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Rich Phase Separation Behavior of Biomolecules

  • Shin, Yongdae
    • Molecules and Cells
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    • v.45 no.1
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    • pp.6-15
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    • 2022
  • Phase separation is a thermodynamic process leading to the formation of compositionally distinct phases. For the past few years, numerous works have shown that biomolecular phase separation serves as biogenesis mechanisms of diverse intracellular condensates, and aberrant phase transitions are associated with disease states such as neurodegenerative diseases and cancers. Condensates exhibit rich phase behaviors including multiphase internal structuring, noise buffering, and compositional tunability. Recent studies have begun to uncover how a network of intermolecular interactions can give rise to various biophysical features of condensates. Here, we review phase behaviors of biomolecules, particularly with regard to regular solution models of binary and ternary mixtures. We discuss how these theoretical frameworks explain many aspects of the assembly, composition, and miscibility of diverse biomolecular phases, and highlight how a model-based approach can help elucidate the detailed thermodynamic principle for multicomponent intracellular phase separation.

Nonlinear finite element vibration analysis of functionally graded nanocomposite spherical shells reinforced with graphene platelets

  • Xiaojun Wu
    • Advances in nano research
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    • v.15 no.2
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    • pp.141-153
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    • 2023
  • The main objective of this paper is to develop the finite element study on the nonlinear free vibration of functionally graded nanocomposite spherical shells reinforced with graphene platelets under the first-order shear deformation shell theory and von Kármán nonlinear kinematic relations. The governing equations are presented by introducing the full asymmetric nonlinear strain-displacement relations followed by the constitutive relations and energy functional. The extended Halpin-Tsai model is utilized to specify the overall Young's modulus of the nanocomposite. Then, the finite element formulation is derived and the quadrilateral 8-node shell element is implemented for finite element discretization. The nonlinear sets of dynamic equations are solved by the use of the harmonic balance technique and iterative method to find the nonlinear frequency response. Several numerical examples are represented to highlight the impact of involved factors on the large-amplitude vibration responses of nanocomposite spherical shells. One of the main findings is that for some geometrical and material parameters, the fundamental vibrational mode shape is asymmetric and the axisymmetric formulation cannot be appropriately employed to model the nonlinear dynamic behavior of nanocomposite spherical shells.

REVIEW OF DIFFUSION MODELS: THEORY AND APPLICATIONS

  • HYUNGJIN CHUNG;HYELIN NAM;JONG CHUL YE
    • Journal of the Korean Society for Industrial and Applied Mathematics
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    • v.28 no.1
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    • pp.1-21
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    • 2024
  • This review comprehensively explores the evolution, theoretical underpinnings, variations, and applications of diffusion models. Originating as a generative framework, diffusion models have rapidly ascended to the forefront of machine learning research, owing to their exceptional capability, stability, and versatility. We dissect the core principles driving diffusion processes, elucidating their mathematical foundations and the mechanisms by which they iteratively refine noise into structured data. We highlight pivotal advancements and the integration of auxiliary techniques that have significantly enhanced their efficiency and stability. Variants such as bridges that broaden the applicability of diffusion models to wider domains are introduced. We put special emphasis on the ability of diffusion models as a crucial foundation model, with modalities ranging from image, 3D assets, and video. The role of diffusion models as a general foundation model leads to its versatility in many of the downstream tasks such as solving inverse problems and image editing. Through this review, we aim to provide a thorough and accessible compendium for both newcomers and seasoned researchers in the field.

Deep Learning-based Delinquent Taxpayer Prediction: A Scientific Administrative Approach

  • YongHyun Lee;Eunchan Kim
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.18 no.1
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    • pp.30-45
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    • 2024
  • This study introduces an effective method for predicting individual local tax delinquencies using prevalent machine learning and deep learning algorithms. The evaluation of credit risk holds great significance in the financial realm, impacting both companies and individuals. While credit risk prediction has been explored using statistical and machine learning techniques, their application to tax arrears prediction remains underexplored. We forecast individual local tax defaults in Republic of Korea using machine and deep learning algorithms, including convolutional neural networks (CNN), long short-term memory (LSTM), and sequence-to-sequence (seq2seq). Our model incorporates diverse credit and public information like loan history, delinquency records, credit card usage, and public taxation data, offering richer insights than prior studies. The results highlight the superior predictive accuracy of the CNN model. Anticipating local tax arrears more effectively could lead to efficient allocation of administrative resources. By leveraging advanced machine learning, this research offers a promising avenue for refining tax collection strategies and resource management.

Free vibration of tapered BFGM beams using an efficient shear deformable finite element model

  • Nguyen, Dinh Kien;Tran, Thi Thom
    • Steel and Composite Structures
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    • v.29 no.3
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    • pp.363-377
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    • 2018
  • An efficient and free of shear locking finite element model is developed and employed to study free vibration of tapered bidirectional functionally graded material (BFGM) beams. The beam material is assumed to be formed from four distinct constituent materials whose volume fraction continuously varies along the longitudinal and thickness directions by power-law functions. The finite element formulation based on the first-order shear deformation theory is derived by using hierarchical functions to interpolate the displacement field. In order to improve efficiency and accuracy of the formulation, the shear strain is constrained to constant and the exact variation of the cross-sectional profile is employed to compute the element stiffness and mass matrices. A comprehensive parametric study is carried out to highlight the influence of the material distribution, the taper and aspect ratios as well as the boundary conditions on the vibration characteristics. Numerical investigation reveals that the proposed model is efficient, and it is capable to evaluate the natural frequencies of BFGM beams by using a small number of the elements. It is also shown that the effect of the taper ratio on the fundamental frequency of the BFGM beams is significantly influenced by the boundary conditions. The present results are of benefit to optimum design of tapered FGM beam structures.

Comparative Evaluation of Surface Temperature among Rooftop Colors of Flat Roof Building Models : Towards Performance Evaluation of Cool Roof (평지붕 건물 축소모형의 지붕색에 대한 표면 온도의 비교평가: 쿨루프 성능평가 차원에서)

  • Ryu, Taek Hyoung;Um, Jung-Sup
    • KIEAE Journal
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    • v.13 no.6
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    • pp.83-91
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    • 2013
  • Cool roofs are currently being emerged as one of important mechanism to save energy in relation to the building. It is specifically proposed that the changing trends of rooftop surface temperature in the flat roof building model could be used effectively as an indicator to reduced cooling load reduced by cool roof since it can present stable temperature record, that is not influenced according to the nearby physical as well as human variables. The temperature of cool roof in summer was lower around $20^{\circ}C$, compared to the general roofs. Such a seasonal or daily comparative study for rooftop temperature in the building model will highlight that the cool roof efficiency could be calculated in much area-wide context according to rooftop color distribution in urban residential area. It is anticipated that this research output could be used as a valuable reference in identifying energy saving by cool roof since an objective monitoring has been proposed based on the rooftop temperature in the building model, fully quantitative performance of thermal infrared image.

Semantic Event Detection in Golf Video Using Hidden Markov Model (은닉 마코프 모델을 이용한 골프 비디오의 시멘틱 이벤트 검출)

  • Kim Cheon Seog;Choo Jin Ho;Bae Tae Meon;Jin Sung Ho;Ro Yong Man
    • Journal of Korea Multimedia Society
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    • v.7 no.11
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    • pp.1540-1549
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    • 2004
  • In this paper, we propose an algorithm to detect semantic events in golf video using Hidden Markov Model. The purpose of this paper is to identify and classify the golf events to facilitate highlight-based video indexing and summarization. In this paper we first define 4 semantic events, and then design HMM model with states made up of each event. We also use 10 multiple visual features based on MPEG-7 visual descriptors to acquire parameters of HMM for each event. Experimental results showed that the proposed algorithm provided reasonable detection performance for identifying a variety of golf events.

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Effects of coupled translational-torsional motion and eccentricity between centre of mass and centre of stiffness on wind-excited tall buildings

  • Thepmongkorn, S.;Kwok, K.C.S.
    • Wind and Structures
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    • v.5 no.1
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    • pp.61-80
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    • 2002
  • Wind tunnel aeroelastic model tests of the Commonwealth Advisory Aeronautical Research Council (CAARC) standard tall building were conducted using a three-degree-of-freedom base hinged aeroelastic(BHA) model. Experimental investigation into the effects of coupled translational-torsional motion, cross-wind/torsional frequency ratio and eccentricity between centre of mass and centre of stiffness on the wind-induced response characteristics and wind excitation mechanisms was carried out. The wind tunnel test results highlight the significant effects of coupled translational-torsional motion, and eccentricity between centre of mass and centre of stiffness, on both the normalised along-wind and cross-wind acceleration responses for reduced wind velocities ranging from 4 to 20. Coupled translational-torsional motion and eccentricity between centre of mass and centre of stiffness also have significant impacts on the amplitude-dependent effect caused by the vortex resonant process, and the transfer of vibrational energy between the along-wind and cross-wind directions. These resulted in either an increase or decrease of each response component, in particular at reduced wind velocities close to a critical value of 10. In addition, the contribution of vibrational energy from the torsional motion to the cross-wind response of the building model can be greatly amplified by the effect of resonance between the vortex shedding frequency and the torsional natural frequency of the building model.

Effects of Group Training Based on the Health Belief Model on Knowledge and Behavior Regarding the Pap Smear Test in Iranian Women: a Quasi-Experimental Study

  • Shobeiri, Fatemeh;Javad, Masoumeh Taravati;Parsa, Parisa;Roshanaei, Ghodratollah
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.6
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    • pp.2871-2876
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    • 2016
  • The Pap smear test is recommended for early diagnosis of cervical cancer. The aim of this study was to assess knowledge and behavior regarding the Pap smear test based on the Health Belief Model (HBM) in women referred to premarital counseling classes, Hamadan, Iran. This quasi-experimental study was conducted on 330 women, who were allocated randomly to two case and control groups (n=165). Two educational session classes were performed in the case group. Two stages in before and after intervention groups were evaluated. Analysis of data was performed by SPSS/16.0, using t-test, $x^2$, and McNemar's test. P-values <0.05 were regarded as significant. There was no significant difference between the mean scores of the various structures of this model in two groups before the intervention. However, after the intervention there were significant increase in mean score of knowledge and all variables of HBM in the intervention group(P<0.001). The findings of this study highlight the important role of education about cervical cancer on changing women's beliefs about cervical screening.

The Role of the Spatial Externalities of Irrigation on the Ricardian Model of Climate Change: Application to the Southwestern U.S. Counties

  • Bae, Jinwon;Dall'erba, Sandy
    • Asian Journal of Innovation and Policy
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    • v.10 no.2
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    • pp.212-235
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    • 2021
  • In spite of the increasing popularity of the Ricardian model for the study of the impact of climate change on agriculture, there has been few attempts to examine the role of interregional spillovers in this framework and all of them rely on geographical proximity-based weighting schemes. We remedy to this gap by focusing on the spatial externalities of surface water flow used for irrigation purposes and demonstrate that farmland value, the usual dependent variable used in the Ricardian framework, is a function of the climate variables experienced locally and in the upstream locations. This novel approach is tested empirically on a spatial panel model estimated across the counties of the Southwest USA over 1997-2012. This region is one of the driest in the country, hence its agriculture relies heavily on irrigated surface water. The results highlight how the weather conditions in upstream counties significantly affect downstream agriculture, thus the actual impact of climate change on agriculture and subsequent adaptation policies cannot overlook the streamflow network anymore.