• Physical Therapy Korea
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• v.14 no.2
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• pp.11-20
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• 2007

The development of neonatal neuromuscular system is accomplished by the functional interaction between the spinal neurons and its target cells, skeletal muscle cells, and the intrinsic and extrinsic factors affecting this process. The aim of this study was to identify the effect of suspension unloading (SU) and neuromuscular electrical stimulation (NMES) upon the development of the neonatal spinal cord. For this study, the neonatal rats were randomly divided into three groups: a control group, an experimental group I, and an experimental group II. The SU for experimental group I and II was applied from postnatal day (PD) 5 to PD 30, and the NMES for experimental group II was applied from PD 16 to PD 30 using NMES that gave isometric contraction with 10 Hz for 30 minutes twice a day. In order to observe the effect of SU and NMES, this study observed neutrophin-3 (NT-3) and microtubule associated protein 2 (MAP2) immunoreactivity in the lumbar spinal cord (L4-5) at the PD 15 and PD 30. The results are as follows. At PD 15, lumbar spinal cord of experimental group I and II had significantly lower NT-3 and MAP2 immunoreactivity than control group. It proved that a microgravity condition restricted the spinal development. At PD 30, lumbar spinal cord of control group and experimental group II had significantly higher NT-3 and MAP2 immunoreactivity than experimental group I. It proved that the NMES facilitated the spinal development by spinal cord-skeletal muscle interaction. These results suggest that weight bearing during the neonatal developmental period is essential for the development of neuromuscular development. Also, the NMES on its target skeletal muscle can encourage the development of the spinal cord system with a full supplementation of the effect of weight bearing, which is an essential factor in neonatal developmental process.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.2
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• pp.1-7
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• 2007

Active magnetic bearing has been adopted to support the rotor by electomagnetic force without mechanical contact and lubrication process. A property of the control system for magnetic bearing is improved in accordance with making higher system gain. If the control system has integral part, an excessive overshoot response is shown by making higher integral gain. Therefore, this paper suggests a PID control system in order to eliminate the overshoot at the first stage and improve response characteristics to an impact disturbance at the status of levitation. The control gain was obtained by LQR design method which has the structure of I-PD control system in the state space. The PID control system containing prefilter has the same structure as the I-PD control system. Therefore, the PID control system adopted is able to be tuned by LQR design method. Finally, this paper shows the effect of the prefilter on the active magnetic bearing system through response experiments for levitation responses.

• Proceedings of the KIEE Conference
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• 2002.11c
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• pp.42-45
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• 2002

In the two-mass motor drive system driving a load through a flexible shaft or transmission system, a shaft torsional vibration is often generated. The overshoot of the motor drive system easily causes vibration. In this case I-PD controller has been generally used in speed control, because of the simplicity of structure. This paper using an analytical pole assignment design, proposes the overshoot formulas, and the settling time formula. The objective of this paper is to provide a design method of I-PD controller by using overshoot formulas, and settling time formula. The simulation results show that we can design the controller with desired overshoot and settling time.

• Proceedings of the KIEE Conference
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• 1997.11a
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• pp.119-121
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• 1997

This paper suggests a design method of the robust model following PD control system using genetic algorithm. This PD control system is designed by applying genetic algorithm with reference model to the optimal determination of proportional and derivative gains that are given by PD servo controller. These proportional and derivative gains are optimized simultaneously in the search domain guaranteeing the robust stability of closed-loop system satisfying different stability margins. The effectiveness of this PD control system is verified by computer simulation.

• Journal of Power System Engineering
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• v.11 no.1
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• pp.134-139
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• 2007

A delivery ship is used to handle the cargo with the crane to/from the ships. The ship is inclined in the direction of a cargo which is hung on a crane. In this case, a arc shaped rail should be in the equilibrium state to get good anti-rolling performance. In this study, a device and control algorithm are developed to take accurate and quick equilibrium of the rail. The device is composed of a hinged immovable support, screw jack and damper. And the control system is based on I-PD control law to consider of control input saturation and overshoot. The controller is composed of integral controller of feedforward path and proportional-derivative controller of feedback path. The parameters of controller is designed to follow the reference signal and to remove overshoot. The simulation results show that the desirable control performance is achieved.

• 제어로봇시스템학회:학술대회논문집
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• 1995.10a
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• pp.428-431
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• 1995

In this paper we propose an on-line tuning method by using genetic algorithm for robust minimax I-PD controller based on new criterion. The new criterion is the Integral of Squared Error (ISE) with a penalty of the derivative of manipulated variable. The work focuses on robust tuning of I-PD controller's parameters in the presence of plant parameter uncertainty. The result of several simulation studies are provided to illustrate the performance of this robust tunig method.

• Biomolecules & Therapeutics
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• v.29 no.5
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• pp.483-491
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• 2021

Parkinson's disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (SN). Matrix metalloproteinases-8 (MMP-8), neutrophil collagenase, is a functional player in the progressive pathology of various inflammatory disorders. In this study, we administered an MMP-8 inhibitor (MMP-8i) in Leucine-rich repeat kinase 2 (LRRK2) G2019S transgenic mice, to determine the effects of MMP-8i on PD pathology. We observed a significant increase of ionized calcium-binding adapter molecule 1 (Iba1)-positive activated microglia in the striatum of LRRK2 G2019S mice compared to normal control mice, indicating enhanced neuro-inflammatory responses. The increased number of Iba1-positive activated microglia in LRRK2 G2019S PD mice was down-regulated by systemic administration of MMP-8i. Interestingly, this LRRK2 G2019S PD mice showed significantly reduced size of cell body area of tyrosine hydroxylase (TH) positive neurons in SN region and MMP-8i significantly recovered cellular atrophy shown in PD model indicating distinct neuro-protective effects of MMP-8i. Furthermore, MMP-8i administration markedly improved behavioral abnormalities of motor balancing coordination in rota-rod test in LRRK2 G2019S mice. These data suggest that MMP-8i attenuates the pathological symptoms of PD through anti-inflammatory processes.

• Journal of Advanced Marine Engineering and Technology
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• v.20 no.3
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• pp.110-120
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• 1996

The purpose of this study is to build up the control scheme that promptly controls the pressure in a hydraulic cylinder having small control volume, using a PCV(proportional control valve) and a digital computer. Object pressure control system has the character to be unstable easily, because the displacement-flow gain of the PCV is so large considering comparatively small volume of the hydraulic cylinder and the time delay of response of PCV is long. Considering the above-mentioned characteristics of the object pressure control system, in this study, a control system is designed with two degree of freedom scheme that is composed by adding a feed-forward control path to I-PD control system, and the reference model is used to decide control parameters. And through some experiments on FF-I-PD, the validity of this control method is confirmed.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.14 no.5
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• pp.27-35
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• 2000

This paper deals with a control strategy for constant output power of SSRT(Soft Switching Resonant Type) FB(Full Bridge) DC-DC converter by an improved phase shift controller. When the FB DC-DC converter for the high density and the high effect control is operated in high speed switching, the switching loss and switching stress of the switching devices are increased. So, the soft switching method, which has the phase shift control with the digital I-PD controller, must be use in order to reduce its. And the output voltage that controlled by the digital I-PD controller tracks a reference without steady state error in variable input voltage. The validity of control strategy that proposed is verified from simulation results and experimental results by the DSP(TMS320C32).

• Proceedings of the KIPE Conference
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• 2008.06a
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• pp.127-129
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• 2008

This paper describes a method of approximate reasoning for fuzzy control of servo system, based on decomposition of -level fuzzy sets. It is propose that logic circuits for fuzzy PI+PD are a body from fuzzy inference to defuzzificaion in cases where the output variable u directly is generated PWM. The effectiveness for robust and faster response of the fuzzy control scheme is verified for a variable parameter by comparison with a PID control and fuzzy control. A position control of DC servo system with a fuzzy logic controller successfully demonstrated.