• Nuclear Engineering and Technology
• /
• 제55권3호
• /
• pp.801-813
• /
• 2023

The events at Three Mile Island in the United States brought about fundamental changes in the ways that simulation would be used in nuclear operations. The need for research simulators was identified to scientifically study human-centered risk and make recommendations for process control system designs. This paper documents the human factors research conducted at the Human Systems and Simulation Laboratory (HSSL) since its inception in 2010 at Idaho National Laboratory. The facility's primary purposes are to provide support to utilities for system upgrades and to validate modernized control room concepts. In the last decade, however, as nuclear industry needs have evolved, so too have the purposes of the HSSL. Thus, beyond control room modernization, human factors researchers have evaluated the security of nuclear infrastructure from cyber adversaries and evaluated human-in-the-loop simulations for joint operations with an integrated hydrogen generation plant. Lastly, our review presents research using human reliability analysis techniques with data collected from HSSL-based studies and concludes with potential future directions for the HSSL, including severe accident management and advanced control room technologies.

• 한국지능시스템학회논문지
• /
• 제14권5호
• /
• pp.635-641
• /
• 2004

A human-friendly interactive system that is based on the harmonious symbiotic coexistence of human and robots is explored. Based on interactive technology paradigm, a robotic cane is proposed for blind or visually impaired travelers to navigate safely and quickly through obstacles and other hazards faced by blind pedestrians. Robotic aids, such as robotic canes, require cooperation between human and robots. Various methods for implementing the appropriate cooperative recognition, planning, and acting, have been investigated. The issues discussed include the interaction of human and robot, design issues of an interactive robotic cane, and behavior arbitration methodologies for navigation planning.

• STI Policy Review
• /
• 제1권2호
• /
• pp.1-18
• /
• 2010

The development and maintenance of human capacity in economies is critical to long term competitiveness, but also for the overall health and environment of regions. Yet, human science and technology-based capacity is multidimensional and has interrelated characteristics which present certain policy challenges. This paper addresses a range of issues specific to a discussion on human capacity in S&T. First, the paper emphasizes the importance of acknowledging the complexity of human capacity issues and how they evolve along the STEM (science, technology, engineering, and mathematics) pipeline. The pipeline is an often used reference to describe the training and development in STEM disciplines, from early childhood education, to more advanced training, and finally to professional collaboration and interaction and serves as a useful organizing framework for the discussion of capacity along the career evolution process. Second, the paper offers an organizing framework for discussion of policy mechanisms that have been developed to address issues and gaps that occur along this STEM pipeline. Specifically, it contrasts the traditional mechanisms of building human capacity in STEM areas with newer "gap filling" and integrated approached to addressed human capacity disparities and priorities. Third, the paper addresses core challenges in human capacity in STEM, including the education and training, participation of women and underrepresented groups, brain drain/brain circulation issues, and the globalization of science. The paper concludes with a discussion of policy implication for the development of human capacity.

• 도서관문화
• /
• 제18권5호
• /
• pp.19-27
• /
• 1977

이 글은 Glynn Harmon이 Annual Review of Information science and Technology (The American Society for Information Science: Vol. 11, 1976, pp.347-380)에 발표한 ‘Information Science Education and Training'을 지면상 초역한 것이다. Harmon 교수는 현재 Texas대학 대학원에서 연구방법론과 정보과학을 강의하고 있으며, ’On the Evolution of Information Science(1971)' 'Human Memory and Knowledge : A System Approach (1973)' 'The Invisible Manpower Market for Information Scientists 91975)' 등의 논문을 발표하였다.

• 기술혁신연구
• /
• 제31권2호
• /
• pp.29-58
• /
• 2023

대학은 끊임없이 새로운 지식을 만들고 기술혁신을 통하여 가치를 생산하는 핵심 기관이다. 본 연구에서는 삼중나선모델(Triple Helix Model)의 변화와 진화를 제시하고자 한다. 이를 위해 선진기술의 습득과 소화, 개선과 추월을 통한 과정에 요구되었던 다양한 인력양성 육성과 정책분석의 질적연구를 활용하였다. 1960년대는 기능공과 기술공 위주로 기능적역량이, 1980년대와 1990년대는 대학원제도가 정착, 고급 인력양성과 함께 정부주도의 대학-기업연구소와의 Triple Helix Model (THM) 혁신활동에 필요한 기능과 기술역량의 인력양성이 강조되었다. 2000년대는 첨단·신산업에 요구되는 창의적 인재양성으로 진화하였고 대학 중심 THM이 본격적으로 추진되는 연구역량이 요구되었고 2010년 이후 창의와 융합역량의 인력양성 방향성을 대학스스로 결정하는 큰 변화로 진화하였고, 이에 본 연구에서는 창조와 융합 인력양성의 지속적 수행을 위한 혁신모델로 '삼중나선싱크로시나리오모델'을 제시한다. 대학은 자유롭게 문제를 찾아내고 정부는 신기술을 위한 지원과, 개인경험과 기업문제를 하나의 시나리오로 엮어 이를 해결하고자 하는 도전의 장이 되어 끊임없는 혁신을 견인해야 한다.

• Animal cells and systems
• /
• 제5권3호
• /
• pp.231-236
• /
• 2001

SINE-R retroposons have been derived from human endogenous retrovirus HERV-K family and found to be hominoid specific. Both SINE-R retroposons and HERV-K family are potentially capable of affecting the expression of closely located genes. From cDNA library of human fetal brain, we identified seven SINE-R retroposons and compared them with sequences derived from GenBank database. The SINE-R retroposons from human feta1 brain showed 85∼97% sequence similarities with the human-specific retroposon SINE-R.C2. They also showed 88∼96% sequence similarities with the sequence of the schizo-cDNA clone that derived from postmortem frontal cortex tissue of a schizophrenic patient. Phylogenetic analysis using the neiqhbor-joining method revealed that the seven new SINE-R retroposons from cDNA library of the human feta1 brain have proliferated independently during human evolution. The data indicate that such SINE-R retroposons are expressed in human fetal brain and deserve further investigation as potential leads to understanding of neuropsychiatric diseases.

• Asian Journal of Innovation and Policy
• /
• 제12권2호
• /
• pp.261-267
• /
• 2023

In the paper of 'Natural Selection Favors AIs over Humans,' Dan Hendrycks applies principles of Darwinian evolution to forecast potential trajectories of AI development. He proposes that competitive pressures within corporate and military realms could lead to AI replacing human roles and exhibiting self-interested behaviors. However, such claims carry the risk of oversimplifying the complex issues of competition and natural selection without clear criteria for judging whether AI is selfish or altruistic, necessitating a more in-depth analysis and critique. Other studies, such as ''The Threat of AI and Our Response: The AI Charter of Ethics in South Korea,' offer diverse opinions on the natural selection of artificial intelligence, examining major threats that may arise from AI, including AI's value judgment and malicious use, and emphasizing the need for immediate discussions on social solutions. Such contemplation is not merely a technical issue but also significant from an ethical standpoint, requiring thoughtful consideration of how the development of AI harmonizes with human welfare and values. It is also essential to emphasize the importance of cooperation between artificial intelligence and humans. Hendrycks's work, while speculative, is supported by historical observations of inevitable evolution given the right conditions, and it prompts deep contemplation of these issues, setting the stage for future research focused on AI safety, regulation, and ethical considerations.

• 생명과학회지
• /
• 제14권6호
• /
• pp.1028-1039
• /
• 2004

6500만년동안, Alu 서열은 RNA-중합효소 III에 의한 전사체를 통해 증폭해왔고, 영장류 게놈 내에 약 140만 복사의 수에 도달되었다. 그들은 가동성 인자 중에서 가장 큰 집단이며, 인간 게놈의 $10\%$를 구성한다. Alu 서열이 유전적으로 기능이 없다고 생각되었지만, 최근 많은 연구자들이 새로운 기능 및 질병과의 관련성을 증명해왔다 이들 Alu 서열은 삽입돌연변이, Alu-매개 재조합, 유전자 발현에 대해 유전자 전환 그리고 스플라이싱 사이트를 유발하고, 유전자 구조, 단백질 서열, 스플라이싱 모티프와 발현 양상에 영향을 준다. 우리는 Alu의 구조와 기원, 그들 패밀리의 컨센서스 서열, Alu의 진화와 분포 그리고 그들의 기능에 대하여 요약 정리하였다. 또한 영장류의 진화과정에 있어 질병과 관련하여 Alu 패밀리의 새로운 연구방향을 제시하였다.

• 기술혁신연구
• /
• 제23권3호
• /
• pp.21-42
• /
• 2015

2년마다 실시되는 UN의 전자정부시스템 평가에서 한국의 전자정부 시스템은 2010, 2012, 2014년 3차례 걸쳐 1위로 평가되었다. 1978년 시작되어 이제는 해외로 수출까지 되는 한국 전자정부 시스템의 진화에 있어서 표준의 역할에 대해서는 그다지 알려진 바가 없다. 한국의 전자정부 시스템 발전에 어떠한 표준들이 어떠한 역할을 수행했으며, 이러한 표준이 제대로 기능하기 위하여 어떠한 제반 환경이 필요하고, 어떠한 노력이 경주되었는지 사례 연구를 수행하여 밝히고자 한다. 행위자 연결망 이론(Actor Network Theory)과 구조화 이론(Structuration theory)을 이론적 기반으로 하여, 표준이 행위자 연결망 이론 관점에서 어떠한 역할을 수행해 왔는지를 전자정부 시스템 발전에 직접 관여되었던 행정자치부 전자 정부담당 현/전직 관리자급 공무원, 표준담당관, NIA 표준 담당관, 민간 SI 업체 등 관련 전문가(관리자급)분들과의 인터뷰와 문헌 연구를 바탕으로 사례 분석을 실시하고자 한다.

• Molecules and Cells
• /
• 제37권7호
• /
• pp.540-546
• /
• 2014

Several types of genetic and epigenetic regulation have been implicated in the development of drug resistance, one significant challenge for cancer therapy. Although changes in the expression of non-coding RNA are also responsible for drug resistance, the specific identities and roles of them remain to be elucidated. Long non-coding RNAs (lncRNAs) are a type of ncRNA (> 200 nt) that influence the regulation of gene expression in various ways. In this study, we aimed to identify differentially expressed lncRNAs in 5-fluorouracil-resistant colon cancer cells. Using two pairs of 5-FU-resistant cells derived from the human colon cancer cell lines SNU-C4 and SNU-C5, we analyzed the expression of 90 lncRNAs by qPCR-based profiling and found that 19 and 23 lncRNAs were differentially expressed in SNU-C4R and SNU-C5R cells, respectively. We confirmed that snaR and BACE1AS were down-regulated in resistant cells. To further investigate the effects of snaR on cell growth, cell viability and cell cycle were analyzed after transfection of siRNAs targeting snaR. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. Our results provide an important insight into the involvement of lncRNAs in 5-FU resistance in colon cancer cells.