• 대한영양사협회학술지
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• 제30권2호
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• pp.112-124
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• 2024

This study investigated the factors associated with HINT-8 (Korean health-related quality of life instrument with eight items), including health habits, hand grip strength, chronic disease, chewing function, mental health, and nutrient intake. In this study, the health-related quality of life (HRQoL; HINT-8) was assessed using the data from the 2019 Korea National Health and Nutrition Examination Survey (KNHANES VIII) among Koreans aged over 65, with HINT-8 being evaluated based on the general characteristics. Of the participants from KNHANES VIII, 1,455 subjects were analyzed using SPSS statistics complex samples (Windows ver. 27.0). The HINT-8 score was significantly lower in females and in those aged 75 years or older, lowest educational level, lowest income level, and single households. Logistic regression analysis, adjusted for the general characteristics, revealed a significant association between a lower HINT-8 group and various factors: low aerobic physical activity (OR=1.71, 95% CI=1.25~2.35), low hand grip strength (OR=1.34, 95% CI=1.02~1.78), chewing difficulties (OR=2.17, 95% CI=1.62~2.92), poor self-rated health status (OR=6.11, 95% CI=4.42~8.45), stressful mental status (OR=3.57, 95% CI=2.27~5.63) and poor calcium status (OR=1.45, 95% CI=1.11~1.88). On the other hand, this study could not reveal a significant association between a lower HINT-8 group and factors such as smoking, drinking, chronic disease, and nutrient intake status, except for calcium intake. This study suggests that HINT-8 is associated with aerobic physical activity, hand grip strength, chewing function, mental health, and calcium intake, but not with smoking, drinking, chronic disease, and nutrient intake.

• Molecules and Cells
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• 제42권1호
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• pp.56-66
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• 2019

Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif. The HIT superfamily can be divided to five classes with functions in galactose metabolism, DNA repair, and tumor suppression. HINTs are highly conserved from archaea to humans and function as tumor suppressors, translation regulators, and neuropathy inhibitors. Although the structures of HINT proteins from various species have been reported, limited structural information is available for fungal species. Here, to elucidate the structural features and functional diversity of HINTs, we determined the crystal structure of HINT from the pathogenic fungus Candida albicans (CaHINT) in complex with zinc ions at a resolution of $2.5{\AA}$. Based on structural comparisons, the monomer of CaHINT overlaid best with HINT protein from the protozoal species Leishmania major. Additionally, structural comparisons with human HINT revealed an additional helix at the C-terminus of CaHINT. Interestingly, the extended C-terminal helix interacted with the N-terminal loop (${\alpha}1-{\beta}1$) and with the ${\alpha}3$ helix, which appeared to stabilize the dimerization of CaHINT. In the C-terminal region, structural and sequence comparisons showed strong relationships among 19 diverse species from archea to humans, suggesting early separation in the course of evolution. Further studies are required to address the functional significance of variations in the C-terminal region. This structural analysis of CaHINT provided important insights into the molecular aspects of evolution within the HIT superfamily.

• 한국치위생학회지
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• 제24권2호
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• pp.109-119
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• 2024

연구목적: 본 연구는 노인들의 구강노쇠 실태를 파악하고 구강노쇠와 건강관련 삶의 질(HINT-8)의 관련성을 확인하는 것이다. 연구방법: 제8기 1차 국민건강영양조사 원시자료를 이용하여 65세 이상 노인의 구강노쇠와 건강관련 삶의 질(HINT-8)의 관련성을 확인하고자 복합표본 교차분석과 일반선형모형, 복합표본 로지스틱 회귀분석을 시행하였다. 연구결과: 건강관련 삶의 질(HINT-8)은 저작불편이 있는 사람은 1.183배, 말하기 불편이 있는 사람은 1.236배, 현존치아 수가 19개 이하인 사람은 1.153배, 칫솔질 평균횟수가 2회 이하인 사람은 1.043배 낮았다(p<0.05). 저작불편이 있는 사람은 저작불편이 없는 사람보다 신체적 건강영역의 삶의 질은 1.246배 낮았고, 사회적 건강영역의 삶의 질은 1.324배 낮았으며, 정신적 건강영역의 삶의 질은 1.089배 낮았다(p<0.05). 말하기 불편이 있는 사람은 말하기 불편이 없는 사람보다 신체적 건강영역의 삶의 질은 1.275배 낮았고, 사회적 건강영역의 삶의 질은 1.449배 낮았으며, 정신적 건강영역의 삶의 질은 1.175배 낮았다(p<0.05). 현존치아 수가 19개 이하인 사람은 현존치아 수가 20개 이상인 사람보다 신체적 건강영역의 삶의 질은 1.331배 낮았고, 사회적 건강영역의 삶의 질은 1.530배 낮았다(p<0.05). 칫솔질 평균횟수 2회 이하인 사람은 칫솔질 평균횟수 3회 이상인 사람보다 긍정적 건강영역의 삶의 질이 1.128배 낮았고, 구강위생용품을 사용하지 않는 사람은 사용하는 사람보다 사회적 건강영역의 삶의 질이 1.242배 낮았다(p<0.05). 결론: 노인의 구강노쇠는 건강관련 삶의 질을 저하시키고 있다는 것이 입증되었다. 노인의 약 55%에서 구강노쇠 증상을 경험하고 있는 것으로 나타나 노인들의 구강노쇠 관리를 할 수 있는 정책 마련과 함께 구강노쇠 관리 전문프로그램 개발이 필요할것 으로 사료된다.

• 대한통합의학회지
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• 제11권3호
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• pp.35-47
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• 2023

Purpose : As the population aging deepens, the number of elderly people with arthritis is also continuously increasing. Accordingly, this study intended to identify the factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis according to household type and provide baseline data for developing a measure to enhance the life quality of the elderly with arthritis. Methods : The factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis were identified based on the raw data from the Korea national health and nutrition examination survey conducted in 2021. Data were analyzed with SPSS Statistics ver 25.0 for windows (IBM Corp), and the significance level (α) was set to .05. Statistical analysis was performed with t-test, ANOVA, multiple regression analysis, and post-hoc analysis with Duncan test. Results : The factors that influenced the health-related quality of life (HINT-8) of single-households were medical aid (β=-.17, p=.045), restriction of activity (β=-.17, p=.023), self-rated health status (β=.29, p<.001), and anxiety scale (β=-.36, p<.001). The factors that influenced the health-related quality of life (HINT-8) of multi-households were an age of 75 or over (β=-.14, p=.011), living in rural (β=-.14, p=.003), the outpatient department treatment experience (β=-.09, p=.047), self-rated health status (β=.26, p<.001), anxiety scale (β=-.29, p<.001), and stress (β=-.22, p<.001). Conclusion : Factors affecting the health-related quality of life (HINT-8) of the elderly with arthritis were found to be different between single-person households and multi-person household. Therefore, it is necessary to prepare measures to improve the quality of life of the elderly with arthritis by considering the factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis according to the household type identified in this study.

• Carbon letters
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• 제13권1호
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• pp.1-16
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• 2012

The near explosion of attention given to graphene has attracted many to its research field. As new studies and findings about graphene synthesis, properties, electronic quality control, and possible applications simultaneous burgeon in the scientific community, it is quite hard to grasp the breadth of graphene history. At this stage, graphene's many fascinating qualities have been amply reported and its potential for various electronic applications are increasing, pulling in ever more newcomers to the field of graphene. Thus it has become important as a community to have an equal understanding of how this material was discovered, why it is stirring up the scientific community and what sort of progress has been made and for what purposes. Since the first discovery, the hype has expediently led to near accomplishment of industrial-sized production of graphene. This review covers the progress and development of synthesis and transfer techniques with an emphasis on the most recent technique of chemical vapor deposition, and explores the potential applications of graphene that are made possible with the improved synthesis and transfer.

• 한국음향학회지
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• 제41권1호
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• pp.108-113
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• 2022

소음상황에서의 어음 이해 능력은 효과적인 의사소통을 위한 중요한 기술이다. 이러한 능력을 평가하는 방법으로 Hearing In Noise Test(HINT) 도구가 제안되어 사용되고 있다. 하지만 국내에서 이 유용한 도구가 초기의 기대와 달리 임상에서 적극적으로 활용되지 못하고 있다. 연령이 높아질수록 정상 청력을 가지고 있을지라도 양이에서 들어오는 신호들을 처리하는데 어려움을 겪게 되고, 특히 배경 소음이 있는 상황에서 듣기는 더욱 어려워진다. 하지만, 어음이해에 상당한 문제점을 갖고 있는 노인 인구들을 임상적으로 평가하는 도구들이 많지 않다. 본 연구에서는 이러한 검사법이 근거하고 있는 기전에 있는 인지적 특성과 임상에서의 문제점을 분 석하여 개선점을 제안하고자 한다. 기본 임상 사례로 정상 청력을 가진 20대와 70대의 대표적 HINT점수를 비교하고, 소음이 어떤 조건에서 제시되는가에 따른 문장 인지 특징을 조명하였다. 대상자의 HINT score는 Quiet(Q), Noise Front(NF), Noise Right(NR), Noise Left(NF)조건에서 분석되었다. 여러 임상적 관점에서 유용한 점은 배경 소음이 있을 때 노인의 경우 청년보다 더 많은 신호대잡음비를 필요함을 나타내는 정량적 변수를 보여주고, 양이차폐감소차이(Binaural Masking Level Difference, BMLD)효과도 보여주고 있다는 점이다. 효과적 임상적 적용에는 세부 연령대별 비교 가능한 표준 자료가 극히 부족한 실정이다. 이러한 유용성 확인과 함께 임상 관련 개선점을 제시하였다.

• 대한간호학회지
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• 제53권3호
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• pp.359-369
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• 2023

Purpose: This study evaluated the internal structure (structural validity, internal consistency, and measurement invariance) of the Health-Related Quality of Life Instrument with Eight Items (HINT-8), developed to measure Korean people's health-related quality of life. Methods: A secondary analysis was conducted using data from the Korea National Health and Nutrition Examination Survey, involving 6,167 adults aged over 18 years. The structural validity of the HINT-8 was assessed using exploratory graph analysis and confirmatory factor analysis. Internal consistency and measurement invariance were analyzed using McDonald's omega (ω) and multigroup confirmatory factor analysis, respectively. Results: The HINT-8 had a single dimension and good internal consistency (ω =.804). The one-dimension HINT-8 exhibited matric invariance but not scalar invariance across sociodemographic groups (sex, age, education, and marital status). Further, it exhibited scalar or partial scalar invariance across medical condition groups (hypertension, diabetes, depressive symptoms, and cancer). Conclusion: The study finds that the HINT-8 demonstrated satisfactory structural validity and internal consistency, indicating its suitability for practice and research. However, the HINT-8 scores cannot be compared across different groups regarding sex, age, education, and marital status, as the interpretation varies within each sociodemographic category. Conversely, interpretation of the HINT-8 is consistent for individuals with and without hypertension, diabetes, depressive symptom, and cancer.

• 한국치위생학회지
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• 제21권5호
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• pp.621-628
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• 2021

Objectives: The purpose of this study was to determine the differences in quality of life between groups that promote oral health and those that treat oral diseases using data from the National Health and Nutrition Examination Survey. Methods: Data analysis was performed using IBM SPSS ver. 21.0 (IBM Co., Armonk, NY, USA). A total of 3,338 subjects were selected as subjects for the study before applying oral health promotion (OHP; 1,132 persons) and oral disease treatment (ODT; 2,206 persons). Complex sample logistic regression analysis was performed to determine the effects of OHP and ODT on health-related quality of life. Results: As a result of confirming the effect of OHP and ODT on the quality of life, which are indicators of the quality of life, HINT-8 had a significant effect even in Model 2, adjusted for demographic characteristics, with a significant difference (p<0.01). Conclusions: The above results confirmed that persons who promote oral health have a significant effect on HINT-8, a quality of life scale developed for Koreans. Therefore, continuous oral care is required to improve quality of life.

• 한국콘텐츠학회논문지
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• 제22권8호
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• pp.347-357
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• 2022

본 연구는 Health-related quality of life instrument with 8 items (HINT-8)을 중심으로 만성폐쇄성폐질환 (Chronic Obstructive Pulmonary Disease, COPD) 환자의 건강관련 삶의 질 정도와 영향요인을 파악하기 위해 2019년 국민건강영양조사에서 폐기능 검사를 수행한 만 40세 이상의 성인 중 1초간 노력성 호기량(forced respiratory volume in 1 second, FEV₁) 대 노력성 폐활량(forced vital capacity)을 측정하여 비율이 0.7 미만인 자 중 건강관련 삶의 질 측정도구인 HINT-8에 누락이 있는 3명을 제외한 총 451명을 대상으로 하였다. SAS program을 이용하여 실수와 가중백분율, 평균과 표준편차, 일반선형모델을 이용하여 분석한 결과, HINT-8 index와 EuroQol five-dimensions 3-level version (EQ-5D-3L) index 두 도구 모두 COPD 환자에게서 건강관련 삶의 질을 측정하는 도구로서 적절하였다. HINT-8을 중심으로 COPD 환자의 건강관련 삶의 질 영향요인은 연령, 성별, 소득, 흡연상태, 동반질환, 스트레스, 주관적 건강상태이었다. COPD 환자의 건강관련 삶의 질을 개선하기 위해서는 금연교육 및 스트레스 관리 등이 포함되어야 하며, 고령, 저소득층 등 대상자의 특성에 맞는 개별화된 관리프로그램이 개발되고 적용되어야 할 것이다.

• 한국통신학회논문지
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• 제25권4B호
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• pp.715-724
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• 2000

본 논문에서는 볼륨 영상의 점진적 무 손실 압축에 효율적인 3차원 대역분할 필터 군을 제안한다. 이를 위해 지금까지 1차원 무 손실 대역분할 필터 군에 적용되어져왔던 ORT(Overlapping Rounding Transform)를 두 가지 형태의 3차원 무 손실 대역분할 필터 군-분리형(separable)과 비 분리형(non-separable)-을 구현하는데 기본적으로 사용하였다. 분리형 필터 군은 1차원 무 손실 대역분할 필터 군을 연속적으로 적용함으로써, 비 분리형 필터 군은 ORT를 3차원으로 확장 적용함으로써 구현되었다. 특히, 기존의 3차원 HINT(Hierachical INTerpolation) 알고리즘은 제안된 ORT 기반 3차원 비 분리형 필터 군으로 일반화된다. 다양한 볼륨 의료 영상에 제안된 방식을 적용함으로서, 제안된 분리형/비 분리형 대역분할 필터 군이 기존의 블록 기반 변환 방식과 3차원 HINT 보다 압축성능(엔트로피)면에서 우수함을 확인하였다.