• 한국식품영양과학회지
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• 제36권1호
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• pp.27-31
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• 2007

한약에서 사용하는 유황은 인체에서 열을 발생하는 물질로서 분류되어 있다. 차전자(車前子), 창출(蒼朮), 백복령, 천궁(川芎) 등은 비만을 치료하는 한약재로 이용되고 있다. 본 연구에서는 유황을 주성분으로 하고 차전자(車前子), 창출(蒼朮), 백복령, 천궁 등의 한약재를 혼합한 항비산을 제조하였다. 항비산을 10%(w/w) 함유한 식이를 C57BL/6J ob/ob mice에 12주 동안 투여하고 체중, 간 조직 및 혈액 지질 조성에 미치는 효과를 조사하였다. 유황이 주로 함유된 항비산을 섭취하는 동안 실험동물의 건강상태는 양호하였다. 항비산을 일반 식이와 병행 공급시 cellulose가 갖는 정도의 체중 감소 효과를 나타냈고, 혈중 총 콜레스테롤이 감소하여 혈중 지질 조성을 개선시키는 작용이 있었다. 또한 실험동물의 간 기능에는 독성을 나타내지 않았다. 따라서 항비산의 임상실험 및 지질 조성 개선 효과에 대한 기전연구가 필요하지만 항비산은 비만인의 체중감량 및 지질 조성 개선에 이용될 수 있을 것으로 사료된다.

• Genomics & Informatics
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• 제20권1호
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• pp.4.1-4.8
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• 2022

Loss of heterozygosity (LOH) is a genomic aberration. In some cases, LOH can be generated without changing the copy number, which is called copy-neutral LOH (CN-LOH). CN-LOH frequently occurs in various human diseases, including cancer. However, the biological and clinical implications of CN-LOH for human diseases have not been well studied. In this study, we compared the performance of CN-LOH determination using three commonly used tools. For an objective comparison, we analyzed CN-LOH profiles from single-nucleotide polymorphism array data from 10 colon adenocarcinoma patients, which were used as the reference for comparison with the CN-LOHs obtained through whole-exome sequencing (WES) data of the same patients using three different analysis tools (FACETS, Nexus, and Sequenza). The majority of the CN-LOHs identified from the WES data were consistent with the reference data. However, some of the CN-LOHs identified from the WES data were not consistent between the three tools, and the consistency with the reference CN-LOH profile was also different. The Jaccard index of the CN-LOHs using FACETS (0.84 ± 0.29; mean value, 0.73) was significantly higher than that of Nexus (0.55 ± 0.29; mean value, 0.50; p = 0.02) or Sequenza (0 ± 0.41; mean value, 0.34; p = 0.04). FACETS showed the highest area under the curve value. Taken together, of the three CN-LOH analysis tools, FACETS showed the best performance in identifying CN-LOHs from The Cancer Genome Atlas colon adenocarcinoma WES data. Our results will be helpful in exploring the biological or clinical implications of CN-LOH for human diseases.

• 한국경영정보학회:학술대회논문집
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• 한국경영정보학회 2007년도 International Conference
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• pp.551-556
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• 2007

This paper attempts to develop a framework for interrelationships among human resources information systems (HRIS), outsourcing, and corporate culture. This research investigates impacts of outsourcing HRIS on corporate culture. In this paper, we hypothesize that outsourcing corporate HRIS is less appealing (1) if the quality of product and customer service matters for a firm, (2) if a firm is concerned with a loss of intellectual property, and (3) if a firm requires maintenance of a distinctive human resource service function that is capable of meeting the challenges of fast changing customer demands in a dynamic business environment. In addition, this study argues companies must be aware of the total costs associated with HRIS before outsourcing its human resource functions. Finally, the impact on employee morale and performance must also be considered By outsourcing HRIS, managers will be able to spend more time and resources dedicated to an employee's professional career development.

• 대한한의학회지
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• 제29권1호
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• pp.95-105
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• 2008

Objectives : Although herbal medicines containing flavonoids have been reported to exert anti-tumor activities, it has not been explored whether Hwang-Jeong (Polygonati sibirici Rhizoma, PsR) exerts anti-tumor activity in human glioma. The present study was therefore undertaken to examine the effect of PsR on cell viability and to determine its underlying mechanism in A172 human glioma cells. Methods : Cell viability was estimated by MTT assay. Reactive oxygen species generation and mitochondrial membrane potential were measured by the fluorescence dyes. The phosphorylation of kinases was evaluated by western blot analysis and caspase activity was estimated using colorimetric assay kit. Results : PsR resulted in loss of cell viability in a dose- and time-dependent manner. PsR did not increase reactive oxygen species (ROS) generation and the PsR-induced cell death was also not affected by antioxidants, suggesting that ROS generation is not involved in loss of cell viability. Western blot analysis showed that PsR treatment caused rapid reduction in phosphorylation of extracellular signal-regulated kinase (ERK) without changes in p38 and Jun-NH2-terminal kinase (JNK). U0126, an inhibitor of ERK, increased the PsR-induced cell death, but inhibitors of p38 and JNK did not affect the cell death. PsR induced depolarization of mitochondrial membrane potential. Caspase activity was not stimulated by PsR and caspase inhibitors did not prevent the PsR-induced cell death. Conclusion : Taken together, these findings suggest that PsR results in human glioma cell death through caspaseindependent mechanisms involving down-regulation of ERK.

• Restorative Dentistry and Endodontics
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• 제41권4호
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• pp.246-254
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• 2016

Objectives: The aim of this investigation was to give insights into the impact of carbohydrate-electrolyte drinks on the likely capacity of enamel surface dissolution and the influence of human saliva exposure as a biological protective factor. Materials and Methods: The pH, titratable acidity (TA) to pH 7.0, and buffer capacity (${\beta}$) of common beverages ingested by patients under physical activity were analyzed. Then, we randomly distributed 50 specimens of human enamel into 5 groups. Processed and natural coconut water served as controls for testing three carbohydrate-electrolyte drinks. In all specimens, we measured surface microhardness (Knoop hardness numbers) and enamel loss (profilometry, ${\mu}m$) for baseline and after simulated intake cycling exposure model. We also prepared areas of specimens to be exposed to human saliva overnight prior to the simulated intake cycling exposure. The cycles were performed by alternated immersions in beverages and artificial saliva. ANOVA two-way and Tukey HDS tests were used. Results: The range of pH, TA, and ${\beta}$ were 2.85 - 4.81, 8.33 - 46.66 mM/L and 3.48 - $10.25mM/L{\times}pH$, respectively. The highest capacity of enamel surface dissolution was found for commercially available sports drinks for all variables. Single time human saliva exposure failed to significantly promote protective effect for the acidic attack of beverages. Conclusions: In this study, carbohydrate-electrolyte drinks usually consumed during endurance training may have a greater capacity of dissolution of enamel surface depending on their physicochemical proprieties associated with pH and titratable acidity.

• 대한인간공학회지
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• 제22권1호
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• pp.31-42
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• 2003

This study describes a modification of the technique for human error analysis in nuclear power plants (NPPs) which adopts advanced Man-Machine Interface (MMI) features based on computerized working environment, such as LCOs. Flat Panels. Large Wall Board, and computerized procedures. Firstly, the state of the art on human error analysis methods and efforts were briefly reviewed. Human error analysis method applied to NPP design has been THERP and ASEP mainly utilizing Swain's HRA handbook, which has not been facilitated enough to put the varied characteristics of MMI into HRA process. The basic concepts on human errors and the system safety approach were revisited, and adopted the process of FMEA with the new definition of Error Segment (ESJ. A modified human error analysis process was suggested. Then, the suggested method was applied to the failure of manual pump actuation through LCD touch screen in loss of feed water event in order to verify the applicability of the proposed method in practices. The example showed that the method become more facilitated to consider the concerns of the introduction of advanced MMI devices, and to integrate human error analysis process not only into HRA/PRA but also into the MMI and interface design. Finally, the possible extensions and further efforts required to obtain the applicability of the suggested method were discussed.

• Journal of the Korean Wood Science and Technology
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• 제47권4호
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• pp.425-441
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• 2019

목재수피의 음향성능을 파악하고자 6가지 수종의 목재수피를 삭편으로 절삭하여 몇 가지 비중조건과 두께로 만든 후 흡음율과 음향투과손실을 전달함수법과 전달행렬법으로 각각 측정하였다. 그 결과, 편백나무수피가 두께 100 mm 일 때의 100-6400 Hz 평균흡음율은 0.90이며 두께 50 mm 일때의 100-6400 Hz 평균흡음율은 0.84이다. 특히 두께 100 mm 일 때의 경우, 1 KHz의 주파수영역에서의 흡음율은 약 100%에 근접하는 높은 흡음율을 나타내었다. 음향투과손실은 측정주파수범위에서 편백나무수피는 500 Hz에서 15.30 dB의 투과손실을 나타내었고 1000 Hz 수치는 15.73 dB이었다. 10 mm 두께의 합판을 수피파티클 배면에 추가한 후에는 투과손실이 20-30 dB 증가하였다. 목재수피는 친환경적이면서 기존의 석고보드보다 흡음율이 높고 음향투과손실이 크게 나타나서 음향성능이 우수한 건축재료로 고려될 수 있다고 생각된다.

• 대한본초학회지
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• 제36권3호
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• pp.39-46
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• 2021

Objectives : Mangifera indica leaves are well known for having a variety of benefits, including anti-inflammatory, anti-tumor, diabetic retinopathy and diabetic vasculosis. However, the effects of Mangifera indica leaves on hair loss inhibition have not been studied. In this study, we investigated to find out the activity of Mangifera indica leaves on hair loss. Methods : 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid(ABTS) analysis was performed to confirm the antioxidant efficacy of the water extract of Mangifera indica leaves (WEML). To examine the effect of WEML on cell viability in dermal papillar (DP) cells, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetra Zolium (MTS) analysis was performed. The changes in the mRNA expression level of the hair loss and hair growth-related genes in dermal papilla cells by WEML treatment were confirmed by quantitative RT-PCR. Results : In dermal papilla (DP) cells, ABTS analysis and MTS analysis of WEML showed antioxidant efficacy and low cytotoxicity. As a result of gene expression analysis through Quantitative RT-PCR, no changes in hair growth-related genes BMP6 and CTNNB1 was confirmed. but inhibitory activity of WEML on hair loss-related genes EGR1, SGK, DKK1, SRD5A1 and SRD5A2 was confirmed. Conclusion : We confirmed that WEML has excellent antioxidant efficacy and a inhibitory activity of hair loss-related genes including 5α-reductase genes. These results suggest that Mangifera indica leaves have a potential activity as a hair loss treatment for hair loss and hair growth. Biochemical or molecular biological research on hair loss is needed.

• 감성과학
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• 제26권3호
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• pp.101-114
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• 2023

반려동물은 점차 인간 삶의 중요한 동반자로 자리매김하고 있다. 이에 연구자들은 반려동물 상실과 이에 따른 애도에 주목하고 있다. 반려동물의 상실은 다른 상실과 달리 대개 그 부적응이 오래 지속되는 복합 애도로 나타나는 경우가 많다. 이러한 현상은 사람(vs. 반려동물)과의 관계가 더 중요하다는 사회적 인식에 기인하며, 이는 반려인이 자신의 상실 경험을 타인에게 제대로 이해받지 못한다고 여기게 만드는 일종의 '제약'으로 작용한다. 즉, 반려인의 지각된 사회적 제약은 이들의 반려동물 상실에 대한 회복을 저해하고 복합 애도를 유발하는 중요한 원인이 된다는 것이다. 따라서 본 연구는 반려동물의 죽음을 경험한 사람들을 대상으로 지각된 사회적 제약이 초기 상실 이후 적응을 방해함으로써 그 충격이 복합 애도로 이어지는 과정을 심화시킬 것이라고 가정하였다. 연구 결과, 예상대로 지각된 사회적 제약은 상실의 충격과 복합 애도의 관계를 조절하는 것으로 나타났다. 구체적으로, 반려동물 상실 충격으로 인한 복합 애도는 사회적 제약을 크게 지각할수록 더 강하게 나타나는 경향이 있었다. 본 연구는 반려동물 상실 경험과 애도를 이해하는 데 지각된 사회적 제약이 중요한 역할을 담당함을 보여줌으로써 사회적 인식 변화 및 개선의 필요성을 제안한다.

• 한국전자통신학회논문지
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• 제18권6호
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• pp.1321-1330
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• 2023

본 연구는 증강현실에서 적용할 캐릭터 생성에서 단일 이미지를 통해 여러 객체에 대한 3D 자세 추정 문제를 연구한다. 기존 top-down 방식에서는 이미지 내의 모든 객체를 먼저 감지하고, 그 후에 각각의 객체를 독립적으로 재구성한다. 문제는 이렇게 재구성된 객체들 사이의 중첩이나 깊이 순서가 불일치 하는 일관성 없는 결과가 발생할 수 있다. 본 연구의 목적은 이러한 문제점을 해결하고, 장면 내의 모든 객체에 대한 일관된 3D 재구성을 제공하는 단일 네트워크를 개발하는 것이다. SMPL 매개변수체를 기반으로 한 인체 모델을 top-down 프레임워크에 통합이 중요한 선택이 되었으며, 이를 통해 거리 필드 기반의 충돌 손실과 깊이 순서를 고려하는 손실 두 가지를 도입하였다. 첫 번째 손실은 재구성된 사람들 사이의 중첩을 방지하며, 두 번째 손실은 가림막 추론과 주석이 달린 인스턴스 분할을 일관되게 렌더링하기 위해 객체들의 깊이 순서를 조정한다. 이러한 방법은 네트워크에 이미지의 명시적인 3D 주석 없이도 깊이 정보를 제공하게 한다. 실험 결과, 기존의 Interpenetration loss 방법은 MuPoTS-3D가 114, PoseTrack이 654에 비해서 본 연구의 방법론인 Lp 손실로 네트워크를 훈련시킬 때 MuPoTS-3D가 34, PoseTrack이 202로 충돌수가 크게 감소하는 것으로 나타났다. 본 연구 방법은 표준 3D 자세벤치마크에서 기존 방법보다 더 나은 성능을 보여주었고, 제안된 손실들은 자연 이미지에서 더욱 일관된 재구성을 실현하게 하였다.