H. S., Seo, H. W., Yoo, S. E. and Lee, B. H. (1998). Cardiovascular pharmacology of SKP-450, a new potassium channel activator, and its major metabolites SKP-818 and SKP-310. Phannacology 56, 111-124 |
11 | Abernethy, D. R. (1989). The pharmacokinetic profile of amlodipine. Am. Heart J. 118, 1100-1103 DOI ScienceOn |
12 | Lee, B. H., Seo, H. W., Yoo, S. E., Kim, S. O., Lim, H. and Shin, H. S. (2001). Differential action of KR-31378, a novel potassium channel activator, on cardioprotective and hemodynamic effects. Drug Dev. Res. 54, 182-190 DOI ScienceOn |
13 | Lee, B. H. and Shin, H. S. (1994). In vivo pharmacological evaluation of newly synthesized nonpeptidic AT1 receptor antagonists in rats. Arch. Pharm. Res. 17, 263-268 DOI |
14 | Lee, B. H., Yoo, S. E. and Shin, H. S. (1998). Hemodynamic profile of SKP-450, a new potassium-channel activator. J. Cardiovase. Pharmacol. 31, 85-94 DOI ScienceOn |
15 | Lee, B. H., Seo, H. W., Kwon, K. J., Yoo, S. E. and Shin, H. S. (1999). In vivo pharmacologic profile of SK-1080, an orally active nonpeptide AT1-receptor antagonist. J. Cardiovasc. Phannacol. 33, 375-382 DOI ScienceOn |
16 | Yamanaka, K., Suzuki, M., Munehasu, S. and Ishiko, J. (1991). Antihypertensive effects of amlodipine, a new calcium antagonist. Nippon Yakurigaku Zasshi 97, 115-126 DOI ScienceOn |