• Journal of Yeungnam Medical Science
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• 제17권1호
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• pp.1-11
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• 2000

Inhibition of cyclooxygenase(COX), and thus prevention of the formation of prostaglandins, provided a unifying explanation of the therapeutic and toxic actions of nonsteroidal anti-inflammatory drugs (NSAIDs). Recently, the discovery of the two isoforms of COX was made by molecular biologists studying neoplastic transformation in chick embryo cells. The constitutive enzyme, COX-1, is obviously responsible for the production of prostaglandins involved in housekeeping functions such as maintenance of integrity of the gastric mucosa, renal blood flow and platelet aggregation. The inducible form of COX (COX-2) is responsible for the formation of prostaglandins that pathologically affects inflammation, pain and fever. Clearly, all the experimental and clinical data support the hypothesis that the beneficial effects of NSAIDs are due to inhibition of the COX-2 enzyme, whereas the gastrotoxicity is due to inhibition of COX-1. The cox-2/COX-1 ratios of the NSAIDs in common use have been measured and compared with epidemiological data on their side effects. There is little evidence to suggest that one NSAID is clearly more effective than another, But substantial individual variability is present with respect to the pharmacology and pharmacokinetics of these drugs: therefore it is essential to adjust the dosage and choose specific drug to the patient's response.

• Fisheries and Aquatic Sciences
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• 제14권4호
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• pp.303-310
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• 2011

We characterized a cytoplasmic actin gene locus in greenling Hexagrammos otakii (Scorpaeniformes). Genomic clones isolated from the greenling DNA library contained two homologous cytoplasmic actin gene copies (HObact2.1 and HObact2.2) in a tail-to-head orientation. Their gene structure is characterized by six translated exons and one non-translated exon. Exon-intron organization and the nucleotide sequences of the two actin gene isoforms are very similar. However, only the HObact2.1 isoform contains microsatellite-like, dinucleotide repeats in the 5'-flanking region (named HOms2002) and intron 1 following the non-translated exon 1 (named HOms769). One microsatellite locus (HOms769) was highly polymorphic while the other (HOms2002) was not. Based on bioinformatic analysis, different transcription factor binding motifs are related to stress and immune responses in the two actin isoforms. Semiquantitative and real-time reverse transcription-PCR assays showed that both isoform transcripts were detectable ubiquitously in all the tissues examined. However, the basal expression levels of each isoform varied across tissues. Overall, the two isoforms showed a similar, but not identical, expression pattern. Our data suggest that the cytoplasmic actin genes may be the result of a recent duplication event in the greenling genome, which has not experienced significant subfunctionalization in their housekeeping roles.

• Journal of Astronomy and Space Sciences
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• 제13권2호
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• pp.30-40
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• 1996

우리별 1,2호의 원격명령부는 지상의 지구국, 또는 위성내 부 컴퓨터로부터 위성의 각부분을 제어하는 명령을 수신하여 적절한 전기적인 신호로 해당 부분에 전달하는 역할을 한다. 원격검침부는 위성의 건강 상태나 운영 상태를 나타내는 각종 정보를 취합하여 지상으로 전달하는 역할을 한다. 원격 검침 및 명령부를 이용하여 위성내의 나머지 부분들을 제어할 수 있으며, 또한 동작 상태를 측정할 수 있으므로 위성내의 어느 시스템보다도 높은 신뢰도가 요구되는 시스템이다. 특히, 저궤도 소형위성이라는 특수한 상황을 고려하여 설계되었으며, 위성 시스템의 전체 구성이 효율적으로 이루어질 수 있도록 개발되었다. 우리별 1, 2호는 1992년 8월과 1993년 9월에 각각 발사되어 지금까지 성공적으로 운용되고 있으며, 탑재된 원격검침 및 명령부도 정상적인 동작을 하고 있다.

• Molecules and Cells
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• 제19권3호
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• pp.334-341
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• 2005

Plants are sessile and rely on a wide variety of growth hormones to adjust growth and development in response to internal and external stimuli. We have identified a gene, designated NAN, encoding a basic helix-loop-helix (bHLH) transcription factor that regulates cell elongation and seed germination in plants. NAN has an HLH motif in its C-terminal region but does not have any other discernible homologies to bHLH proteins. A bipartite nuclear localization signal is located close to the HLH motif. An Arabidopsis mutant, nan-1D, in which NAN is activated by the insertion of the 35S enhancer, exhibits growth retardation with short hypocotyls and curled leaves. It is also characterized by reduced seed germination and apical hook formation, symptomatic of GA deficiency or disrupted GA signaling. The phenotypic effects of nan-1D were increased by treatment with paclobutrazol (PAC), an inhibitor of gibberellic acid (GA) biosynthesis. NAN is constitutively expressed throughout the life cycle. Our observations indicate that NAN has a housekeeping role in plant growth and development, particularly in seed germination and cell elongation, and that it may modulate GA signaling.

• 대한가정학회지
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• 제36권9호
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• pp.153-166
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• 1998

In this study commuter marriage was defined as a family in which working husband and wife, who have professional job having family orientation and job orientation, come and go lived separately for more than days a week for working in different region. This study examined the determinants of living separately the merits and demerits of commuter marriage, relation with family, family finance and household work for twelve case wives fitted for above definition, and the findings are as the following. The main cause of commuter marriage was wife's work place. The merits of commuter marriage were that wives can devote to their own increased time and that they had fresh feeling to their husbands. The demerit were mental burden to mother-in-laws and their mothers who take charge of home management and the high cost of living for double housekeeping. In the area of relation with family, they and their husbands call above one time per day for communication although they live separately for three or four days, do not insist on norms of living together, and overcome difficulties of commuter marriage well. In the area of family six couples used allowances method. They have high living cost like traffic expenses, telephone charges, and housing expenses because of double living. In the area of household work, they mainly manage family life with the help of household helpers like mother-in-laws or their own mothers.

• 한국양식학회지
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• 제22권1호
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• pp.51-55
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• 2009

Transcriptional response of the second isoform of glyceraldehyde (GAPDH-2) to infectious challenges using various bacterial species and the rockbream iridovirus (RBIV) was examined in the spleen of the barred knifejaw (Oplegnathus fasciatus). Bacterial challenges of the juvenile barred knifejaws with Escherichia coli, Edwardsiella tarda, Vibrio anguillarum and Streptococcus iniae resulted in the significant elevation of the GAPDH-2 transcripts in the spleen up to 12-fold relative to that in the non-challenged controls (PBS-injected). In addition, the barred knifejaw fingerlings injected with RBIV stock also represented the highly upregulated mRNA expression of the GAPDH-2 up to more than 20-fold when compared to that of control fingerings. Results obtained from this study strongly suggest that the GAPDH-2 is no longer a housekeeping glycolytic protein and rather than that it might be associated with immune-relevant cellular activities. From this finding, the traditional dogma for the use of GAPDH as an invariant standard for gene expression assays should be carefully revised depending on the kinds of biological stimulations applied in this species.

• 조명전기설비학회논문지
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• 제26권3호
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• pp.1-8
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• 2012

This study investigated current status of lighting environment, residents' awareness of lighting and lighting use according to behavior in the living room of apartment to determine current lighting trends and their related problems. The living rooms of newly-built apartment units(133~165[$m^2$] and larger than 166[$m^2$] within the past five years) were examined. The results are summarized as follows. 1. Resident satisfaction with current living room lighting was the highest in 'illumination' and the lowest was 'energy savings' regardless of the size of living room. 2. This kind of ceiling lighting layout, 133~165[$m^2$] unit used central lighting and larger than 166[$m^2$] units used central lighting and cove lighting. Regarding light sources, 133~165[$m^2$] linear FL, halogen, larger than 166[$m^2$] bulb-type FL are widely used. LED are now being found in the living room corridor and kitchen walls of newly-built apartment houses. 3. Watching TV and reading books were commonly behaved in the living room. Conversations between family, having desserts, resting, housekeeping, and entertaining were usually done weekdays, while having desserts and conversations between family were done weekends. Use of lighting as main behaviors is properly and differently required due to the distinct uses of lighting as residents' behaviors or their life style.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2004년도 추계학술발표대회 논문집
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• pp.157-158
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• 2004

In this study, we try to understand the present condition of elderly housing facilities in Contra Costa County, California, USA. We got the basic information of 92 facilities through the interview with the chief of elderly housing department in Contra Costa County, California. In practical way of research, this study bears various components of the elderly housing facilities, which are type of facility, financial aids, type of apartment, and provided living services. The short summerising of researches are; The present conditions of elderly housing facilities can be classified as Independent Living(53), Congregate Housing(23), Assisted Living(33), Dementia Care(12). The financial aid conditions are shown like SSI, HA, HUD. The types of apartment are studio type, 1 bedroom type, 2 bedroom type. These facilities provides meals, housekeeping, transportation, small pets. As a result of studying the present condition of elderly housing facilities in Contra Costa County, we propose the basic statistical report on the most general type of housing, financial aids, type of services that people of the states want to get.

• Genomics & Informatics
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• 제2권2호
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• pp.92-98
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• 2004

A cDNA microarray experiment is one of the most useful high-throughput experiments in medical informatics for monitoring gene expression levels. Statistical analysis with a cDNA microarray medical data requires a normalization procedure to reduce the systematic errors that are impossible to control by the experimental conditions. Despite the variety of normalization methods, this. paper suggests a more general and synthetic normalization algorithm with a control gene set based on previous studies of normalization. Iterative normalization method was used to select and include a new control gene set among the whole genes iteratively at every step of the normalization calculation initiated with the housekeeping genes. The objective of this iterative normalization was to maintain the pattern of the original data and to keep the gene expression levels stable. Spatial plots, M&A (ratio and average values of the intensity) plots and box plots showed a convergence to zero of the mean across all genes graphically after applying our iterative normalization. The practicability of the algorithm was demonstrated by applying our method to the data for the human photo aging study.

• 동서간호학연구지
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• 제11권2호
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• pp.116-123
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• 2005

Purpose: The purpose of this study was to analyze the influencing factors on adolescent's self-efficacy. Method: This was a descriptive study. The data were collected from 7th through 12th graders(N=1710) enrolled in middle schools(N=873) and high schools(N=837) in the metropolitan area of Daegu. The instruments had used for this study were the self-efficacy, the life event checklist, and Family APGAR. The data were analyzed using frequency, t-test, Pearson correlation coefficient, and multiple regression analysis. Result: Pearson correlation analysis revealed that there were negative correlations between the self-efficacy and the stress. However, in case of the subjects who recorded higher scores at self-efficacy they showed higher scores at family function. Stepwise multiple regression analysis revealed that powerful predictors of adolescent's self-efficacy were family function and relations of schoolmate. Conclusion: From these results, we can find that the family function and relations of schoolmate were actual factors theta affected the self-efficacy of adolescents. Accordingly, affirmative emotion in family, harmonic communication among family members and sharing housekeeping works is recommended as a useful method in order to enhance the family function, and then the self-efficacy of adolescence will be increased.