• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.4
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• pp.914-925
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• 1998

This paper considers the evaluation of the hybrid acquistion perdformance for the pilot signal in the direct sequence code division multiple access(DS/CDMA) forward link. the hybrid acquisition is introduced by the combination of two schemes, the parallel and serial acquisions. The mean acquisition time of the proposed scheme is derived to consider both the best case(the correct code-phase offsets are included i one subset) and the worst case(the correct code-phase offsets exist at the boundary of two subsets), which are cause by the distribution of the correct code-phase offsets in the subset. Expressions for the detection, false alarm, and miss probabilities are derived for the case of multiple correct code-phase offsets and multipath Rayleigh fading channel. Numerical results present the hybrid acquistion performance with repect to design parameters such as postdetectio integration length in the search and verification modes, subset size, and number of I/Q noncoherent correlators, and compare the hybrid acquistion with the parallel acquistion in terms of the minimum acquistion time under the same hardware complexity.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.3
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• pp.265-273
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• 2024

This study aims to explore possible effect of RNA polymerase I subunit D (POLR1D) on proliferation and angiogenesis ability of colorectal cancer (CRC) cells and mechanism herein. The correlation of POLR1D and Yin Yang 1 (YY1) expressions with prognosis of CRC patients in TCGA database was analyzed. Quantitative realtime polymerase chain reaction (qRT-PCR) and Western blot were applied to detect expression levels of POLR1D and YY1 in CRC cell lines and CRC tissues. SW480 and HT-29 cells were transfected with si-POLR1D or pcDNA3.1-POLR1D to achieve POLR1D suppression or overexpression before cell migration, angiogenesis of human umbilical vein endothelial cells were assessed. Western blot was used to detect expressions of p38 MAPK signal pathway related proteins and interaction of YY1 with POLR1D was confirmed by dual luciferase reporter gene assay and chromatin immunoprecipitation (ChIP). TCGA data showed that both POLR1D and YY1 expressions were up-regulated in CRC patients. High expression of POLR1D was associated with poor prognosis of CRC patients. The results showed that POLR1D and YY1 were highly expressed in CRC cell lines. Inhibition or overexpression of POLR1D can respectively suppress or enhance proliferation and angiogenesis of CRC cells. YY1 inhibition can suppress CRC progression and deactivate p38 MAPK signal pathway, which can be counteracted by POLR1D overexpression. JASPAR predicted YY1 can bind with POLR1D promoter, which was confirmed by dual luciferase reporter gene assay and ChIP. YY1 transcription can up-regulate POLR1D expression to activate p38 MAPK signal pathway, thus promoting proliferation and angiogenesis ability of CRC cells.

• Journal of Electrical Engineering and Technology
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• v.11 no.3
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• pp.560-574
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• 2016

This paper presents a novel method for power system harmonic estimation based on the Park transform. The proposed method firstly extends the signal to a group of three-phase signals in a-b-c coordinate. Then, a linear fitting based method is adopted to estimate the fundamental frequency. Afterwards, the Park transform is utilized to convert the three-phase signals from a-b-c coordinate to d-q-0 coordinate. Finally, the amplitude and phase of a harmonic component of interest can be calculated using the d-axis and q-axis components obtained. Simulation studies have been conducted using matrix laboratory (MATLAB) and power system computer aided design/electromagnetic transients including direct current (PSCAD/EMTDC). Simulation studies in MATLAB have considered three scenarios, i.e., no-frequency-deviation scenario, frequency-deviation scenario and the scenario in the presence of inter-harminics. The results have demonstrated that the proposed method achieves very high accuracy in frequency, phase and amplitude estimation under noisy conditions, and suffers little influence of the inter-harmonics. Moreover, comparison studies have proved that the proposed method is superior to FFT and Interpolated FFT with the Hanning Window (IpFFTHW). Finally, a popular case in PSCAD/EMTDC has been employed to further verify the effectiveness of the proposed method.

• The Journal of the Acoustical Society of Korea
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• v.15 no.6
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• pp.81-89
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• 1996

It is very important for ultrasonic test method to evaluate the integrity of the class I components in nuclear power plants. However, as the rltrasonic test is affected by internal structures and configurations of test materials, backscattering, that is, time invariant noise is generated in large grain size materials. Due to the above reason, the received signal results in low signal to noise(S/N) ratio. Split spectrum processing(SSP) technique is effective to suppress the grain noise. The conventional SSP technique. however, has been applied to unique algorithm. This paper shows that MPO(minimization and polarity threshold) algorithm which two algorithms are applied simulatancously, was utilized, the signal processing time was shorten by using the new constant-Q SSP with the FIR filter which frequency to bandwidth ratio is constant and the optimum parameters were analysed for the signal processing to longitudinal wave and shear wave with the same requirements of inspection on nuclear power plant site. Moreover, the new ultrasonic test instrument, the reference block of the same product form and material specification, stainless stell test specimens and copper test specimens block of the same fabricated for the application of new SSP technique. As the result of experimental test with new ultrasonic test instrument and test specimens, the signal to noise ratio was improved by appying the new SSP technique.

• Journal of the Mineralogical Society of Korea
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• v.31 no.4
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• pp.295-306
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• 2018

Despite the utility of solid-state NMR, NMR studies of iron-bearing silicate glasses remain a challenge because the variations in the peak position and width with increasing iron content reflect both paramagnetic effect and iron-induced structural changes. Therefore, it is essential to elucidate the effect of temperature on the NMR signal for iron-bearing silicate glasses. Here, we report the $^{29}Si$ and $^{27}Al$ MAS NMR spectra for $(Mg_{0.95}Fe_{0.05})SiO_3$ and $Fe_2O_3$-bearing $CaAl_2Si_2O_8$ (anorthite) glasses with varying spinning speed to interpret the NMR spectra for iron-bearing silicate glasses. The increase in the spinning speed results in an increase in the sample temperature. The current NMR results allow us to understand the origins of the changes in NMR signal with increasing iron content and to provide information on the dipolar interaction between nuclear spins. The $^{29}Si$ NMR spectra for $(Mg_{0.95}Fe_{0.05})SiO_3$ glass and $^{27}Al$ NMR spectra for $Fe_2O_3$-bearing $CaAl_2Si_2O_8$ glasses show that the peak shape and position of iron-bearing glasses do not change with increasing spinning speed up to 30 kHz. These results suggest that the NMR signal in the Fe-bearing glasses may stem from the 'survived nuclear spins' beyond the cutoff radius from the Fe, not from the paramagnetic shift. Based on the current results, the observed apparent shifts toward lower frequency of Al peak for $Fe_2O_3$-bearing $CaAl_2Si_2O_8$ glasses with increasing $Fe_2O_3$ at all spinning speed (15 kHz to 30 kHz) indicate the increase in the fraction of ${Q^4}_{Al}$(nSi) with lower n (i.e., 1 or 2) with increasing $Fe_2O_3$ and the spatial proximity between Fe and ${Q^4}_{Al}$(nSi) with higher n (i.e., 3 or 4). The present results show that changes in the NMR signal for iron-bearing silicate glasses reflect the actual iron-induced structural changes. Thus, it is clear that the applications of solid-state NMR for iron-bearing silicate glasses hold strong promise for unraveling the atomic structure of natural silicate glasses.

• Molecules and Cells
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• v.21 no.1
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• pp.42-51
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• 2006

We investigated the mechanism of contraction induced by S1P in esophageal smooth muscle cells. Western blot analysis demonstrated that $S1P_1$, $S1P_2$, $S1P_3$, and $S1P_5$ receptors existed in the cat esophagus. Only penetration of EDG-5 ($S1P_2$) antibody into permeabilized cells inhibited S1P-induced contraction. Pertussis toxin (PTX) also inhibited contraction, suggesting that it was mediated by $S1P_2$ receptors coupled to a PTXsensitive $G_i$ protein. Specific antibodies to $G_{i2}$, $G_q$ and $G_{\beta}$ inhibited contraction, implying that the S1P-induced contraction depends on PTX-insensitive $G_q$ and $G_{\beta}$ dimers as well as the PTX-sensitive $G_{i2}$. Contraction was not affected by the phospholipase $A_2$ inhibitor DEDA, or the PLD inhibitor ${\rho}$-chloromercuribenzoate, but it was abolished by the PLC inhibitor U73122. Incubation of permeabilized cells with $PLC{\beta}3$ antibody also inhibited contraction. Contraction involved the activation of a PKC pathway since it was affected by GF109203X and chelerythrine. Since $PKC{\varepsilon}$ antibody inhibited contraction, $PKC{\varepsilon}$ may be required. Preincubation of the muscle cells with the MEK inhibitor PD98059 blocked S1P-induced contraction, but the p38 MAP kinase inhibitor SB202190 did not. In addition, co-treatment of cells with GF 109203X and PD98059 did not have a synergistic effect, suggesting that these two kinases are involved in the same signaling pathway. Our data suggest that S1P-induced contraction in esophageal smooth muscle cells is mediated by $S1P_2$ receptors coupled to PTX-sensitive $G_{i2}$ proteins, and PTX-insensitive $G_q$ and $G_{\beta}$ proteins, and that the resulting activation of the $PLC{\beta}3$ and $PKC{\varepsilon}$ pathway leads to activation of a p44/p42 MAPK pathway.

• Journal of Broadcast Engineering
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• v.16 no.1
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• pp.96-107
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• 2011

Recently, studies of 3D HDTV broadcasting technology have been processed actively. Korea is making efforts to modify Advanced Television Systems Committee (ATSC) 8-Vestigial Side Band (8-VSB) systems for terrestrial 3D HDTV broadcasting services. We intend to adopt a new frame structure to use PN (Pseudo-Noise) sequence as frame header, and VSB modulation. PN sequence is used to recover carrier freqeuncy offset, carrier phase error. In this paper, we will describe this system as the modified ATSC systems. The receiver of the modified ATSC system should be able to estimate and recover carrier frequency offset exactly. A existing ATSC systems inserts pilot to recover carrier frequency offset, on the other hand the modified ATSC systems use PN sequence to recovery carrier frequency offset without the use of pilot. In this paper, we introduce carrier frequency recovery (CFR) scheme for the modified ATSC systems. The proposed CFR scheme is composed of coarse CFR scheme using Fitz algorithm and fine CFR scheme using a simple PN sequence correlation algorithm. And, the symbol information of QAM modulated signal is contained in both In-phase (I)channel and Quadrature-phase (Q)channel. However the symbol information of VSB modulated signal is contained in I channel, and Q channel is just Hilbert transform of I channel. For the reason, VSB modulated symbols can not have fixed phase like QAM modulated symbols, and VSB modulated symbols is more sensitive to carrier frequency offset. Therefore we perform phase correction of received PN sequence to improve performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.12C
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• pp.1029-1034
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• 2010

For All Digital QPSK receivers, a phase recovery scheme is required to fix the arbitrarily rotated I/Q quadrature signals due to the transmission path and clock mismatch between the transmitter and the receiver. The conventional Costas phase recovery loop scheme requires a separate AGC(Automatic Gain Control) to obtain the performance independent of input signal power. This paper proposes a simple scheme which separates the phase and amplitude of the input signal via CORDIC algorithm and performs the phase recovery and amplitude compensation simultaneously. The proposed scheme can considerably reduce the logic resources in hardware implementation, has been verified by C++ and Model Sim simulations.

• Smart Structures and Systems
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• v.19 no.2
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• pp.195-202
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• 2017

The aim of this paper is to develop a novel method to determine the severity of a damage in a thin plate. This paper presents a novel fault detection and diagnosis approach employing a new electromagnetic acoustic transducer, called EMAT, together with a complex signal processing method. The method consists in the recognition of a fault that exists within the structure, the fault location, i.e. the identification of the geometric position of damage, and the determining the significance of the damage, which indicates the importance or severity of the defect. The main scientific novelties presented in this paper is: to develop of a new type of electromagnetic acoustic transducer; to incorporate wavelet transforms for signal representation enhancements; to investigate multi-parametric analysis for noise identification and defect classification; to study attenuation curves properties for defect localization improvement; flaw sizing and location algorithm development.

• Toxicological Research
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• v.17
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• pp.83-88
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• 2001

Most reactive oxygen species (ROS) are free radicals and implicated in the development of a number of disease processes including artherosclerosis, neurodegenerative disorders, aging and cancer. ROS are byproducts of a number of in vivo metabolic processes and are formed deliberately as part of nor-mal inflammatory response. On the other hand, ROS are generated either as by products of oxygen reduction during xenobiotic metabolism or are liberated as the result of the futile redox cycling of the chemical agents including several chemical carcinogens. A better understanding of the mechanisms of free radical toxicity may yield valuable clue to risks associated with chemical exposures that leading to the development of chronic diseases including cancer. The molecular biology of ROS-mediated alterations in gene expression, signal transduction and carcinognesis is one of the important subjects in free radical toxicology. Epidemiological studies suggest that high intake of vegetables and fruits are associated with the low incidence of human cancer. Many phytopolyphenols such as tea polyphenols, curcumin, resveratrol, apigenin, genistein and other flavonoids have been shown to be cancer chemopreventive agents. Most of these compounds are strong antioxidant and ROS scavengers in vitro and effective inducers of antioxidant enzymes such as superoxide dismutatse, catalase and glutathione peroxidase in vivo. Several cellular transducers namely receptor tyrosine kinase, protein kinase C, MAPK, PI3K, c-jun, c-fos, c-myc, NFkB, IkB kinase, iNOS, COX-2, Bcl-2, Bax, etc have been shown to be actively modulated by phyto-polyphenols. Recent development in free radical toxicology have provided strong basis for understanding the action mechanisms of cancer chemoprevention.