• 생명과학회지
• /
• 제8권5호
• /
• pp.479-485
• /
• 1998

Xenopus 수정란의 동물극분리편에 IGF-1(Insulin-like Growth Factor-1)을 고농도로 처리해 주었을 때의 기관유도효과를 실험하였다. Activin A는 동물극 분리배양조직으로부터 다양한 기관을 분화시키며 이러한 효과는 처리 시간과 농도에 의존한다. 본 연구에서는 activin A 뿐만 아니라 IGF-1을 복합처리하여 특정 기관의 분화양상을 관찰하였다. Activin A는 100ng/ml 의 농도로, IGF-1은 0-500 ng/ml의 범위로 조합 처리하였다. 분리편은 정상배가 st. 43에 이를 때까지 배양하였으며, 이때 activin A를 100ng/ml의 고농도로 처리하면 조직이 파괴되는 것이 일반적이다. 그리고 신관의 발생에 대해서는 activin A와 retinoic acid의 복합처리가 매우 효과적인 방법으로 알려져 있으나, IGF-1의 첨가에 의해 신관을 비롯한 다른 조직들이 분화되었다. 또한, 눈의 분화는 activin A 1-100ng/m1와 IGF-1 500ng/ml의 농도범위에서 일어났다. Activin A의 저농도 (1ng/ml)처리에서는 혈구양세포가 분화하고 배양조직은 풍선처럼 부풀게되나 IGF-1의 첨가로 눈이 발생하게 되어 activin A상의 눈의 발생농도범위가 확대되었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권3호
• /
• pp.803-807
• /
• 2012

For patients with neck and upper thoracic esophageal carcinoma, it is difficult to control lymph node metastases with conventional dose therapy. In this study, we assessed the feasibility of simplified intensity-modulated radiotherapy (sIMRT) and concurrent chemotherapy for 44 patients and boosted high-dose to metastatic lymph nodes. Three radiation treatment volumes were defined: PGTVnd, with which 68.1Gy was delivered in high dose group (hsIMRT group), and 60Gy in the conventional dose group (csIMRT group); PTV1, featuring 63.9Gy in the hsIMRT group and 60Gy in the csIMRT group; PTV2, with 54Gy given to both groups. The sIMRT plan included 5 equi-angular coplanar beams. All patients received the cisplatin and 5-FU regimen concurrently with radiotherapy. The treatment was completed within six weeks and one case with grade three acute bronchitis was observed in hsIMRT group. For esophageal lesions, 80% complete response (CR) and 20% partial response (PR) rates were found in the hsIMRT group, and 79.2% CR, with 20.8% PR, in the csIMRT group; for lymph node lesions, 75% CR and 25% PR rates were observed in the hsIMRT group, with 45.8% and 37.5% respectively in the csIMRT group (P<0.05). The differences in 1-, 2- and 3-year relapse-free survival rates were all statistically significant (P<0.05). The major toxicity observed in both groups was Grade I~II leucopenia. sIMRT can generate a desirable dose distribution in treatment of neck and upper thoracic esophageal carcinoma with a better short-term efficacy. Boosted high dosing to metastatic lymph nodes can increase the relapse-free survival rate.

• Archives of Pharmacal Research
• /
• 제21권6호
• /
• pp.769-773
• /
• 1998

Brazilin was examined for its effects on the induction of immunological tolerance. Brazilin was administered to C57BL/6 female mice for 2 consecutive days before the immunization with high dose SRBC (109 cells) which can produce immunological tolerance. Delayed type hypersensitivity, IgM plaque forming cells, ConA induced IL-2 production and mitogen- or antigen-induced proliferation of lymphocytes were measured as evaluation parameters. Administration of brazilin prior to immunization could keep the DTH and IL-2 production almost optimaly immunized levels. Brazilin also inhibited the elevation of non-specific suppressor cell activity. ConA induced proliferation of splenocytes in high dose SRBC immunized mice was significantly decreased by pretreatment of brazilin. And this might be one of the reason for augmentation of DTH by brazilin. However, IgM plaque forming cells were not affected by the treatment of brazilin. These results indicate that brazilin prevents the induction of mmunological tolerance caused by high dose SRBC by suppressing the elevation of suppressor cell activity and by inhibiting the decrease in IL-2 production in C57BL/6 female mice.

• Radiation Oncology Journal
• /
• 제10권1호
• /
• pp.115-120
• /
• 1992

물팬톰내에 조사된 10 MV X-선의 심부율을 입자의 수송이론을 근거로 한 1차원적인 모델을 이용하여 계산하였다. 계산된 이론식의 매개상수는 9개로 줄일 수 있었으며 실측치를 이용하여 비선형 회귀분석 방법으로 얻을 수 있다. 조사면과 선원간의 거리 및 깊이에따른 3차원적인 흡수선량분포의 계산식은 고에너지 광자선이 조사된 물팬톰내에서의 Beam Profile에 대한 시도함수를 이용하여 수송이론에의한 심부율계산을 3차원적으로 확장하였으며 흡수 선량 분포는 3차원적 위치의 함수로 널리 계산할 수 있다. 이 모델을 사용하여 계산된 이론값은 실험값과 $\pm12\%$ 이내의 만족할만큼 잘 일치하였다.

• Journal of Yeungnam Medical Science
• /
• 제5권1호
• /
• pp.147-151
• /
• 1988

식도암 환자에서 외부 방사선 치료와 고 선량률 강내 치료를 병용하여 자각 증상의 호전은 물론 식도 촬영상에서도 좋은 반응을 보인 환자에서 장기간이 경과후에 발생한 식도 출혈과 식도 기관루를 경험하였기에 문헌 고찰도 함께 하였다

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 1993년도 추계학술대회 논문집
• /
• pp.80-84
• /
• 1993

In this research, we studied the variation of the dielectric loss absorption of the dielectric loss absorption of the sample according with the change to $\^$60/Co-${\gamma}$-ray irradiation dose of the influence of temperature and applied voltage. In order to investigate the effect of irradiation oriented polypropylene film, we have observed dissipation factor within the temperature range of 30∼130 [$^{\circ}C$] and voltage range of 100∼250$^{\circ}C$ [V]. As for the dependency of temperature by dissipation factor, the ${\alpha}$-peak which appears at high temperature increases accordingly to the increasement of irradiation dose which is contributed by the crystal region and moves towards the high temperature. The ${\beta}$-peak which appears at low temperature is origined from dipoles and molecular motions in the amorphous region. As for the dependency of voltage by tan$\delta$, at low temperature the peak of the tan$\delta$, at low temperature the peak of the tan$\delta$ shifts accordingly to the increasement of irradiation dose towards the high temperature region.

• Archives of Pharmacal Research
• /
• 제27권11호
• /
• pp.1154-1160
• /
• 2004

We investigated the neurotoxic effects of capsaicin (CAP) on pain sensitivity and on the expression of capsaicin receptor, the vanilloid receptor (VR1), in rats. High-dose application of CAP has been known to degenerate a large fraction of the sensory neurons. Although the neurotoxic effects of CAP are well documented, the effects of CAP on the vanilloid receptor (VR1) are not yet known. In this paper, we investigated the effects of high-dose application of CAP on the expression of VR1 in rats. Thermal and mechanical pain sensitivity was reduced when neonatal rats were treated with a high dose of CAP. This reduction of pain sensitivity was significantly decreased after initiating carrageenan-induced inflammation. The expression of VR1 in dorsal root ganglia (DRG) isolated from the CAP-treated rats was reduced compared to that from the vehicle-treated rats. Therefore, we can conclude that the neurotoxic effect of CAP is related to the decrease of VR1 expression.

• Journal of Yeungnam Medical Science
• /
• 제29권2호
• /
• pp.129-131
• /
• 2012

A 70-year-old male came to the emergency room of the authors' hospital because of sudden cardiac arrest due to inferior wall ST elevation myocardial infarction. His coronary angiography revealed multiple severe coronary spasms in his very long left anterior descending artery. After an injection of intracoronary nitroglycerine, his stenosis improved. The cardiac arrest relapsed, however, accompanied by ST elevation of the inferior leads, while the patient was on diltiazem and nitrate medication to prevent coronary spasm. Recovery was not achieved even with cardiac massage, intravenous injection of epinephrine and atropine, and intravenous infusion of nitroglycerine. The patient eventually recovered through high-dose nicorandil intravenous infusion without ST elevation of his inferior leads. Therefore, intravenous infusion of a high dose of nicorandil must be considered a treatment option for cardiac arrest caused by refractory coronary vasospasm.

• Child Health Nursing Research
• /
• 제11권4호
• /
• pp.456-464
• /
• 2005

Purpose: To determine the effects of hand massage on nausea and vomiting, and anxiety in children with Iymphocytic leukemia receiving high dose chemotherapy. Method: The children were assigned to an experimental group(15) or a control group(15). All of the children were diagnosed with acute Iymphocytic leukemia and admitted for high dose chemotherapy at C University Medical Center in Seoul. The hand massage was performed for 10 minutes twice a day over three days. To measure the effects of hand massage, the Index of Nausea and Vomiting by Rhodes et al. and the State-Trait Anxiety Inventory for children by Spielberger were used. The level of anxiety was measured by systolic blood pressure, diastolic blood pressure, and pulse rate. Results: The score for nausea and vomiting decreased in the experimental group. State anxiety for the experimental group was significantly more positive than for the control group at the 2nd measurement. There was a significant difference in systolic blood pressure between the two groups. The level of diastolic blood pressure in the two groups decreased significantly over time. Conclusion: Hand massage could be effective in decreasing nausea and vomiting, state anxiety, pulse rate and blood pressure in children with acute leukemia receiving high dose chemotherapy.

• 대한방사선치료학회지
• /
• 제10권1호
• /
• pp.30-44
• /
• 1998

Accurate delivery of doses using a high dose rate(HDR) brachytherapy, remote afterloading system(RALS) depends on knowing the strength of the radioactive source at the time of treatment, the precision and consistency of the timer, and the ability of the unit to position the source at the proper dwell location along the applicator. Periodic Quality Assurance(QA) on HDR machines is a part of the standard protocol of any user. The safety of the patient & staff, positional accuracy, temporal accuracy, and dose delivery accuracy are periodically(weekly, quarterly, monthly) estimated using HDR source(Ir-192), treatment planning devices, measurement devices, and overall treatment devices with regard to treatment delivery. The overall measurement results are estimated successfully and assessed its clinical significance. As a result, our HDR brachytherapy units has been very accurate until now. The QA program protocol permits routine clinical use and provides a high confidence level in the accurate operation of HDR units. Therefore, regular QA of HDR brachytherapy is essential for successful treatment.