• Korean Circulation Journal
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• v.53 no.5
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• pp.273-293
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• 2023

Pulsed field ablation (PFA) was recently rediscovered as an emerging treatment modality for the ablation of cardiac arrhythmias. Ultra-short high voltage pulses are leading to irreversible electroporation of cardiac cells subsequently resulting in cell death. Current literature of PFA for pulmonary vein isolation (PVI) consistently reported excellent acute and long-term efficacy along with a very low adverse event rate. The undeniable benefit of the novel ablation technique is that cardiac cells are more susceptible to electrical fields whereas surrounding structures such as the pulmonary veins, the phrenic nerve or the esophagus are not, or if at all, minimally affected, which results in a favorable safety profile that is expected to be superior to the current standard of care without compromising efficacy. Nevertheless, the exact mechanisms of electroporation are not yet entirely understood on a cellular basis and pulsed electrical field protocols of different manufactures are not comparable among one another and require their own validation for each indication. Importantly, randomized controlled trials and comparative data to current standard of care modalities, such as radiofrequency- or cryoballoon ablation, are still missing. This review focuses on the "pearls" and "pitfalls" of PFA, a technology that has the potential to become the future leading energy source for PVI and beyond.

• Biomedical Science Letters
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• v.10 no.4
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• pp.361-366
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• 2004

The purpose of this study was to determine the effect of high voltage pulsed current (HVPC) stimulation on proliferative activities of basal keratinocytes by measured nucleolar organizer region (NOR) expression and thickness of spinous layer in aged rat skin. Fifty-one weeks old twelve male Sprague-Dawley rats (300∼350g) were divided into control and HVPC stimulation groups. Each animal's hair on the back were removed. The HVPC stimulation group received an negative monophasic twin peak pulsed current stimulation with 50 V, while the control group was given the same treatment without electricity. The rats were sacrificed after 3 weeks. The biopsy specimens were fixed in formalin, embedded in paraffin and stained with hematoxyline-eosin and silver nitrate. The thickness of basal to granular layer of the epidennis were measured using a light microscope and computerized image analysis system. The number of argyrophilic nucleolar organizer region (AgNOR) were counted using a light microscope and computerized image analysis system and calculated as the mean number of AgNOR per nucleus in the basal keratinocyte. By using a Student's t-test, an increase in the thickness of basal-spinous layer (P<0.001) of epidermis can be observed in HVPC stimulation rats as compared with the control rats, whereas the thickness of the granular layer is not affected. A Student's t-test showed a significantly higher mean NOR number per nucleus of the basal keratinocyte in the HVPC stimulation rats than control rats (P<0.001). There was significantly positive correlation between the NOR number and the thickness of basal-spinous layer (r=0.80, P<0.05). These results suggest that the HVPC stimulation may increase the thickness of spinous layer in the epidennis due to increased proliferative activities of basal keratinocytes in epidennis in aged rat skin.

• Proceedings of the KIPE Conference
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• 1998.07a
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• pp.162-165
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• 1998

The non-thermal pasteurization of foods using High Voltage High Current Pulsed Electric Fields (HVHC-PEF) is a promising technology and a sound complement or replacement to traditional thermal pasteurization. The conventional thermal method also inactivates bacteria and other microorganisms harmful to humans, but degrades natural color, flavor, texture and nutrients. At this point, a nonthermal pasteurization technique, HVPEF is thought to be a new processing technique which is able to produce a good quality foods nutritional as well as sensuous. In this paper, the system for HVHC-PEF pasteurization is presented. It use square wave pulse instead of exponential ones. So, power rating of system is reduced considerably. Design considerations for 20kV 500A class equipment are analyzed and experimental results are discussed.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.28 no.1
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• pp.1-8
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• 2014

The conventional Three-Stage electronic ballast is stable, but Two-Stage electronic ballast has been researching because of efficiency. Three-Stage electronic ballast is consisted of PFC circuit, buck converter, and inverter circuit, but Two-stage is consisted of PFC circuit, Buck-Inverter full bridge circuit. The Buck-Inverter full bridge inverter consists of two half bridge inverters for low frequency switching, and high frequency switching. In the case of street lamp it is far from a lamp to a ballast, the conventional pulsed high voltage ignitor can not turn on the HID lamps because of reduction of ignition voltage. Therefore, it needs to do the research on a resonant ignition to turn on the HID lamps. Therefore, in the Two-Stage electronic ballast which has the resonant tank for ignition, the transient resonant current because of low frequency changing is analyzed, the novel algorithm is proposed to resuce the transient current.

• Proceedings of the KIEE Conference
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• 1996.07c
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• pp.1910-1912
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• 1996

This paper presents the results of laboratory experimentals to remove $SO_2$ and $NO_x$ by a pulsed corona discharge in the wire-plate reactor. A rotating spark gap switch was used to generate the pulse by chewing the dc high voltage. Repetition frequency of the pulse was 60Hz and rising time of 50ns. The photo pictures of positive streamer corona taken by ICCD camera, pulse voltage and current were measured using a digital oscilloscope. Simultaneous effects of $C_{2}H_{4}$ injection and heterogeneous chemical reactions on nonthermal plasma process to remove $SO_2$ and $NO_x$ from flue gas were investigated in the present study

• Physical Therapy Korea
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• v.13 no.3
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• pp.33-40
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• 2006

The purpose of this study was to assess the effects of High-Voltage Pulsed Current (HVPC) and ultrasound on adjuvant-induced arthritis in rats. Adjuvant arthritis was induced in female Sprauge-Dawley rats by the subcutaneous injection of a single dose of $.1m{\ell}$ of Complete Freund's Adjuvant (CFA) (1 mg of Mycobacterium Butyricum suspended in $.1m{\ell}$ paraffin oil) into the right hind paw. A randomized, parallel-groups design of 24 subjects was used. All rats were randomly assigned to control (n=8), ultrasound (n=8), and HVPC (n=8) were compared with those of injured rats. The rats in the pulsed ultrasound group were treated at 1 MHz frequency with $.5W/cm^2$ intensity in 1:4 mode for 5 minutes per day. The rats in the HVPC group were treated at 120 pulses per second and $50{\mu}s$ phase duration, 20 mA intensity for 30 min per day. Treatment was done in the left and right hind limb for 2 weeks. We evaluated clinical, radiographic, hematologic and histopathologic findings before and after treatment and obtained the following results. 1. Edema of the right hind paw was more significantly reduced in the ultrasound and HVPC groups than the control group on days 9, 12, and 14 (p<.05). Edema of the left hind paw was more significantly reduced in ultrasound and HVPC groups than the control group on days 12, 14 (p<.05). 2. WBC counts of the ultrasound and HVPC groups as compared with the control group were becoming remarkably decreased after the treatment. 3. In radiologic findings, arthritis formation was seen according to the score of arthritis, which was the highest in the control group, upon the observation of radiographs of the left and right hind paws. However, no statistically significant difference was present in the score within three groups. 4. In the histopathologic findings, ultrasound and HVPC groups had effectively suppressed erosions of articular cartilage and inflammatory cell infiltrations. Therefore, the results of the study show that rats that were treated with the ultrasound and HVPC effectively suppressed adjuvant arthritis. However, no statistically significant difference was present between the ultrasound group and the HVPC group.

• Journal of the Korean Society of Industry Convergence
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• v.4 no.3
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• pp.311-318
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• 2001

The application of a pulsed power system is being extended to a environmental and industrial fields. The non-dissolution waste water pollutants from industrial plants can be processed by applying high voltage pulses with a fast rising time (a few nanoseconds) and short duration (nano to microseconds) in a pulsed corona discharge reactor. The nano-pulse generator with a magnetic switch has been developed. Its corona current in load can be adjusted by pulse width and repetition rate. we investigated the performance of the nano-pulse generator using the dummy load which is composed of resistor and capacitor equivalent to the actual reactor. This paper descibes the electrical characteristics of the nano-pulse generator that produces a 300 ns pulse at maximum repetition rate of 400 pps with a voltage of 40 kV across a $640{\Omega}$ load. In this paper we briefly discuss a configuration of system and test results.

• Korean Journal of Materials Research
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• v.30 no.7
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• pp.333-337
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• 2020

Orthorhombic DyMnO₃ films are fabricated epitaxially on Nb-1.0 wt%-doped SrTiO₃ single crystal substrates using pulsed laser deposition technique. The structure of the deposited DyMnO₃ films is studied by X-ray diffraction, and the epitaxial relationship between the film and the substrate is determined. The electrical transport properties reveal the diodelike rectifying behaviors in the all-perovskite oxide junctions over a wide temperature range (100 ~ 340 K). The forward current is exponentially related to the forward bias voltage, and the extracted ideality factors show distinct transport mechanisms in high and low positive regions. The leakage current increases with increasing reverse bias voltage, and the breakdown voltage decreases with decrease temperature, a consequence of tunneling effects because the leakage current at low temperature is larger than that at high temperature. The determined built-in potentials are 0.37 V in the low bias region, and 0.11 V in the high bias region, respectively. The results show the importance of temperature and applied bias in determining the electrical transport characteristics of all-perovskite oxide heterostructures.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 1996.11a
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• pp.104-108
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• 1996

This paper deals with the design considerations and characteristics analysis of a SCR rectifier in pulsed over load operation. The Pulse repetition rate is one every 150 seconds and each current pulse width is 10 seconds. Therefore the characteristics of the transformer and SCR rectifier which consist the pulsed DC power supply are different from those of the conventional AC/DC power converters having continuous load. The variations of the DC output voltage drop, PF and THD versus the %Z of the transformer is analyzed through simulations and the experimental results thought to be useful in design high power pulsed DC power suppler.

• Proceedings of the KIPE Conference
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• 2020.08a
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• pp.230-232
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• 2020

식품을 보다 신선하고 오래 보관하기 위하여 처리 및 보존에 관한 여러 방법들이 연구되고 있다. 특히 열에 민감한 유제품 또는 액체 식품들에 대하여 열을 가하지 않는 비열처리 방식의 기술들이 연구되고 있다. 그 중 식품 내 미생물의 활성화와 고유한 속성의 변화를 최소화하는 방법으로 Pulsed Electric Field 방식에 대한 연구가 활발히 진행되고 있다. 하지만 해당방식은 기존의 열처리 방식에 비해 경제적인 면에서 단점을 가지고 있다. 이에 본 논문에서는 기존 Pulsed Electric Filed 방식의 효율을 높이고 비용을 저감할 수 있는 회로를 제안한다. 전압제어 방식의 DC/DC Power stage 부를 전류제어 방식으로 바꾸어 기존 회로의 Charging resistor를 사용하지 않음으로써 전력손실을 줄이고 비용 및 전기요금을 줄이고자 하였다. 본 논문에서는 시뮬레이션을 통해 제안회로를 검증하였다.