• Journal of the Korean Dietetic Association
• /
• v.30 no.2
• /
• pp.112-124
• /
• 2024

This study investigated the factors associated with HINT-8 (Korean health-related quality of life instrument with eight items), including health habits, hand grip strength, chronic disease, chewing function, mental health, and nutrient intake. In this study, the health-related quality of life (HRQoL; HINT-8) was assessed using the data from the 2019 Korea National Health and Nutrition Examination Survey (KNHANES VIII) among Koreans aged over 65, with HINT-8 being evaluated based on the general characteristics. Of the participants from KNHANES VIII, 1,455 subjects were analyzed using SPSS statistics complex samples (Windows ver. 27.0). The HINT-8 score was significantly lower in females and in those aged 75 years or older, lowest educational level, lowest income level, and single households. Logistic regression analysis, adjusted for the general characteristics, revealed a significant association between a lower HINT-8 group and various factors: low aerobic physical activity (OR=1.71, 95% CI=1.25~2.35), low hand grip strength (OR=1.34, 95% CI=1.02~1.78), chewing difficulties (OR=2.17, 95% CI=1.62~2.92), poor self-rated health status (OR=6.11, 95% CI=4.42~8.45), stressful mental status (OR=3.57, 95% CI=2.27~5.63) and poor calcium status (OR=1.45, 95% CI=1.11~1.88). On the other hand, this study could not reveal a significant association between a lower HINT-8 group and factors such as smoking, drinking, chronic disease, and nutrient intake status, except for calcium intake. This study suggests that HINT-8 is associated with aerobic physical activity, hand grip strength, chewing function, mental health, and calcium intake, but not with smoking, drinking, chronic disease, and nutrient intake.

• Molecules and Cells
• /
• v.42 no.1
• /
• pp.56-66
• /
• 2019

Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif. The HIT superfamily can be divided to five classes with functions in galactose metabolism, DNA repair, and tumor suppression. HINTs are highly conserved from archaea to humans and function as tumor suppressors, translation regulators, and neuropathy inhibitors. Although the structures of HINT proteins from various species have been reported, limited structural information is available for fungal species. Here, to elucidate the structural features and functional diversity of HINTs, we determined the crystal structure of HINT from the pathogenic fungus Candida albicans (CaHINT) in complex with zinc ions at a resolution of $2.5{\AA}$. Based on structural comparisons, the monomer of CaHINT overlaid best with HINT protein from the protozoal species Leishmania major. Additionally, structural comparisons with human HINT revealed an additional helix at the C-terminus of CaHINT. Interestingly, the extended C-terminal helix interacted with the N-terminal loop (${\alpha}1-{\beta}1$) and with the ${\alpha}3$ helix, which appeared to stabilize the dimerization of CaHINT. In the C-terminal region, structural and sequence comparisons showed strong relationships among 19 diverse species from archea to humans, suggesting early separation in the course of evolution. Further studies are required to address the functional significance of variations in the C-terminal region. This structural analysis of CaHINT provided important insights into the molecular aspects of evolution within the HIT superfamily.

• Journal of Korean society of Dental Hygiene
• /
• v.24 no.2
• /
• pp.109-119
• /
• 2024

Objectives: This study aimed to confirm the correlation between oral frailty and health-related quality of life (HINT-8) among older adults in Korea. Methods: The data of 1,318 individuals aged ≥65 years who participated in the eighth Korean National Health and Nutrition Examination Survey (2019) were analyzed using complex sample statistical analysis. Results: Chewing discomfort was found to decrease the HINT-8 scores by 1.246, 1.324, and 1.089 times in the physical, social, and mental domains, respectively. Speech discomfort was found to decrease the HINT-8 scores by 1.275, 1.449, and 1.175 times in the physical, social, and mental domains, respectively. The HINT-8 scores of participants with ≤19 natural teeth were lower in the physical and social domains. Similarly, the HINT-8 scores of participants with brushing frequency of ≤2 were lower in the positive health domain. Non-use of oral hygiene products led to a reduction in the HINT-8 score in the social health domain. Conclusions: Oral frailty in older adults reduces the health-related quality of life. Thus, it is necessary to formulate policies to manage oral frailty in this population and develop specialized programs for the management of oral frailty.

• Journal of The Korean Society of Integrative Medicine
• /
• v.11 no.3
• /
• pp.35-47
• /
• 2023

Purpose : As the population aging deepens, the number of elderly people with arthritis is also continuously increasing. Accordingly, this study intended to identify the factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis according to household type and provide baseline data for developing a measure to enhance the life quality of the elderly with arthritis. Methods : The factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis were identified based on the raw data from the Korea national health and nutrition examination survey conducted in 2021. Data were analyzed with SPSS Statistics ver 25.0 for windows (IBM Corp), and the significance level (α) was set to .05. Statistical analysis was performed with t-test, ANOVA, multiple regression analysis, and post-hoc analysis with Duncan test. Results : The factors that influenced the health-related quality of life (HINT-8) of single-households were medical aid (β=-.17, p=.045), restriction of activity (β=-.17, p=.023), self-rated health status (β=.29, p<.001), and anxiety scale (β=-.36, p<.001). The factors that influenced the health-related quality of life (HINT-8) of multi-households were an age of 75 or over (β=-.14, p=.011), living in rural (β=-.14, p=.003), the outpatient department treatment experience (β=-.09, p=.047), self-rated health status (β=.26, p<.001), anxiety scale (β=-.29, p<.001), and stress (β=-.22, p<.001). Conclusion : Factors affecting the health-related quality of life (HINT-8) of the elderly with arthritis were found to be different between single-person households and multi-person household. Therefore, it is necessary to prepare measures to improve the quality of life of the elderly with arthritis by considering the factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis according to the household type identified in this study.

• Carbon letters
• /
• v.13 no.1
• /
• pp.1-16
• /
• 2012

The near explosion of attention given to graphene has attracted many to its research field. As new studies and findings about graphene synthesis, properties, electronic quality control, and possible applications simultaneous burgeon in the scientific community, it is quite hard to grasp the breadth of graphene history. At this stage, graphene's many fascinating qualities have been amply reported and its potential for various electronic applications are increasing, pulling in ever more newcomers to the field of graphene. Thus it has become important as a community to have an equal understanding of how this material was discovered, why it is stirring up the scientific community and what sort of progress has been made and for what purposes. Since the first discovery, the hype has expediently led to near accomplishment of industrial-sized production of graphene. This review covers the progress and development of synthesis and transfer techniques with an emphasis on the most recent technique of chemical vapor deposition, and explores the potential applications of graphene that are made possible with the improved synthesis and transfer.

• The Journal of the Acoustical Society of Korea
• /
• v.41 no.1
• /
• pp.108-113
• /
• 2022

Speech recognition in noise situation is an important skill for effective communication. Hearing In Noise Test (HINT) has been suggested as a clinical tool to evaluate these aspects. However, this tool has not been used widely in domestic clinics. In this study, psychophysical aspects of HINT and burdens in clinical application were analyzed to improve the applicability of the tool. The difficulty in understanding speech in the elderly population is due to hearing loss based on aging of peripheral and central auditory pathways. As typical clinical cases, HINT scores for young and elderly listeners (20s vs 70s) were compared. Four conditions of HINT test were Quiet (Q), Noise Front (NF), Noise Right (NR), and Noise Left (NL). Quantitative scores showed that the elderly listener required more Signal to Noris Ratio (SNR) values than the younger counterpart in noisy situations. Although both showed Binaural Masking Level Difference (BMLD) effect, the strength was smaller in the elder. However, the age-matched normalized data were not established in detail for clinical application. Confirmed usefulness of HINT and the related improvement in clinical measuring procedure were suggested.

• Journal of Korean Academy of Nursing
• /
• v.53 no.3
• /
• pp.359-369
• /
• 2023

Purpose: This study evaluated the internal structure (structural validity, internal consistency, and measurement invariance) of the Health-Related Quality of Life Instrument with Eight Items (HINT-8), developed to measure Korean people's health-related quality of life. Methods: A secondary analysis was conducted using data from the Korea National Health and Nutrition Examination Survey, involving 6,167 adults aged over 18 years. The structural validity of the HINT-8 was assessed using exploratory graph analysis and confirmatory factor analysis. Internal consistency and measurement invariance were analyzed using McDonald's omega (ω) and multigroup confirmatory factor analysis, respectively. Results: The HINT-8 had a single dimension and good internal consistency (ω =.804). The one-dimension HINT-8 exhibited matric invariance but not scalar invariance across sociodemographic groups (sex, age, education, and marital status). Further, it exhibited scalar or partial scalar invariance across medical condition groups (hypertension, diabetes, depressive symptoms, and cancer). Conclusion: The study finds that the HINT-8 demonstrated satisfactory structural validity and internal consistency, indicating its suitability for practice and research. However, the HINT-8 scores cannot be compared across different groups regarding sex, age, education, and marital status, as the interpretation varies within each sociodemographic category. Conversely, interpretation of the HINT-8 is consistent for individuals with and without hypertension, diabetes, depressive symptom, and cancer.

• Journal of Korean society of Dental Hygiene
• /
• v.21 no.5
• /
• pp.621-628
• /
• 2021

Objectives: The purpose of this study was to determine the differences in quality of life between groups that promote oral health and those that treat oral diseases using data from the National Health and Nutrition Examination Survey. Methods: Data analysis was performed using IBM SPSS ver. 21.0 (IBM Co., Armonk, NY, USA). A total of 3,338 subjects were selected as subjects for the study before applying oral health promotion (OHP; 1,132 persons) and oral disease treatment (ODT; 2,206 persons). Complex sample logistic regression analysis was performed to determine the effects of OHP and ODT on health-related quality of life. Results: As a result of confirming the effect of OHP and ODT on the quality of life, which are indicators of the quality of life, HINT-8 had a significant effect even in Model 2, adjusted for demographic characteristics, with a significant difference (p<0.01). Conclusions: The above results confirmed that persons who promote oral health have a significant effect on HINT-8, a quality of life scale developed for Koreans. Therefore, continuous oral care is required to improve quality of life.

• The Journal of the Korea Contents Association
• /
• v.22 no.8
• /
• pp.347-357
• /
• 2022

This study was attempted to identify the health-related quality of life of Chronic Obstructive Pulmonary Disease (COPD) patients and factors influencing the quality of life, focusing on Health-related quality of life with 8 items (HINT-8). The subjects of this study were 451 adults aged 40 years or older who performed lung function tests and whose ratio is less than 0.7 by measuring forced respiratory volume in 1 second [FEV₁] to forced vital capacity in the 2019 National Health and Nutrition Examination Survey, It was analyzed using SAS program. As a result, both the HINT-8 index and EuroQol five-dimensions 3-level version (EQ-5D-3L) index were appropriate as tools to measure the health-related quality of life in COPD patients, and the factors affecting the health-related quality of life were age, gender, income, and smoking status, comorbidities, stress, and subjective health status. Therefore, in order to improve the health-related quality of life of COPD patients, an individualized management program suitable for the characteristics of subjects such as the low-income class and the elderly, including smoking cessation education and stress management, should be developed and applied.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.25 no.4B
• /
• pp.715-724
• /
• 2000

This Paper presents 3-D subband filter banks which are effective for progressive and lossless compression of volumetric images. For such a purpose, ORT(Overlapping Rounding Transform), applied so far to 1-D losslesssubband filter banks, is now used to implement two types of 3-D lossless subband filter banks: separable andnon-separable types. Separable fiter banks are implemented form applying 1-D lossless filter banks consecutively.Non-separable later banks are developed by expanding the 1-D ORT into 3-D one. In particular, the proposed ORT based 3-D non-separable filter banks generalizes the 3-D HINT(Hierarchical INTerpolation) algorithm.Through the experiment comparisons on various volumetric medical images, we prove that the proposedseparablefnon-separable filter banks perform better, in terms of compression ratio (first order entropy), than theother lossless compression techniques such as block based transform and conventional 3-D HINT.