• 동의신경정신과학회지
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• 제20권2호
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• pp.85-99
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• 2009

Objectives : This study aimed to understand the influence of acupuncture on the human body by comparing changes within human bodies before and after people in normal health are treated with acupuncture at the acupoints HT7 and PC9, which are related to mental functions. Methods : The study was performed from January 3, 2008 to March 5, 2008 on 60 healthy males and females in their 20s. HRV, EEG, skin conductance response, respiration and peripheral skin temperature were measured for 5 minutes before acupuncture simulation was applied to the acupoints HT7 and PC9. During 20 minutes of acupuncture treatment, the same items were continuously measured to determine whether there had been any changes, and they were then measured for 5 minutes after the removal of the acupuncture needles in order to implement a comparative analysis. Results : 1. The HRV measurement showed that in the course of before, during and after acupuncture stimulation, heart rate, HF and HF norm decreased significantly (P<0.05) at HT7. LF, LF norm, and LF/HF ratio increased significantly (P>0.05), while heart rate, HF and HF norm decreased significantly (P<0.05) at PC9. 2. Skin conductance response increased significantly (P<0.05) at PC9 during and after the acupuncture simulation periods, compared with the pre acupuncture period. 3. the peripheral skin temperature increased significantly (P<0.05) both at HT7 and PC9 in the course of before, during and after acupuncture stimulation. 4. Compared with the pre-acupuncture period, respiration rate increased both at HT7 and at PC9 during and after the acupuncture simulation periods, but not in a statistically significance. 5. In the EEG measurement, when compared with the pre-acupuncture period at HT7, mid ${\beta}$ wave decreased significantly (P<0.05) during acupuncture treatment. Compared with the measurements during acupuncture treatment at PC9, low ${\beta}$ wave increased significantly (P<0.05) after the acupuncture needles were removed. Conclusions : When acupuncture treatment is applied at the acupoints HT7 and PC9, the activation of parasympathetic nerves decreases and the activation of sympathetic nerves increases in the HRV measurement. It was determined that PC9 makes the sympathetic nerves become highly activated in a skin conduction response. The effect of stability in the brain wave seemed to bo shown at HT7 than PC9.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2307-2312
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• 2015

Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/ kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 추계학술대회
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• pp.484-487
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• 2014

본 논문에서는 근거리에서 심박동, 호흡, 맥박 등 인체 신호를 효율적으로 검출할 수 있는 소출력 안테나 특성에 대하여 분석하였다. 이러한 환경에서 안테나는 펄스 신호를 사용하므로 광대역에서 임피던스가 주파수에 안정적인 특성이 요구된다. 이러한 요구 특성은 이득과 trade-off 관계가 있으나 본 논문에서는 근거리에서 사용하므로 방향성 및 이득을 높이기 위한 어레이 형태는 고려하지 않았다. 일반적으로 이러한 요구 사항을 만족하는 안테나는 주파수 독립(Frequency Independent) 안테나로 분류된다. 스파이럴(spiral), 시뉴어스(sinuous), 대수 주기(log-periodic) 안테나 등이 해당되며 소형으로 구현될 수 있다. 본 논문에서는 중심 주파수가 5 GHz인 UWB 펄스 트랜시버에 원형 패치 안테나와 시뉴어스 안테나를 접속하고 시험한 결과를 분석해서 기술하였다.

• 한국생산제조학회지
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• 제23권3호
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• pp.299-309
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• 2014

When using an automotive heating, ventilation, and air conditioning (HVAC) system, we can obtain fresh outside air while maintaining the interior vehicle temperature. In this study, a correction equation considering experimental data for automotive indoor air leakage is defined to simulate the ratio of fresh air to recirculated air in the automobile cabin. With this correction equation, numerical results are compared with experimental data and validated. The $CO_2$ concentration in the automotive cabin is evaluated by considering various boarding conditions and mass flow rates of the HVAC system. The $CO_2$ concentration model derived in this study is expected to be used to control the effective air conditioning and become a basic research tool for automotive air quality control system development.

• Toxicological Research
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• 제18권3호
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• pp.215-226
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• 2002

Acute or repeated physical exercise affects a large number of physiological parameters including hemodynamics, respiration, pH, temperature, gastrointestinal function and biotransformation, which determine the pharmacokinetics of drugs and chemicals. The rate and the amount of a chemical reaching the active site are altered by physical exercise, which results in significant changes in pharmacolosical/toxicological activity of the chemical. This aspect of physical exercise has vast implication in therapeutics and in safety evaluation, particularly for chemicals that have a low margin of safety. However there appears to be a wide inter- and intraindividual variation in the effects of physical exercise depend-ing on the duration, intensity and type of exercise, and also on the properties of each chemical. It is suggested that more studies need to be done to determine which factor(s) plays a major role in the disposition of chemicals in human/animals performing physical exercise. Certain chemicals induce severe toxicity due to metabolic conversion to reactive intermediate metabolites. it is suggested that repeated exercise may enhance the free radical scavenging system by increasing the activity of antioxidant enzymes. This area of research remain to be explored to elucidate the interaction of exercise and chemical on the antioxidant system.

• Biomolecules & Therapeutics
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• 제6권4호
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• pp.406-411
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• 1998

The pre-mixed $_{13}C$-urea powder preparation in ${Helikit}_{TM}$ for test of Helicobacter pylori was evaluated for pharmacological properties. The oral doses of the preparation used in mice were 30-fold as compared to human doses. The results obtained in the present study demonstrate that spontaneous movement, hexobarbital-induced hypnosis, rotarod performance, body temperature, acetic acid-induced writhing syndrome, chemical and electroshock convulsion, pupil size and intestinal propulsion had not been affected at the oral doses of 230, 700 and 2100 mg/kg in mice. The blood pressure was slightly elevated as given intravenously in rats at a dose of 5 mg/kg of the preparation, but respiration was not influenced at the dose. In isolated guinea pig ileum and rat fundus preparation, the preparation at a concentration of $1{\times}10^{4}$ g/ml neither caused any direct effect nor inhibited the contraction produced by acetylcholine, histamine or 5-hydroxytryptamine. These results reported here provide evidence that pre-mixed $^{13}C$ 13/C-urea powder preparation is free of general pharmacological properties performed in oral administration.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.232-235
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• 1997

Apnea refers to episode of apnea (or not breathing) lasting more than 10 seconds that occur while sleeping. These episodes, whitch can occur hundreds of times per night, may transiently awaken resulting in fragmentation of sleep. Although the precise cause of Sudden Infant Death Syndrome(SIDS) are still unclear, there is evidence to suggest that hypoxaemia may be a contributory actor. Transcutaneous oxygen monitor can be used, but it is very difficult to use or baby stayed at home. In this reason, monitors whitch is easy or deal with are reqiured. In 1972, Steinschieder reported that two of the five infants noted to have apnea lasting or more than 20 seconds later died of SIDS episode, he also suggested that home monitoring or neonates should be used or managing apnea at home. Transthoracic electrical impedance technique is used or acquiring respiration waveform and detecting episode of apnea state. Transthoracic electrical impedance measurements have been made from the human trunk over the frequency range 9.6KHz to 614KHz. We conclude that application of impedance technique or detecting apnea state is proper or neonates.

• 환경위생공학
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• 제6권2호
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• pp.59-68
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• 1991

The word of stress was wsed in the field of physics as a external force from 17th century, but the meaning of this stress had chafed to the internal and exteral demand fort the human body in medical area. All the stumulants which make stress was called as j stressor. When animals get stress blucose excreted from liver to adapt for the emergent state ant some related hormone secrete convert protein and lipid to glucose for the purpose of energy supply to muscle. As a results heart rate, blood pressure, respiration rate are increased and musclse are strengthed. These physiolgical reactions ate controlled by autonomic nerve system under the control of hyothalamus in brain. Autonomic nerve system and endocrinary system are react harmoiously to stress reaction. According to the stress reaction, adrenomedullary system are stimulated, and epinephrine, morepinephrine are exceted. Author experimented the effect of the immobilizational stress to rat by analyzing the variaition of catecholamine secrction, the Na concentration and the effect of the antistresf effect by Panax Ginseng which is a traditional Korean herb medicine. The concentration of the norepinephrine, epinephrin, and dopamin in normal rat are 1 578 ng/ml, 0.365 ng/ml, and 0.731 ng/ml respectively, but in the immobilyzed stress groIn the concentration were increased to 1.915 ng.ml, 0.854 ng/ml, and 2,361 ng/ml which she the high show the higher concentration of catecholamine to stressor.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2004년도 Proceedings of 2004 Korea-Japan Joint Seminar on Particle Image Velocimetry
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• pp.125-134
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• 2004

The improvement of artificial respiration method has brought about the decrease in mortality of pulmonary diseases patients. Various respiratory curative methods, inclusive of HFOV (High Frequency Oscillatory Ventilation), have been developed for more effectual and less harmful management of acute respiratory failure. However, the mechanism of gas transfer and diffusion in a bronchiole has not yet been clarified in detail. As a first approach to the problem, we measured oscillatory flows in a Y-shaped micro-channels as bronchiole model by micro Particle Image Velocimetry(micro PIV). In order to establish the fundamental technique of PIV measurements on oscillatory air flow in a micro-channel, we used about 500-nm-diameter incense smoke particles, a diode laser, a high speed camera including an objective lens, and a HFOV, which is effective technique for medical care of pulmonary disease patients, especially, infants. The bronchiole model size is that parent tube is $500\{mu}m$ width and $500\{mu}m$ depth, and daughter tubes are $450\{mu}m$ width and $500\{mu}m$ depth. From this study made on the phenomenon of fluid in micro size bronchus branch of a lung, we succeeded to get time series velocity distribution in a micro scale bronchial mode. The experimental results of velocity distribution changing with time obtained by micro PIV can give fundamental knowledge on oscillatory airflow in micro-channel.

• 대한의용생체공학회:의공학회지
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• 제19권5호
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• pp.539-546
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• 1998

본 연구에서는 시각과 청각자극을 대표하는 색과 음악자극 하에서 인감의 감성을 정량적으로 평가하고 색감성과 음악감성 사이의 상관성을 조사하였다. 감성의 정량화를 위하여 7점 척도 20항목의 설문지를 통한 의미 미분법과 요인분석을 사용하여 피험자의 주관적 평가를 수행하였고, 뇌전도, 심전도, 피부 전도도, 호흡률 등의 생체신호를 측정, 분석하였다. 피험사의 주관적 평가로부터 각 자극에 대한 대표 감성어휘를 도출하였으며, 생체신호의 분석을 통하여 본 논문에서 제안한 정규화된 변수 값으로 색자극콰 음악자극에 대한 감성을 정량적으로 평가하여 지표화할 수 있었다. 또한 색자극과 음악자극 사이의 상관성을 Kendall의 상관계수로 분석한 결과 0.461에서 0.810의 상관성이 있음을 확인하였다. 본 연구에서 사용한 감성어휘 추출방법이나 감성지표 개발 방법은 감성제품 개발이나 색치료, 음악치료 등에 이용될 수 있다.