• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.4155-4161
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• 2016

Biliary obstruction is a common clinical manifestation of various conditions, including extrahepatic cholangiocarcinoma. However, a screening test for diagnosis of extrahepatic cholangiocarcinoma in patients with biliary obstruction is not yet available. According to the rationale that the biliary system plays a major role in lipid metabolism, biliary obstruction may interfere with lipid profiles in the body. Therefore, plasma lipidomics may help indicate the presence or status of disease in biliary obstruction suspected extrahepatic cholangiocarcinoma. This study aimed to use plasma lipidomics for diagnosis of extrahepatic cholangiocarcinoma in patients with biliary obstruction. Plasma from healthy volunteers, patients with benign biliary obstruction extrahepatic cholangiocarcinoma, and other related cancers were used in this study. Plasma lipids were extracted and lipidomic analysis was performed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Lipid profiles from extrahepatic cholangiocarcinoma patients showed significant differences from both normal and benign biliary obstruction conditions, with no distinction between the latter two. Relative intensity of the selected lipid mass was able to successfully differentiate all extrahepatic cholangiocarcinoma samples from patient samples taken from healthy volunteers, patients with benign biliary obstruction, and patients with other related cancers. In conclusion, lipidomics is a non-invasive method with high sensitivity and specificity for identification of extrahepatic cholangiocarcinoma in patients with biliary obstruction.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1713-1716
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• 2016

Background: Liver fluke infection is associated with cholangiocarcinoma; the bile duct cancer found frequently in the northeast and north of Thailand. Prevention and control particularly requires health education and behavior change. Objective: This study aimed to improve health behavior among village health volunteers (VHV) regarding liver fluke exposure in an epidemic area. Materials and Methods: A quasi-experimental study was performed during July 2015 to January 2016 in Sang Kha district of Surin province, Thailand. A total of 67 VHVs underwent a health education program (HEP) and data were collected on knowledge, attitude, and practice (KAP) before and after participation for HEP 3 months with a pre-designed questionnaire. The Students paired T-test was used for comparisons of mean KAP levels before/after the intervention. Results: The results revealed that knowledge (P-value=0.004), attitude (P-value=0.004), and practice level (P-value=0.000) were significantly improved after participation in the HBP. Attitude was significantly associated with knowledge (r=0.266, p<0.05), and practice (r=0.348, p<0.01). Conclusions: The implementation of health education among VHVs is feasible and increases their KAP. This improvement should have potential in liver fluke prevention and control in local communities in rural Thailand.

• Restorative Dentistry and Endodontics
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• 제35권3호
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• pp.198-210
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• 2010

30% 과산화수소를 함유한 전문가 미백제인 레메화이트(Remewhite, Remedent Inc., Deurle, Belgium)를 시험군 피험자 37명, 시험용 미백제에서 과산화수소를 제외한 동일한 제재를 대조약으로 대조군 피험자 34명에게 1일 3회씩, 2차례에 걸쳐서 시행하였다. 미백의 임상적 안전성은 전기치수검사, 치은염증지수, 지각과민증, 이상반응, 활력징후 등을 통하여 평가하였다. 미백시행 직후, 14주 후, 26주 후에 평가하여 다음과 같은 결론을 얻었다. 30% 과산화수소를 함유한 전문가 미백제를 임상적 적용시에 전기치수검사 결과에서는 미백 전후에 차이가 없었다. 치은염증지수, 지각과민증 평가 결과에서는 시험군에서 다소 경미한 통증 반응이 나타났으나 시간이 지나면서 사라지는 것을 확인하였다. 따라서 30% 과산화수소를 함유한 전문가 미백제를 사용하여 미백시에 임상적 안전성을 확인할 수 있었다.

• The Korean Journal of Pain
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• 제22권1호
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• pp.39-46
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• 2009

Background: Ketamine has an indirect sympathetic stimulation effect. We investigated heart rate variability (HRV) as a marker of cardiac autonomic function after a target controlled infusion (TCI) of ketamine with a plasma concentration of 30 or 60 ng/ml. Methods: In 20 adult volunteers, the mean of the R wave to the adjacent R wave interval (RRI), the range of RRI, the root mean square successive difference of intervals (RMSSD), the total power, the low frequency (LF, 0.04-0.15 Hz) power, the high frequency (HF, 0.15-0.4 Hz) power, the normal unit HF (nuHF), the normal unit LF (nuLF), the LF/HF ratio and the SD1 and the SD2 in the Poincare plot were measured before and after a TCI of ketamine. We observed for any psychedelic symptoms or sedation. Results: There were no differences in the mean and range of the RRI, RMSSD, total power, LF power, HF power, nuHF, nuLF, LF/HF ratio, SD1 and SD2 between before and after ketamine administration. The OAA/S score was higher and there were more psychedelic symptoms with a 60 ng/ml plasma concentration than with a 30 ng/ml plasma concentration. Conclusions: This study did not show any effect of a low plasma concentration of ketamine on the autonomic nervous system.

• The Korean Journal of Pain
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• 제21권2호
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• pp.126-130
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• 2008

Background: Females generally have a lower pain and temporal summation threshold than men. However, the results of studies designed to evaluate gender differences in the thresholds of heat pain and the temporal summation have been inconsistent. Newly developed device, CHEPS (Contact Heat Evoked Potential Stimulation) model of PATHWAY, have superiority on its fast rise and return time in temperature. Therefore we investigated gender differences in heat pain and temporal summation threshold. Methods: Forty healthy volunteers (20 males and 20 females) were enrolled in this study. A thermode was applied to the volar side of each volunteer's left forearm and heat pain and the temporal summation threshold was then measured. The heat pain threshold was estimated using the staircase method by starting from $36^{\circ}C$ and then increasing the temperature in $0.5^{\circ}C$ increments. The temporal summation threshold was estimated by applying five successive stimulation of the same temperature starting at $2^{\circ}C$ lower than the heat pain threshold and then increasing the temperature in $0.5^{\circ}C$ increments. Results: The mean heat pain thresholds was found to be $41.63{\pm}1.63^{\circ}C$ for males and $41.60{\pm}1.84^{\circ}C$ for females and the temporal summation thresholds were found to be $40.83{\pm}1.64^{\circ}C$ for males and $40.77{\pm}1.93^{\circ}C$ for females. The differences between males and females were not statistically significant. Conclusions: The result of this study suggested that there are no gender differences in heat pain and temporal summation threshold.

• Biomolecules & Therapeutics
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• 제6권4호
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• pp.417-422
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• 1998

Loxoprofen sodium (sodium 2-[4-(2-oxocyclopentylmethyl)phenyl] propionate dehydrate) is a nonsteroidal antiinflammatory drug of $\alpha$-phenyl propionic acid derivative. To test the bioequivalence of loxoprofen, the pharmacokinetic parameters of new preparation of loxoprofen, LENOX was compared with LOXONIN as a reference drug. Fourteen healthy volunteers were entered to the stydy (Yonsei University College of Medicine, Severance Hospital IRB approval No. 9608). They were administered 60 mg of loxoprofen in 2$\times$2 cross-over design. There was one week of drug-free interval between doses. The blood sample was taken on schedule up to 8 hours, and the plasma concentration loxoprofen was measured by reverse phase high-performance liquid chromatography (HPLC) with UV-detector. There were no significant difference between two preparations when AUC, Cmax, and Tmax were compared by ANOVA. The mean differences of AUC, Cmax, and Tmax were within 20% of the reference drug: the values were 2.22,5.61, and 12.50%, respectively. The confidence limits of AUC and Cmax but not Tmax satisfied the bioequivalence criteria. These results suggest that the tested LENOX is bioequivalent to the reference drug.

• 한국임상약학회지
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• 제10권1호
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• pp.19-24
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• 2000

The effect of cimetidine on the pbarmacokinetic parameters of cyclosporine (intravenous administration) were determined in 6 healthy volunteers (22-48 years old, 48-62 kg) by cross-over design. Cyclosporine and cyclosporine metabolites in whole blood were analysed by fluororescence polarization immunoassay (TDx-FLX). The blood concentrations of cyclosporine After pretreatment with cimetidine (200 mg bid, for 3days) were increased significantly at 8-12 hrs compared to the control (p<0.05). The ratios of blood concentrations of cyclosporine metabolites (M1, M17) to parent drug were decreased significantly at 8-12 hrs (p<0.05). Total body clearance (CL) was also decreased significantly (p<0.05), and area under the curve $(AUC,\%)$ was increased but not significant.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1984년도 학술대회지
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• pp.89-95
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• 1984

Hydrocortisone과 ginseng 그리고 hydrocortisone과 ginseng의 혼합물이 phytohaemagglutinin (PHA-P)으로 유도한 모세혈관 림파구 변형에 미치는 영향을 검토하기 위하여 정상인 4명을 대상으로 연구하였다. 인삼의 농도를 0.16${\mu}g$/ml에서 1.60${\mu}g$/ml까지 증가시킴에 따라 PHA-P의 림파구 변형에 상관성이 있는 억제현상을 보였으며, hydrocortisone 500${\mu}g$/ml과 ginseng 0.8${\mu}/g$/ml을 동시 투여하였을 경우 각각 단일 물질 투여시 보다 상당한 PHA-P 변형의 억제효과를 나타냈다. 이는 인삼이 in vitro상에서 steroid와 유사한 효과를 갖고 있음을 시사해 주며, 면역에 hydrocortisone과 더불어 상당한 효과를 가지고 있다는 것을 보여주고 있다. in vivo상에서 6명의 정상인을 대상으로 PHA-P 변형에 대하여 인삼의 효과를 연구한 결과 4주에 이르러 상당한 억제효과가 관찰되었다.

• Journal of Hospice and Palliative Care
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• 제22권4호
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• pp.185-197
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• 2019

목적: 호스피스 자원봉사자는 환자와 가족의 곁에서 보이지 않는 손의 역할을 하며 호스피스 완화의료팀 내에서 중추적인 역할을 수행하고 있다. 본 연구는 호스피스 자원봉사자 역량강화를 위한 지속교육과정의 효과를 혼합연구방법을 통해 파악하고자 하였다. 방법: 본 연구는 G도 J시에 소재한 G대학교의 매주 4시간씩 총 20시간의 호스피스 자원봉사자 지속교육 과정에 참여한 호스피스 자원봉사자 30명을 대상으로 하였다. 자료의 양적연구를 위해 대상자의 교육 전후 호스피스 태도, 의미 있는 삶, 자기효능감, 자원봉사활동 만족도를 조사하였다. 자료는 SPSS Window 20.0을 사용하여 기술통계, paired t-test, Wilcoxon signed-rank test로 분석하였다. 질적 연구를 위해 교육 참여자들에게 포커스그룹 인터뷰를 시행하였으며, 수집된 자료는 내용분석하였다. 결과: 호스피스 자원봉사자 지속교육 과정의 효과에 대한 양적연구 결과, 호스피스 자원봉사자의 호스피스 태도(t=-2.52, P=0.018)와 자기효능감(z=-2.06, P=0.40)을 향상시키는 것으로 나타났다. 질적 연구 결과, 참여자들은 자신의 신체를 다치지 않으면서 효과적으로 환자들을 돌볼 수 있는 방법과 영적 돌봄을 제공할 수 있는 실제적인 방법을 알기 원하였다. 참여자들은 삶의 마무리를 돕는 봉사에 대한 자부심과 베푸는 기쁨이 나의 삶에 감사로 돌아오기 때문에 지속적으로 봉사활동을 하고 있었으며, 개인시간 할애가 많음에도 불구하고 환자를 잘 돌보고 싶은 열정으로 지속적 배움에 대한 열의를 나타냈다. 결론: 호스피스 자원봉사자들은 지속교육 과정을 통해 환자와 가족을 돌보기 위한 역량 강화를 원하였으며, 이러한 교육은 호스피스 태도와 자기효능감을 높이는 것으로 나타났다. 자원봉사자들의 역량강화를 위해서는 대상자들의 신체적·사회적·영적인 접근을 모두 강화시키는 지속교육이 필요하다. 효율적이고 체계화된 지속교육을 위해서는 웹기반 교육과정 개발 및 지역별 컨소시엄 형성이 도움이 될 수 있다.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2001년도 제6차 학술대회 초록집
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• pp.111-111
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• 2001

목적： To evaluate the feasibility of the event-related functional MR study using power grip studying the hand motor system 대상 및 방법： Event-related functional MRI was performed on a 1.5T MR unit in seven norm volunteers (man=7, right-handedness=2, left-handedness=5, mean age： 25 years). A single-shot GRE-EPI sequence (TR/TE/flip angle： 1000ms/40ms/90, FOV = 240 mm matrix= 64$\times$64, slice thickness/gap = 5mm/0mm, 7 true axial slices) was used for functiona MR images. A flow-sensitive conventional gradient echo sequence (TR/TE/flip angl 50ms/4ms/60) was used for high-resolution anatomical images. To minimize the gross hea motion, neck-holders (MJ-200, USA) were used. A series of MR images were obtained in axial planes covering motor areas. To exclude motion-corrupted images, all MR images wer surveyed in a movie procedure and evaluated using the estimation of center of mass of ima signal intensities. Power grip task consisted of the powerful grip of all right fingers and hand movement ta used very fast right finger tapping at a speed of 3 per 1 second. All tasks were visual-guid by LCD projector (SHARP, Japan). Two tasks consisted of 134 phases including 7 activatio and 8 rest periods. Active stimulations were performed during 2 seconds and rest period were 15 seconds and total scan time per one task was 2 min 14 sec. Statistical maps we obtained using cross-correlation method. Reference vector was time-shifted by 4 seconds an Gaussian convolution with a FWHM of 4 seconds was applied to it. The threshold in p val for the activation sites was set to be 0.001. All mapping procedures were peformed usin homemade program an IDL (Research Systems Inc., USA) platform. We evaluated the activation patterns of the motor system of power grip compared to hand movement in t event-related functional MRI.