• Journal of Dairy Science and Biotechnology
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• 제33권3호
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• pp.223-229
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• 2015

Milk is a food with high nutritional value as it contains abundant water, proteins, vitamins, lactose, fat, minerals, enzymes, etc. However, in order to make milk suitable for intake, it should be thermally treated to eliminate microbiologically hazardous factors. Heat treatment is an essential sanitation process for milk, but various precautions must be taken in order to process and preserve it. Therefore, various techniques should be developed to minimize the nutrient loss and to ensure that milk is safe for consumption, conservation, and distribution. However, the existing thermal pasteurization methods are harmful and increase the nutrient loss; moreover, no new thermal pasteurization methods are being researched that are safe for the human health and minimize the nutrient loss. Hence, this study aims to review new processes for thermal (low temperatures) and no thermal pasteurization methods that can minimize the nutrient loss during milk pasteurization.

• BMB Reports
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• 제48권7호
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• pp.373-379
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• 2015

Humans have acquired many distinct evolutionary traits after the human-chimpanzee divergence. These phenotypes have resulted from genetic changes that occurred in the human genome and were retained by natural selection. Comparative primate genome analyses reveal that loss-of-function mutations are common in the human genome. Some of these gene inactivation events were revealed to be associated with the emergence of advantageous phenotypes and were therefore positively selected and fixed in modern humans (the "less-ismore" hypothesis). Representative cases of human gene inactivation and their functional implications are presented in this review. Functional studies of additional inactive genes will provide insight into the molecular mechanisms underlying acquisition of various human-specific traits. [BMB Reports 2015; 48(7): 373-379]

• 인지과학
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• 제30권3호
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• pp.157-174
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• 2019

인공 지능으로 인한 정체성 위협은 지능 과제에 대한 동기 및 수행을 저해할 수 있다. 본 연구는 실험기법을 활용하여 개인의 지능 과제 수행 저하 현상이 인공 지능으로 인한 위협에 노출됨으로써 나타나는지 조사하였다. 또한 본 연구는 집단 정체성 확인(group identity affirmation)이 과제 수행 저하 현상을 완화해줄 수 있는지 확인하였다. 구체적으로, 인공지능 위협이 높은 조건에서는 낮은 조건에서보다 지적 과제 수행이 낮을 것으로 예측하였다. 또한 이와 같은 수행 저하 효과는 집단 확인 조건에서 나타나지 않을 것으로 예측하였다. 대학생 참가자 210명을 대상으로 실험 연구를 시행하여 예상과 일관된 결과를 발견하였다. 인공지능으로 인한 정체성 위협은 참가자의 지적 과제 수행을 떨어뜨렸으며, 이와 같은 수행 저하 현상은 집단가치 비 확인 조건에서 발견됐지만 집단 가치 확인 조건에서는 발견되지 않았다. 논의에서는 이론적 실용적 함의를 다루었다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2006년도 추계학술대회
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• pp.19-24
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• 2006

Mothers against decapentaplegic homolog 4 (SMAD4) is a tumor suppressor gene associated with gastrointestinal carcinogenesis. The aim of the present study was to characterize more precisely its role in the development and progression of human gastric carcinoma. In this study, using tissue microarray analysis of 283 gastric cancers and related lesions, we found loss of SMAD4 protein expression in the cytoplasm (36/114, 32%) and in the nucleus (46/114, 40%) of gastric cancer cells. The loss of nuclear SMAD4 expression in primary tumors correlated significantly with poor survival, and was an independent prognostic marker in multivariate analysis. We also found a substantial decrease in SMAD4 expression at both the RNA and protein level in several human gastric carcinoma cell lines. To identify the genetic and/or epigenetic mechanisms of altered SMAD4 expression in gastric carcinoma, loss of heterozygosity (LOH), promoter hypermethylation, and exon mutations were examined. We found that LOH (20/70, 29%) and promoter hypermethylation (4/73, 5%) were associated with the loss of SMAD4 expression. SMAD4 protein levels wore also affected in certain gastric carcinoma cell lines following incubation with Mc132, a proteasome inhibitor. Taken together, our results indicate that the loss of SMAD4, especially loss of nuclear SMAD4 expression, is involved in gastric cancer progression. The loss of SMAD4 in gastric carcinomas is due to several mechanisms, including LOH, hypermethylation, and proteasome degradation.

• Nutrition Research and Practice
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• 제9권5호
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• pp.459-465
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• 2015

BACKGROUND/OBJECFTIVES: The effect of St. John's Wort extract (SJW) on MG-63 cell proliferation and trabecular bone loss induced by ovariectomy was examined. MATERIALS/METHODS: Proliferation, expression of estrogen receptor (ER) ${\alpha}$ and ER ${\beta}$, and gene expressions of osteoprotegerin (OPG), osteocalcin (OC) and alkaline phosphatase (ALP) were examined in MG-63 cells treated with or without SJW. Ovariectomized rats were treated with SJW at the dose of 100 or 200 mg/kg/day, ${\beta}$-estradiol-3-benzoate (E2), or vehicle only (OVX-C), and sham operated rats were treated with vehicle only (Sham-C). Serum ALP and C-telopeptide (CTX), and femoral trabecular bone loss were examined. RESULTS: SJW increased MG-63 cell proliferation and expression of ER ${\alpha}$ and ER ${\beta}$, and positive effect was shown on gene expressions of ALP, OC and OPG. SJW also showed estrogen like effect on bone associated with slowing down in trabecular bone loss. Histopathology by H&E showed rats treated with SJW displayed denser structure in metaphyseal region of distal femur compared with rats in OVX-C. SJW was shown to reduce serum CTX in OVX rats. CONCLUSION: The present study provides new insight in preventing estrogen deficiency induced bone loss of SJW and possibility for its application in bone health supplement.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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• 제2권2호
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• pp.123-133
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• 1998

As the results of investigation, the noise level was between 60 dB and 80 dB in the area of explosion. The residents living within 1 Km would feel uncomfortable. However, hearing loss is not happened by this range. The maximum range that the human can hear is 20,000 Hz and the maximum range that the dog can hear is between 20 Hz and 40,000 Hz. The auditory range for humans to be uncomfortable toward noise is between 1,000 Hz and 2,000 Hz. As the result of this experiment, the auditory range of dog is more wide than of a human. The change of hair cells in the Corti's organ occurred when the dog was exposed to 1,000 Hz at 100 dB for 1 month. Therefore, the structure change of the ear could happen by hearing loss because of noise, but the structure change of hair cells is the worst symptom by hearing loss because of noise.

• 전기학회논문지
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• 제64권2호
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• pp.349-352
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• 2015

This paper estimates electrical fire damage cost-effect to analyze electrical safety efficiency by applying a cost-benefit analysis method for analyzing the efficiency of a business public interest. Electrical fire loss statistics data was presented as direct costs and casualties, including deaths due to an electrical fire, this paper adds overhead "Incidental Cost of Accidents to the Employer" by W. H. Heinrich was applied to estimate the cost of economic loss. Also wounded, including the loss of human deaths by referring to the car accident insurance claims costs and human development estimated the losses caused by an electrical fire. And to perform a cost-benefit analysis of the electrical safety as a result of future work. In this paper, the economic effect of the electric field of safety and public interest work to systematically presented.

• Asian-Australasian Journal of Animal Sciences
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• 제19권2호
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• pp.266-272
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• 2006

Numerous reports have evaluated the predictive ability of carcass probes for meat quality using measurements taken early postmortem or near 24 h. The intervening time period, however, has been largely ignored. In this study, the capacity of three probes [pH, electrical conductivity (EC), and grading probe light reflectance (GP)] to predict pork longissimus muscle quality (drip and cooking losses, Warner-Bratzler shear, $L^*$, n = 30) was evaluated at 45 min, 90 min, 3, 6, 12, 24, and 48 h postmortem. The strongest relationships were observed between cooking loss and 6 h EC and GP ($R^2$ = 0.66, 0.72), and $L^*$ and GP ($R^2$ = 0.57-0.66, 12-48 h). pH was most valuable early postmortem ($R^2$ = 0.63, 90 min with cooking loss). GP at 6 h most effectively ($R^2$ = 0.84) predicted a two factor (cooking loss+$L^*$) meat quality index. Results emphasize the predictive value of measures taken between 3 and 12 h postmortem.

• Nutrition Research and Practice
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• 제8권5호
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• pp.571-579
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• 2014

BACKGROUND/OBJECTIVES: The objectives were to investigate the effect of a 12-wk intervention with behavioral modification on clinical characteristics and dietary intakes of young and otherwise healthy obese and to identify factors for successful weight loss. The goal was to lose 0.5 kg per week by reducing 300-500 kcal/day and by increasing physical activities. SUBJECTS AND METHODS: Forty four obese subjects (BMI > 25) and 19 normal weight subjects (BMI 18.5-23) finished the 12-week intervention. Obese subjects participated in 5 group educations and 6 individual counseling sessions. Normal weight subjects attended 6 individual counseling sessions for evaluations of dietary intake and exercise pattern. Anthropometric and clinical characteristics and 3-day dietary records were evaluated at baseline and week12. RESULTS: Weight and serum triglyceride and free fatty acid concentrations in obese group decreased significantly with intervention. Intakes of energy, fat, and cholesterol decreased significantly in the obese. Active participation, realistic weight loss goal setting, and weight gain after high school graduation not during childhood were identified as key factors for successful weight loss. CONCLUSIONS: The 12-week intervention with behavioral modification resulted in reduced energy and fat intakes and led to significant weight loss and improvements of clinical characteristics in the obese. The finding that those who became obese during childhood lost less weight indicates the importance of 'early' intervention.

• 한국전자파학회논문지
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• 제17권3호
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• pp.259-266
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• 2006

본 논문에서는 인체 모델 시뮬레이터를 이용해 인체 내부에 소스를 인가한 경우에 대한 전파 특성을 제시하였다. 시뮬레이터는 인체 캐드 및 조직 데이터로 구성된 인체 자료에 FDTD 기법을 적용하였다. 시뮬레이터에 대한 정확성을 검증한 후, 전계 소스가 소장 중앙에 인가된 경우에서 소화관 중 소장을 포함하는 수평층의 수신파를 계산하였다. 시뮬레이션 결과로부터 다양한 수신 지점에 대해 단위 길이 당 경로 손실을 구함으로써 인체전파 특성을 보였다.