• 여성건강간호학회지
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• 제1권2호
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• pp.260-274
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• 1995

In order to help the theory development for "women health", and to apply to the women client care, the concept analysis of "women health" was done. According to the concept analysis method by Walker & Avant, the characters of concept "women health" were analyzed from literature. The results were as followings : first, it emphasizes reproductive focused health care(childbirth-oriented) and normal development process regarded as abnormal. Second, it is affected by cultual environment. Third, it is related with sex. Forth, it considers the human, feminine and maternal aspects. Fifth, it need woman-centered nursing approach to promote woman's quality of life. Sixth, it stresses not only wholistic human health promotion but also the harmony between human and environment. Seventh, it is needed to be considered woman's various experiences as important and it approaches phenomenogically and interdisciplinary. Eighth, it needed to understands person-situation interactional aspect. Ninth, it can promote the adaptation power to surrounding environment. Above results can elucidate the concept of "women health", and will be a basis of theory development of "women health" In practical nursing, these results will be a basis for the promotion of women health and for the increase of life quality.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권2호
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• pp.71-79
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• 2013

The human-associated microbiota is diverse, varies between individuals and body sites, and is important in human health. Microbes in human body play an essential role in immunity, health, and disease. The human microbiome has been studies using the advances of next-generation sequencing and its metagenomic applications. This has allowed investigation of the microbial composition in the human body, and identification of the functional genes expressed by this microbial community. The gut microbes have been found to be the most diverse and constitute the densest cell number in the human microbiota; thus, it has been studied more than other sites. Early results have indicated that the imbalances in gut microbiota are related to numerous disorders, such as inflammatory bowel disease, colorectal cancer, diabetes, and atopy. Clinical therapy involving modulating of the microbiota, such as fecal transplantation, has been applied, and its effects investigated in some diseases. Human microbiome studies form part of human genome projects, and understanding gleaned from studies increase the possibility of various applications including personalized medicine.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.465-469
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• 2015

Background: Orostachys japonicus A. Berger (A. Berger) is commonly used as a folk remedy for cancer therapy. However, the mechanisms of its anti-cancer activity are poorly investigated in human cancer cells. In this study, we investigated whether flavonoids extracted from Orostachys japonicus A. Berger (FEOJ) might have anticancer effects in human leukemia cells, focusing on cell death mechanisms. Materials and Methods: U937 human leukemic cancer cells were used. Results: FEOJ induced apoptosis in a dose-dependent manner in human U937 cancer cells. Flow cytometry revealed significant accumulation of cells with sub-G1 DNA content at the concentrations of $200{\mu}g/mL$ and $400{\mu}g/mL$. FEOJ-induced apoptosis was caspase-dependent through loss of mitochondrial membrane potential (MMP, ${\Delta}{\Psi}m$) in human U937 cancer cells, which might be associated with suppression of Bcl-2 and XIAP proteins. FEOJ induced the p38 MAPK signaling pathway, playing at least in part an important role in FEOJ-induced apoptosis. Conclusions: This study suggested that FEOJ may induce caspase-dependent apoptosis in human leukemic cells by regulating MMP (${\Delta}{\Psi}m$) through suppressing Bcl-2 and X-IAP. In addition, the results indicated that upstream p38 MAPK signaling regulates the apoptotic effect of FEOJ. This study provides evidence that FEOJ might have anti-cancer potential for human leukemic cells.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2006년도 제33회 추계학술대회 발표논문집
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• pp.20-22
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• 2006

• BMB Reports
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• 제47권2호
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• pp.104-109
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• 2014

FAM176A (family with sequence similarity 176 member A) is a novel molecule related to programmed cell death. A decreased expression of FAM176A has been found in several types of human tumors in including lung cancers. In the present study, we investigated the biological activities of FAM176A on the human non-small cell lung cancer cell line H1299 cells. We constructed a recombinant adenovirus 5-FAM176A vector (Ad5-FAM176A) and evaluated the expression and anti-tumor activities in vitro. Cell viability analysis revealed that the adenovirus-mediated increase of FAM176A inhibited the growth of the tumor cells in a dose- and time-dependent manner. This inhibitory effect was mediated by both autophagy and apoptosis that involved caspase activation. In addition, cell cycle analysis suggested that Ad5-FAM176A could induce cell cycle arrest at the G2/M phase, all of which suggested that adenovirus-mediated FAM176A gene transfer might present a new therapeutic approach for lung cancer treatment.

• 한국치위생학회지
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• 제14권2호
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• pp.241-250
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• 2014

Objectives : The purpose of the study was to examine the ethical requirements for the protection of human subjects in the publication guidelines of dental health journals. Methods : The guidelines of 27 dental health journals were reviewed to determine ethical standards alone, with Helsinki Declaration, by an institutional review board (IRB), informed consent, protection of subject privacy and confidentiality, and no conflicts of interest. Results : 1. Dentistry journals listed on National Research Foundation of Korea had a conflict of interest disclosure provisions of the contribution(76.9%) and the IRB approval(61.5%). 2. Half of the dental health journals were not listed on National Research Foundation of Korea Society but they agreed the advance posting provisions. 3. Dental hygiene journals provide 100% of ethics alone and receive 75% of IRB in the papers. 4. Dental health and dental hygiene journals have conflicts of interest disclosure regulations(59.2%) and IRB approval(51.8%). 5. There existed statistically significant differences between the dental health journals whether they were listed on the human subjects and ethical standards for protection in National Research Foundation of Korea or not. Conclusions : While the publication guidelines of dental health journals have followed to a greater extent in recent years, there is still a need for further instructions to ensure that the authors satisfy all ethical requirements in conducting research on human subjects. IRB approval for dental journals must be standardized and reinforced reflecting the characteristics of each journals. The researchers should obey the code of ethics suitable for education and the editors must review the paper continuously.

• 한국융합학회논문지
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• 제12권9호
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• pp.169-178
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• 2021

우리는 곧 포스트 코로나 시대를 마주하게 될 것이다. 현재, 한국보건복지인력개발원에서 운영 중인 보건복지 인력 대상 직무교육 본래 목적 달성과 교육 일관성 유지를 위한 변화 혁신이 필요한 시점이다. 본 고에서는 보건·복지 직무교육 콘텐츠를 집적하여 효율적·효용성 있는 교육과정 운영을 위한 대안을 찾기 위해 국내·외 문헌고찰을 했다. 이를 통해 오픈 플랫폼 구축 가능성을 점검하고 충분한 대안으로서 제시할 수 있을 것으로 판단했다. 오픈 플랫폼의 수요자는 보건복지 서비스 인력(종사자), 전문가(교수, 관련기관 공직자, 전문가 등), 대상 국민, 관련 시민사회단체 등이다. 또한, 제공자(suppliers)는 강사진(연구자, 교수, 관련기관 공직자, 전문가 등), 보건복지개발원을 포함 보건복지 관련 공공기관이 될 것이다. 보건복지 부문 직무교육 오픈 플랫폼 구축을 통해 대상자의 교육 접근성과 학습관리시스템 운영이 가능하겠다, 무엇보다도, 교육 전문가의 업무 중복과 예산 효율화에 기여할 수 있을 것이라 기대한다.

• 동아시아식생활학회지
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• 제25권2호
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• pp.340-351
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• 2015

To investigate male office workers' dietary habits and their perception and intake of health functional foods, 234 male employees were surveyed by questionnaire. The results were categorized into three age groups: under 35 years, 35 and 45 years, and over 45 years. The over 45 years group had significantly better dietary habits than the others (p<0.05). The most common reason for skipping breakfast was lack of time. Frequency of drinking alcohol was higher in the older group, where tiredness after drinking was lower in the younger group. The perception score of health functional foods was highest in the over 45 years group. Perception of health functional foods was more positive as the age of the groups increased (p<0.01). The number of health functional foods consumed, duration of intake, and beneficial health effects were higher in older groups. Although older people are more concerned about health than relatively younger people, they did not necessarily have reduced the amounts of smoking and drinking. Instead, they simply showed higher intakes of health functional foods to prevent and cure disease and improve their health. Therefore, older people need to receive education about their dietary and living habits instead of simply eating health functional foods. It is necessary to provide correct information about health functional foods by nutritional education.

• 한국재난정보학회 논문집
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• 제3권2호
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• pp.129-146
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• 2007

The disaster preparedness system in Korea has been developed in spite of many obstacles, but there are still many problems for response to various kinds of disasters in 21th century. Disaster response system in Korea was focused on policy, administration, hardwares in the past. But in the future it is necessary to change the system to adapt the global needs about the human based disaster response system and capacity to assist the international disaster by official assistance and research for that field. Because nearly all the disasters are associated with the safety, welfare, injury, disability and survival of human, health disaster preparedness and response system should be a important part in the whole disaster system considering the common value of human right to disaster preparedness for human.

• 지역사회간호학회지
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• 제9권2호
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• pp.441-457
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• 1998

The purpose of this study is to provide fundamental information for the development of new sex education image media through the analysis of those tools produced by Planned Parenthood Federation of Korea. Twenty three video tapes related to the sex education were analysed. The data were sampled on the basis of the sex education instructions for primary and secondary schools published by the Seoul Office of Education in 1996 and the list of sex education information composed by the Planned Parenthood Federation of Korea with the following requirements. 1) The education materials are oriented to the middle and high school students as well a juveniles and are being used in public health centers and schools. 2) The education materials are not confined to the single subject such as AIDS or contraception. Because this study is focused on the analysis of image media, an analysis method widely and effectively used in public media study was chosen. The frequency analysis and percentage treatment were done by an SAS program. The results of the study are as follows : 1. An analysis of the material structure type showed that the frequency of the following subjects in 15 video tapes, composed as drama and cartoon, had this decreasing orde : sex behavior, sex relation ships, sex health, human development, personal technique, and society and culture. 2. The eight tapes of explanation and counseling showed a different sequence from that of the drama and cartoon material, primarily treating human development with 5419 seconds (47.9%) of type. The following were also considered in decreasing order: at 2000seconds (17.6%) sex behavior, at 1366 seconds (12.1%) sex health, at 1240 seconds (11.0%) society and culture, at 667 seconds (6.0%) relation ships, and at 611 seconds (5.4%) personal technique. 3. In a thematic analysis those education materials dealing with human development show this frequency sequence: anatomic physiology, reproduction, and adolescence. In relation, ships the sequence is dates, love, marriage and vows, and family. For personal technique, it is expressed as asking for help, and an empnasis on moral values. For sex behavior, they focus on abstinence, the co-responsibility of sex behavior, the sexual response of the human, and sexual nightmares. For the sex health area, the focus is contraception with abortion and reproductive health following that. In society and culture diversity is considered. 4. An analysis of the differences in production and content between 1980s and 1990s was also done. For materials produced in the 1980s the frequency of the subjects follows this order: sex behavior, human development, relation ships, sex health, personal technique, and society and culture with sub subjects such as abstinence, dating, adolescence, anatomic physiology, reproduction, calls for help, and the sexual response of a human being. For materials produced in the 1990s, highest frequency was sex behavior, the same as the 1980s. The rest of the material follows this decreasing order: relationships, human development, sex health, society and culture, and personal technique with sub subjects such as dating, co-resposibility in sex behavior, abstinence, and love frequently considered.