• Applied Chemistry for Engineering
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• v.21 no.2
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• pp.188-194
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• 2010

The electrolyzed sterilizing water is useful functional aqueous solution, which is produced by electrolyzing aqueous solution. Electrolytic supplement such as salt or hydrochloric acid is added into tap water. Electrolyzed sterilizing water is classified as three types; strongly acidic electrolyzed water, weakly acidic electrolyzed water, and sodium hypochlorite water. In this study, preparation principles, advantages, and disadvantages of electrolyzed sterilizing water were analyzed. The technology trend in electrolyzed sterilizing water was analyzed based on patent application year, countries, main applicants, and each technologies.

• Clinical and Experimental Pediatrics
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• v.46 no.2
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• pp.198-202
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• 2003

Of all toxic inhalant exposures, chlorine is one of the most common toxic chemical inhalants. When acutely inhaled, it can be responsible for symptoms ranging from upper air way irritation to more serious respiratory effects. It can also deteriorate lung function and lead to death. Chlorine and its compounds such as chlorinated cyanurates and hypochlorites are commonly used in water disinfection. The chemical agents discussed in this article are sodium dichloroiso cyanurate and calcium hypochlorite which are the two most popular products for swimming pool chlorination. They are both strong oxidizing agents which are soluble in water. Between the above two alkali agents, acid-base interaction occurred and generated heat. And the acid drove the combination of hypochlorous and chloride ions to form chlorine gas. We have experienced, two boys who had inhalation injuries caused by an accidental explosion which occurred in a swimming pool by mixing two different chlorinating agents : sodium dichloroiso cyanurate and calcium hypochlorite. The children suffered from respiratory difficulties after the exposure. They both required intensive care management and one needed the support of mechanical ventilation.

• International Journal of Vascular Biomedical Engineering
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• v.2 no.2
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• pp.1-9
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• 2004

The history of studies in biology regarding reactive oxygen species (ROS) is approximately 40 years. During the initial 30 years, it appeared that these studies were mainly focused on the toxicity of ROS. However, recent studies have identified another action regarding oxidative signaling, other than toxicity of ROS. Basically, it is suggested that ROS are reactive, and degenerate to biomolecules such as DNA and proteins, leading to deterioration of cellular functions as an oxidative stress. On the other hand, recent studies have shown that ROS act as oxidative signaling in cells, resulting in various gene expressions. Recently ROS emerged as critical signaling molecules in cardiovascular research. Several studies over the past decade have shown that physiological effects of vasoactive factors are mediated by these reactive species and, conversely, that altered redox mechanisms are implicated in the occurrence of metabolic and cardiovascular diseases ROS is a collective term often used by scientist to include not only the oxygen radicals($O2^{-{\cdot}},\;{^{\cdot}}OH$), but also some non-radical derivatives of oxygen. These include hydrogen peroxide, hypochlorous acid (HOCl) and ozone (O3). The superoxide anion ($O2^{-{\cdot}}$) is formed by the univalent reduction of triplet-state molecular oxygen ($^3O_2$). Superoxide dismutase (SOD)s convert superoxide enzymically into hydrogen peroxide. In biological tissues superoxide can also be converted nonenzymically into the nonradical species hydrogen peroxide and singlet oxygen ($^1O_2$). In the presence of reduced transition metals (e.g., ferrous or cuprous ions), hydrogen peroxide can be converted into the highly reactive hydroxyl radical (${^{\cdot}}OH$). Alternatively, hydrogen peroxide may be converted into water by the enzymes catalase or glutathione peroxidase. In the glutathione peroxidase reaction glutathione is oxidized to glutathione disulfide, which can be converted back to glutathione by glutathione reductase in an NADPH-consuming process.

• Journal of the Korean Electrochemical Society
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• v.11 no.2
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• pp.95-99
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• 2008

This study has made the electrode that is coated zirconium oxide on the titanium by ESD(Electrostatic spray deposition) coating methode. It has investigated the effects of the etching method of a Ti substrate as the preparation, making of zirconium oxide film and electrochemical characteristics of the electrode that is etched on the titanium. The HCl etching develops a fine and homogeneous roughness on the Ti substrate. Fabrication and material properties of the metal oxide electrode, which is known to be so effective to generate ozone and hypochlorous acid (HOCl) as power oxidant, were studied. A proper metal oxide material is focus zirconium oxide through reference. A coating method to enhance the fabrication reproducibility of the zirconium oxide electrode was used ESD coating method by zirconium oxychloride. Zirconium oxide films on the Ti substrate were tested using SEM, XRD, Cyclic voltammetry.

• Journal of Korean Society on Water Environment
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• v.33 no.4
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• pp.487-493
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• 2017

This study was conducted to propose measures of water quality management as the water criteria for waterscape facilities which have been highlighted as alternatives to wading pools in summer season was legislated. The number of public waterscape facilities has reached 290 sites in Gyeounggi province and 971 sites in South Korea in 2017. The water tank capacity of 80.3 % public waterscape facilities was less than $100m^3$. Facilities with disinfection system were only 6.5 % and facilities with filtration function were also very low at 6.9 %. Most of the waterscape facilities, about 93%, are expected to be vulnerable to complying with revised water quality criteria because they have to be disinfected by handling. Chlorine disinfectants, which are more persistent than ozone or ultraviolet sterilization methods, are more preferred. However, care should be taken when adding disinfectans because hypochlorous acid, which is an effective component of chlorine disinfectant, remains after the disinfection, but it is easily decomposed with time. For this study, ${\bigcirc}{\bigcirc}$ park floor fountain with a capacity of $63m^3$ was selected and the amount of free residual chlorine concentration was measured by injecting a certain amount of chlorine bleach. As a result, it took 5 hours to decrease from the water quality standard of 4 mg/L to 0.04 mg/L. If the waterscape facility is operated for 7 to 8 hours, the chlorine bleach should be re-injected after 5 hours. In addition, the problem of pH increase due to the input of chlorine disinfectant is expected, and the neutralization method using vinegar was proposed.

• Journal of Advanced Marine Engineering and Technology
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• v.41 no.3
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• pp.276-280
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• 2017

In this study, we investigated the effect of sterilization and the neutralization of treated ballast water using seawater electrolysis. The electrolysis apparatus has a cation-selective membrane for passing the cation and a titanium electrode in each cell. We examined the sterilization effect after an incubation period of 24 hr. The oxidation reaction during electrolysis caused, the solution to become strongly acidic due to the generation of a hydroxyl group, and the oxidation reduction potentials(ORP) was increased to 800 - 1200mV. After the reduction reaction, the solution became alkaline(pH 9 - 12), and ORP was decreased to - 900 - - 750 mV. It might be possible to control the pH of ballast water through electrolysis. In addition, we demonstrated the effects of sterilization of ballast water containing generated hypochlorous acid using electrolysis under high ORP condition.

• Journal of Environmental Health Sciences
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• v.48 no.3
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• pp.167-175
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• 2022

Background: Disinfection is essential to provide drinking water from a water source. The disinfection process mainly consists of the use of chlorine and ozone, but when chlorine is used as a disinfectant, the problem of disinfection by-products arises. In order to resolve the issue of disinfection by-products, electro-chlorination technology that produces chlorine-based disinfectants from salt water through electrochemical principles should be applied. Objectives: This study surveys the possibility of optimally producing active chlorine from synthetic NaCl solutions using an electro-chlorination system through RSM. Methods: Response surface methodology (RSM) has been used for modeling and optimizing a variety of water and wastewater treatment processes. This study surveys the possibility of optimally producing active chlorine from synthetic saline solutions using electrolysis through RSM. Various operating parameters, such as distance of electrodes, sodium chloride concentration, electrical potential, and electrolysis time were evaluated. Results: Various operating parameters, such as distance of electrodes, sodium chloride concentration, electrical potential, and electrolysis time were evaluated. A central composite design (CCD) was applied to determine the optimal experimental factors for chlorine production. Conclusions: The concentration of the synthetic NaCl solution and the distance between electrodes had the greatest influence on the generation of hypochlorite disinfectant. The closer the distance between the electrodes and the higher the concentration of the synthetic NaCl solution, the more hypochlorous acid disinfectant was produced.

• Korean Journal of Mineralogy and Petrology
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• v.33 no.3
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• pp.243-250
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• 2020

The purpose of this study is to find out the possibility of applying microwave-hypochlorous acid leaching to effectively leaching Au in hydrothermal minerals on board. The comparative leaching experiment were confirmed that the leaching rate of Au with(T1)/with out(T2) of microwave nitric acid leaching. In addition, the leaching rate of Au on the conventional leaching by mechanical agitation(T3) and microwave leaching was compared. The result of microwave nitric acid leaching(solid-liquid ratio; 10%, leaching temperature; 90 ℃, leaching time; 20 min) confined that the metal leaching rate was high in the order of As>Pb>Cu>Fe>Zn, and the content of Au in the leaching residue was increased from 33.77 g/ton to 60.02 g/ton. As a result of the comparative leaching experiment using a chloride solvent, the dissolution rate of Au was high in the order of T1(61.10%)>T3(53.30%)>T2(17.30%). Therefore, chloride, which can be manufactured using seawater and that can be recycled by collecting chlorine gas generated in the leaching process, is expected to be an optimal solvent for Au leaching. In addition, the application of microwaves is believed to be effective in terms of time, efficiency and energy.

• Journal of Food Hygiene and Safety
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• v.38 no.6
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• pp.508-516
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• 2023

The consumption of enoki mushrooms has been associated with cases of listeriosis produced by Listeria monocytogenes, highlighting the significance of sanitizing food-contact surface, such as the velcro used in welding processing of enoki mushrooms, to ensure microbial safety. We investigated the inhibitory activity of nine chemical disinfectants at regular concentrations against L. monocytogenes isolated from a mushroom farm environment. The bacterial suspension was prepared in phosphate buffered saline and mushroom extract broth and inoculated onto the velcro surface. After inoculation, most disinfectants reduced the initial 8 log CFU/coupon concentration by less than 2 log CFU/coupon during a 5-min treatment. Slightly acidic hypochlorous water showed a reduction of approximately 4 log CFU/coupon when tested for more than 30 min at the maximum allowable concentration of 200 mg/L. Sodium hypochlorite solution showed a reduction of approximately 5 log CFU/coupon when used at 100 mg/L for 60 min. Peracetic acid, at the maximum allowable concentration of 300 mg/L, showed the most effective reduction of 5 log CFU/coupon or more when the surface was treated with 37.5 mg/L for 30 min. These results indicate that peracetic acid can be used as the disinfectant strategy to control cross-contamination of L. monocytogenes on the velcro surface of plastic wrappers used in the welding processing of enoki mushrooms.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.4037-4043
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• 2012

Despite progress in elucidating mechanisms associated with colorectal cancer and improvement of treatment methods, it remains a frequent cause of death worldwide. New and more effective therapies are therefore urgently needed. Recent studies have shown that immunogenicity of whole ovarian tumor cells and subsequent T cell response were potentiated by oxidation modification with hypochlorous acid (HOCl) in vitro and ex vivo. These results prompted us to investigate the protective antitumor response with an HOCl treated CT26 colorectal cancer cell vaccine in an in vivo mouse model. Administration of HOCl modified vaccine triggered robust antitumor immunity to autologous tumor cells in mice and prolonged survival period significantly. In addition, increased necrosis and apoptosis were found in tumor tissue from the oxidation group. Interestingly, ELISPOT assays showed that specific T cell responses were not elicited in response to the immunizing cellular antigen, in contrast to raising sera antibody titer and antibody binding activity shown by ELISA assay and flow cytometry. Further evaluation of the mechanisms underlying HOCl modified vaccine mediated humoral immunity highlighted the role of antibody-dependent cell-mediated cytotoxicity. These results combined with previous studies suggest that HOCl oxidation modified whole cell vaccine has wide applicability as a cancer vaccine because it can target both T cell- and B cell-specific responses. It may thus represent a promising approach for the immunotherapy of colorectal cancer.