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The Study of Synergy between the BchE-k Variant and the ApoE Gene in the Alzheimer Dementia of the Korean Population

  • Shin, Eun-Sim;Yoon, Song-Ro;Choi, Soo-Kyung;Kim, Soo-Young
    • Journal of Genetic Medicine
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    • v.3 no.1
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    • pp.29-32
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    • 1999
  • The Apolipoprotein E type 4 allele (ApoE ${\varepsilon}4$) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease. The BchE-k variant, which is the common variant of the BchE gene, has been reported to show allelic association with AD in subjects who are also carriers of the ${\varepsilon}4$ allele of the ApoE, especially in subjects over the age of 75. This study was performed to evaluate the distribution of the ApoE and the BchE genotypes in the healthy and AD groups and to evaluate the synergy between the BchE-k variant and the ApoE ${\varepsilon}4$ in AD. The ApoE and the BchE genotypes were determined in DNA samples from 610 healthy people and 60 LOAD patients by using ARMS by standard agarose gel electrophoresis. The effect of the ApoE ${\varepsilon}4$ was closely related to AD(p<0.05). A comparison between the AD patients and the healthy individuals, both with the ${\varepsilon}4$ allele, indicated an interaction between the BchE-k and the ApoE ${\varepsilon}4$(p<0.05). The association of the BchE-k with AD was limited to carriers of the ApoE ${\varepsilon}4$ allele, among whom the presence of the BchE-k gave an odds ratio of AD 3.48 (95% C.I. 1.3-9.2). Therefore, these results suggested that further evidence of an association between the ApoE ${\varepsilon}4$ and LOAD, and the BchE-k acts in synergy with the ApoE ${\varepsilon}4$ as a susceptibility gene for AD.

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Crystal Structure and Physical Property of Tetragonal-like Epitaxial Bismuth Ferrites Film

  • Nam, Joong-Hee;Biegalski, Michael;Christen, Hans M.;Kim, Byung-Ik
    • Proceedings of the Korean Magnestics Society Conference
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    • 2011.06a
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    • pp.7-8
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    • 2011
  • Basically, the lattice mismatch between film and substrate can make those BiFeO3(BFO) films distorted with strain structure. BFO phase can be stabilized on LaAlO3(LAO) represents the example of a multiferroic with giant axial ratio. Its crystal structure is not strictly tetragonal, but tetragonal with a slight monoclinic distortion and related to the rotation of the oxygen octahedra. In this study, we show that phases with a tetragonal-like epitaxial BFO films can indeed be ferroelectric and also can be stabilized via epitaxial growth onto LAO. Recent reports on epitaxial BFO films show that the crystal structure changes from nearly rhombohedral ("R-like") to nearly tetragonal("T-like") at strains exceeding approximately -4.5%, with the "T-like" structure being characterized by a highly enhanced c/a ratio. While both the "R-like" and the "T-like" phases are monoclinic, our detailed x-ray diffraction results reveal asymmetry change from MA and MC type, respectively. By applying additional strain or by modifying the unit cell volume of the film by substituting Ba for Bi, the monoclinic distortion in the "T-like" MC phase is reduced, i.e. the system approaches a true tetragonal symmetry. There are two different M-H loops for $Bi_{1-x}Ba_xFeO_{3-{\delta}}$(BBFO) and BFO films on SrTiO3(STO) & LAO substrates. Along with the ferroelectric characterization, these magnetic data indicate that the BFO phase stabilized on LAO represents the first example of a multiferroic with giant axial ratio. However, there is a significant difference between this phase and other predicted ferroelectrics with a giant axial ratio: its crystal structure is not strictly tetragonal, but tetragonal with a slight monoclinic distortion. Therefore, in going from bulk to highly-strained films, a phase sequence of rhombohedral(R)-to-monoclinic ["R-like" MA-to-monoclinic, "T-like" MC-to-tetragonal (T)] is observed. This sequence is otherwise seen only near morphotropic phase boundaries in lead-based solid-solution perovskites (i.e. near a compositionally induced phase instability), where it can be controlled by electric field, temperature, or composition. Our results show that this evolution can occur in a lead-free, stoichiometric material and can be induced by stress alone. Those major results are summarized as follows ; 1) Ba-doping increases the unit cell volume, 2) BBFO on LAO can be fully strained up to x=0.08 as a strain limit (Fig. 1), 3) P(E) & M(H) properties can be tuned by the variation of composition, strain, and film thickness.

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A Study on the Bond Behavior of Used Deformed Bars in High-Strength Concrete (고강도콘크리트에 사용된 이형철근의 부착거동)

  • 박경호;이두영
    • Proceedings of the Korea Concrete Institute Conference
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    • 1999.04a
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    • pp.647-652
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    • 1999
  • The purpose of this study is to find the bond properties of deformed bars in hign-strength concrete by experimental and analytical method. In this study the following variables were adopted, i.e. (1) the compressive strength of concrete : 270, 400 and 600kg/$\textrm{cm}^2$ (2) the corrosion the bars : corroded and normal bars (3) the mixing ratio of natural and smashed fine aggregate : 7 : 3 and 5 : 5 (natural sand : smashed sand) For analytical method, the finite element analysis is performed. And the Pull-out test is performed as the experimental method.

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The rocognition of two-dimensional objects using the inverse histogram (인버스 히스토그램을 이용한 다수의 이차원 물체 인식)

  • 박성혁;고명삼
    • 제어로봇시스템학회:학술대회논문집
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    • 1986.10a
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    • pp.331-336
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    • 1986
  • Because the threshold technique using the histogram of intensity is the most attractive for segmentation in the sense of fast image processing, this paper defined the new function of inverse histogram of intensity and found out a threshold by means of it. The segmented errors are removed by regulating a scan size of blob coloring. Blob-coloring algorithm presented by [6] was reproved for good performance i.e., no change of feature in bolobs after blob coloring. The ratio of successful recognition was about 85 percents.

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Signal Processing Techniques for Recovering Input Waveforms in Dispersive Lamb Wave Propagation (분산성 램파의 전파에서 입력 파형의 복원을 위한 신호처리)

  • Jeong, Hyunjo;Cho, Sungjong
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2013.04a
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    • pp.694-695
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    • 2013
  • An experimental study has been made with the use of time reversal concepts to recover the input waveform in a long range propagation of dispersive Lamb waves. Three techniques have been tested: Regular TR, 1 bit TR and Inverse filter (IF). The IF approach was found to completely recover the original input signal. Moreover, the IF technique significantly increases the contrast, i.e., the ratio of the recovered signal and the sideband signal.

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A Detailed Analysis of the Part Load Ratio and Cooling Energy Characteristics of Chiller Operation in an Office Building (사무소 건물에서 냉동기의 부분부하율 및 냉방 에너지 성능 특성 분석)

  • Seo, Byeong-Mo;Yu, Byeong-Ho;Lee, Kwang-Ho
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.27 no.11
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    • pp.567-573
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    • 2015
  • Commercial buildings account for significant portions of the total building energy in Korea, and thus, a variety of research on chiller operation has been carried out. However, most of the studies were carried out on the chiller itself, i.e., the part load ratio characteristics and the corresponding electricity energy consumption patterns were not analyzed in existing studies. In this study, the part load ratio and the operating characteristics of the vapor compression chiller were analyzed within an office building equipped with the conventional variable air volume system. As a result, significant portions of total operating hours, cooling load, and energy consumption turned out to be in the part load ratio range of 0 through 50%. Thus, energy consumption was significantly affected by the chiller COP at low part load conditions, indicating that chiller operation at the part load is an important factor in commercial buildings.

Characteristic Study of Micro-Nozzle according to the Ratio of Nozzle Expansion and Specific heats (노즐 팽창비와 비열비에 따른 마이크로 노즐의 특성연구)

  • Oh Hwayoung;Huh Hwanil;Moon Seonghwan
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • v.y2005m4
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    • pp.381-385
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    • 2005
  • Recently, spacecraft technology trends can be expressed three words, i.e. 'faster, cheaper and smaller'. Among these systems, micro propulsion device is an essential component. Also micro nozzle is the most important part in the micro propulsion device. In case of cold-gas thruster, micro nozzle converts the stored energy in a pressurized gas into kinetic energy through expansion ratio. In this paper we report characteristics of micro nozzle with throat expansion ratio and ratio of specific heats. We measure thrusts using strain gauge based thrust measurement system. We can estimate the micro nozzle performance through experiments.

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Estimation of the PAR Irradiance Ratio and Its Variability under Clear-sky Conditions at Ieodo in the East China Sea

  • Byun, Do-Seong;Cho, Yang-Ki
    • Ocean Science Journal
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    • v.41 no.4
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    • pp.235-244
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    • 2006
  • Determining 'photosynthetically active radiation' (PAR) is a key part of calculating phytoplankton productivity in a biogeochemical model. We explore the daily and seasonal variability in the ratio of PAR irradiance to total irradiance that occurred at Ieodo Ocean Research Station (IORS) in the East China Sea under clear-sky conditions in 2004 using a simple radiative transfer model (RTM). Meteorological data observed at IORS and aerosol optical properties derived from Aerosol Robotic Network observations at Gosan are used for the RTM. Preliminary results suggest that the use of simple PAR irradiance-ratio values is appropriate in calculating phytoplankton productivity as follows: an average of $0.44\;({\pm}0.01)$ in January to an average of $0.48\;({\pm}0.01)$ in July, with average daily variabilities over these periods of about $0.016\;({\pm}0.008)$ and $0.025\;({\pm}0.008)$, respectively. The model experiments demonstrate that variations in the major controlling input parameters (i.e. solar zenith angle, precipitable water vapor and aerosol optical thickness) cause PAR irradiance ratio variation at daily and seasonal timescales. Further, increases (>0.012) in the PAR irradiance ratio just below the sea-surface are positively correlated with high solar zenith angles and strong wind stresses relative to those just above the sea-surface.

A Study on the Change of Unit Floor Plan of Apartment House in Korea-Focused on Interior Image Preference using Computer Simulation- (아파트 단위 평면 변화과정에 관한 연구-안방 및 거실 중심으로-)

  • 김경순
    • Korean Institute of Interior Design Journal
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    • no.12
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    • pp.50-56
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    • 1997
  • In the past thirty years, apartment house has been greatly developed and the housing supply has improved some degree. However, the fact is that interior space planning of apartment house still has a lot of problems. The purpose of this study is to research the change of interior room. The 160 examples of unit floor plan(40-85m2 i.e. 12.1py-25.7py) were selected and classified according to master bedroom type and living room area when was constructed by the city of Seoul and KNHC from 1970 to 1990. And then, the change of each area, size and ratio were analyzed and researched. The result of this research can be summarized as follows: 1. Size of unit floor plan was on the increase from 16.02py to 17.86py. 2. 2 bedroom type, master bedroom showed a rise of size and occupancy ratio. Living room grew larger than 1982-1991 for size and occupancy ratio. 3. 3 bedroom type, master bedroom was increased in size and occupancy ratio was reduced to 19.99%. Size of living room became broader than master bedroom and occupancy ratio(1972-1981) increased over 1982-1991. Through this analysis and research, this study is to provide the basic data for actural design process and to suggest future trend of apartment house.

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Economic Valuation for Nursery-Phase Production - Focusing on the tidal flat Oyster - (해면 중간육성 생산방식의 경제성 분석 - 갯벌 참굴 산업을 중심으로 -)

  • Choi, Jong-Du
    • The Journal of Fisheries Business Administration
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    • v.43 no.3
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    • pp.31-41
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    • 2012
  • This paper was conducted to study the economic valuation for Nursery-Phase production of the tidal flat oyster in Korea. Benefit-cost(B/C) model used to indicate the effects of economic valuation. Using discounting rates(i.e., 4.5%, 6.5% and 8.5%), the model compared revenues and costs that occur at different times from 2012 to 2018. This study also estimated various submodels, which are Benefit Cost Ratio(B/C ratio), Net Present Value(NPV), Internal Ration of Return(IRR), to compare profit of Nursery-Phase production styles and analyzed returns to evaluate the scenarios. Sensitivity analysis were conducted for various scenarios. The results suggest as follows. First, the oyster spat to the shell height of 3~5cm was more profit than the shell height of 1~3cm. Second, all of sensitivity analysis with submodels were economic valuation such that B/C ratio > 1, NPV > 0 and IRR > discounting rate. Third, the payback period was about 3years after installed Nursery-Phase production system.