• Title/Summary/Keyword: Human research subjects

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Preparation of Lip Balm Utilizing Functionalities of Colorants Extracted from Marine Algae (해조류 추출색소의 기능성을 활용한 립밤 제조)

  • Choi, Min;Yoo, Dong Il;Shin, Younsook
    • Textile Coloration and Finishing
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    • v.26 no.2
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    • pp.124-130
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    • 2014
  • The aim of this study is to utilize the algae extracts with functionalities such as antioxidant and antimicrobial properties for preparing lip balm. Functional properties of extracts from Dictyota coriacea and Ulva pertusa were evaluated in terms of DPPH radical scavenging activity and antimicrobial activity. Lip balms contained the algae extracts were tested its efficacy by measuring the moisture retention of lip skin after applying human subjects. According to the results of skin moisture retention measurement, lip balm was effective to increase the moisture retention of lip skin. It is considered that the utilization of colorants extracted from algae which are verified of antioxidant effect and antimicrobial activity is valuable and useful in developing the cosmetic products.

Changes of Insulin-like Growth factor-I, II and IGF-Binding Protein-3 on Fasting and Postprandial state in Diabetes (당뇨환자의 식사 전후에 따른 혈중 Insulin-like growth factor(IGF-I), IGF-II 및 Insulin-like growth factor binding proteins(IGFBP)-3의 변화)

  • Heo, Young-Ran;Kang, Chang-Won;Cha, Youn-Soo
    • Korean Journal of Human Ecology
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    • v.9 no.1
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    • pp.81-88
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    • 2006
  • IGFs and IGFBPs have an important role in controlling glucose homeostasis. This study was conducted to investigate the changes of insulin-like growth factor(IGF)-I. IGF-II and IGF binding proteins (IGFBPs) on fasting and postprandial state in Korean diabetes, Twenty eight healthy subjects and fifty seven diabetic patients participated in this study. The healthy subjects were not knowingly suffered from any disease and were not receiving any medical treatment, and diabetic subjects were undergo medical treatment, continuously. Weight and height were measured and body mass index (BMI) was calculated as weight (kg) divided by the square of height (m2). Blood pressure was measured. Plasma lipid profiles were analyzed by enzymatic methods, plasma Insulin and glucose levels were measured in fasting and postprandial state, respectively. The levels of serum IGFs and IGFBP-3 were measured by radioimmunoassay (RIA). The levels of glucose and insulin were significantly higher in diabetes than normal subjects on fasting as well as postprandial state (p<0.0l). The levels of IGF-I was significantly lower in diabetes than normal subjects, however in postprandial state, there was no significant difference between diabetes and control subjects, The levels of IGF-II were significantly lower in diabetes than control subjects both fasting and postpradial state, The level of IGFBP-3 were not significantly different between diabetes and normal subjects. Fasting IGF-I, IGF-II and IGFBP-3 levels were positively correlated with those levels on postprandial state, fasting IGe levels of IGF-I levels were positively correlated with fasting insulin levels, and postprandial IGF-I levels were positively correlated with fasting glucose, postprandial insulin and postprandial insulin levels, plasma triglyceride levels were correlated with plasma triglyceride levels. The IGFBP-3 levels were not correlated with IGF components, glucose, insulin and plasma lipids, These results demonstrate that in diabetes, the components IGF-I/IGFBPs system were significantly correlated with plsma glucose and insulin levels both fasting and postprandial state.

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Evaluation on Skin Irritation of Bee Venom in Human (봉독의 인체 피부자극성 평가)

  • Han, Eun-Hye;Lim, Mi-Kyung;Lee, Sang Ho;Park, Keun-Tae;Park, Ji-eun;Lim, Young-Hee;Sim, Insuk
    • Korean Journal of Pharmacognosy
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    • v.48 no.3
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    • pp.202-207
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    • 2017
  • The purpose of this study was to investigate the skin irritation of bee venom (melittin) in human. Skin irritation test was performed at 0.05% bee venom by 48 h single patch test in 30 healthy volunteers with no skin disease and skin sensitization test was performed by local lymph node assay in animal. In single patch test, 28 human subjects showed no reaction and 2 subjects showed 1+ or 3+ grade skin reaction. In a skin sensitization test of bee venom conducted using mice. no erythema was observed on the dorsal side of mice up to 8 days after application of bee venom on the skin. The results of the average stimulation index by ATP values showed that there was no irritation to the mice skin at 0.005% and 0.01% of bee venom. Therefore, bee venom is not likely to induce a significant skin irritation under 0.05% concentration.

Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial

  • Yang, Yi;Wang, Hong;Zhang, Ming;Shi, Mengxue;Yang, Cailing;Ni, Qiang;Wang, Qi;Li, Jing;Wang, Xuemei;Zhang, Chen;Li, Zhi
    • Journal of Ginseng Research
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    • v.46 no.4
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    • pp.543-549
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    • 2022
  • Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue.

Analysis of Research in the Korean Journals of Play therapy (국내 놀이치료연구 동향 : 놀이치료 관련 학회지 게재논문 중심으로 (1997-2003))

  • Park, Soo-Young;Lee, Jae-Yeon
    • Korean Journal of Human Ecology
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    • v.14 no.1
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    • pp.47-57
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    • 2005
  • We conducted a content analysis of the researches published for a 7-year period (1997-2003) in the Korean Journal of Play Therapy (Korean Association for Play Therapy) and The Journal of Play Therapy (Korean Association of Psychological Rehabilitation for Children). Specifically, we analyzed a total of 156 articles for research contents, instruments, subjects, statistical analytic methods, and references. The results of the study are as follows: First, the principal areas of research activity and publication were specific theoretical review, personality, and adjustment research. Most outcomes, processes, and outcome researches were conducted in a form of case study. Second, typical samples contained 4 to 6 year old children or elementary schoolers. A lot of them were counseling center clients or normally adapted children. Third, 37% of the articles used ANOVA-related statistical analytic methods, and 35% of them used descriptive statistical analytic methods. Lastly, many articles averagely cited foreign references written 11 years prior to domestic references.

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The Effects of Leisure Constraints and Leisure Sufficiency of Late Middle-Aged Adults on Their Life Satisfaction (중년후기 성인이 지각하는 여가제약 및 여가충족이 생활만족도에 미치는 영향)

  • Park, Ji-Soo;Park, Kyung-Rhan
    • Korean Journal of Human Ecology
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    • v.18 no.3
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    • pp.689-703
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    • 2009
  • The purpose of this study is to investigate the relationships among 'leisure constraints', 'leisure sufficiency' and 'life satisfaction' perceived by late middle-aged adults. The subjects of this research were 275 adults from 50 to 64. The results are as follows: 1) Among 5 categories of 'leisure constraints', the subjects perceive' financial constraints' as the most important, and in order of importance, 'social constraints', 'physical constraints', and 'familial constraints' followed. 2) Among five 'leisure activities', a factor perceived most sufficiently by middle-aged adults is 'simple relaxation' and followed by 'social activities', 'activities with family'. 'learning activities', and 'play-recreation activities'. 3) The factors influencing life satisfaction perceived by late-middle aged adults are 'religion', 'financial constraints', 'education', 'familial constraints', 'physical constraints', 'learning activities', and 'play-recreation activities'. These 7 factors explain 38.9% of total variation. Also, the 'leisure constraints' has a greater impact on their 'life satisfaction' than on their 'leisure sufficiency'.

Types of Students' Death Attitudes Majoring in Human Service Area : Q-Methodological Approach (휴먼서비스 전공분야 대학생의 죽음태도 유형 -Q 방법론적 접근-)

  • Jo Kae-Hwa;Lee Hyun Ji;Lee Yun Ju
    • Journal of Korean Academy of Nursing
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    • v.35 no.5
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    • pp.829-841
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    • 2005
  • Purpose: The purpose of this study was to analyze death attitudes of students majoring In the human service area, such as nursing science, education, and social welfare. Method: The Q-methodology which provides a method of analyzing the subjectivity of each item was used, The 38 selected Q-statements from each of 42 subjects were classified into a shape of normal distribution using a 9 point scale. The collected data was analyzed using a QUANL PC program. Result: Four types of death attitudes for research subjects in nursing, education, and social welfare areas were identified. Type I is fatalistic admission, Type II is pursuit of existential life, Type III is uncertainty of life after death, and Type IV is separation-connection between life and death. Conclusion: The results of the study indicate that different approaches of death educational programs are recommended based on the four types of death attitudes.

Factors influencing Human Papillomavirus Vaccination intention in Female High School Students: Application of Planned Behavior Theory (계획된 행위이론을 적용한 여고생의 인유두종 바이러스 백신 접종 의도에 미치는 영향요인)

  • Sung, Min Hee;Sung, Mi-Hae
    • Women's Health Nursing
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    • v.24 no.1
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    • pp.71-79
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    • 2018
  • Purpose: The purpose of this study was to identify effects of attitude, subjective norm, and perceived behavior control toward Human Papillomavirus (HPV) on HPV vaccination intention in female high school students. Methods: Subjects of this study were female students aged 16 to 17 years, the optimal age group of HPV vaccination, arbitrarily selected from three high schools in B city. A total of 140 students agreed to participate in this study. Data were analyzed using descriptive statistics, t-test, ANOVA, correlation, and stepwise multiple regression. Results: Attitude, subjective norm, and perceived behavior control toward HPV were factors influencing HPV vaccination intention of subjects. Perceived behavior control toward HPV vaccination was the most influential factor. These factors accounted for 49% of HPV vaccination intention. Conclusion: These results suggest a need to increase perceived behavior control to increase HPV vaccination intention. The government needs to establish a national policy system such as financial support for HPV vaccines and free vaccinations so that students are aware that HPV vaccines can be easily inoculated.

Review of Biophoton of Human Beings - Domestic Papers (인체에서 방사되는 생물광자(生物光子)에 대한 소고)

  • Yi Seung-Ho;Kim Jin-Soo;Park Hi-Joon;Yang Joon-Mo;Soh Kwang-Sup;Lim Sabina
    • The Journal of Korean Medicine
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    • v.27 no.1 s.65
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    • pp.57-77
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    • 2006
  • Objectives : The purpose of this study is to review research papers published by Korean research groups on biophoton of human beings based on experiment subject and methodology. Methods : In order to review human biophoton research executed in Korea, all the papers published in Korean and international journals by Korean research groups were selected. Several key foreign papers were also reviewed for clarification of this study. Based on experiment subjects, experiment methodology, and interpretation of experiment results were analyzed. On each experiment, its original interpretation was directly quoted. Issues on the experiment methodology and interpretation were expressed at the end of each subject. Results and Conclusions : We found that experiments on human biophoton were compelling. However it seemed that more experiments, especially on their sample sizes, are needed to demonstrate its clinical application. Interpretations based on Korean traditional medicine also need to be elaborated more. In order to do accomplish clinical application of biophoton, interdisciplinary works are required. Some suggestions on biophoton experiments were made.

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