• Journal of Preventive Medicine and Public Health
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• 제38권2호
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• pp.175-181
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• 2005

Objectives: This study estimated the burden of disease due to high alcohol consumption using DALY, a composite indicator recently developed by the Global Burden of Disease study group. The results were analyzed by age and sex. Methods: Firstly, high alcohol consumption-related diseases, and their relative risk (RR), were selected. Secondly, population attributable fractions (PAFs) were computed using formulae, including the relative risk (RR) and prevalence of exposure (Pe). Thirdly, the DALYs of high alcohol consumption-related diseases were estimated. Lastly, the attributable burdens of diseases due to high alcohol consumption wereconcluded as being the sum of the products that multiplied the DALYs of high alcohol consumption-related diseases by their population attributable fraction (PAF). Results : The burden of high alcohol consumption in Korea was 2992.3 person years (PYs) per 100,000 persons in men, and 1426.6 in women. For men, the high alcohol consumption-induced diseases with the five biggest burdens were liver cirrhosis, hypertensive disease, liver cancer, cerebral infarction and intracerebral hemorrhage. For women, these were cerebral infarction, intracerebral hemorrhage, hypertensive disease, liver cirrhosis and liver cancer. Conclusion: This study highlighted the attributable fraction of diseases due to exposure to high alcohol consumption, by quantifying the results of exposure to risk factors. Therefore, it is now possible to assess interventions for risk factors in quantifiable terms in each population. Finally, measuring the risk factor burdens was expected to contribute to priority setting and effective resource allocation in public health policy.

• The Journal of Asian Finance, Economics and Business
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• 제10권1호
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• pp.133-143
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• 2023

The detrimental impacts of financial instability on the world economy during the financial crisis highlighted the requirement to understand the existing financial circumstances. Stability and developments in financial conditions are important for economic prosperity. This study analyses the impact of geopolitical risk on the economic conditions of some specific emerging economies using monthly data from January 1999 to September 2016 by applying a fixed-effects panel data model. The estimation results demonstrated that geopolitical risk has a significant, negative impact on financial conditions. It shows geopolitical risk could be seen as a key factor that contributes towards financial conditions. Further, it implies that negative shocks of high geopolitical risk experienced by emerging economies are one of the primary reasons for the financial conditions' deterioration. The findings provide important insights for governments, policymakers, and investors. For instance, governments and politicians should refrain from expressing or producing tension, economic discomfort, or news that is likely to increase a high geopolitical risk. Maintaining a close eye on geopolitical risk and its sources may also help to stabilize financial conditions and develop a well-functioning financial system. As a result, investors would be better informed about an economy's economic and financial conditions, allowing them to diversify their international portfolios and devise investing strategies during uncertain economic times.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제41권2호
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• pp.59-65
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• 2015

The extraction of third molars is a common task carried out at dental/surgery clinics. Postoperative pain is one of the two most common complications of this surgery, along with dry socket. Knowledge of the frequent risk factors of this complication is useful in determining high-risk patients, planning treatment, and preparing the patients mentally. Since the risk factors for postoperative pain have never been summarized before while the risk factors for dry socket have been highly debated, this report summarizes the literature regarding the common predictors of postextraction pain. Except for surgical difficulty and the surgeon's experience, the influences of other risk factors (age, gender and oral contraceptive use) were rather inconclusive. The case of a female gender or oral contraceptive effect might mainly be associated with estrogen levels (when it comes to dry socket), which can differ considerably from case to case. Improvement in and unification of statistical and diagnostic methods seem necessary. In addition, each risk factor was actually a combination of various independent variables, which should instead be targeted in more comprehensive studies.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4725-4732
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• 2012

Aim: The incidence of stomach cancer in Mizoram is highest in India. We have conducted a population based matched case-control study to identify environmental and genetic risk factors in this geographical area. Methods: A total of 102 histologically confirmed stomach cancer cases and 204 matched healthy population controls were recruited. GSTM1 and GSTT1 genotypes were determined by PCR and H. pylori infections were determined by ELISA. Results: Tobacco-smoking was found to be an important risk factor for high incidence of stomach cancer in Mizoram. Meiziol (local cigarette) smoking was a more important risk factor than other tobacco related habits. Cigarette, tuibur (tobacco smoke infused water) and betel nut consumption synergistically increased the risk of stomach cancer. Polymorphisms of GSTM1 and GSTT1 genes were not found to be directly associated with stomach cancer in Mizoram. However, they appeared to be effect modifiers. Persons habituated with tobacco smoking and/or tuibur habit had increased risk of stomach cancer if they carried the GSTM1 null genotype and GSTT1 non-null genotype. Conclusion: Tobacco smoking, especially meiziol is the important risk factor for stomach cancer in Mizoram. GSTM1 and GSTT1 genes modify the effect of tobacco habits. This study is a first step in understanding the epidemiology of stomach cancer in Mizoram, India.

• 한국학교보건학회지
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• 제36권2호
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• pp.52-61
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• 2023

Purpose: The purpose of the study was to compare the characteristics between adolescents who have run away from home before and who have contemplated running away from home before, and to find risk factors that predict runaway behavior among them. Methods: The data of 「the survey on adolescents' right to adequate housing and the way to ensure their housing with the focus on social exclusion」 by the National Youth Policy Institute (2020) were analyzed. A total of 494 adolescents were included in the study. Descriptive statistics, x2 test, t-test, and simple and multiple logistic regressions were carried out using SAS 9.2. Results: Gender, depression, anxiety, self-esteem, and school level were significantly different between the two groups. From the multivariate analysis, the adjusted odds ratio for runaway behavior was significantly higher in male students (AOR: 2.14, p<.001), lower in the middle economic class than in the high economic class (AOR: 0.64, p=.051), lower in the 4th quartile group of self-esteem (AOR: 0.52, p=.041), and higher in high school students (AOR: 1.55, p=.050). Conclusion: Considering that male students, students from wealthier families, students with low self-esteem, and high school students are high-risk groups for runaway behavior, among adolescents who have contemplated running away before, interventions targeting these groups are needed.

• 한국재난정보학회 논문집
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• 제19권3호
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• pp.719-728
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• 2023

연구목적: 이동식크레인은 높은 사망률에 기여하는 기계로 최근 6년간(2016~2021) 사고사망사례 중 건설업 2,574건을 분석한 고위험요인(SIF)정보에서 이동식크레인의 사고는 총 61건의 재해가 발생하였다. 현장의 안전대책에도 불구하고 제대로 활용이 안되고 있다. 본 연구에서는 표준 리스크 평가 지수를 제시하여 사고예방에 기여하고자 한다. 연구방법: 전문가 면담과 사망사고 사례분석, 현장실태분석, 문헌조사를 통해 위험성평가의 4M방식의 표준 리스크 평가 지수 방법을 제시하고자 한다. 연구결과: 현장 8개현장 위험성평가를 분석한 결과 재해예방에 실질적인 기여를 할 수 없다는 결론을 얻었으며, 표준 리스크 평가 지수 방식의 개선방안으로 적용하여야 한다. 결론: 건설현장에서 표준 리스크 평가 지수방식으로 전환함으로써 안전보건관계자 및 근로자가 쉽게 이용할 수 있고 재해감소에 기여할 수 있을 것으로 제안한다.

• Clinical and Experimental Pediatrics
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• 제58권3호
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• pp.84-88
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• 2015

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children, and can result in coronary artery lesions (CAL). A patient with KD who is resistant to treatment with intravenous immunoglobulin (IVIG) has a higher risk of developing CAL. Incomplete KD has increased in prevalence in recent years, and is another risk factor for the development of CAL. Although the pathogenesis of KD remains unclear, there has been increasing evidence for the role of genetic susceptibility to the disease since it was discovered in 1967. We retrospectively reviewed previous genetic research for known susceptibility genes in the pathogenesis of KD, IVIG resistance, and the development of CAL. This review revealed numerous potential susceptibility genes including genetic polymorphisms of ITPKC, CASP3, the transforming growth factor-${\beta}$ signaling pathway, B lymphoid tyrosine kinase, FCGR2A, KCNN2, and other genes, an imbalance of Th17/Treg, and a range of suggested future treatment options. The results of genetic research may improve our understanding of the pathogenesis of KD, and aid in the discovery of new treatment modalities for high-risk patients with KD.

• The Journal of Advanced Prosthodontics
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• 제3권1호
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• pp.25-32
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• 2011

PURPOSE. The purpose of this study was to assess the prevalence and extent of clinical attachment loss of periodontal tissue and to find out variables related to clinical attachment loss (CAL) in Korean adults older than 40 years of age. MATERIALS AND METHODS. Data were collected from 2,519 subjects who were part of a cohort study conducted in Ansan city by Korea University Medical School for Korean Genome project. Age, sex, smoking, drinking, fast glucose, blood pressure, obesity and total cholesterol levels were examined. The oral examination included probing pocket depth, gingival recession and CAL of Ramford's teeth. The severity of periodontitis was classified based on the mean value of CAL. The relationship between each risk factor and the severity of CAL was independently estimated using the chi-square test, the test or one-way ANOVA. Multiple regression analysis was used to determine the significance of each factor in the periodontal disease. RESULTS. The prevalences of clinical attachment between 1 and 3 mm, between 3 and < 5 mm, and ${\geq}$ 5 mm were 80.27%, 16.75% and < 1%, respectively. Although the univariate analysis showed age, gender, smoking, fasting glucose, blood pressure and total cholesterol levels were significantly related to the severity of CAL, multiple regression analysis indicated that age (P < .0001), gender (P < .0001) and smoking (P < .05) were only significantly related. CONCLUSION. Older age, male gender and smoking were significant risk factor for the increase of CAL, and these may be useful indicators of periodontitis high-risk groups.

• 한국컴퓨터정보학회논문지
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• 제17권10호
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• pp.175-183
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• 2012

본 연구는 다문화가정 청소년을 대상으로 위험요인과 보호요인이 학교적응유연성에 어떠한 영향을 미치는지 또한, 어떤 보호요인이 위험요인을 조절하여 학교적응유연성에 긍정적인 영향을 미치는지를 검증하였다. 연구결과 위험요인은 학교적응유연성에 부(－)적인 영향을, 보호요인은 정(+)적인 영향을 미치는 것으로 나타났으며, 높은 자존감은 부정적 양육태도를, 긍정적 태도는 부정적 양육태도와 부부갈등을, 교사지지는 부정적 양육태도를 조절하여 통계적 유의수준 하에서 학교적응유연성을 높이는 것으로 나타났다. 연구의 시사점으로 위험요인과 보호요인의 조절관계를 토대로 다문화가정 청소년의 학교적응유연성을 높이기 위한 위험요인 감소 방안을 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3083-3088
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• 2012

We investigated the prognostic value of pituitary tumor transforming gene 1 (PTTG1) expression according to clinicopathological features among localized or locally advanced prostate cancer cases receiving hormone therapy. A retrospective study involved 64 patients receiving combined androgen blockade treatment was performed. PTTG1 expression was determined by immunohistochemical staining using initial needle biopsy specimens for diagnosis. Associations of PTTG1 with various clinicopathological features and disease-free survival were examined via uni- and multivariate analyses. No association between PTTG1 expression and clinical T stage, Gleason score, pretreatment PSA levels, risk groups was found (p =0.682, 0.184, 0.487, 0.571, respectively). Univariate analysis revealed that increased PTTG1 expression, T3 stage and high risk group were associated with increased risk of disease progression (p =0.000, 0.042, and 0.001), and high PSA level had a tendency to predict disease progression (p =0.056). Cox hazard ratio analysis showed that PTTG1 low expression (p =0.002), PTTG1 high expression (p =0.000) and high risk group (p =0.0147) were significantly related to decreased disease-free survival. In conclusion, PTTG1 expression determined by immunohistochemical staining in needle biopsy specimens for diagnosis is a negative prognostic factor for progression in localized or locally advanced prostate cancer receiving hormone therapy.