• Genomics & Informatics
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• v.17 no.3
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• pp.24.1-24.8
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• 2019

Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being recognized as a major contributor that may permanently program change of organ structure and function toward the development of diseases, in which epigenetic mechanisms are involved. Recent researches indicate early-life environmental factors modulate the microbiome development and the microbiome might be mediate diet-epigenetic interaction. This review aims to define which nutrients involve microbiome development during the critical window of susceptibility to disease, and how microbiome modulation regulates epigenetic changes and influences human health and future prevention strategies.

• BMB Reports
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• v.39 no.3
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• pp.335-338
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• 2006

Methylglyoxal (MG) is an endogenous physiological metabolite which is present in increased concentrations in diabetics. MG reacts with the amino acids of proteins to form advanced glycation end products. In this in vitro study, we investigated the effect of MG on the structure and function of ceruloplasmin (CP) a serum oxidase carrier of copper ions in the human. When CP was incubated with MG, the protein showed increased electrophoretic mobility which represented the aggregates at a high concentration of MG (100 mM). MG-mediated CP aggregation led to the loss of enzymatic activity and the release of copper ions from the protein. Radical scavengers and copper ion chelators significantly prevented CP aggregation. CP is an important protein that circulates in plasma as a major copper transport protein. It is suggested that oxidative damage of CP by MG may induce perturbations of the copper transport system and subsequently lead to harmful intracellular condition. The proposed mechanism, in part, may provide an explanation for the deterioration of organs in the diabetic patient.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.544-544
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• 2000

From ancient times. the diagnosis method of the oriental medicine has been Performed by curing diseases by means of rectifying and adjusting the unbalance in the Physiological function of the five viscera and the six bowels of a human body. Diseases have been diagnosed by the condition of blood circulation that cycles a human body through blood vessels by dint of the vitality of the heart, Based on such a systematic pulse diagnosis method, the article presents parameters that will be beneficial to clinical application on the basis of its analysis of the filtering for eliminating noises from pulse signals inputted from sensor group the digital hardware dealing with signals necessary for recognition algorithm. and the structure of diagnosis algorithm and components of pulse waveform.

• The Journal of Korea CHUNA Manual Medicine
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• v.3 no.1
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• pp.85-96
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• 2002

Objectives : The purpose of this study is to get knowledge about osteopathy and to applicate the osteopathy to oriental medicine. Methods: We investigated several books and literatures on osteopathy related sites explored by internet to know the general theories and present conditions of osteopathy in Korea and other countries. Results & Conclusion : 1. The principles of osteopathy are as follows. First, the human being is a dynamic unit of function. Second, the body possesses self regulating mechanisms which are self healing in nature. Third, structure and function are reciprocally interrelated. Fourth, the body rational therapy is based upon knowledge and use of the above three principles. 2. Doctors of osteopathy evaluate the musculoskeletal system to identify structural problems and to support the body's natural tendency toward health and self healing. 3. We can applicate the osteopathy to oriental clinical medicine based on interpreting the principles of osteopathy.

• Safety and Health at Work
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• v.6 no.1
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• pp.9-17
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• 2015

The human hand is a complex structure that performs various functions for activities of daily living and occupations. This paper presents a literature review on the methodologies used to evaluate hand functions from a biomechanics standpoint, including anthropometry, kinematics, kinetics, and electromyography (EMG). Anthropometry describes the dimensions and measurements of the hand. Kinematics includes hand movements and the range of motion of finger joints. Kinetics includes hand models for tendon and joint force analysis. EMG is used on hand muscles associated with hand functions and with signal-processing technology.

• Journal of Institute of Control, Robotics and Systems
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• v.17 no.12
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• pp.1248-1255
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• 2011

In daily life, another major role of human hand is a communicative function using hand gestures besides grasp function. Therefore, if amputees can express their intention by the prosthetic hand, they can much actively participate in social activities. Thus, this paper propose myoelectric multi-function prosthetic hand which can express 6 useful hand gestures such as Rock, Scissors, Paper, Indexing, Ok and Thumb-up. It was designed as under-actuated structure to minimize volume and weight of the prosthetic hand. Moreover, in order to effectively control various hand gestures by only two EMG sensors, we propose a control strategy that the signal type are expanded as "Strong" and "Light", and hand gestures are hierarchically classified for the intuitive control. Finally, we prove the validity of the developed prosthetic hand with the experiment.

• Toxicological Research
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• v.26 no.3
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• pp.171-175
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• 2010

The human genome contains approximately 13 orphan cytochrome P450 (P450, CYP) genes, of which the apparent function or substrate has not been identified. However, they seem to possess their own biological relevance in some tissues or developmental stages. Here, we characterized the heterologously expressed CYP2W1, an orphan P450 enzyme. The recombinant CYP2W1 protein containing a $6{\times}$(His)-tag at Nterminus has been expressed in Escherichia coli and purified. Expression level of CYP2W1 holoenzyme was around 500 nmol P450 holoenzyme per liter culture medium. The reduced CO difference spectrum of CYP2W1 showed a maximum absorption at 449 nm. CYP2W1 indicated the significant induction to bioactivate Trp-P-1, MeIQ, and IQ in E. coli DJ701 tester strain. However, the bioactivation of B[$\alpha$]P, and NNK by CYP2W1 was relatively low. The model structure of CYP2W1 suggested the characteristic P450 folds with the lengths and orientations of the individual secondary elements. The F-G loop is situated on the distal side of heme to accommodate the flexibility of active site of CYP2W1. These studies can provide useful information for the finding of its biological roles and structure-function relationships of an orphan CYP2W1 enzyme.

• Applied Microscopy
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• v.48 no.1
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• pp.1-5
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• 2018

Cryo-transmission electron microscopy (cryo-TEM) allows us to perform structural analysis of a analyses of large protein complexes, which are difficult to analyze using X-ray crystallography or nuclear magnetic resonance. The most common examples of proteins used are ribosomes and proteasomes. In this paper, we briefly describe the advantage of cryo-TEM and the process of two-dimensional classification by considering a human proteasome as an example.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.10a
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• pp.532-538
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• 1998

In this paper, a new adaptive fuzzy inference method using neural network based fuzzy reasoning is proposed to make a fuzzy logic control system more adaptive and more effective. In most cases, the design of a fuzzy inference system rely on the method in which an expert or a skilled human operator would operate in that special domain. However, if he has not expert knowledge for any nonlinear environment, it is difficult to control in order to optimize. Thus, using the proposed adaptive structure for the fuzzy reasoning system can controled more adaptive and more effective in nonlinear environment for changing input membership functions and output membership functions. The proposed fuzzy inference algorithm is called adaptive neuro-fuzzy control(ANFC). ANFC can adapt a proper membership function for nonlinear plant, based upon a minimum number of rules and an initial approximate membership function. Nonlinear function approximation and rotary inverted pendulum control system ar employed to demonstrate the viability of the proposed ANFC.

• Biomedical Science Letters
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• v.20 no.3
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• pp.103-110
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• 2014

Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They are multidomain proteins and their activities are regulated by tissue inhibitor of metalloproteinases (TIMPs). The uncontrolled regulation of MMPs is involved in various pathologic processes, such as tumor invasion, migration, host immune escape, extravasation, angiogenesis, and tumor growth. Especially, matrix metalloproteinase-9 (MMP-9) is one of the metastasis-accelerating genes involved in metastasis of various types of human cancers. Here, we review the member of MMP family and discusses their domain structure and function, enzyme activation, the mechanism of inhibition by TIMPs. In particular, we focus the role of MMP-9 in relation to cancer metastasis.